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CLASS: Prof. Aras Kadioglu, University of Liverpool

Date: 14 November 2017

Venue: UCD Conway Lecture Theatre

Time: 12 noon

SpeakerProf. Aras Kadioglu, Professor of Bacterial Pathogenesis, University of Liverpool

Title: 'The role of immune tolerance & regulation in pneumococcal carriage and invasive disease'

Keywords: Pneumococcal disease, carriage, Treg, vaccines, immunity

Abstract: Streptococcus pneumoniae is a major human pathogen causing 1.3 million deaths worldwide annually due to invasive diseases such as pneumonia, meningitis and sepsis. Nasopharyngeal carriage is an essential first step in this process, however the interactions of the pneumococcus with host cells and immunity during carriage is not well described. We do not know for example how carriage may develop into invasive disease or how carriage is sustained longer term. To address these questions, we have in the past few years focused on the role of cellular immunity during carriage and have discovered the key role of T regulatory cells in maintaining and regulating pneumococcal carriage. Our investigations have also uncovered a previously unknown role for the pneumococcal toxin pneumolysin in driving carriage and Treg responses and how susceptibility to invasive disease is dependant on a delicate balance between density of colonisation and Treg responses. 

Biography: Prof. Aras Kadioglu was born in Cambridge, but grew up in Liverpool, Washington DC and Ankara before returning to the UK to read for a BSc in Microbiology at the University of Leicester, where he was also awarded a PhD in Immunology in 1996 on the role of CD4 T cell recirculation and adhesion in chronic inflammatory disease. He continued along the theme of cellular chronic inflammation during his first postdoctoral position at the Hammersmith Hospital Imperial College before moving back to the University of Leicester to start work on a new Wellcome Trust funded project investigating host immune responses to pneumococcal infection. Promoted to Lecturer in Respiratory Infection in 2005, then Reader in 2009, Ara Kadioglu returned to Liverpool as Professor of Bacterial Pathogenesis in 2011 at the newly established Institute of Infection & Global Health, University of Liverpool.

Refreshments available outside the lecture theatre from 11.40am

21 Dr. Dave Carter, Oxford Brookes University
28 Prof. Saoirse O'Sullivan, University of Nottingham

05 Dr. Rachel McLoughlin, Trinity College Dublin
12 Dr. Ian Macaulay, Earlham Institute

Associate sponsors of the Conway Lecture & Seminar Series 2017/2018

BioSciences  Cruinn Diagnostics Ltd ‌



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