Tiziana Tenuta
joined the Centre for BioNano Interactions as a PhD Student in November 2006. Her research involves the synthesis, detailed characterisation and study of smart nano- and micro-particles at quasi constant hydrophobicity, based on N-isopropylacrylamide / N-tert-butylacrylamide. Positive and negative charges are introduced using increasing amounts of acrylic acid or DMAPA in order to control the different absorption of proteins on the nanoparticles surface (Protein Corona). This synthetic procedure requires skills in handling chemical compounds as well as the control of each thermodynamic variable as a function of time.
Tiziana is undertaking the complete physical characterization of the synthesized nanoparticles at different temperatures using Photon Correlation Spectroscopy, Nanosight LM10 Nanoparticle Analysis System, Zeta Potential and Circular Dichroism Spectroscopy. The characterization is carried out in water, buffer, and in cell media (10% Foetal Calf Serum (FCS)) which are solutions of increasing complexity and biological relevance. Tiziana’s research involves also the drug loading of the synthesized nanoparticles to deliver drugs into human cells in a specific location (Nanomedicine).
Tiziana is a member of the Italian National Chemical Association and a member of the Regional Chemical Association of Calabria. She graduated in 2002 with a degree in Chemistry from the University of Calabria - Cosenza- Italy. She also worked in the Valle Crati Company as Technical Assistant for Monitoring Atmospheric Chemical Pollution: suspended particulate, total and non methane hydrocarbon, ozone, benzene, toluene, ethyl benzene, o-m-p xylene, sulfur dioxide, nitrogen oxide, carbon monoxide
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