Professor Robert O'Neill BSc, PhD
Contact Details
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Biography:
BSc (Chemistry, University College Dublin, 1976); Ryan Gold Medal (Chemistry, 1976); PhD (Electrochemistry, supervised by Prof. David Feakins, UCD, 1980). Postdoctoral research (1980 - 83) with John Albery, FRS (Chemistry, Imperial College London) and Marianne Fillenz, MD, PhD (Physiology, Oxford University). Research Fellowships (1983 - 85) in Physiology (Worcester College, Oxford) and Neurochemistry (Beit Memorial Fellowship in Medical Research) at Oxford University. Appointed to UCD in 1985 and is now Professor of Electrochemistry. Recently, Science Foundation Ireland (SFI) Principal Investigator under the Investigator Programme, Basic Research, and Research Frontiers schemes. |
Research Interests
| In Professor O'Neill's Electrochemistry & Biosensors Laboratory, physical chemistry principles and microcomputer technology are combined to design sensors for molecules that are important in biomedical systems. Devices include both classical electrochemical materials and those incorporating biological components, usually an enzyme. An example of a recently engineered biosensor for targeting brain neurotransmitter glutamate involved immobilising glutamate oxidase (GluOx) in a polymer/protein (PPD/BSA) composite film synthesised in situ on lipid (PEA) coated Pt microcylinders. Studies with these probes include basic thermodynamic, kinetic and stability investigations, as well as analytical applications in complex systems such as brain tissue where blocking of interference molecules, such as AA, is critical. |
Book Chapters
| O'Neill, R.D. (2012) 'Characterization of Polymer-Enzyme Composite Biosensors for Brain Monitoring In Vivo' In: Marinesco, S; Dale, N (eds). NeuroMethods: Microelectrode Biosensors. New York: Springer (Humana Press). [Details] |
| Lowry, J.P. & O'Neill, R.D. ; (2006) 'Neuroanalytical chemistry in vivo using electrochemical sensors' In: Encyclopedia of Sensors. California: American Scientific Publishers. [Details] |
| O'Neill R.D. and J.P. Lowry; (2000) 'Voltammetry in vivo for chemical analysis of the living brain' In: (Edited by Meyers R.), John Wiley & Sons Ltd., Chichester (eds). Encyclopedia of Analytical Chemistry. [Details] |
| O'Neill R.D.; (1997) 'Neurochemical analysis using sensors' In: (Edited by Fraser D.M.), John Wiley & Sons, Chichester (eds). Biosensors in the Body: Continuous In Vivo Monitoring. [Details] |
| O'Neill R.D.; (1995) 'The measurement of brain ascorbate in vivo and its link with excitatory amino acid neurotransmission' In: (Edited by Boulton A.A., Baker G.B. and Adams R.N.), Humana Press, New Jersey (eds). Voltammetric Methods in Brain Systems. [Details] |
| O'Neill R.D.; (1995) 'Lipid-modified electrodes for chemical analysis in vivo' In: (Edited by Frangopol P.T., Nikolelis D.P. and Krull U.J.), Iasi University Press, Iasi (eds). Current Topics in Biophysics (Vol.3. [Details] | |||||||||
| O'Neill R.D. and Fillenz M.; (1987) 'Simultaneous monitoring of glutamate release, dopamine release and uric acid levels in the unrestrained rat: correlations with motor activity' In: (Edited by Justice J.B., Jr.), Humana Press, New Jersey (eds). Voltammetry in the Neurosciences: Principles, Methods and Applications. [Details] | |||||||||
| O'Neill R.D.; (1986) 'The effects of intracerebral and systemic administration of drugs on transmitter release in the unrestrained rat measured using microcomputer-based voltammetry' In: (Edited by Smyth M.R. and Vos J.G.), Elsevier, Amsterdam (eds). Electrochemistry, Sensors and Analysis. [Details] | |||||||||
| Fillenz M., O'Neill R.D. and Grunewald R.A.; (1986) 'Changes in extracellular brain ascorbate concentration as an index of excitatory amino acid release' In: (Edited by Joseph M.H., Fillenz M., Macdonald I.A. and Marsden C.A.), Ellis Horwood, Chichester (eds). Monitoring Neurotransmitter Release During Behaviour. [Details] | |||||||||
| Killoran, S.J. and O'Neill, R.D. ; (2006) 'Electrosynthesis and permselective characterisation of mixed polymers of o-phenylenediamine for biosensor applications' In: Monitoring Molecules in Neuroscience. Cagliari: University of Cagliari. [Details] | |||||||||
| McMahon C.P. and O'Neill R.D.; (2003) 'Oxygen dependence of biosensors for brain glucose and glutamate' In: (edited by Kehr J., Fuxe K., Ungerstedt U. and Svensson T.H.), Karolinska University Press, Stockholm (eds). Monitoring Molecules in Neuroscience. [Details] | |||||||||
| O'Neill R.D. and J.D. Craig; (2001) 'The importance of base electrode condition in the fabrication of biosensors' In: (Edited by O'Connor W.T., Lowry J.P., O'Connor J.J. and O'Neill R.D.), National University of Ireland, Dublin (eds). Monitoring Molecules in Neuroscience. [Details] | |||||||||
| Kane D.A. and R.D. O'Neill; (1999) 'A comparison of carbon paste and carbon fiber electrodes in a protein/lipid matrix: implications for voltammetry in vivo' In: Edited by Rollema H., Abercrombie E., Sulzer D. and Zackheim J.), The State University of New Jersey, Newark (eds). Monitoring Molecules in Neuroscience. [Details] | |||||||||
