Dr. Evelyn Murphy | UCD Conway

Research

Dr Evelyn Murphy BSc, PhD

Book Chapters:

Eijbouts A, E. Murphy E. (1999) 'The role of the hypothalmic-pitutary adrenal axis in patients with rheumatoid arthritis' In: * (eds). Ballieres Clinical Rheumatology. [Details]

Peer Reviewed Journals:

Mix KS, McMahon K, McMorrow JP, Walkenhorst D , Smyth AM, Petrella BL, Gogarty M, Fearon U, Veale D, Attur MG, Abramson SB and Murphy EP. (2012) 'Orphan nuclear receptor NR4A2 induces synoviocyte proliferation, invasion, and MMP-13 transcription'. Arthritis and Rheumatism, . [Details]

McMorrow J and Murphy EP (2011) 'Inflammation: a role for NR4A orphan nuclear receptors'. Biochemical Society Transactions, 39 (2):688-693. [Details]

Ralph, J.A., Ahmed, A.U., Santos, L.L., Clark, A., McMorrow, J., Murphy, E.P., Morand, E.F. (2010) 'Identification of NURR1 as a Mediator of MIF Signalling During Chronic Arthritis: Effects on Glucocorticoid-Induced MKP1'. American Journal of Pathology, 177 (5):2366-2378. [Details]

Zocco D, McMorrow JP and Murphy EP (2010) 'Histamine modulation of peripheral CH receptor 1a expression is dependent on calcium signalling and NF-kB/p65 transcriptional activity'. Molecular immunology, 47 :1426-1437. [Details]

Brayden DJ, Keely S, Ryan SM, Haddleton DM, Limer A, Mantovani G, Murphy EP, Colgan SP, (2009) 'Dexamethasone-pDMAEMA polymeric conjugates reduce inflammatory biomarkers in human intestinal epithelial monolayers'. Journal of controlled release : official journal of the Controlled Release Society, 135 (1):35-43. [DOI] [Details]

Aherne CM, McMorrow J, Kane D, FitzGerald O, Mix KS and Murphy EP. (2009) ' Identification of the orphan receptor NR4A2 as a transcriptional regulator of IL-8 expression in human inflammatory arthritis'. Molecular immunology, 46 :3345-3357. [Details]

