Research
- Research Programmes
- Researchers
- Postdoctoral & Research Fellows
- Featured Researchers
- Conway Fellows
- Conway Clinical Associate Fellows
- Conway Fellows (A-Z)
- Professor Mohamed Al-Rubeai
- Professor Alan Baird
- Dr. John Baugh
- Dr. Orina Belton
- Dr. Oliver Blacque
- Professor Billy Bourke
- Professor David Brayden
- Dr. Lorraine Brennan
- Professor Geraldine Butler
- Dr. Gerard Cagney
- Professor Dolores J. Cahill
- Professor Sean Callanan
- Dr. Marguerite Clyne
- Dr. John Crean
- Dr. Paul Crossey
- Professor Mark Crowe
- Professor Seamas Donnelly
- Professor Michael (Joe) Duffy
- Professor Jim Egan
- Professor Guiliano Elia
- Professor Paul Engel
- Professor Alex Evans
- Dr. Paul Evans
- Dr. Neil Ferguson
- Professor Oliver Fitzgerald
- Professor William Gallagher
- Professor Declan Gilheany
- Professor Catherine Godson
- Professor Stephen Gordon
- Professor Andrew Green
- Professor Patrick Guiry
- Dr. Jana Haase
- Dr. Chandralal Hewage
- Professor Des Higgins
- Professor Suzanne Jarvis
- Professor Michael Keane
- Dr. Breandan Kennedy
- Professor Boris Kholodenko
- Professor Therese Kinsella
- Professor Ulla Knaus
- Professor Walter Kolch
- Professor. Gil Lee
- Professor Brendan Loftus
- Professor Pat Lonergan
- Professor David MacHugh
- Dr. Patricia Maguire
- Professor Kevin Malone
- Professor J.Paul.G Malthouse
- Professor Finian Martin
- Dr. Margaret Mc Gee
- Professor Fionnuala McAuliffe
- Dr. Gethin McBean
- Dr. Amanda McCann
- Dr. Edward McKone
- Professor Paul McLoughlin
- Dr. Hilary McMahon
- Dr. Tara McMorrow
- Professor Walter McNicholas
- Professor Wim Meijer
- Dr. Anika Mostaert
- Professor Grace Mulcahy
- Dr. Keith Murphy
- Dr. Evelyn Murphy
- Dr. Jarlath Nally
- Professor Phillip Newsholme
- Dr. Jens Nielsen
- Dr. Peter O'Brien
- Dr. Kevin O'Connor
- Dr. John O'Connor
- Professor Ronan O'Connell
- Dr. Tadhg O'Croinin
- Dr. James O'Gara
- Professor Donal F. O'Shea
- Professor Stefan Oscarson
- Dr. Francesca Paradisi
- Professor William Powderly
- Professor Prem Puri
- Professor Ciaran Regan
- Professor Helen Roche
- Professor Pauline Rudd
- Professor Dimitri Scholz
- Dr. Noreen Sheehy
- Professor Denis Shields
- Professor Jeremy Simpson
- Dr. Albert Smolenski
- Dr. Matthias Tacke
- Professor Cormac Taylor
- Dr. Emma Teeling
- Professor Douglas Veale
- Professor Dominic Walsh
- Professor William Watson
- Professor Matthias Wilm
- Dr. Xiangming Zhu
- Core Technologies
Dr Albert Smolenski MD
Contact Details
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Biography:
since 2008 Lecturer in Vascular Biology, UCD School of Medicine and Medical Science 2002-2007 Independent Research Group Leader and Lecturer, Institute for Biochemistry II, University of Frankfurt 1995-2002 Research Fellow, Institute of Clinical Biochemistry and Pathobiochemistry, University of Würzburg 1993-1994 Intern, Department of Cardiology, University of Göttingen 1991-1992 MD, Institute of Physiological Chemistry, University of Münster |
Research Interests
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Blood platelets play
an important role in haemostasis and thrombosis leading to myocardial infarction and
stroke. Platelet functions are tightly controlled by intracellular signalling
networks. We are investigating these signalling networks in order to understand
the regulation of thrombus formation and to identify new diagnostic
and therapeutic targets in cardiovascular disease. |
Recent Postgraduates
| Olga Neumüler Rap1GAP2 interacting proteins in platelets Simone Kobe de Oliveira Phosphodiesterase interacting proteins Oliver Danielewski Rap1 signaling in platelets Pavel Riha Cyclic nucleotide signaling in platelets Mick Burckhardt Endothelial dysfunction |