| Ryan M.R., Lowry J.P. and O'Neill R.D.; (1996) 'Partial optimisation of a glutamate biosensor for neurochemical analysis in vivo' In: (Edited by Gonzalez-Mora J.L., Borges R. and Mas M.), University of La Laguna, Tenerife (eds). Monitoring Molecules in Neuroscience. [Details] | |||||||||
| El Atrash S.S. and O'Neill R.D.; (1994) 'Glucose detection at sub ascorbate potentials using mediated enzyme electrodes' In: (Edited by Louilot A., Durkin T., Spampinato U. and Cador M.), Seignosse (eds). Monitoring Molecules in Neuroscience. [Details] | |||||||||
| Fumero B., Guadalupe T., Gonzalez-Mora J.L., O'Neill R.D. and Mas M.; (1991) 'Differential dynamics of brain metabolites as assessed by fixed and removable microdialysis probes' In: (Edited by Rollema H., Westerink B. and Drijfhout J.W.), University Centre for Pharmacy, Groningen (eds). Monitoring Molecules in Neuroscience. [Details] | |||||||||
| Brose N., O'Neill R.D., Boutelle M.G. and Fillenz M.; (1986) 'The effect of the benzodiazepine receptor contra-agonist FG7142 on circadian motor activity in the rat' In: (Edited by Elsner N. and Rathmayer W.), Thieme Verlag, Stuttgart (eds). Beiträge zur 14. Göttinger Neurobiologentagung. [Details] | |||||||||
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Edited Books
| O'Connor W.T., Lowry J.P., O'Connor J.J., and O'Neill R.D (Ed.). (2001) Monitoring Molecules in Neuroscience (2001). Dublin: National University of Ireland, Dublin. [Details] |
| O'Connor,W.T.; O'Connor,J.J.; Lowry,J.P.; O'Neill,R.D (Ed.). (2002) Journal of Neuroscience Methods, Vol. 119. Amsterdam: Elsevier Science B. V. [Details] |
Peer Reviewed Journals
Rocchitta,G.; Secchi,O.; Alvau,M.D.; Migheli,R.; Calia,G.; Bazzu,G.; Farina,D.; Desole,M.S.; O'Neill,R.D.; Serra,P.A. (2012) 'Development and characterization of an implantable biosensor for telemetric monitoring of ethanol in the brain of freely moving rats'. Analytical Chemistry, 84 (16):7072-7079.  [DOI] [Details] |
| Salazar,P.; Martin,M.; O'Neill,R.D.; Roche,R.; Gonzalez-Mora,J.L. (2012) 'Improvement and characterization of surfactant-modified Prussian Blue screen-printed carbon electrodes for selective H2O2 detection at low applied potentials'. Journal of Electroanalytical Chemistry, 674 :48-56. [DOI] [Details] |
| Finnerty N.J., O'Riordan S.L., Brown F.O., Serra P.A., O'Neill R.D. and Lowry J.P.; (2012) 'In vivo characterisation of a Nafion-modified Pt electrode for real-time nitric oxide monitoring in brain extracellular fluid'. Analytical Methods, 4 (2):550-557. [DOI] [Details] |
| Salazar P., Martin M., O'Neill R.D., Roche R. and Gonzalez-Mora J.L.; (2012) 'Surfactant-promoted Prussian Blue-modified carbon electrodes: Enhancement of electro-deposition step, stabilization, electrochemical properties and application to lactate microbiosensors for the neurosciences'. Colloids and Surfaces, 92 :180-189. [DOI] [Details] |
| Salazar,P.; Martin,M.; O'Neill,R.D.; Roche,R.; Gonzalez-Mora,J.L. (2012) 'Biosensors based on Prussian Blue modified carbon fiber electrodes for monitoring lactate in the extracellular space of brain tissue'. International Journal of Electrochemical Science, 7 :5910-5926. [Details] |
| Rothwell S.A. and O'Neill R.D.; (2011) 'Effects of applied potential on the mass of non-conducting poly(ortho-phenylenediamine) electro-deposited on EQCM electrodes: comparison with biosensor selectivity parameters'. Physical Chemistry Chemical Physics, 13 (12):5413-5421. [DOI] [Details] |
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| Salazar P., O'Neill R.D., Martin M., Roche R. and Gonzalez-Mora J.L.; (2011) 'Amperometric glucose microbiosensor based on a Prussian Blue modified carbon fiber electrode for physiological applications'. Sensors and Actuators B-Chemical, 152 (2):137-143. [DOI] [Details] | |||||||||
| Rothwell,S.A.; McMahon,C.P.; O'Neill,R.D.; (2010) 'Effects of polymerization potential on the permselectivity of poly(o-phenylenediamine) coatings deposited on Pt-Ir electrodes for biosensor applications'. Electrochimica Acta, 55 (3):1051-1060. [DOI] [Details] | |||||||||
| Salazar,P.; Martin,M.; Roche,R.; Gonzalez-Mora,J.L.; O'Neill,R.D.; (2010) 'Microbiosensors for glucose based on Prussian Blue modified carbon fiber electrodes for in vivo monitoring in the central nervous system'. Biosensors & Bioelectronics, 26 :748-753. [DOI] [Details] | |||||||||
| Rothwell,S.A.; Killoran,S.J.; O'Neill,R.D.; (2010) 'Enzyme immobilization strategies and electropolymerization conditions to control sensitivity and selectivity parameters of a polymer-enzyme composite glucose biosensor'. Sensors, 10 (7):6439-6462. [DOI] [Details] |
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| Salazar,P.; Martin,M.; Roche,R.; O'Neill,R.D.; Gonzalez-Mora,J.L.; (2010) 'Prussian Blue-modified microelectrodes for selective transduction in enzyme-based amperometric microbiosensors for in vivo neurochemical monitoring'. Electrochimica Acta, 55 :6476-6484. [DOI] [Details] | |||||||||
