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Bionanoparticle in-situ: protein (biomolecule) corona

Understanding the “biological identity” of nanomaterials, or what is actually presented to cells and living systems is crucial to the success of nanomedicine and nanosafety.  The first evidence is emerging in the literature of protein-corona-induced functional impacts, which also suggests that correlating the physico-chemical nature of nanoparticles with the identity, quantity and confirmation of proteins bound to the nanoparticles will, in future, enable prediction of protein coronas (and eventually functional impacts) via quantitative structure-activity relationships (QSARs).

The research in CBNI aims to develop approaches to study nanoparticle coronas in situ, and methods to recover intact coronas from cells, tissues etc.  This research strand is central to several others, including visualisation and uptake and interaction of NPs with biological barriers and the environment.  The central premise is that the protein (biomolecule) corona determines the uptake, transport, final localisation and functional impacts (fate & behaviour) of nanoparticles.