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Joint UCD CASL-ACAM-Physics Seminar

Title: "Conformational Transitions of Nucleic Acids under External Forces: Examples and a Stochastic Path Integral Theory for their Kinetics"

Speaker: Prof. Ioan Andricioaei, School of Physical Sciences, University of California, Irvine

Date: Thursday, April 28th, at 3:00pm

Location: CASL Seminar Room, ground floor

Abstract:

I will present molecular dynamics simulations of several examples of conformational transitions that nucleic acids and their complexes undergo upon the application of external forces and/or torques: (1) DNA supercoil relaxation by topoisomerases, (2) the condensation of DNA by  dendrimers and, time permitting, (3) RNA unfolding. Then I will showcase the use of the formalism of stochastic path integrals to deduce the kinetics of these transitions, from simulation trajectories or experimental single molecule recordings of the transition, under other conditions that those that are actually simulated or recorded.
URL: http://www.chem.uci.edu/faculty/andricio