| Zain, ZM,O'Neill, RD,Lowry, JP,Pierce, KW,Tricklebank, M,Dewa, A,Ab Ghani, S; (2010) 'Development of an implantable D-serine biosensor for in vivo monitoring using mammalian D-amino acid oxidase on a poly (o-phenylenediamine) and Nafion-modified platinum-iridium disk electrode'. Biosensors & Bioelectronics, 25 :1454-1459. [DOI] [Details] | |||||||||
| AL Mulla,I.; Lowry,J.P.; Serra,P.A.; O'Neill,R.D.; (2009) 'Development of a voltammetric technique for monitoring brain dopamine metabolism: compensation for interference caused by DOPAC electrogenerated during homovanillic acid detection'. Analyst, 134 (5):893-898. [DOI] [Details] | |||||||||
| Bazzu,G.; Puggioni,G.M.; Dedola,S.; Calia,G.; Rocchitta,G.; Migheli,R.; Desole,M.S.; Lowry,J.P.; O'Neill,R.D.; Serra,P.A.; (2009) 'Real-time monitoring of brain tissue oxygen using a miniaturized biotelemetric device implanted in freely-moving rats'. Analytical Chemistry, 81 (6):2235-2241. [DOI] [Details] | |||||||||
| Rothwell,S.A.; Kinsella,M.E.; Zain,Z.M.; Serra,P.A.; Rocchitta,G.; Lowry,J.P.; O'Neill,R.D.; (2009) 'Contributions by a novel edge effect to the permselectivity of an electrosynthesized polymer for microbiosensor applications'. Analytical Chemistry, 81 (10):3911-3918. [DOI] [Details] | |||||||||
| Calia,G.; Rocchitta,G.; Migheli,R.; Puggioni,G.M.; Spissu,Y.; Bazzu,G.; Mazzarello,V.; Lowry,J.P.; O'Neill,R.D.; Desole,M.S.; Serra,P.A.; (2009) 'Biotelemetric monitoring of brain neurochemistry in conscious rats, using microsensors and biosensors'. Sensors, 9 (4):2511-2523. [DOI] [Details] | |||||||||
| Killoran,S.J.; O'Neill,R.D. ; (2008) 'Characterization of permselective coatings electrosynthesized on Pt-Ir from the three phenylenediamine isomers for biosensor applications'. Electrochimica Acta, 53 (24):7303-7312. [DOI] [Details] | |||||||||
| Rothwell,S.A.; Killoran,S.J.; Neville,E.M.; Crotty,A.M.; O'Neill,R.D.; (2008) 'Poly(o-phenylenediamine) electrosynthesized in the absence of added background electrolyte provides a new permselectivity benchmark for biosensor applications'. Electrochemistry Communications, 10 (7):1078-1081. [DOI] [Details] | |||||||||
| O'Neill,R.D.; Lowry,J.P.; Rocchitta,G.; McMahon,C.P.; Serra,P.A.; (2008) 'Designing sensitive and selective polymer/enzyme composite biosensors for brain monitoring in vivo'. Trac-Trends in Analytical Chemistry, 27 (1):78-88. [DOI] [Details] | |||||||||
| Migheli,R.; Puggioni,G.M.; Dedola,S.; Rocchitta,G.; Calia,G.; Bazzu,G.; Esposito,G.; Lowry,J.P.; O'Neill,R.D.; Desole,M.S.; Miele,E.; Serra,P.A.; (2008) 'Novel integrated microdialysis-amperometric system for in vitro detection of dopamine secreted from PC12 cells: Design, construction, and validation'. Analytical Biochemistry, 380 (2):323-330. [DOI] [Details] | |||||||||
| Killoran SJ, Rai DK, O'Neill RD ; (2007) 'Comparison of phenylenediamine isomers for the synthesis of permselective biosensor polymers for neurochemical analysis'. Journal of Neurochemistry, 102 :196-197. [Details] | |||||||||
| Rothwell SA, O'Neill RD ; (2007) 'Pt fibre as a novel electrode material in PPD-based biosensor design for neurotransmitter glutamate'. Journal of Neurochemistry, 102 :198-198. [Details] | |||||||||
| Kinsella ME, Lowry JP, O'Neill RD ; (2007) 'Biosensor for the neurotransmitter L-glutamic acid: Development and characterisation'. Journal of Neurochemistry, 102 :197-197. [Details] | |||||||||
| Rocchitta,G.; Migheli,R.; Dedola,S.; Calia,G.; Desole,M.S.; Miele,E.; Lowry,J.P.; O'Neill,R.D.; Serra,P.A.; (2007) 'Development of a distributed, fully automated, bidirectional telemetry system for amperometric microsensor and biosensor applications'. Sensors and Actuators B-Chemical, 126 (2):700-709. [Details] | |||||||||
| Kirwan, S. M., Rocchitta, G., McMahon, C. P., Craig, J. D., Killoran, S. J., O'Brien, K. B., Serra, P. A., Lowry, J. P., O'Neill, R. D.; (2007) 'Modifications of poly(o-phenylenediamine) permselective layer on Pt-Ir for biosensor application in neurochemical monitoring'. Sensors, 7 (4):420-437. [Details] | |||||||||
| O'Brien, K. B., Killoran, S. J., O'Neill, R. D., Lowry, J. P.; (2007) 'Development and characterization in vitro of a catalase-based biosensor for hydrogen peroxide monitoring'. Biosensors & Bioelectronics, 22 (12):2994-3000. [Details] | |||||||||
| McMahon, C. P., Rocchitta, G., Kirwan, S. M., Killoran, S. J., Serra, P. A., Lowry, J. P., O'Neill, R. D.; (2007) 'Oxygen tolerance of an implantable polymer/enzyme composite glutamate biosensor displaying polycation-enhanced substrate sensitivity'. Biosensors & Bioelectronics, 22 (7):1466-1473. [Details] | |||||||||
| Serra, P. A., Rocchitta, G., Bazzu, G., Manca, A., Puggioni, G. M., Lowry, J. P., O'Neill, R. D.; (2007) 'Design and construction of a low cost single-supply embedded telemetry system for amperometric biosensor applications'. Sensors and Actuators B-Chemical, 122 (1):118-126. [Details] | |||||||||
