Research
- Novel nanoparticle synthesis, functionalisation and dispersion
- Bionanoparticle in-situ: protein (biomolecule) corona
- Bionanoparticle Imaging in cells and tissue
- Functional Impacts of Nanoparticles
- High Throughput Approaches
- Nanoparticle Interactions in the Environment
- Nanoparticle Interactions with the Brain
- Theory and Computation
- Publications
Bionanoparticle in-situ: protein (biomolecule) corona
Understanding the “biological identity” of nanomaterials, or what is actually presented to cells and living systems is crucial to the success of nanomedicine and nanosafety. The first evidence is emerging in the literature of protein-corona-induced functional impacts, which also suggests that correlating the physico-chemical nature of nanoparticles with the identity, quantity and confirmation of proteins bound to the nanoparticles will, in future, enable prediction of protein coronas (and eventually functional impacts) via quantitative structure-activity relationships (QSARs).
The research in CBNI aims to develop approaches to study nanoparticle coronas in situ, and methods to recover intact coronas from cells, tissues etc. This research strand is central to several others, including visualisation and uptake and interaction of NPs with biological barriers and the environment. The central premise is that the protein (biomolecule) corona determines the uptake, transport, final localisation and functional impacts (fate & behaviour) of nanoparticles.
- BioNanoInteract
- INSPIRE
- EU FP7 3MiCRON
- Dr. Marco Monopoli
- Dr. Francesca Baldelli Bombelli
- Mr. Andrzej Pitek
- Ms. Dorota Walczyk
Walczyk, D., Bombelli, F.B., Monopoli, M.P., Lynch, I., Dawson, K.A. What the cell "sees" in bionanoscience. J. Am. Chem. Soc. 2010, 132, 5761-5768.
Hellstrand, E., Lynch, I., Andersson, A., Drakenberg, T., Dahlbäck, B., Dawson, K.A., Linse, S., Cedervall, T. Complete high-density lipoproteins in nanoparticle corona. FEBS J. 2009, 276, 3372-3381.
Lundqvist, M., Stigler, J., Cedervall, T., Elia, G., Lynch I., Dawson K. Nanoparticle Size and Surface Properties determine the Protein Corona with possible implications for Biological Impacts. PNAS, 2008, 105, 14265-14270.