Atopic dermatitis (AD) is a chronic or relapsing inflammatory disease of the skin that has a high prevalence rate among children.
People suffering from AD usually have dry, scaly skin and severe itch. Scratching the itchy skin can lead to the production of lesions, aggravates inflammation and itch, and increases the risk of infection. As a result, patients with AD experience significant impairment in their quality of life.
In addition to skin barrier abnormalities, a dysregulation of the immune system can be detected in AD patients and in corresponding mouse models. As the nervous system plays an essential role in regulating immune responses in the skin, understanding the molecular mechanisms and signalling pathways by which this neuro-immune communication occurs will undoubtedly help the development of targeted and mechanism-based therapies against AD.