| McMahon, CP; Rocchitta, G; Serra, PA; Kirwan, SM; Lowry, JP; O'Neill, RD; ; (2006) 'Control of the oxygen dependence of an implantable polymer/enzyme composite biosensor for glutamate'. Analytical Chemistry, 78 (7):2352-2359. [Details] | |||||||||
| McMahon, CP; Rocchitta, G; Serra, PA; Kirwan, SM; Lowry, JP; O'Neill, RD; ; (2006) 'The efficiency of immobilised glutamate oxidase decreases with surface enzyme loading: an electrostatic effect, and reversal by a polycation significantly enhances biosensor sensitivity'. Analyst, 131 (1):68-72. [Details] | |||||||||
| O'Neill RD; (2005) 'Long-term monitoring of brain dopamine metabolism in vivo with carbon paste electrodes'. Sensors, 5 :317-342. [Details] | |||||||||
| McMahon, C.P. and R.D. O'Neill; (2005) 'A polymer-enzyme composite biosensor with high glutamate sensitivity and low oxygen dependence'. Analytical Chemistry, 77 :1196-1199. [Details] | |||||||||
| McMahon, CP; Killoran, SJ; O'Neill, RD; ; (2005) 'Design variations of a polymer-enzyme composite biosensor for glucose: Enhanced analyte sensitivity without increased oxygen dependence'. Journal of Electroanalytical Chemistry, 580 (2):193-202. [Details] | |||||||||
| McMahon, CP; O'Neill, RD; ; (2005) 'Polymer-enzyme composite biosensor with high glutamate sensitivity and low oxygen dependence'. Analytical Chemistry, 77 (4):1196-1199. [Details] | |||||||||
| O'Neill, R.D., S.C. Chang, J.P. Lowry and C.J. McNeil; (2004) 'Comparisons of platinum, gold, palladium and glassy carbon as electrode materials in the design of biosensors for glutamate'. Biosensors & Bioelectronics, 19 :1521-1528. [Details] | |||||||||
| Craig J.D. and R.D. O'Neill; (2003) 'Electrosynthesis and permselective characterisation of phenol-based polymers for biosensor applications'. Analytica Chimica Acta, 495 :33-43. [Details] | |||||||||
| Craig, JD; O'Neill, RD; ; (2003) 'Comparison of simple aromatic amines for electrosynthesis of permselective polymers in biosensor fabrication'. Analyst, 128 (7):905-911. [Details] | |||||||||
| Craig, JD; O'Neill, RD; ; (2003) 'Electrosynthesis and permselective characterisation of phenol-based polymers for biosensor applications'. Analytica Chimica Acta, 495 (1-2):33-43. [Details] | |||||||||
| Dixon B.M., J.P. Lowry and R.D. O'Neill; (2002) 'Characterization in vitro and in vivo of the oxygen dependence of an enzyme/polymer biosensor for monitoring brain glucose'. Journal of Neuroscience Methods, 119 :135-142. [Details] | |||||||||
| Dixon, BM; Lowry, JP; O'Neill, RD; ; (2002) 'Characterization in vitro and in vivo of the oxygen dependence of an enzyme/polymer biosensor for monitoring brain glucose'. Journal of Neuroscience Methods, 119 (2):135-142. [Details] | |||||||||
| O'Connor, WT; O'Connor, JJ; Lowry, JP; O'Neill, RD; ; (2002) '9th International Conference on In Vivo Methods Monitoring Molecules in Neuroscience, June 16-19, 2001, University College Dublin, Ireland - Foreword'. Journal of Neuroscience Methods, 119 (2):105-107. [Details] | |||||||||
| Craig J.D. and R.D. O'Neill; (2001) 'Selectivity of biosensor polymer films for neurochemical analysis'. Irish Journal of Medical Science, 170 :28-28. [Details] | |||||||||
| O'Neill R.D. and J.D. Craig; (2001) 'Preconditioning the electrode surface as a strategy in the design of biosensors for brain analysis in vivo'. Irish Journal of Medical Science, 170 :29-29. [Details] | |||||||||
| Lowry J.P., M.R. Ryan and R.D. O'Neill; (1998) 'Behaviourally induced changes in extracellular levels of brain glutamate monitored at 1 s resolution with an implanted biosensor'. Annals of Chemistry, 35 :87-89. [Details] | |||||||||
| Lowry J.P., O'Neill R.D., Boutelle M.G. and Fillenz M.; (1998) 'Continuous monitoring of extracellular glucose concentrations in the striatum of freely moving rats with an implanted glucose biosensor'. Neurochemistry, 70 :391-396. [Details] | |||||||||
| O'Neill R.D., J.P. Lowry and M. Mas; (1998) 'Monitoring brain chemistry in vivo: voltammetric techniques, sensors and behavioral applications'. Critical Reviews in Neurobiology, 12 :69-127. [Details] | |||||||||
| Lowry J.P., Miele M., O'Neill R.D., Boutelle M.G. and Fillenz M.; (1998) 'An amperometric glucose-oxidase/poly(o-phenylenediamine) biosensor for monitoring brain extracellular glucose: in vivo characterisation in the striatum of freely-moving rats'. Journal of Neuroscience Methods, 79 :65-74. [Details] | |||||||||
| Lowry, JP; Ryan, MR; O'Neill, RD; ; (1998) 'Behaviourally induced changes in extracellular levels of brain glutamate monitored at 1 s resolution with an implanted biosensor'. Analytical Communications, 35 (3):87-89. [Details] | |||||||||
| Kane, DA; O'Neill, RD; ; (1998) 'Major differences in the behaviour of carbon paste and carbon fibre electrodes in a protein-lipid matrix: implications for voltammetry in vivo'. Analyst, 123 (12):2899-2903. [Details] | |||||||||
| Kane D.A. and R.D. O'Neill; (1998) 'Major differences in the behaviour of carbon paste and carbon fibre electrodes in a protein-lipid matrix: implications for voltammetry in vivo'. Analyst, 123 :2899-2903. [Details] | |||||||||