Peer Reviewed Journals
| Gegenbauer, K., Elia, G., Blanco-Fernandez, A and Smolenski, A.; (2012) 'Regulator of G-protein signaling protein 18 integrates activating and inhibitory signaling in platelets'. Blood, 119 (16):3799-3807. [DOI] [Details] |
| Steele BM, Harper MT, Smolenski AP, Alkazemi N, Poole AW, Fitzgerald DJ, Maguire PB. (2012) 'WNT-3a modulates platelet function by regulating small GTPase activity'. FEBS Letters, 586 (16):2267-2272. [Details] |
| Beyer, S,Lakshmanan, A,Liu, YY,Zhang, XL,Wapnir, I,Smolenski, A,Jhiang, S; (2011) 'KT5823 Differentially Modulates Sodium Iodide Symporter Expression, Activity, and Glycosylation between Thyroid and Breast Cancer Cells'. Endocrinology, 152 :782-792. [DOI] [Details] |
| Smolenski A; (2011) 'Novel roles of cAMP/cGMP dependent signaling in platelets'. Journal of Thrombosis and Haemostasis, . [DOI] [Details] |
| Gambaryan, S,Kobsar, A,Rukoyatkina, N,Herterich, S,Geiger, J,Smolenski, A,Lohmann, SM,Walter, U; (2010) 'Thrombin and Collagen Induce a Feedback Inhibitory Signaling Pathway in Platelets Involving Dissociation of the Catalytic Subunit of Protein Kinase A from an NF kappa B-I kappa B Complex'. J BIOL CHEM, 285 :18352-18363. [DOI] [Details] |
| Keane, C,Tilley, D,Cunningham, A,Smolenski, A,Kadioglu, A,Cox, D,Jenkinson, HF,Kerrigan, SW; (2010) 'Invasive Streptococcus pneumoniae trigger platelet activation via Toll-like receptor 2'. Journal of Thrombosis and Haemostasis, 8 :2757-2765. [DOI] [Details] | |||||||||
| Neumüller O, Hoffmeister M, Babica J, Prelle C, Gegenbauer K, Smolenski AP, ; (2009) 'Synaptotagmin-like protein 1 interacts with the GTPase-activating protein Rap1GAP2 and regulates dense granule secretion in platelets'. Blood, 114 (7):1396-1404. [DOI] [Details] | |||||||||
| Hoffmeister M, Riha P, Neumüller O, Danielewski O, Schultess J, Smolenski AP,; (2008) 'Cyclic nucleotide-dependent protein kinases inhibit binding of 14-3-3 to the GTPase-activating protein Rap1GAP2 in platelets'. Journal of Biological Chemistry, 283 (4):2297-2306. [DOI] [Details] | |||||||||
| de Oliveira SK, Smolenski A, ; (2008) 'Phosphodiesterases link the aryl hydrocarbon receptor complex to cyclic nucleotide signaling'. Biochemical Pharmacology, . [DOI] [Details] | |||||||||
| de Oliveira SK, Hoffmeister M, Gambaryan S, Müller-Esterl W, Guimaraes JA, Smolenski AP, ; (2007) 'Phosphodiesterase 2A forms a complex with the co-chaperone XAP2 and regulates nuclear translocation of the aryl hydrocarbon receptor'. Journal of Biological Chemistry, 282 (18):13656-13663. [DOI] [Details] | |||||||||
| Bryan PM, Smirnov D, Smolenski A, Feil S, Feil R, Hofmann F, Lohmann S, Potter LR, ; (2006) 'A sensitive method for determining the phosphorylation status of natriuretic peptide receptors: cGK-Ialpha does not regulate NPR-A'. Biochemistry, 45 (4):1295-1303. [DOI] [Details] | |||||||||
| Das A, Smolenski A, Lohmann SM, Kukreja RC, ; (2006) 'Cyclic GMP-dependent protein kinase Ialpha attenuates necrosis and apoptosis following ischemia/reoxygenation in adult cardiomyocyte'. Journal of Biological Chemistry, 281 (50):38644-38652. [DOI] [Details] | |||||||||
| Gambaryan S, Butt E, Tas P, Smolenski A, Allolio B, Walter U, ; (2006) 'Regulation of aldosterone production from zona glomerulosa cells by ANG II and cAMP: evidence for PKA-independent activation of CaMK by cAMP'. American journal of physiology. Endocrinology and metabolism, 290 (3):1-33. [DOI] [Details] | |||||||||
