Dr. Amanda McCann | UCD Conway

Research

Dr Amanda McCann BA, PhD.

Peer Reviewed Journals:

Mc Cormack O, Chung WY, Fitzpatrick P, Cooke F , Flynn B , Harrison M, Fox E, Gallagher E, Mc Goldrick A, Dervan PA, McCann A, Kerin MJ (2007) 'Progesterone Receptor B (PRB) promoter hypermethylation in sporadic breast cancer'. Breast Cancer Research and Treatment, . [Details]

Doi T, Puri P, McCann A, Bannigan J, Thompson J (2011) 'Epigenetic effect of cadmium on global de novo DNA hypomethylation in the cadmium-induced ventral body wall defect (VBWD) in the chick model'. Toxicological sciences : an official journal of the Society of Toxicology, 120 (2):475-480. [DOI] [Details]

Jin Y, Amaral A, McCann A, Brennan L (2011) 'Homocysteine levels impact directly on epigenetic reprogramming in astrocytes'. Neurochemistry international, . [DOI] [Details]

Watson, J. A.,Watson, C. J.,McCrohan, A. M.,Woodfine, K.,Tosetto, M.,McDaid, J.,Gallagher, E.,Betts, D.,Baugh, J.,O'Sullivan, J.,Murrell, A.,Watson, R. W.,McCann, A. (2009) 'Generation of an epigenetic signature by chronic hypoxia in prostate cells'. Hum Mol Genet, 18 (1919):3594-6043594.

[Details]

Hosey, AM,Gorski, JJ,Murray, MM,Quinn, JE,Chung, WY,Stewart, GE,James, CR,Farragher, SM,Mulligan, JM,Scott, AN,Dervan, PA,Johnston, PG,Couch, FJ,Daly, PA,Kay, E,McCann, A,Mullan, PB,Harkin, DP (2007) 'Molecular basis for estrogen receptor alpha deficiency in BRCA1-linked breast cancer'. Journal of the National Cancer Institute, 99 :1683-1694. [DOI] [Details]

Prencipe M, McGoldrick A, Perry AS, O'Grady A, Phelan S, McGrogan B, Fitzpatrick P, Watson JA, Furlong F, Brennan DJ, Lawler M, Kay E, McCann A. (2010) 'MAD2 downregulation in hypoxia is independent of promoter hypermethylation'. Cell cycle (Georgetown, Tex.), 9 (14):2856-2865. [Details]