| McAteer K. and R.D. O'Neill; (1997) 'Strategies for decreasing ascorbate interference'. Biosensors & Bioelectronics, 12 :vii-vii. [Details] | |||||||||
| Ryan M.R., J.P. Lowry and R.D. O'Neill; (1997) 'Biosensor for neurotransmitter L-glutamic acid designed for efficient use of L-glutamate oxidase and effective rejection of interference'. Analyst, 122 :1419-1424. [Details] | |||||||||
| McAteer K. and R.D. O'Neill; (1996) 'Strategies for decreasing ascorbate interference at glucose oxidase-modified poly(o-phenylenediamine)-coated electrodes'. Analyst, 121 :773-777. [Details] | |||||||||
| Lowry J.P., M.G. Boutelle, R.D. O'Neill and M. Fillenz; (1996) 'Characterization of carbon paste electrodes in vitro for simultaneous amperometric measurement of changes in oxygen and ascorbic acid concentrations in vivo'. Analyst, 121 :761-766. [Details] | |||||||||
| Duff A. and R.D. O'Neill; (1995) 'The importance of probe size in monitoring neurochemical signals in behaving animals'. Behavioral Brain Research, 71 :41-42. [Details] | |||||||||
| El Atrash S.S. and R.D. O'Neill; (1995) 'Characterisation in vitro of a naphthoquinone-mediated glucose oxidase-modified carbon paste electrode designed for neurochemical analysis in vivo'. Electrochimica Acta, 40 :2791-2797. [Details] | |||||||||
| Mas M., B. Fumero, R.D. O'Neill and J.L. Gonzalez-Mora; (1995) 'Fixed versus removable microdialysis probes for in vivo neurochemical analysis: Implications for behavioral studies'. Neurochemistry, 64 :1900-1901. [Details] | |||||||||
| O'Neill R.D. and J.P. Lowry; (1995) 'On the significance of brain extracellular uric acid detected with in-vivo monitoring techniques: a review'. Behavioral Brain Research, 71 :33-49. [Details] | |||||||||
| Lowry J.P. and R.D. O'Neill; (1994) 'Partial characterization in vitro of glucose oxidase-modified poly(phenylenediamine)-coated electrodes for neurochemical analysis in vivo'. Electroanalysis, 6 :369-379. [Details] | |||||||||
| O'Neill R.D.; (1994) 'Microvoltammetric techniques and sensors for monitoring neurochemical dynamics in vivo - a review'. Analyst, 119 :767-779. [Details] | |||||||||
| Lowry J.P., McAteer K., El Atrash S.S. and O'Neill R.D.; (1994) 'Efficient glucose detection in anaerobic solutions using an enzyme-modified electrode designed to detect H2O2: implications for biomedical applications'. Journal of the Chemical Society-Chemical Communications, (21):2483-2484. [Details] | |||||||||
| Duff A. and R.D. O'Neill; (1994) 'Effect of probe size on the concentration of brain extracellular uric acid monitored with carbon paste electrodes'. Neurochemistry, 62 :1496-1502. [Details] | |||||||||
| Fumero B., Guadalupe T., Valladares F., Mora F., O'Neill R.D., Mas M. and Gonzalez-Mora J.L.; (1994) 'Fixed versus removable microdialysis probes for in vivo neurochemical analysis: Implications for behavioral studies'. Neurochemistry, 63 :1407-1415. [Details] | |||||||||
| Marguerettaz X., O'Neill R. and Fitzmaurice D.; (1994) 'Heterodyads: electron transfer at a semiconductor electrode-liquid electrolyte interface modified by an adsorbed spacer-acceptor complex'. Journal of the American Chemistry Society, 116 :2629-2630. [Details] | |||||||||
| Lowry J.P., McAteer K., El Atrash S.S., Duff A. and O'Neill R.D.; (1994) 'haracterization of glucose oxidase-modified poly(phenylenediamine)-coated electrodes in vitro and in vivo: homogeneous interference by ascorbic acid in hydrogen peroxide detection'. Analytical Chemistry, 66 :1754-1761. [Details] | |||||||||
| O'Neill R.D.; (1993) 'Sensor-tissue interactions in neurochemical analysis with carbon paste electrodes in vivo'. Analyst, 118 :433-438. [Details] | |||||||||
| Lowry J.P. and R.D. O'Neill; (1992) 'Strategies for reducing ascorbate interference at glucose oxidase modified conducting organic salt electrodes'. Journal of Electroanalytical Chemistry, 334 :183-194. [Details] | |||||||||
| Lowry J.P. and R.D. O'Neill; (1992) 'Homogeneous mechanism of ascorbic acid interference in hydrogen peroxide detection at enzyme-modified electrodes'. Analytical Chemistry, 64 :453-456. [Details] | |||||||||
| O'Neill R.D.; (1992) 'In vivo monitoring of uric acid with chronically implanted probes'. Neurochemistry, 59 :785-786. [Details] | |||||||||
| O'Neill R.D., Gonzalez-Mora J.L., Boutelle M.G., Ormonde D.E., Lowry J.P., Duff A., Fumero B., Fillenz M. and Mas M.; (1991) 'Anomalously high concentrations of brain extracellular uric acid detected with chronically implanted probes: implications for in vivo sampling techniques'. Neurochemistry, 57 :22-29. [Details] | |||||||||
| O'Neill R.D.; (1991) 'Electrochemical detection of neurotransmitter dynamics in vivo'. Journal of Biomedical Sciences, 2 :66-74. [Details] | |||||||||
| O'Neill R.D.; (1990) 'Uric acid levels and dopamine transmission in rat striatum: diurnal changes and effects of drugs'. Brain Research, 507 :267-272. [Details] | |||||||||