O'Kane, M., T. Markham, A. McEvoy, U. Fearon, D. Veale, O. FitzGerald, B. Kirby and E. Murphy (2008) 'Increased expression of the orphan nuclear receptor NURR1 in psoriasis and modulation following TNF-α inhibition'. Journal of Investigative Dermatology, 128 :300-310. [Details]
Gallagher, J,Howlin, J,McCarthy, C,Murphy, EP,Bresnihan, B,FitzGerald, O,Godson, C,Brady, HR,Martin, F (2003) 'Identification of Naf1/ABIN-1 among TNF-alpha-induced expressed genes in human synoviocytes using oligonucleotide microarrays'. FEBS Letters, 551 (NA):8-12. [DOI] [Details]
Mix, K., Mukundan, G., Al-Mussawir, H., Abramson, S.B., Brinckerhoff, C.E. and Murphy, E. (2007) 'Transcriptional regulation of matrix metalloproteinase gene expression by the orphan nuclear receptor NURR1 in cartilage'. Journal of Biological Chemistry, 282 (13):9492-9504. [Details]
Ralph, JA, Zocco, D, Bresnihan, B, FitzGerald, O, McEvoy, AN, Murphy, EP, (2007) 'A role for type 1 alpha corticotropin-releasing hormone receptors in mediating local changes in chronically inflamed tissue'. American Journal of Pathology, 170 :1121-1133. [Details]
Anquetin G, Rawe SL, McMahon K, Murphy EP, Murphy PV. (2008) 'Synthesis of novel migrastatin and dorrigocin A analogues from D-glucal'. Chemistry-A European Journal, 14 (5):1592-1600. [Details]
Fitzgerald, D.C., Meade, K.G., McEvoy, A.N., Lillis, L., Murphy, E.P., Machugh, D.E., Baird, A.W. (2007) 'Tumour necrosis factor-alpha (TNF-alpha) increases nuclear factor kappaB (NFkappaB) activity in and interleukin-8 (IL-8) release from bovine mammary epithelial cells'. Veterinary Immunology and Immunopathology, 116 (1/2):59-68. [Details]
O'Kane, M., Murphy, E.P. & Kirby, B. (2006) 'The role of Corticotropin Releasing Hormone in immune-mediated cutaneous disease'. Experimental Dematology, :143-153. [Details]
Rawe SL, Doyle D, Zaric V, Rozas I, McMahon K, Tosin M, Bunz HM, Murphy EP, O' Boyle KM, Murphy PV. (2006) 'N-Glycosyl-thiophene-2-carboxamides: synthesis, structure and effects on the growth of diverse cell types'. Carbohydrate Research, 341 (10):370-390. [Details]
Mix, KS; Brinckerhoff, CE; Murphy, EP; (2005) 'Orphan nuclear receptor NURR1 represses matrix metalloproteinase-1 transcription in chondrocytes'. Arthritis and Rheumatism, 52 (9):706-706. [Details]
Ralph J, McEvoy A, Kane D, Bresnihan B, FitzGerald O and Murphy E.P. (2005) 'Modulation of orphan nuclear receptor NURR1 expression by methotrexate in human inflammatory joint disease involves adenosine A2A receptor mediated responses'. Journal of Immunology, 55 :555-565. [Details]
McEvoy, AN; Bresnihan, B; FitzGerald, O; Murphy, EP; (2004) 'Cyclooxygenase 2-derived prostaglandin E-2 production by corticotropin-releasing hormone contributes to the activated cAMP response element binding protein content in rheumatoid arthritis synovial tissue'. Arthritis and Rheumatism, 50 (4):1132-1145. [Details]
Ralph, JA; McEvoy, AN; Bresnihan, B; FitzGerald, O; Murphy, EP; (2004) 'Inhibitory effects of low-dose methotrexate on expression of the orphan receptor NURR1 are mediated through the adenosine type A2 receptor'. Arthritis and Rheumatism, 50 (9):568-568. [Details]
Benito MJ, Murphy E, Murphy E, FitzGerald O, van den Berg W, Bresnihan B. (2004) 'Increased NF-kB1 (p50) expression at sites adjacent to the cartilage-pannus junction in rheumatoid arthritis'. Arthritis and Rheumatism, 50 :1788-1799. [Details]
OHara R, Murphy E, Whitehead A.S., FitzGerald O. and Bresnihan B. (2004) 'Local expression of the serum amyloid A and formyl peptide receptor-like 1 genes in synovial tissue is associated with matrix metalloproteinase production in patients with inflammatory arthritis'. Arthritis and Rheumatism, 50 :1781-1787. [Details]
R OHara, EP Murphy, A S Whitehead, O FitzGerald, B Bresnihan. (2000) 'Acute phase serum amyloid A production by rheumatoid arthritis synovial tissue'. Arthritis Care and Research, 2 :142-144. [Details]
McEvoy A, Bresnihan B, FitzGerald O and Murphy E. (2004) 'COX-2-derived prostaglandin E2 production by CRH contributes to the activated cAMP Response Element Binding Protein (CREB) content in Rheumatoid Arthritis synovial tissue'. Arthritis and Rheumatism, 50 :1132-1145. [Details]
Ralph, JA; Bresnihan, B; FitzGerald, O; Murphy, EP; (2003) 'Methotrexate inhibits the production of the transcription factor NURR1 in human inflammatory joint disease'. Arthritis and Rheumatism, 48 (9):417-417. [Details]
McEvoy A., Bresnihan B, FitzGerald O and Murphy E. (2002) 'Corticotropin-Releasing Hormone signaling in vascular endothelium is mediated through the cAMP/CREB pathway'. Annals of the New York Academy of Sciences, 966 :119-130. [Details]
McEvoy A, Conneely O.M., Bresnihan B., FitzGerald O and Murphy E. (2002) 'Activation of nuclear orphan receptor NURR1 transcription by NFkB and CREB in rheumatoid arthritis synovial tissue'. Journal of Immunology, 168 :2979-2987. [Details]
Murphy E, McEvoy A, Conneely OM, Bresnihan B and Fitzgerald O. (2001) 'Involvement of the nuclear orphan receptor NURR1 in the regulation of Corticotropin Releasing Hormone expression and actions in human inflammatory arthritis'. Arthritis and Rheumatism, 44 :782-793. [Details]
McEvoy A, Bresnihan B, FitzGerald O and Murphy E. (2001) 'Corticotropin Releasing Hormone (CRH) signaling in synovial tissue from patients with early inflammatory arthritis is mediated by the type 1a CRH receptor'. Arthritis and Rheumatism, 44 :1761-1767. [Details]
Eijsbouts A and Murphy E. (1999) 'The role of the Hypothalamic-Pituitary-Adrenal axis in Rheumatoid Arthritis'. Ballieres Clinical Rheumatology, 13 :599-613. [Details]
Murphy E. and Conneely O.M. (1997) 'Neuroendocrine regulation of the Hypothalamic Pituitary Adrenal Axis by the NURR1/NUR77 subfamily of nuclear receptors'. Molecular Endocrinology, 16 :39-47. [Details]
Murphy E., Dobson A.D.W., Keller C. and Conneely O.M. (1996) 'Differential regulation of transcription by the NURR1/NUR77 subfamily of nuclear transcription factors'. GENE EXPRESSION, 5 :169-179. [Details]
Hide