Watson JA, Watson CJ, McCann A, Baugh J (2010) 'Epigenetics, the epicenter of the hypoxic response'. Epigenetics : official journal of the DNA Methylation Society, 5 (4):293-296. [Details]
Prencipe M, Fitzpatrick P, Gorman S, Tosetto M, Klinger R, Furlong F, Harrison M, O'Connor D, Roninson IB, O'Sullivan J, McCann A (2009) 'Cellular senescence induced by aberrant MAD2 levels impacts on paclitaxel responsiveness in vitro'. British journal of cancer, 101 (11):1900-1908. [DOI] [Details]
McCann A, McGrogan BT, Gilmartin B, Carney DN, (2008) 'Taxanes, microtubules and chemoresistant breast cancer'. 1785 (2):96-132. [DOI] [Details]
McCann A, Watson JA, Burling K, Fitzpatrick P, Kay E, Kelly J, Fitzpatrick JM, Dervan PA, (2009) 'Urinary insulin-like growth factor 2 identifies the presence of urothelial carcinoma of the bladder'. Bju International, 5 (NA):694-697. [DOI] [Details]
Rexhepaj, E., Brennan, D. J., Holloway, P., Kay, E. W., McCann, A. H., Landberg, G., Duffy, M. J., Jirstrom, K., and Gallagher, W. M. (2008) 'Novel image analysis approach for quantifying expression of nuclear proteins assessed by immunohistochemistry: application to measurement of estrogen and progesterone receptor levels in breast cancer'. Breast cancer research : BCR, 10 (5). [DOI] [Details]
Mc Cormack, O., Chung, W. Y., Fitzpatrick, P., Cooke, F., Flynn, B., Harrison, M., Fox, E., Gallagher, E., Mc Goldrick, A., Dervan, P. A., Mc Cann, A., Kerin, M. J., (2008) 'Growth arrest-specific gene 6 expression in human breast cancer'. British Journal of Cancer, 98 (6):1141-1146. [DOI] [Details]
Armstrong, ME,Gantier, M,Li, LL,Chung, WY,McCann, A,Baugh, JA,Donnelly, SC (2008) 'Small interfering RNAs induce macrophage migration inhibitory factor production and proliferation in breast cancer cells via a double-stranded RNA-dependent protein kinase-dependent mechanism'. J IMMUNOL, 180 :7125-7133. [Details]
Kerin MJ, Mc Cormack O, Chung WY, Fitzpatrick P, Cooke F, Flynn B, Harrison M, Fox E, Gallagher E, Goldrick AM, Dervan PA, Mc Cann A, (2008) 'Growth arrest-specific gene 6 expression in human breast cancer'. Cancer, 98 (6):1141-1146. [DOI] [Details]
Gallagher, E. M.,O'Shea, D. M.,Fitzpatrick, P.,Harrison, M.,Gilmartin, B.,Watson, J. A.,Clarke, T.,Leonard, M. O.,McGoldrick, A.,Meehan, M.,Watson, C.,Furlong, F.,O'Kelly, P.,Fitzpatrick, J. M.,Dervan, P. A.,O'Grady, A.,Kay, E. W.,McCann, A. (2008) 'Recurrence of urothelial carcinoma of the bladder: a role for insulin-like growth factor-II loss of imprinting and cytoplasmic E-cadherin immunolocalization'. Clin Cancer Res, 14 (21):6829-38. [Details]
Meehan, M.,Melvin, A.,Gallagher, E.,Smith, J.,McGoldrick, A.,Moss, C.,Goossens, S.,Harrison, M.,Kay, E.,Fitzpatrick, J.,Dervan, P.,Mc Cann, A. (2007) 'Alpha-T-catenin (CTNNA3) displays tumour specific monoallelic expression in urothelial carcinoma of the bladder'. Genes Chromosomes Cancer, 46 (6):587-93. [Details]
O'Sullivan, FM,Murphy, SK,Simel, LR,McCann, A,Callanan, JJ,Nolan, CM (2007) 'Imprinted expression of the canine IGF2R, in the absence of an anti-sense transcript or promoter methylation'. Evolution and Development, 9 :579-589. [Details]
O'Brien SL, Fagan A, Fox EJ, Millikan RC, Culhane AC, Brennan DJ, McCann AH, (2007) 'CENP-F expression is associated with poor prognosis and chromosomal instability in patients with primary breast cancer'. International Journal of Cancer, 120 (7):1434-1443. [Details]
