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Focusing on cancer proteomics

The current special focus issue of Nature Reviews Cancer contains three review papers from UCD Conway and Systems Biology Ireland researchers.

Integrating biobanks: addressing the practical and ethical issues to deliver a valuable tool for cancer research
R. William G. Watson, Elaine W. Kay & David Smith
The integration of existing national and institutional biobanks is required to form larger resources that can be used to study the complexity and heterogeneity of cancer. This article discusses the main practical and ethical issues associated with the integration of biobanks for cancer research.
p646 | doi:10.1038/nrc2913 Nature Review Cancer Watson

Functional proteomics to dissect tyrosine kinase signalling pathways in cancer
Walter Kolch & Andrew Pitt
Proteomics approaches are increasingly being used to functionally characterize proteins and signalling pathways, including the roles of complexes and post-translational modifications. This Review illustrates how these techniques have been used to find new aspects of receptor tyrosine kinase-mediated signal transduction pathways in cancer.
p618 | doi:10.1038/nrc2900 Nature Review Cancer Kolch

Antibody-based proteomics: fast-tracking molecular diagnostics in oncology
Donal J. Brennan, Darran P. O'Connor, Elton Rexhepaj, Fredrik Ponten & William M. Gallagher
Antibody-based proteomics facilitates the high-throughput evaluation of candidate biomarkers. What insights can be gained, and what are the clinical applications of antibody-based proteomics?
p605 | doi:10.1038/nrc2902 Nature Review Cancer Gallagher