| Galler AB, Garcia Arguinzonis MI, Baumgartner W, Kuhn M, Smolenski A, Simm A, Reinhard M, ; (2006) 'VASP-dependent regulation of actin cytoskeleton rigidity, cell adhesion, and detachment'. Histochemistry and Cell Biology, 125 (5):457-474. [DOI] [Details] | |||||||||
| Fiedler B, Feil R, Hofmann F, Willenbockel C, Drexler H, Smolenski A, Lohmann SM, Wollert KC,; (2006) 'cGMP-dependent protein kinase type I inhibits TAB1-p38 mitogen-activated protein kinase apoptosis signaling in cardiac myocytes'. Journal of Biological Chemistry, 281 (43):32831-32840. [DOI] [Details] | |||||||||
| Dittrich M, Birschmann I, Pfrang J, Herterich S, Smolenski A, Walter U, Dandekar T,; (2006) 'Analysis of SAGE data in human platelets: features of the transcriptome in an anucleate cell'. Thrombosis and haemostasis, 95 (4):643-651. [Details] | |||||||||
| Schultess J, Danielewski O, Smolenski AP, ; (2005) 'Rap1GAP2 is a new GTPase-activating protein of Rap1 expressed in human platelets'. Blood, 105 (8):3185-3192. [DOI] [Details] | |||||||||
| Cha B, Kim JH, Hut H, Hogema BM, Nadarja J, Zizak M, Cavet M, Lee-Kwon W, Lohmann SM, Smolenski A, Tse CM, Yun C, de Jonge HR, Donowitz M, ; (2005) 'cGMP inhibition of Na+/H+ antiporter 3 (NHE3) requires PDZ domain adapter NHERF2, a broad specificity protein kinase G-anchoring protein'. Journal of Biological Chemistry, 280 (17):16642-16650. [DOI] [Details] | |||||||||
| Danielewski O, Schultess J, Smolenski A, ; (2005) 'The NO/cGMP pathway inhibits Rap 1 activation in human platelets via cGMP-dependent protein kinase I'. Thrombosis and haemostasis, 93 (2):319-325. [DOI] [Details] | |||||||||
| Smolenski A, Schultess J, Danielewski O, Garcia Arguinzonis MI, Thalheimer P, Kneitz S, Walter U, Lohmann SM, ; (2004) 'Quantitative analysis of the cardiac fibroblast transcriptome-implications for NO/cGMP signaling'. Genomics, 83 (4):577-587. [DOI] [Details] | |||||||||
| Jacob A, Smolenski A, Lohmann SM, Begum N, ; (2004) 'MKP-1 expression and stabilization and cGK Ialpha prevent diabetes- associated abnormalities in VSMC migration'. American Journal of Physiology and Cell Physiology, 287 (4):1-86. [DOI] [Details] | |||||||||
| Gambaryan S, Butt E, Marcus K, Glazova M, Palmetshofer A, Guillon G, Smolenski A, ; (2003) 'cGMP-dependent protein kinase type II regulates basal level of aldosterone production by zona glomerulosa cells without increasing expression of the steroidogenic acute regulatory protein gene'. Journal of Biological Chemistry, 278 (32):29640-29648. [DOI] [Details] | |||||||||
| Schäfer A, Burkhardt M, Vollkommer T, Bauersachs J, Münzel T, Walter U, Smolenski A, ; (2003) 'Endothelium-dependent and -independent relaxation and VASP serines 157/239 phosphorylation by cyclic nucleotide-elevating vasodilators in rat aorta'. Biochemical Pharmacology, 65 (3):397-405. [Details] | |||||||||
| Wollert KC, Fiedler B, Gambaryan S, Smolenski A, Heineke J, Butt E, Trautwein C, Lohmann SM, Drexler H, ; (2002) 'Gene transfer of cGMP-dependent protein kinase I enhances the antihypertrophic effects of nitric oxide in cardiomyocytes'. Hypertension, 39 (1):87-92. [Details] | |||||||||
| Gambaryan S, Palmetshofer A, Glazova M, Smolenski A, Kristjansson GI, Zimmer M, Lohmann SM, ; (2002) 'Inhibition of cGMP-dependent protein kinase II by its own splice isoform'. Biochemical and biophysical research communications, 293 (5):1438-1444. [DOI] [Details] | |||||||||
| Zabel U, Kleinschnitz C, Oh P, Nedvetsky P, Smolenski A, Müller H, Kronich P, Kugler P, Walter U, Schnitzer JE, Schmidt HH, ; (2002) 'Calcium-dependent membrane association sensitizes soluble guanylyl cyclase to nitric oxide'. Nature Cell Biology, 4 (4):307-311. [DOI] [Details] | |||||||||