Show All

Conference Publications:

Ryan, S. M., McMorrow, J. P., Murphy, E. P. & Brayden, D. J. (2010) Salmon calcitonin reduces expression of a novel biomarker family in inflammatory arthritis:a new target for controlled release formulations? Transactions of the 37th Int. Soc. Controlled Release Society, Portland, Oregon [Details]

Viviana Marzaioli, Jason P. McMorrow, Alice McEvoy and Evelyn P. Murphy. (2010) Histamine contributes to inflammatory joint disease by regulating the expression of RANKL and OPG through altered NR4A activity in human chondrocyte cells Arthritis and Rheumatism 62 (10)1482, [Details]

Jason P. McMorrow, Evelyn P. Murphy, Bruce N. Cronstein. (2010) Identification of the NR4A family of orphan nuclear receptors as mediators of adenosine A2A receptor activation Arthritis and Rheumatism 62(10)1522, [Details]

Jason P. McMorrow, Ursula Fearon, Douglas Veale, Oliver Fitzgerald and Evelyn P. Murphy. (2010) Contribution of NR4A2 Gene Expression in the Modulation of Thrombospondin-1 in Human Joint Disease Arthritis and Rheumatism 62 (10) 1508, [Details]

Ryan SM, McMorrow JP, Murphy EP and Brayden DJ (2009) Salmon calcitonin as a potential therapeutic for osteoarthritis and rheumatoid arthritis Proc. Intern. Symposium. Control. Rel. Bioact. Mat [Details]

McMorrow, J. P., Murphy, E. P., (2008) Journal of Neuroimmunology Transcriptional repression of thrombospondin-1 gene expression by NR4A2 in inflammatory joint disease , pp.172-172 [Details]

Zocco, D., Murphy, E. P., (2008) Journal of Neuroimmunology Histamine modulates the expression of corticotrophin-releasing-hormone receptor type I in human inflammatory arthritis , pp.171-171 [Details]
Gogarty, M, Murphy, EP, Fearon, U, Veale, DJ, Bresnihan, B, FitzGerald, O, (2007) ANN RHEUM DIS Placenta growth factor (PLGF) expression in inflammatory arthritis , pp.35-36 [Details]
Gogarty, M., Murphy, E. P., Fearon, U., Veale, D. J., Bresnihan, B., FitzGerald, O., (2007) Annals of the Rheumatic Diseases Abundant placenta growth factor (PlGF) expression in the inflammatory joint , pp.141-141 [Details]
O'Kane, M., Kirby, B., FitzGerald, O. & Murphy, E.P. (2006) Corticotropin-releasing hormone, corticotropin-releasing hormone receptor and NURR1 are increased in psoriasis lesional skin British Journal of Dermatology [Details]
Gogarty, M., Murphy, E.P., Veale, D., Bresnihan, B., FitzGerald, O. (2005) Alternative splicing of the VEGFR-1 (flt-1) and its ligands in human inflammatory arthritis ARTHRITIS AND RHEUMATISM [Details]
Aherne, C.M., Mix, K.S. & Murphy, E.P. (2005) Modulation of the transcriptional activity of the nuclear receptor NURR1 by pro-inflammatory mediators ARTHRITIS AND RHEUMATISM 52 (9): S707-S708, [Details]
Mix, K.S., Brinckerhoff, C.E. & Murphy, E.P. (2005) Orphan nuclear receptor NURR1 represses matrix metalloproteinase-1 transcription in chondrocytes ARTHRITIS AND RHEUMATISM [Details]
Ralph J, McEvoy A, Kane D, Bresnihan B, FitzGerald O and Murphy E (2004) Modulation of orphan nuclear receptor NURR1 expression by methotrexate in human inflammatory joint disease involves adenosine A2A receptor mediated responses ARTHRITIS AND RHEUMATISM [Details]
Ralph JA, McEvoy AN, Bresnihan B, FitzGerald O and Murphy E. (2002) Modulation of type 1 CRH receptor expression by inflamed human synovial tissue: Involvement in the pathological changes associated with increased vascular permeability ARTHRITIS AND RHEUMATISM [Details]
McEvoy A, Bresnihan B, FitzGerald O and Murphy E. (2002) COX-2-derived prostaglandin E2 production by CRH contributes to the activated cAMP Response Element Binding Protein (CREB) content in Rheumatoid Arthritis synovial tissue ARTHRITIS AND RHEUMATISM [Details]
Hide

Show All