Dr Eoghan McGarrigle BSc, PhD
Contact Details
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Biography:
| I studied chemistry at University College Dublin obtaining my PhD with Declan Gilheany in the area of M(salen) mediated asymmetric epoxidation. Following my PhD, I carried out postdoctoral research developing a method for the synthesis of P-stereogenic phosphorus compounds. This work was patented and has been commercialised by Celtic Catalysts. In 2005, I moved to the University of Bristol as the Research Officer in the group of Varinder Aggarwal. My research in Bristol has focused on the development of organosulfur catalysts and reagents in organic synthesis. Two projects from this period have resulted in reagents been made commercially available. In 2009, I was appointed as course manager of the Bristol Chemical Synthesis Doctoral Training Centre. In July 2012, I joined the School of Chemistry and Chemical Biology in University College Dublin as an independent research group leader. My new position is funded by Science Foundation Ireland under the Starting Investigators Research Grant scheme. |
Research Interests
| My research interests lie in the field of Organic Chemistry and include: catalysis, carbohydrate chemistry, heterocycle synthesis, organosulfur chemistry, ylide chemistry, ligand synthesis, stereoselective synthesis, synthesis of biologically active molecules including natural products. For more information and for information on opportunities to join my group please see my website: http://mcgarrigleresearch.wordpress.com/ |
Research Projects
| Sponsor : Science Foundation Ireland (SFI) Title : Towards the Development of 21st Century Synthetic Methods for Glycoscience: Catalyst-Controlled Stereoselective Glycosylation Start Date / End Date : 01-JUL-12 / 01-JUL-16 |
Current Postgraduate Students
| Gary Bradshaw, Doctor of Philosophy (PhD) - Thesis Supervisor |
Peer Reviewed Journals
E I Balmond, D M Coe, M C Galan, E M McGarrigle (2012) 'α-Selective Organocatalytic Synthesis of 2-Deoxygalactosides'. Angewandte Chemie International Edition, 51 :9152-9155.  [DOI] [Details] |
| Illa, O., Arshad, M., Ros, A., McGarrigle, E. M., Aggarwal, V. K. (2010) 'Practical and Highly Selective Sulfur Ylide Mediated Asymmetric Epoxidations and Aziridinations Using an Inexpensive, Readily Available Chiral Sulfide. Applications to the Synthesis of Quinine and Quinidine'. Journal of the American Chemical Society, 132 (6). [Details] |
| Riches, S. L., Saha, C., Filgueira, N. F., Grange, E., McGarrigle, E. M., Aggarwal, V. K. (2010) 'On the Mechanism of Ylide-Mediated Cyclopropanations: Evidence for a Proton-Transfer Step and Its Effect on Stereoselectivity'. Journal of the American Chemical Society, 132 (22):7626-7630. [Details] |
| Yar, M., McGarrigle, E. M., Aggarwal, V. K. (2008) 'An annulation reaction for the synthesis of morpholines, thiomorpholines, and piperazines from beta-heteroatom amino compounds and vinyl sulfonium salts'. Angewandte Chemie-International Edition, 47 (20):3784-3786. [Details] |
| Bergin, E., O'Connor, C. T., Robinson, S. B., McGarrigle, E. M., O'Mahony, C. P., Gilheany, D. G. (2007) 'Synthesis of P-stereogenic phosphorus compounds. Asymmetric oxidation of phosphines under appel conditions'. Journal of the American Chemical Society, 129 (31). [Details] |
| McGarrigle, E. M., Fritz, S. P., Favereau, L., Yar, M., Aggarwal, V. K. (2011) 'An Efficient Synthesis of Imidazolinium Salts Using Vinyl Sulfonium Salts'. Organic Letters, 13 (12):3060-3063. [Details] |
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| Yar, M., McGarrigle, E. M., Aggarwal, V. K. (2009) 'Bromoethylsulfonium Salt-A More Effective Annulation Agent for the Synthesis of 6-and 7-Membered 1,4-Heterocyclic Compounds'. Organic Letters, 11 (2):257-260. [Details] |
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| O'Mahony, C. P., McGarrigle, E. M., Renehan, M. F., Ryan, K. M., Kerrigan, N. J., Bousquet, C., Gilheany, D. G. (2001) 'Asymmetric alkene epoxidation with chromium oxo salen complexes. A systematic study of salen ligand substituents'. Organic Letters, 3 (22):3435-3438. [DOI] [Details] |
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| McGarrigle, E. M., Gilheany, D. G. (2005) 'Chromium- and manganese-salen promoted epoxidation of alkenes'. Chemical Reviews, 105 (5):1563-1602. [Details] |
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| McGarrigle, E. M., Myers, E. L., Illa, O., Shaw, M. A., Riches, S. L., Aggarwal, V. K. (2007) 'Chalcogenides as organocatalysts'. Chemical Reviews, 107 (12):5841-5883. [Details] |
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Book Chapters
| E M McGarrigle, V K Aggarwal (2007) 'Ylide-Based Reactions' In: P I Dalko (eds). Enantioselective Organocatalysis: Reactions and Experimental Procedures. Weinheim: Wiley¿VCH. [Details] |
| E M McGarrigle, V K Aggarwal (2009) 'Trimethylsulfoxonium Iodide, first update' In: L A Paquette, D Crich, P L Fuchs, G A Molander (eds). Encyclopedia of Reagents for Organic Synthesis. New York: John Wiley & Sons Ltd. [DOI] [Details] |
| V K Aggarwal, E M McGarrigle, M A Shaw (2011) 'Epoxidation and Aziridination of Carbonyl Groups and Imines' In: G A Molander (eds). Science of Synthesis: Stereoselective Synthesis 2: Stereoselective Reactions of Carbonyl and Imino Groups. Stuttgart: Georg-Thieme-Verlag KG. [Details] |
| M Yar, E M McGarrigle, V K Aggarwal (2012) 'Sulfonium, Ethenyldiphenyl-, 1,1,1-Trifluoromethanesulfonate' In: L A Paquette, D Crich, P L Fuchs, G A Molander (eds). Encyclopedia of Reagents for Organic Synthesis. New York: John Wiley & Sons Ltd. [DOI] [Details] |
| O Illa, E M McGarrigle, V K Aggarwal (2012) 'Bicyclo[2.2.1]heptan-2-one, 7,7-dimethyl-1-(1S,3S,4R)-2- thiabicyclo[2.2.1]hept-3-yl-, (1S,4R)' In: L A Paquette, D Crich, P L Fuchs, G A Molander (eds). Encyclopedia of Reagents for Organic Synthesis. New York: John Wiley & Sons Ltd. [DOI] [Details] |
Honours and Awards
| Year: 2012. Title: SFI SIRG Awardee |
Associations
| Association: Royal Society of Chemistry, Function/Role: Member |
Patents
| Patent WO 2005118603 : Chiral Phosphorus Compounds |
Employment
| Employer: School of Chemistry, University of Bristol Position: Researcher Officer for the group of Prof. Varinder Aggarwal FRS |
| Employer: Bristol Chemical Synthesis Doctoral Training Centre Position: Course Manager |
Education
| Year 2003 Institution: University College Dublin Qualification: PhD Subject: Organic Chemistry |
| Year 1998 Institution: Qualification: BSc Subject: |
Internal Collaborators
External Collaborators
| Prof Varinder K Aggarwal FRS (University of Bristol, UK) Dr Craig P Butts (University of Bristol, UK) Dr M Carmen Galan (University of Bristol, UK) Prof Paul G Pringle (University of Bristol, UK) Dr Muhammad Yar (CIT Lahore, Pakistan) |