Mc Cormack O, Chung WY, Fitzpatrick P, Cooke F, Flynn B, Harrison M, Fox E,Gallagher E, McGoldrick A, Dervan PA, McCann A, Kerin MJ. (2008) 'Progesterone receptor B (PRB) promoter hypermethylation in sporadic breast cancer: Progesterone receptor B hypermethylation in breast cancer'. Breast Cancer Research and Treatment, 111 :45-53. [Details]
Nolan CM, O'Sullivan FM, Murphy SK, Simel LR, McCann A, Callanan JJ, (2007) 'Imprinted expression of the canine IGF2R, in the absence of an anti-sense transcript or promoter methylation'. Evolution and Development, 6 (NA):579-589. [DOI] [Details]
Gallagher, E,Goldrick, AM,Chung, WY,Cormack, OM,Harrison, M,Kerin, M,Dervan, PA,Cann, AM (2006) 'Gain of imprinting of SLC22A18 sense and antisense transcripts in human breast cancer'. GENOMICS, 88 (1):12-17. [DOI] [Details]
Carder, PJ; Murphy, CE; Dervan, P; Kennedy, M; McCann, A; Saunders, PTK; Shaaban, AM; Foster, CS; Witton, CJ; Bartlett, JMS; Walker, RA; Speirs, V; (2005) 'A multi-centre investigation towards reaching a consensus on the immunohistochemical detection of ER beta in archival formalin-fixed paraffin embedded human breast tissue'. Breast Cancer Research and Treatment, 92 (3):287-293. [Details]
Carder, PJ,Murphy, CE,Dervan, P,Kennedy, M,McCann, A,Saunders, PTK,Shaaban, AM,Foster, CS,Witton, CJ,Bartlett, JMS,Walker, RA,Speirs, V (2005) 'A multi-centre investigation towards reaching a consensus on the immunohistochemical detection of ER beta in archival formalin-fixed paraffin embedded human breast tissue'. Rea, 92 :287-293. [DOI] [Details]
Carder, PJ; Murphy, CE; Dervan, P; Kennedy, M; McCann, A; Saunders, PTK; Shaaban, AM; Foster, CS; Witton, CJ; Bartlett, JMS; Walker, RA; Speirs, V; (2005) 'A multi-centre investigation towards reaching a consensus on the immunohistochemical detection of ER beta in archival formalin-fixed paraffin embedded human breast tissue'. Breast Cancer Research and Treatment, 92 (3):287-293. [Details]
Balfe, P; McCann, A; McGoldrick, A; McAllister, K; Kennedy, M; Dervan, P; Kerin, MJ; (2004) 'Estrogen receptor alpha and beta profiling in human breast cancer'. Ejso, 30 (5):469-474. [Details]
Balfe, PJ; McCann, AH; Welch, HM; Kerin, MJ; (2004) 'Estrogen receptor beta and breast cancer'. Ejso, 30 (10):1043-1050. [Details]
Shahbazi, RI; McCann, A; Frawley, A; Doran, P; Chung, WY; Dervan, P; Kerin, MJ; (2004) 'Validation of gamma-actin as a potential target in breast cancer'. British Journal of Surgery, 91 (9):1216-1216. [Details]
Balfe, P; McCann, A; McGoldrick, A; McAllister, K; Kennedy, M; Dervan, P; Kerin, MJ; (2004) 'Estrogen receptor alpha and beta profiling in human breast cancer'. Ejso, 30 (5):469-474. [Details]
Shahbazi, RI; McCann, A; Frawley, A; Doran, P; Chung, WY; Dervan, P; Kerin, MJ; (2004) 'Validation of gamma-actin as a potential target in breast cancer'. British Journal of Surgery, 91 (9):1216-1216. [Details]
Mc Cormack, OM; Mc Cann, AH; Chung, WY; Cooke, F; Flynn, B; Gallagher, E; Mc Goldrick, A; Welch, HM; Dervan, PA; Kerin, MJ; (2004) 'Progesterone receptor B promoter hypermethylation in breast carcinoma; correlation with mRNA and protein levels'. Breast Cancer Research and Treatment, 88 (NA):176-176. [Details]
Balfe, P,McCann, A,McGoldrick, A,McAllister, K,Kennedy, M,Dervan, P,Kerin, MJ (2004) 'Estrogen receptor alpha and beta profiling in human breast cancer'. Ejso, 30 :469-474. [DOI] [Details]
