Dr. Chandralal Hewage

Research

Dr Chandralal Hewage BSC, MPHIL, PHD

Peer Reviewed Journals:

Malthouse JP, Howe N, Rogers L, Hewage C, (2009) 'Oxyanion and Tetrahedral Intermediate Stabilization by subtilisin: Detection of a new tetrahedral adduct'. Biochimica et biophysica acta, 1794 (8):1251-1258. [DOI Link] [Details]

Venneti KC, Alana I, O'Harte FP, Malthouse JP, Hewage CM. (2008) 'Conformational studies of GIP in membrane mimicking environment: Studies towards the bioactive conformation'. JOURNAL OF BIOLOGICAL CHEMISTRY, . [Details]

Anusha P Subasinghage AP. Conlon JM, Hewage CM (2008) 'Conformational analysis of the broad-spectrum antibacterial peptide, ranatuerin-2CSa: identification of a full length helix-turn-helix motif'. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, . [Details]

Brennan L, McClenaghan NH, Scullion SM, Mion B, Hewage C, Malthouse JP, Flatt PR, Newsholme P, (2008) 'Prolonged L-alanine exposure induces changes in metabolism, Ca2+ handling and desensitization of insulin secretion in clonal pancreatic beta-cells'. Clinical science (London, England : 1979), (NA). [DOI Link] [Details]

Neville H McClenaghan, Siobhan M Scullion, Brian Mion, Chandralal Hewage, J Paul G Malthouse, Peter R Flatt, Philip Newsholme and Lorraine Brennan (2008) ' Prolonged L-alanine exposure induces changes in metabolism, Ca2+ handling and desensitization of insulin secretion in clonal pancreatic beta-cells'. Clinical Science, . [Details]

Subasinghage, A. R., Conlon, J. M., Hewage, C. M., (2008) 'Conformational analysis of the broad-spectrum antibacterial peptide, ranatuerin-2CSa: Identification of a full length helix-turn-helix motif'. Biochimica Et Biophysica Acta-Proteins and Proteomics, 1784 (6):924-929. [Details]