| Jacob A, Molkentin JD, Smolenski A, Lohmann SM, Begum N, ; (2002) 'Insulin inhibits PDGF-directed VSMC migration via NO/ cGMP increase of MKP-1 and its inactivation of MAPKs'. American Journal of Physiology and Cell Physiology, 283 (3):1-13. [DOI] [Details] | |||||||||
| Fiedler B, Lohmann SM, Smolenski A, Linnemuller S, Pieske B, Schroder F, Molkentin JD, Drexler H, Wollert KC, ; (2002) 'Inhibition of calcineurin-NFAT hypertrophy signaling by cGMP-dependent protein kinase type I in cardiac myocytes'. Proceedings of the National Academy of Sciences of the United States of America, 99 (17):11363-11368. [DOI] [Details] | |||||||||
| Begum N, Sandu OA, Ito M, Lohmann SM, Smolenski A, ; (2002) 'Active Rho kinase (ROK-alpha ) associates with insulin receptor substrate-1 and inhibits insulin signaling in vascular smooth muscle cells'. Journal of Biological Chemistry, 277 (8):6214-6222. [DOI] [Details] | |||||||||
| Hanada S, Terada Y, Inoshita S, Sasaki S, Lohmann SM, Smolenski A, Marumo F,; (2001) 'Overexpression of protein kinase G using adenovirus inhibits cyclin E transcription and mesangial cell cycle'. American journal of physiology. Renal physiology, 280 (5):1-9. [Details] | |||||||||
| Mülsch A, Oelze M, Klöss S, Mollnau H, Töpfer A, Smolenski A, Walter U, Stasch JP, Warnholtz A, Hink U, Meinertz T, Münzel T, ; (2001) 'Effects of in vivo nitroglycerin treatment on activity and expression of the guanylyl cyclase and cGMP-dependent protein kinase and their downstream target vasodilator-stimulated phosphoprotein in aorta'. Circulation, 103 (17):2188-2194. [Details] | |||||||||
| Sauzeau V, Le Jeune H, Cario-Toumaniantz C, Smolenski A, Lohmann SM, Bertoglio J, Chardin P, Pacaud P, Loirand G, ; (2000) 'Cyclic GMP-dependent protein kinase signaling pathway inhibits RhoA-induced Ca2+ sensitization of contraction in vascular smooth muscle'. Journal of Biological Chemistry, 275 (28):21722-21729. [DOI] [Details] | |||||||||
| Smolenski A, Poller W, Walter U, Lohmann SM, ; (2000) 'Regulation of human endothelial cell focal adhesion sites and migration by cGMP-dependent protein kinase I'. Journal of Biological Chemistry, 275 (33):25723-25732. [DOI] [Details] | |||||||||
| Oelze M, Mollnau H, Hoffmann N, Warnholtz A, Bodenschatz M, Smolenski A, Walter U, Skatchkov M, Meinertz T, Münzel T, ; (2000) 'Vasodilator-stimulated phosphoprotein serine 239 phosphorylation as a sensitive monitor of defective nitric oxide/cGMP signaling and endothelial dysfunction'. Circulation Research, 87 (11):999-1005. [Details] | |||||||||
| Butt E, Bernhardt M, Smolenski A, Kotsonis P, Fröhlich LG, Sickmann A, Meyer HE, Lohmann SM, Schmidt HH, ; (2000) 'Endothelial nitric-oxide synthase (type III) is activated and becomes calcium independent upon phosphorylation by cyclic nucleotide-dependent protein kinases'. Journal of Biological Chemistry, 275 (7):5179-5187. [Details] | |||||||||
| Sporbert A, Mertsch K, Smolenski A, Haseloff RF, Schönfelder G, Paul M, Ruth P, Walter U, Blasig IE, ; (1999) 'Phosphorylation of vasodilator-stimulated phosphoprotein: a consequence of nitric oxide- and cGMP-mediated signal transduction in brain capillary endothelial cells and astrocytes'. Brain Research, 67 (2):258-266. [Details] | |||||||||
| Hoenderop JG, Vaandrager AB, Dijkink L, Smolenski A, Gambaryan S, Lohmann SM, de Jonge HR, Willems PH, Bindels RJ, ; (1999) 'Atrial natriuretic peptide-stimulated Ca2+ reabsorption in rabbit kidney requires membrane-targeted, cGMP-dependent protein kinase type II'. Proceedings of the National Academy of Sciences of the United States of America, 96 (11):6084-6089. [Details] | |||||||||