| O'Neill R.D., Sheiha L., Waghorne W.E. and Feakins D.; (1990) 'A new method for determining ionic solvent transport numbers and free energy of transfer of electrolytes from water to mixed aqueous solvents'. Journal of the Chemical Society-Chemical Communications, (2):99-100. [Details] | |||||||||
| Lyne P.D. and R.D. O'Neill; (1990) 'Stearate-modified carbon paste electrodes for detecting dopamine in vivo: decrease in selectivity caused by lipids and other surface-active agents'. Analytical Chemistry, 62 :2347-2351. [Details] | |||||||||
| Ormonde D.E. and R.D. O'Neill; (1990) 'The oxidation of ascorbic acid at carbon paste electrodes. Modified response following contact with surfactant, lipid and brain tissue'. Journal of Electroanalytical Chemistry, 279 :109-121. [Details] | |||||||||
| O'Neill R.D.; (1989) 'Diurnal changes in rat motor activity and striatal homovanillic acid levels recorded in the presence and absence of food'. Proceedings Royal Irish Academy, Section A, 89B :329-334. [Details] | |||||||||
| Lyne P.D. and R.D. O'Neill; (1989) 'Selectivity of stearate-modified carbon paste electrodes for dopamine and ascorbic acid'. Analytical Chemistry, 61 :2323-2324. [Details] | |||||||||
| Lyne P.D. and R.D. O'Neill; (1989) 'Evidence that stearate modified electrodes do not differentiate between dopamine and ascorbate after contact with brain tissue'. Journal of Neuroscience Methods, 29 :296-296. [Details] | |||||||||
| Ormonde D.E. and R.D. O'Neill; (1989) 'Effects of surfactants on carbon paste electrodes: implications for voltammetry in vivo'. Journal of Neuroscience Methods, 29 :296-296. [Details] | |||||||||
| Ormonde D.E. and R.D. O'Neill; (1989) 'Altered response of carbon paste electrodes after contact with brain tissue. Implications for modified electrode use in vivo'. Journal of Electroanalytical Chemistry, 261 :463-469. [Details] | |||||||||
| Lowry J.P. and R.D. O'Neill; (1989) 'Detection of brain extracellular uric acid - dependence on probe size'. Journal of Neuroscience Methods, 29 :297-297. [Details] | |||||||||
| Brose N., O'Neill R.D., Boutelle M.G. and Fillenz M.; (1989) 'The effects of anxiolytic and anxiogenic benzodiazepine receptor ligands on motor activity and levels of ascorbic acid in the nucleus accumbens and striatum of the rat'. Neuropharmacology, 28 :509-514. [Details] | |||||||||
| Brose N., O'Neill R.D., Boutelle M.G. and Fillenz M.; (1988) 'Dopamine in the basal ganglia and benzodiazepine-induced sedation'. Neuropharmacology, 27 :589-595. [Details] | |||||||||
| Marsden C.A., Joseph M.H., Kruk Z.L., Maidment N.T., O'Neill R.D., Schenk J.O. and Stamford J.A.; (1988) 'In vivo voltammetry - Present electrodes and methods'. Neuroscience, 25 :389-400. [Details] | |||||||||
| Brose N., O'Neill R.D., Boutelle M.G., Anderson S.M.P. and Fillenz M.; (1987) 'Effects of an anxiogenic benzodiazepine receptor ligand on rat motor activity and dopamine release in nucleus accumbens and striatum'. Journal of Neuroscience Research, 7 :2917-2926. [Details] | |||||||||
| O'Neill R.D.; (1986) 'Effects of intranigral injection of taurine and GABA on striatal dopamine release monitored voltammetrically in the unrestrained rat'. Brain Research, 382 :28-32. [Details] | |||||||||
| O'Neill R.D. and M. Fillenz; (1986) 'Microcomputer-controlled voltammetry in the analysis of transmitter release in rat brain'. Annals of the New York Academy of Sciences, 473 :337-348. [Details] | |||||||||
| Fillenz M. and R.D. O'Neill; (1986) 'Effects of light reversal on the circadian pattern of motor activity and voltammetric signals recorded in rat forebrain'. Journal of Physiology, 374 :91-101. [Details] | |||||||||
| O'Neill R.D.; (1986) 'Adenosine modulation of striatal neurotransmitter release monitored in vivo using voltammetry'. Neuroscience Letters, 63 :11-16. [Details] | |||||||||
| Fillenz M. and R.D. O'Neill; (1985) 'Circadian changes in rat motor activity and forebrain dopamine release: effect of light reversal'. Journal of Physiology, 364 :64P-64P. [Details] | |||||||||
| O'Neill R.D. and M. Fillenz; (1985) 'Circadian changes in extracellular ascorbate in rat cortex, accumbens, striatum and hippocampus: correlations with motor activity'. Neuroscience Letters, 60 :331-336. [Details] | |||||||||
| O'Neill R.D. and M. Fillenz; (1985) 'Detection of homovanillic acid in vivo using microcomputer-controlled voltammetry: simultaneous monitoring of rat motor activity and striatal dopamine release'. Neuroscience, 14 :753-763. [Details] | |||||||||
| O'Neill R.D. and M. Fillenz; (1985) 'Simultaneous monitoring of dopamine release in rat frontal cortex, nucleus accumbens and striatum: effect of drugs, circadian changes and correlations with motor activity'. Neuroscience, 16 :49-55. [Details] | |||||||||
| Fillenz M., O'Neill R.D. and Ryan E.; (1984) 'Effects of the two enantiomers of 3-PPP on dopamine release monitored in vivo and on dopamine synthesis measured in vitro'. British Journal of Pharmacology, 81 :119P-119P. [Details] | |||||||||
| O'Neill R.D., Fillenz M., Grunewald R.A., Bloomfield M.R., Albery W.J., Jamieson C.M., Williams J.H. and Gray J.A.; (1984) 'Voltammetric carbon paste electrodes monitor uric acid and not 5HIAA at the 5-hydroxyindole potential in the rat brain'. Neuroscience Letters, 45 :39-46. [Details] | |||||||||
