Acne is one of the most prevalent inflammatory diseases in adolescents worldwide. Acne can have a significant impact on patient's quality of life leading to low self-esteem and depression, employment refusal and may result in scarring.

Although the pathophysiological components of acne are known, the molecular mechanisms and pathways that lead to the development of severe acne and to recalcitrant forms, are still poorly understood.

Using -omics technologies, as well as disease models (in vitro, ex vivo and in vivo), we aim to determine the central pathways involved in the development of the different stages of acne, and to define novel, innovative therapies that will be tested in our clinical trial unit.