| Smolenski A, Bachmann C, Reinhard K, Hönig-Liedl P, Jarchau T, Hoschuetzky H, Walter U, ; (1998) 'Analysis and regulation of vasodilator-stimulated phosphoprotein serine 239 phosphorylation in vitro and in intact cells using a phosphospecific monoclonal antibody'. Journal of Biological Chemistry, 273 (32):20029-20035. [Details] | |||||||||
| Gambaryan S, Wagner C, Smolenski A, Walter U, Poller W, Haase W, Kurtz A, Lohmann SM, ; (1998) 'Endogenous or overexpressed cGMP-dependent protein kinases inhibit cAMP-dependent renin release from rat isolated perfused kidney, microdissected glomeruli, and isolated juxtaglomerular cells'. Proceedings of the National Academy of Sciences of the United States of America, 95 (15):9003-9008. [Details] | |||||||||
| Smolenski A, Burkhardt AM, Eigenthaler M, Butt E, Gambaryan S, Lohmann SM, Walter U, ; (1998) 'Functional analysis of cGMP-dependent protein kinases I and II as mediators of NO/cGMP effects'. Naunyn-Schmiedeberg's archives of pharmacology, 358 (1):134-139. [Details] | |||||||||
| Friebe A, Müllershausen F, Smolenski A, Walter U, Schultz G, Koesling D, ; (1998) 'YC-1 potentiates nitric oxide- and carbon monoxide-induced cyclic GMP effects in human platelets'. Molecular pharmacology, 54 (6):962-967. [Details] | |||||||||
| Vaandrager AB, Smolenski A, Tilly BC, Houtsmuller AB, Ehlert EM, Bot AG, Edixhoven M, Boomaars WE, Lohmann SM, de Jonge HR, ; (1998) 'Membrane targeting of cGMP-dependent protein kinase is required for cystic fibrosis transmembrane conductance regulator Cl- channel activation'. Proceedings of the National Academy of Sciences of the United States of America, 95 (4):1466-1471. [Details] | |||||||||
| Lohmann SM, Vaandrager AB, Smolenski A, Walter U, De Jonge HR, ; (1997) 'Distinct and specific functions of cGMP-dependent protein kinases'. Trends in biochemical sciences, 22 (8):307-312. [Details] | |||||||||
| Vaandrager AB, Tilly BC, Smolenski A, Schneider-Rasp S, Bot AG, Edixhoven M, Scholte BJ, Jarchau T, Walter U, Lohmann SM, Poller WC, de Jonge HR, ; (1997) 'cGMP stimulation of cystic fibrosis transmembrane conductance regulator Cl- channels co-expressed with cGMP-dependent protein kinase type II but not type Ibeta'. Journal of Biological Chemistry, 272 (7):4195-4200. [Details] | |||||||||
| Stöhr S, Meyer T, Smolenski A, Kreuzer H, Buchwald AB, ; (1995) 'Effects of heparin on aortic versus venous smooth muscle cells: similar binding with different rates of [3H]thymidine incorporation'. Vascular Pharmacology, 25 (5):782-788. [Details] | |||||||||
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Education
| Year 2003 Institution: University of Würzburg, Germany Qualification: HABILITATION Subject: Clinical Biochemistry and Pathobiochemistry |
| Year 1994 Institution: University of Münster, Germany Qualification: MD Subject: Medicine |
Internal Collaborators
| Dr. Giuliano Elia, UCD Conway Institute Proteomics and mass spectrometry Dr. Patricia Maguire, UCD Conway Institute Platelet proteomics and signalling Prof. Denis Shields, UCD CASL (Complex & Adaptive Systems Laboratory) Bioinformatics Dr. John Baugh, UCD Conway Institute Cyclic nucleotide pathways
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External Collaborators
| Dr. Stepan Gambaryan, University of Würzburg, Germany Dr. Steve Kerrigan, RCSI (Royal College of Surgeons in Ireland) Dr. Martin Cann, Durham University Dr. Meike Hoffmeister, University of Frankfurt, Germany Prof. Ulrich Walter, University of Mainz, Germany Dr. Suzanne Lohmann, University of Würzburg, Germany
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