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Publication from CBNI researchers featured in Nanowerk Spotlight - Effects of the Presence or Absence of a Protein Corona on Silica Nanoparticle Uptake and Impact on Cells

Tuesday, 24 July 2012

The cellular response to nanomaterials depends on the environment

(Nanowerk Spotlight) Understanding and controlling the interaction of nanomaterials with the human body is vital for the safe and effective development of nanotechnology. The overall response of the body to a nanomaterial results from a series of cell-nanomaterial interactions. In studying cell-nanomaterial interactions, researchers often assume that the form that a nanomaterial takes when it comes into contact with a cell is the same as the form it had following synthesis. This is not always a valid assumption. Following synthesis, many nanomaterials have high surface energies. When such a nanomaterial enters a physiological environment, it attempts to lower its surface energy by adsorbing surrounding biomolecules including proteins, lipids, small molecules, saccharides, and nucleic acids. Provided the adsorbed biomolecules are retained, they define a new interface between the nanomaterial and its surroundings. It is this interface that mediates subsequent cellular association and response.

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The cellular response to nanomaterials depends on the environment