| O'Neill R.D., Fillenz M., Sundstrom L. and Rawlins J.N.P.; (1984) 'Voltammetrically monitored brain ascorbate as an index of excitatory amino acid release in the unrestrained rat'. Neuroscience Letters, 52 :227-233. [Details] | |||||||||
| Albery W.J., Goddard N.J., Beck T.W., Fillenz M. and O'Neill R.D.; (1984) 'Theoretical and experimental studies of linear sweep voltammetry in the rat brain'. Journal of Electroanalytical Chemistry, 161 :221-233. [Details] | |||||||||
| Grunewald R.A., O'Neill R.D., Fillenz M. and Albery W.J.; (1983) 'The origin of circadian and amphetamine-induced changes in the extracellular concentration of brain ascorbate'. Neurochemistry International, 5 :773-778. [Details] | |||||||||
| O'Neill R.D., Fillenz M. and Albery W.J.; (1983) 'The development of linear sweep voltammetry with carbon paste electrodes in vivo'. Journal of Neuroscience Methods, 8 :263-273. [Details] | |||||||||
| O'Neill R.D., Grunewald R.A., Fillenz M. and Albery W.J.; (1983) 'The effect of unilateral cortical lesions on the circadian changes in rat striatal ascorbate and homovanillic acid levels measured in vivo using voltammetry'. Neuroscience Letters, 42 :105-110. [Details] | |||||||||
| Fillenz M. and O'Neill R.D.; (1983) 'Differences in feed-back regulation of dopamine release in the striatum and frontal cortex in the rat'. Journal of Physiology, 349 :11P-11P. [Details] | |||||||||
| Feakins D., O'Neill R.D. and Waghorne W.E.; (1983) 'Washburn numbers. Part 5. Relative solvent transport numbers for ion constituents in dioxan+water and DMSO+water systems'. Journal of the Chemical Society-Faraday Transactions, 79 :2289-2298. [Details] | |||||||||
| Albery W.J., Fillenz M. and O'Neill R.D.; (1983) 'The compartment model for chronically implanted voltammetric electrodes in the rat brain'. Neuroscience Letters, 38 :175-180. [Details] | |||||||||
| Albery W.J., Fillenz M. and O'Neill R.D.; (1983) 'Monitoring ascorbate and monoamine transmitter metabolites in the rat using voltammetry: some new developments'. British Journal of Pharmacology, 79 :260P-260P. [Details] | |||||||||
| O'Neill R.D.; (1983) 'Electrochemistry in brain tissue: a developing technique in neurobiology'. J. Instit. Chem. Ire :5-10. [Details] | |||||||||
| O'Neill R.D., Grunewald R.A., Fillenz M. and Albery W.J.; (1983) 'Simultaneous monitoring of motor activity and neurotransmitter release in the rat striatum'. Neuroscience Letters, 14 :268-268. [Details] | |||||||||
| O'Neill R.D., Fillenz M., Albery W.J. and Goddard N.J.; (1983) 'The monitoring of ascorbate and monoamine transmitter metabolites in the striatum of unanaesthetised rats using microprocessor-based voltammetry'. Neuroscience, 9 :87-93. [Details] | |||||||||
| Albery W.J., Fillenz M., Goddard N.J., McIntyre W.E. and O'Neill R.D.; (1982) 'Changes in brain dopamine metabolites using microprocessor-controlled voltammetry in the rat'. Journal of Physiology, 332 :107P-107P. [Details] | |||||||||
| Feakins D., O'Neill R.D. and Waghorne W.E.; (1982) 'Preferential solvation of ions and solvent transport'. Pure Apllied Chemistry, 54 :2317-2326. [Details] | |||||||||
| O'Neill R.D., Grunewald R.A., Fillenz M. and Albery W.J.; (1982) 'Linear sweep voltammetry with carbon paste electrodes in the rat striatum'. Neuroscience, 7 :1945-1954. [Details] | |||||||||
| Feakins D., O'Neill R.D., Waghorne W.E. and Ward A.J.I.; (1982) 'Washburn numbers. Part 4. The Erdey-Gruz experiment. Relative solvent transport numbers for ion constituents in mixtures of water with raffinose, glycine, allyl alcohol, DMSO and dioxan'. Journal of the Chemical Society-Faraday Transactions, 78 :1431-1449. [Details] | |||||||||
| O'Neill R.D., M. Fillenz and W.J. Albery; (1982) 'Circadian changes in homovanillic acid and ascorbate levels in the rat striatum using microprocessor-controlled voltammetry'. Neuroscience Letters, 34 :189-193. [Details] | |||||||||
| Grunewald R.A., O'Neill R.D., Fillenz M. and Albery W.J.; (1981) 'Voltammetric measurements in unanaesthetised rats'. Neuroscience Letters, 7 . [Details] | |||||||||
| Feakins D., O'Neill R.D., Waghorne W.E. and Ward A.J.I.; (1979) 'Relative solvent transport of ion constituents in aqueous organic solvents'. Journal of the Chemical Society-Chemical Communications, :1029-1030. [Details] | |||||||||
| Feakins D., deValera E., McCarthy P.J., O'Neill R.D. and Waghorne W.E.; (1978) 'Relative solvent transport of ions in binary aqueous mixtures: an unambiguous assignment to ionic constituents'. Journal of the Chemical Society-Chemical Communications, :218-219. [Details] | |||||||||
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Conference Publications
| Salazar,P.; Martin,M.; O'Neill,R.D.; Roche,R.; Gonzalez-Mora,J.L. (2012) The use of Nafion to mitigate the oxygen deficit in glucose microbiosensors Monitoring Molecules in Neuroscience: 14th International Conference; London, , 16-SEP-12 - 20-SEP-12 [Details] |