Hewage CM, Alana I, O'Harte FPM (2007) 'Structural studies of glucose-dependent insulinotropic polypeptide (GIP) in micellular media'. Diabetologia, 50 (1):0593-0593. [Details]
Brennan L, Scullion SM, Mion B, Hewage C, Malthouse JG, Flatt PR, Newsholme P, McClenaghan NH. (2007) 'Prolonged alanine exposure induces changes in metabolism, Ca2+ handling and desensitization of insulin secretion in clonal pancreatic beta cells'. Diabetologia, 50 (1):0509-0509. [Details]
Cosgrove S, Rogers L, Hewage CM, Malthouse JP. (2007) 'NMR Study of the Inhibition of Pepsin by Glyoxal Inhibitors: Mechanism of Tetrahedral Intermediate Stabilization by the Aspartyl Proteases'. BIOCHEMISTRY, . [Details]
Spink E, Hewage C, Malthouse JP (2007) 'Determination of the Structure of Tetrahedral Transition State Analogues Bound at the Active Site of Chymotrypsin Using (18)O and (2)H Isotope Shifts in the (13)C NMR Spectra of Glyoxal Inhibitors'. BIOCHEMISTRY, . [Details]
Malthouse JP, Spink E, Hewage C, (2007) 'Determination of the structure of tetrahedral transition state analogues bound at the active site of chymotrypsin using 18O and 2H isotope shifts in the 13C NMR spectra of glyoxal inhibitors'. Biochemistry, 44 (NA):12868-12874. [DOI Link] [Details]
Malthouse JP, Spink E, Cosgrove S, Rogers L, Hewage C, (2007) '13C and 1H NMR studies of ionizations and hydrogen bonding in chymotrypsin-glyoxal inhibitor complexes'. J BIOL CHEM, 11 (NA):7852-7861. [DOI Link] [Details]
Hewage CM, AlaÃ±a I, Malthouse JP, O'Harte FP, (2007) 'The bioactive conformation of glucose-dependent insulinotropic polypeptide by NMR and CD spectroscopy'. Proteins, 1 (NA):92-99. [DOI Link] [Details]
Malthouse JP, Cosgrove S, Rogers L, Hewage CM, (2007) 'NMR study of the inhibition of pepsin by glyoxal inhibitors: mechanism of tetrahedral intermediate stabilization by the aspartyl proteases'. Biochemistry, 39 (NA):11205-11215. [DOI Link] [Details]
Malthouse JP, Spink E, Hewage C, (2007) 'Determination of the structure of tetrahedral transition state analogues bound at the active site of chymotrypsin using 18O and 2H isotope shifts in the 13C NMR spectra of glyoxal inhibitors'. Biochemistry, 44 (NA):12868-12874. [DOI Link] [Details]
Spink, E, Cosgrove, S, Rogers, L, Hewage, C, Malthouse, JPG, (2007) 'C-13 and H-1 NMR studies of ionizations and hydrogen bonding in chymotrypsin-glyoxal inhibitor complexes'. J BIOL CHEM, 282 :7852-7861. [Details]
Alana, I, Malthouse, JPG, OHarte, FPM, Hewage, CM, (2007) 'The bioactive conformation of glucose-dependent insulinotropic polypeptide by NMR and CD spectroscopy'. Proteins, 68 :92-99. [Details]
Higgs, R, Lynn, DJ, Cahalane, S, Alana, I, Hewage, CM, James, T, Lloyd, AT, OFarrelly, C, (2007) 'Modification of chicken avian beta-defensin-8 at positively selected amino acid sites enhances specific antimicrobial activity'. Immunogenetics, 59 :573-580. [Details]
Cosgrove S, Rogers L, Hewage CM, Malthouse JP. (2007) 'NMR Study of the Inhibition of Pepsin by Glyoxal Inhibitors: Mechanism of Tetrahedral Intermediate Stabilization by the Aspartyl Proteases'. Biochemistry, 46 (39):11205-11215. [Details]
Malthouse JP, Spink E, Cosgrove S, Rogers L, Hewage C, (2007) '13C and 1H NMR studies of ionizations and hydrogen bonding in chymotrypsin-glyoxal inhibitor complexes'. J BIOL CHEM, 11 (NA):7852-7861. [DOI Link] [Details]
Alana I, Parker JC, Gault VA, Flatt PR, O'Harte FP, Malthouse JP, Hewage CM. (2006) 'NMR and alanine scan studies of glucose-dependent insulinotropic polypeptide in water'. JOURNAL OF BIOLOGICAL CHEMISTRY, . [Details]
Brennan L, Alves PM, Hewage C, Malthouse JP, McBean GJ. (2006) 'Impact of the gliotoxin L-serine-O-sulphate on cellular metabolism in cultured rat astrocytes'. International Neurochemistry, . [Details]
Cadogan JI, Hewage CM, McNab H, Macpherson AD, Nicolson IS, Reed D, Sadler IH. (2006) 'Generation and contrasting gas-phase reactivity of 2-(2-alkenylpyrrol-1-yl)phenoxyl and thiophenoxyl radicals'. ORGANIC & BIOMOLECULAR CHEMISTRY, . [Details]
Alana I, Malthouse JP, O'Harte FP, Hewage CM. (2007) 'Bioactive conformation of glucose-dependent insulinotropic polypeptide by NMR and CD spectroscopy'. PROTEINS: Structure, Func. and Bioinfor, 68 (1):92-99. [Details]
Higgs R, Lynn DJ, Cahalane S, Alana I, Hewage CM, James T, Lloyd AT, O'Farrelly C. (2007) 'Modification of chicken avian beta-defensin-8 at positively selected amino acid sites enhances specific antimicrobial activity'. Immunogenetics, 59 (7):573-580. [Details]
Spink E, Cosgrove S, Rogers L, Hewage C, Malthouse JP. (2007) '13C and 1H NMR studies of ionizations and hydrogen bonding in chymotrypsin-glyoxal inhibitor complexes'. Journal of Biological Chemistry, 282 (11):7852-7861. [Details]
Brennan, L; Hewage, C; Malthouse, JPG; McClenaghan, NH; Flatt, PR; Newsholme, P; (2006) 'Investigation of the effects of sulfonylurea exposure on pancreatic beta cell metabolism'. FEBS Journal, 273 (22):5160-5168. [Details]
Brennan, L., Hewage, C., Malthouse, J.P.G., McClenaghan, N.H., Flatt, P.R., Newsholme, P. (2006) 'NMR analysis reveals prolonged sulphonylurea exposure impacts on the regulation of pancreatic beta-cell metabolism'. FEBS JOURNAL, . [Details]
Brennan, L; Alves, PM; Hewage, C; Malthouse, JPG; McBean, GJ; (2006) 'Impact of the gliotoxin L-serine-O-sulphate on cellular metabolism in cultured rat astrocytes'. Neurochemistry International, 48 (8):739-745. [Details]
Alana, I; Parker, JC; Gault, VA; O'Harte, FPM; Malthouse, JPG; Hewage, CM; (2006) 'NMR and modelling studies of glucose-dependent insulinotropic polypeptide (GIP)'. Journal of Peptide Science, 12 (NA):185-185. [Details]
Djurdjevic-Pahl, A; Hewage, C; Malthouse, JPG; (2005) 'Ionisations within a subtilisin-glyoxal inhibitor complex'. Biochimica Et Biophysica Acta-Proteins and Proteomics, 1749 (1):33-41. [Details]
Hewage CM, Alana I, O'Harte FP, Malthouse JP (2005) 'Structural studies of the glucose-dependent insulinotropic polypeptide (GIP) by NMR and molecular modelling'. FEBS JOURNAL, 272 :S373-S373. [Details]
Brennan L, Hewage C, Malthouse JG, McClenaghan NH, Flatt PR, Newsholme P. (2005) 'Effects of anti-diabetic drugs on beta cell glucose metabolism in a clonal cell line, BRIN-BD11'. DIABETOLOGIA, 48 :A163-A163. [Details]
Alana, I; Hewage, CM; Malthouse, JPG; Parker, JC; Gault, VA; O'Harte, FPM; (2004) 'NMR structure of the glucose-dependent insulinotropic polypeptide fragment, GIP(1-30)amide'. Biochemical and Biophysical Research Communications, 325 (1):281-286. [Details]
Brooks, SJ; Doyle, EM; Hewage, C; Malthouse, JPG; Duetz, W; O'Connor, KE; (2004) 'Biotransformation of halophenols using crude cell extracts of Pseudomonas putida F6'. Applied Microbiology and Biotechnology, 64 (4):486-492. [Details]
Brennan L, Hewage C, Malthouse JP, McBean GJ. (2004) 'Gliotoxins disrupt alanine metabolism and glutathione production in C6 glioma cells: a 13C NMR spectroscopic study'. NEUROCHEMISTRY INTERNATIONAL, 45 (8):1155-1165. [Details]
Alana I, Hewage CM, Malthouse JP, Parker JC, Gault VA, O'Harte FP. (2004) 'NMR structure of the glucose-dependent insulinotropic polypeptide fragment, GIP(1-30)amide'. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 325 (1):281-286. [Details]
Brennan, L; Hewage, C; Malthouse, JPG; McBean, GJ; (2004) 'Gliotoxins disrupt alanine metabolism and glutathione production in C6 glioma cells: a C-13 NMR spectroscopic study'. Neurochemistry International, 45 (8):1155-1165. [Details]
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Other Journals:

