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Summer 2012 issue of Conway Focus

Highlights in this issue include:

Tracking the secretory pathway in cells
Secretion is a fundamental process essential to almost every cell type in the body. Professor Jeremy Simpson and EMBL collaborators used genetic and sophisticated microscopy techniques to assess 8 million individual cells to reveal those genes that influence the transport network or secretory pathway. Nature Cell Biology

Gremlin key to tackling pulmonary hypertension
Professor Paul McLoughlin and his team identified, for the first time, a molecular mechanism that accounts for the unique vascular remodelling of the pulmonary circulation in response to hypoxia or low levels of oxygen. Circulation

Predicting toxicity in the drug development pipeline
A proof-of-principle study from UCD researchers led by Professor Steve Pennington may benefit the pharmaceutical industry in the future by providing a roadmap for large scale pre-clinical toxicology biomarker verification studies. Molecular & Cellular Proteomics
 
Identifying proteins critical to bovine embryo survival
Professor Mark Crowe and Dr Giuliano Elia describe, for the first time, the protein landscape of the uterine environment in any domesticated species before implantation. Journal of Proteome Research