| Martin,M.; Salazar,P.; O'Neill,R.D.; Roche,R.; Gonzalez-Mora,J.L. (2012) A new NO sensor based on a Prussian Blue modified electrode Monitoring Molecules in Neuroscience: 14th International Conference; London, , 16-SEP-12 - 20-SEP-12 [Details] |
| Salazar,P.; Martin,M.; Roche,R.; Gonzalez-Mora,J.L.; O'Neill,R.D.; (2010) Glutamate biosensor based on Prussian Blue modified carbon fiber microelectrodes for in-vivo neurochemical monitoring . In: Westerink,B.; Clinckers,R.; Smolders,I.; Sarre,S.; Michotte,Y eds. Proceedings of the 13th International Conference on In Vivo Methods Vrije Universiteit Brussel, Brussels, , 12-SEP-10 - 16-SEP-10 , pp.292-294 [Details] |
| Rothwell,S.A.; O'Neill,R.D.; (2008) The importance of edge effects on the permselectivity of model implantable biosensors . In: Phillips,P.E.M.; Sandberg,S.G.; Ahn,S.; Phillips,A.G eds. Proceedings of the 12th International Conference on In Vivo Methods Vancouver, Canada, , 10-AUG-08 - 14-AUG-08 , pp.135-138 [Details] |
| Kinsella,M.E.; Lowry,J.P.; O'Neill,R.D.; (2007) Biosensor for the neurotransmitter L-glutamic acid: development and characterisation 21st Biennial Meeting of the International Society for Neuroscience Conference Cancun, Mexico, , 19-AUG-07 - 24-AUG-07 , pp.197-197 [Details] |
| Killoran,S.J.; Rai,D.K.; O'Neill,R.D.; (2007) Comparison of phenylenediamine isomers for the synthesis of permselective biosensor polymers for neurochemical analysis 21st Biennial Meeting of the International Society for Neuroscience Conference Cancun, Mexico, , 19-AUG-07 - 24-AUG-07 , pp.196-197 [Details] | |||||||||
| Rothwell,S.A.; O'Neill,R.D.; (2007) Pt fibre as a novel electrode material in PPD-based biosensor design for neurotransmitter glutamate 21st Biennial Meeting of the International Society for Neuroscience Conference Cancun, Mexico, , 19-AUG-07 - 24-AUG-07 , pp.198-198 [Details] | |||||||||
| Kirwan, S.M., Rocchitta, G., Lowry, J.P. O'Neill, R.D.; (2006) Designing a polymer/enzyme composite biosensor suitable for clinical monitoring of glutamate in brain ECF 11th International Conference on In-Vivo Methods [Details] | |||||||||
| O'Brien, K.B., Killoran, S.J., O'Neill, R.D. Lowry, J.P.; (2006) Development of a catalase based biosensor for the detection of endogenous hydrogen peroxide in brain extracellular fluid 11th International Conference on In-Vivo Methods [Details] | |||||||||
| Killoran, S.J. & O'Neill, R.D.; (2006) Electrosynthesis and permselective characterisation of mixed polymers of o-phenylenediamine for biosensor applications 11th International Conference on In-Vivo Methods [Details] | |||||||||
| Govindarajan, S., McNeil, C.J., Mendelow, A.D., Chambers, I.R. O'Neill, R.D.; (2006) In vivo continuous human brain monitoring of glutamate using enzyme based biosensors 11th International Conference on In-Vivo Methods [Details] | |||||||||
| Bolger, F.B., Serra, P.A., Dalton, M., O'Neill, R.D., Fillenz, M. Lowry, J.P.; (2006) Real-time monitoring of brain extracellular lactate 11th International Conference on In-Vivo Methods [Details] | |||||||||
| Rocchitta, G., McMahon, C.P., Serra, P.A., Kirwan, S.M., Bolger, F.B., Lowry, J.P. O'Neill, R.D.; (2006) Significant enhancement of glutamate biosensor sensitivity, using a polycation-modified polymer/enzyme composite sensing layer 11th International Conference on In-Vivo Methods [Details] | |||||||||
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Editorial
| O'Connor, WT,O'Connor, JJ,Lowry, JP,O'Neill, RD; (2002) 9th International Conference on In Vivo Methods Monitoring Molecules in Neuroscience, June 16-19, 2001, University College Dublin, Ireland - Foreword. Editorial [DOI] [Details] |
| MARSDEN, CA,JOSEPH, MH,KRUK, ZL,MAIDMENT, NT,ONEILL, RD,SCHENK, JO,STAMFORD, JA; (1988) INVIVO VOLTAMMETRY - PRESENT ELECTRODES AND METHODS. Editorial [Details] |
Honours and Awards
| Year: 2006. Title: SFI Research Frontiers Grant |
| Year: 2006. Title: Professorship |
| Year: 2004. Title: SFI Investigator Programme Grant |
| Year: 2004. Title: SFI Basic Research Grant |
| Year: 1998. Title: Associate Professorship |
| Year: 1992. Title: President's Research Award |
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| Year: 1991. Title: College Overseas Study Award |
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| Year: 1990. Title: College Overseas Study Award |
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| Year: 1988. Title: Royal Irish Academy Bicentennial Award |
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| Year: 1985. Title: Beit Memorial Fellowship, Oxford |
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| Year: 1984. Title: Physiology Research Fellowship Worcester College, Oxford |
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| Year: 1976. Title: Hugh Ryan Memorial Gold Medal |
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Employment
| Employer: University College Dublin Position: Professor |
| Employer: Oxford University Position: Beit Fellow in Neurochemistry |