Shahbazi, RI; McCann, A; Frawley, A; Doran, P; Chung, WY; Dervan, P; Kerin, MJ; (2004) 'Validation of gamma-actin as a potential target in breast cancer'. British Journal of Surgery, 91 (9):1216-1216. [Details]
Balfe P, McCann A, McGoldrick A, McAllister K, Kennedy M, Dervan P, Kerin MJ. (2004) 'Estrogen receptor alpha and beta profiling in human breast cancer'. European Journal of Surgical Oncology, 30 (5):469-474. [Details]
Balfe, P; McCann, A; McGoldrick, A; Kennedy, M; McAllister, K; Dervan, P; Kerin, MJ; (2003) 'Antiestrogen therapy could be harmful in patients with oestrogen receptor-beta dominant tumours'. British Journal of Surgery, 90 (NA):102-103. [Details]
Balfe, P; McCann, A; McGoldrick, A; Kennedy, M; McAllister, K; Dervan, P; Kerin, MJ; (2003) 'Antiestrogen therapy could be harmful in patients with oestrogen receptor-beta dominant tumours'. British Journal of Surgery, 90 (NA):102-103. [Details]
Greene, LM; Twal, WO; Duffy, MJ; McDermott, EW; Hill, AD; O'Higgins, NJ; McCann, A; Dervan, P; Argraves, W; Gallagher, WM; (2003) 'Elevated expression and altered processing of fibulin-1 protein in human breast cancer'. British Journal of Cancer, 88 (6):871-878. [Details]
Greene, LM, Twal, WO, Duffy, MJ, McDermott, EW, Hill, AD, O'Higgins, NJ, McCann, A, Dervan, P, Argraves, W, Gallagher, WM, (2003) 'Elevated expression and altered processing of fibulin-1 protein in human breast cancer'. British Journal of Cancer, 88 (6):871-878. [Details]
Cooke, FJ; McCann, AH; Balfe, P; McAlister, K; Kennedy, M; Dervan, P; Kerin, MJ; (2003) 'Epigenetic control of the oestrogen receptor genes in breast cancer'. British Journal of Surgery, 90 (NA):42-43. [Details]
Greene, LM,Twal, WO,Duffy, MJ,McDermott, EW,Hill, AD,O'Higgins, NJ,McCann, A,Dervan, P,Argraves, W,Gallagher, WM (2003) 'Elevated expression and altered processing of fibulin-1 protein in human breast cancer'. Cancer, 88 :871-878. [DOI] [Details]
Greene, LM; Twal, WO; Duffy, MJ; McDermott, EW; Hill, AD; O'Higgins, NJ; McCann, A; Dervan, P; Argraves, W; Gallagher, WM; (2003) 'Elevated expression and altered processing of fibulin-1 protein in human breast cancer'. British Journal of Cancer, 88 (6):871-878. [Details]
Greene, L. M., Twal, W. O., McDermott, E. W., Hill, A. D., O Higgins, N. J., McCann, A. H., Dervan, P. A., Duffy, M. J., Argraves, W. S., and Gallagher, W. M. (2003) 'Elevated expression and altered processing of fibulin-1 protein in human breast cancer'. British Journal of Cancer, 88 (6):871-878. [Details]
Greene, LM; Twal, WO; Duffy, MJ; McDermott, EW; Hill, AD; O'Higgins, NJ; McCann, A; Dervan, P; Argraves, W; Gallagher, WM; (2003) 'Elevated expression and altered processing of fibulin-1 protein in human breast cancer'. British Journal of Cancer, 88 (6):871-878. [Details]
Cooke, FJ; McCann, AH; Balfe, P; McAlister, K; Kennedy, M; Dervan, P; Kerin, MJ; (2003) 'Epigenetic control of the oestrogen receptor genes in breast cancer'. British Journal of Surgery, 90 (NA):42-43. [Details]
Pedersen, I.S., Dervan, P.A., McGoldrick, A., Harrison, M., Ponchel, F., Speirs, V., Isaacs, J.D., Gorey, T., and McCann, A. (2002) 'Promoter switch: a novel mechanism causing biallelic PEG1/MEST expression in invasive breast cancer'. Human Molecular Genetics, 11 (12). [Details]
McGoldrick, A; McCann, A; Fitzpatrick, J; Smith, J; Dervan, PA; (2002) 'Microarray generated oncogene copy number profiling in human bladder cancer'. British Journal of Cancer, 86 (NA):23-23. [Details]
