Professor in Dermatology, UCD School of Medicine
Neuroimmunology of skin diseases: a translational approach
The task of my research is to understand the cross-communication between two important body systems: the nervous and immune systems and, in particular, the role of the sensory nervous system in skin inflammation (atopic dermatitis, rosacea) and itch (pruritus). References: Steinhoff M et al. Nature Med 2000; J Neurosci 2003; Seeliger S et al. FASEB J 2003; Am J Pathol 2010; Frateschi S et al. Nature Comm 2011; Liu et al. Science Sig 2011
As a clinical dermatologist as well as a basic scientist by training (DMSc, PhD in Human biology), I aim to understand the molecular mechanisms that control skin inflammation and itch or pain with a focus on neuronal cytokine receptors, proteases and neuropeptide receptors. Itch or pruritus, is a significant unmet need, and recent publications about this subject in journals such as Cell, Science, Nature and Journal of Clinical Investigation document the importance of understanding the molecular mechanisms of pruritus.
Clinical: Complex general dermatology, atopic dermatitis, pruritus/itch; rosacea/acne; wound healing (2003-2009); dermatological oncology (1999-2006); sclerotherapy and foam sclerozation therapy (2003-09), translation of genomics from basic science to clinic, translational medicine.
Basic science: Neuroimmunology, inflammation, pruritus, G protein-coupled receptor signalling, neuropeptide receptors, protease-activated receptors, transient receptor potential (TRP) ion channels, peptidases; non-melanoma skin cancer, cytokine receptors, signal transduction, genomics, confocal laser scan microscopy.
Prof Steinhoff's Team 2016
My research team currently comprises 2 postdoctoral fellows, 2 PhD students. My clinical team comprises a clinical research fellow.