Science Foundation Ireland (SFI) Principal Investigator, UCD Charles Institute of Dermatology
Systems Biology Ireland (SBI), UCD School of Medicine
Quantitative and Systems Analysis of (Patho)Physiological Signaling Networks
Network-centric approaches to drug development and cancer treatment have become essential in recent years. However, the function and biological output of signal transduction networks (STN) is context-dependent. My group will study how STN relevant in colon cancer are context- and tissues-specific quantitatively modulated in (patho)physiologically-relevant primary cells and organoids. We will study how STN control cellular phenotypes by investigating how they generate cell type-specific vs. -general functions, and how cancer mutations affect these interactions and outputs. Using protein engineering, we will generate mutations that rewire cancer-relevant STN in a designed fashion. This approach may provide better mechanism-driven diagnostics and treatments.
Colon cancer | 3D tissue models | protein engineering | CRISPR-Cas9 | network rewiring | core signaling pathways