McGoldrick, A; McCann, A; Fitzpatrick, J; Smith, J; Dervan, PA; (2002) 'Has bladder cancer MET its maker?'. Journal of Pathology, 198 (NA):41-41. [Details]
McGoldrick, A; McCann, A; Fitzpatrick, J; Smith, J; Dervan, PA; (2002) 'Microarray generated oncogene copy number profiling in human bladder cancer'. British Journal of Cancer, 86 (NA):23-23. [Details]
Pedersen, IS,Dervan, P,McGoldrick, A,Harrison, M,Ponchel, F,Speirs, V,Isaacs, JD,Gorey, T,McCann, A (2002) 'Promoter switch: a novel mechanism causing biallelic PEG1/MEST expression in invasive breast cancer'. Gene, 11 :1449-1453. [Details]
Pedersen, IS; Dervan, P; McGoldrick, A; Harrison, M; Ponchel, F; Speirs, V; Isaacs, JD; Gorey, T; McCann, A; (2002) 'Promoter switch: a novel mechanism causing biallelic PEG1/MEST expression in invasive breast cancer'. Human Molecular Genetics, 11 (12):1449-1453. [Details]
Pedersen, IS; Dervan, P; McGoldrick, A; Harrison, M; Ponchel, F; Speirs, V; Isaacs, JD; Gorey, T; McCann, A; (2002) 'Promoter switch: a novel mechanism causing biallelic PEG1/MEST expression in invasive breast cancer'. Human Molecular Genetics, 11 (12):1449-1453. [Details]
McGoldrick, A; McCann, A; Fitzpatrick, J; Smith, J; Dervan, PA; (2002) 'Has bladder cancer MET its maker?'. Journal of Pathology, 198 (NA):41-41. [Details]
Cooke, FJ; Balfe, P; McCann, AH; Dervan, P; Kennedy, M; Kerin, M; (2002) 'An investigation into the methylation status of oestrogen receptor beta and its subsequent expression in human breast cancer'. European Journal of Human Genetics, 10 (NA):83-84. [Details]
McGoldrick, A; McCann, A; Fitzpatrick, J; Smith, J; Dervan, PA; (2002) 'Microarray generated oncogene copy number profiling in human bladder cancer'. British Journal of Cancer, 86 (NA):23-23. [Details]
McGoldrick, A; McCann, A; Fitzpatrick, J; Smith, J; Dervan, PA; (2002) 'Has bladder cancer MET its maker?'. Journal of Pathology, 198 (NA):41-41. [Details]
Cooke, FJ; Balfe, P; McCann, AH; Dervan, P; Kennedy, M; Kerin, M; (2002) 'An investigation into the methylation status of oestrogen receptor beta and its subsequent expression in human breast cancer'. European Journal of Human Genetics, 10 (NA):83-84. [Details]
Pedersen, I.S., Dervan, P.A., Broderick, D., Harrison, M., Miller, N., Delany, E., O'Shea, D., Costello, P., McGoldrick, A., Keating, G., Tobin, B., Gorey, T., and McCann, A. (1999) 'Frequent loss of imprinting of PEG1/MEST in invasive breast cancer'. Cancer Research, 59 (21):5449-5451. [Details]
Fabre, A; McCann, AH; O'Shea, D; Broderick, D; Keating, G; Tobin, B; Gorey, T; Dervan, PA; (1999) 'Loss of heterozygosity of the Wilms' tumor suppressor gene (WT1) in in situ and invasive breast carcinoma'. Human Pathology, 30 (6):661-665. [Details]
Costello, PJ; McCann, AH; Gorey, T; Dervan, PA; (1999) 'Some non high grade ductal carcinomas in situ are polyclonal'. Laboratory Investigation, 79 (1):17-17. [Details]
Fabre, A,McCann, AH,O'Shea, D,Broderick, D,Keating, G,Tobin, B,Gorey, T,Dervan, PA (1999) 'Loss of heterozygosity of the Wilms' tumor suppressor gene (WT1) in in situ and invasive breast carcinoma'. Human Pathology, 30 :661-665. [Details]
Costello, PJ; McCann, AH; Gorey, T; Dervan, PA; (1999) 'Some non high grade ductal carcinomas in situ are polyclonal'. Laboratory Investigation, 79 (1):17-17. [Details]