Cadogan, J.I., Hewage, C.M., McNab, H., Macpherson, A.D., Nicolson, I.S., Reed, D., Sadler, I.H. (2006) 'Generation and contrasting gas-phase reactivity of 2-(2-alkenylpyrrol-1-yl)phenoxyl and thiophenoxyl radicals' Org Biomol Chem 4 (12) :2446-2451. [Details]

Alana, I., Parker, J.C., Gault, V.A., Flatt, P.R., O'Harte, F.P., Malthouse, J.P., Hewage, C.M. (2006) 'NMR and alanine scan studies of glucose-dependent insulinotropic polypeptide in water' J. Biol. Chem 281 (24) :16370-16376. [Details]

Dabos KJ, Nelson LJ, Hewage CH, Parkinson JA, Howie AF, Sadler IH, Hayes PC, Plevris JN (2004) 'Comparison of bioenergetic activity of primary porcine hepatocytes cultured in four different media' Cell Transplant 13 (3) :213-229. [Details]

Conference Publications:

Brennan, L., Hewage, C., Malthouse, J.P.G, Colhoun, H. (2006) Analysis of metabolic profiles of biofluids from patients with type 1 Diabetes Mellitus Metabolomics Conference Boston, USA, [Details]

Brennan, L., Hewage, C., Malthouse, J.G., McCenaghan, N.H., Flatt, P.R. and Newsholme P. (2005) Effects of anti-diabetic drugs on beta cell glucose metabolism in a clonal cell line, BRIN-BD11 EASD Athens, Greece, [Details]