Pedersen, IS,Dervan, PA,Broderick, D,Harrison, M,Miller, N,Delany, E,O'Shea, D,Costello, P,McGoldrick, A,Keating, G,Tobin, B,Gorey, T,McCann, A (1999) 'Frequent loss of imprinting of PEG1/MEST in invasive breast cancer'. Cancer, 59 (NA):5449-5451. [Details]
Miller, N; McCann, A; O'Connell, D; Pedersen, IS; Spiers, V; Gorey, T; Dervan, PA; (1998) 'Mono-allelic expression of the Mas proto-oncogene in human breast tissue'. European Journal of Human Genetics, 6 (NA):147-147. [Details]
Costello, P; McCann, AH; Moore, E; Gorey, T; Dervan, PA; (1998) 'Clonal analysis of breast DCIS on microdissected tumour cells using differential methylation of HUMARA (Xq12)'. MODERN PATHOLOGY, 11 (1):18-18. [Details]
Miller, N; McCann, A; O'Connell, D; Pedersen, IS; Spiers, V; Gorey, T; Dervan, PA; (1998) 'Mono-allelic expression of the Mas proto-oncogene in human breast tissue'. European Journal of Human Genetics, 6 (NA):147-147. [Details]
Costello, P; McCann, AH; Moore, E; Gorey, T; Dervan, PA; (1998) 'Clonal analysis of breast DCIS using differential methylation of HUMARA'. British Journal of Cancer, 78 (NA):11-11. [Details]
Costello, P; McCann, AH; Moore, E; Gorey, T; Dervan, PA; (1998) 'Clonal analysis of breast DCIS on microdissected tumour cells using differential methylation of HUMARA (Xq12)'. LABORATORY INVESTIGATION, 78 (1):18-18. [Details]
McGarry, Y; Lewis, S; McCann, A; Moran, E; Sinha, SK; Kelehan, P; Dervan, P; (1998) 'Distribution of the antigen recognised by the monoclonal antibody P1H10 in ovarian and breast tissue'. British Journal of Cancer, 78 (NA):68-68. [Details]
Miller, N,McCann, AH,O'Connell, D,Pedersen, IS,Spiers, V,Gorey, T,Dervan, PA (1997) 'The MAS proto-oncogene is imprinted in human breast tissue'. Genomics, 46 :509-512. [Details]
McCann AH, Miller N, O'Meara A, Pedersen I, Keogh K, Gorey T, Dervan PA (1996) 'Biallelic expression of the IGF2 gene in human breast disease'. Human Molecular Genetics, 5 (8):1123-1127. [Details]
Costello P, McCann A, Carney DN, Dervan PA. (1995) 'Prognostic Significance of Microvessel density in lymph node negative breast carcinoma'. Human Pathology, 26 (11):1181-1184. [Details]
MCCANN, AH; KIRLEY, A; CARNEY, DN; CORBALLY, N; MAGEE, HM; KEATING, G; DERVAN, PA; (1995) 'AMPLIFICATION OF THE MDM2 GENE IN HUMAN BREAST-CANCER AND ITS ASSOCIATION WITH MDM2 AND P53 PROTEIN STATUS'. British Journal of Cancer, 71 (5):981-985. [Details]
McCann, A.H., Dervan, P.A., O'Regan, M., Codd, M.B., Gullick, W.J., Tobin, B.M., and Carney, D.N. (1991) 'Prognostic significance of c-erbB-2 and estrogen receptor status in human breast cancer'. Cancer Research, 51 (12):3296-3303. [Details]
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Conference Publications:

Brennan, D.J., Hewitt, S.M., Fox, E.J.P., O'Brien, S., Jirstrom, K., Duffy, M.J., Landberg, G., McCann, A. & Gallagher, W.M. (2006) Automated quantitative analysis of immunohistochemistry linked to clinical outcome Automated quantitative analysis of immunohistochemistry linked to clinical outcome Dublin, Ireland, [Details]

Brennan, D.J., Hewitt, S.M., Fox, E.J.P., O'Brien, S., Jirstrom, K., Duffy, M.J., Landberg, G., McCann, A., & Gallagher, W.M. (2006) Automated quantitative analysis of immunohistochemistry linked to clinical outcome * Dublin, Ireland, [Details]

Abstract

Greene, L. M., Twal, W. O., Maguire, T., McCann, A., Dervan, P., Duffy, M. J., Argraves, W. S., and Gallagher, W. M. (2001) Proteolytic processing of fibulin-1 in human breast tumors is linked with estrogen receptor status. Abstract [Details]