Dr. Gethin McBean | UCD Conway

Research

Dr Gethin McBean BA, PhD.

Book Chapters:

McBean G. (2007) 'Sulfur-containing amino acids' In: Lajtha A., Oja S., Schousboe A. and Saransaari P (eds). Handbook of Neurochemistry and Molecular Neurobiology. Vol.4, Amino acids and peptides in the nervous system. Berlin, Heidelberg: Springer-Verlag. [Details]

McBean G.J. (1997) 'Receptors in the nervous system' In: Lynch M.A. and O'Meara S., Academic Press, San Diego (eds). Neuroscience Labfax. [Details]

McBean G. J., Horner E. B., Coueé I., Philips J. P., O'Brien M., Lee T. C. and Tipton K. F. (1990) 'Enzymes and glial cells in brain damage and neurodegenerative disease' In: Dostert P., Reiderer P., Strolin Benedetti M. and Roncucci R. (eds). Early markers in Parkinson's and Alzheimer's Diseases Vol. 1. Vienna: Springer-Verlag. [Details]

Peer Reviewed Journals:

Kandil, S., Brennan, L. and McBean, GJ (2010) 'Glutathione depletion causes a JNK and p38MAPK-mediated increase in expression of cystathionine-gamma-lyase and upregulation of the transsulfuration pathway in C6 glioma cells'. Neurochemistry International, 56 :611-619. [DOI] [Details]

Vines, A., McBean, G.J., Blanco-Fernández, A. (2010) 'A flow-cytometric method for continuous measurement of intracellular Ca2+ concentration'. Cytometry Part A, 77 (11):1091-1097. [Details]

Godson C, Decker Y, McBean G, (2009) 'Lipoxin A4 inhibits IL-1{beta}-induced IL-8 and ICAM-1 expression in 1321N1 human astrocytoma cells'. American journal of physiology. Cell physiology, 296 (NA):C1420-C1427. [DOI] [Details]

McBean GJ, Murphy A, Vines A, (2009) 'Stimulation of EAAC1 in C6 glioma cells by store-operated calcium influx'. Biochimica et biophysica acta, 1788 :551-558. [DOI] [Details]

Kandil, S., Brennan, L., McBean, G., (2008) 'Differential effects of two gliotoxins on glutathione content in rat C6 glioma cells'. Journal of Neuroimmunology, 197 (2):169-169. [Details]

Matthaes, S., McBean, G., (2008) 'The cystine-glutamate exchanger in 1321N1 astrocytoma cells'. Journal of Neuroimmunology, 197 (2):168-168. [Details]

Vines, A., McBean, G., (2008) 'Calcium-mediated regulation of glutamate uptake in rat primary astrocytes'. Journal of Neuroimmunology, 197 (2):169-169. [Details]
McBean GJ, Montgomery T, Buon C, Eibauer S, Guiry PJ, Keenan AK, (2007) 'Comparative potencies of 3,4-methylenedioxymethamphetamine (MDMA) analogues as inhibitors of [3H]noradrenaline and [3H]5-HT transport in mammalian cell lines'. British Journal of Pharmacology, 7 (NA):1121-1130. [DOI] [Details]
McBean GJ, Quinn ST, Guiry PJ, Schwab T, Keenan AK, (2006) 'Blockade of noradrenaline transport abolishes 4-methylthioamphetamine-induced contraction of the rat aorta in vitro'. Autonomic & autacoid pharmacology, 4 (NA):335-344. [DOI] [Details]
Brennan, L; Alves, PM; Hewage, C; Malthouse, JPG; McBean, GJ; (2006) 'Impact of the gliotoxin L-serine-O-sulphate on cellular metabolism in cultured rat astrocytes'. Neurochemistry International, 48 (8):739-745. [Details]
Berry, CB; Hayes, D; Murphy, A; Wiessner, M; Rauen, T; McBean, GJ; (2005) 'Differential modulation of the glutamate transporters GLT1, GLAST and EAAC1 by docosahexaenoic acid'. Brain Research, 1037 (1-2):123-133. [Details]
Hayes, D; Wiessner, M; Rauen, T; McBean, GJ; (2005) 'Transport of L-[C-14]cystine and L-[C-14]cysteine by subtypes of high affinity glutamate transporters over-expressed in HEK cells'. Neurochemistry International, 46 (8):585-594. [Details]
McBean GJ, Brennan L, Hewage C, Malthouse JP, (2004) 'Gliotoxins disrupt alanine metabolism and glutathione production in C6 glioma cells: a 13C NMR spectroscopic study'. NEUROCHEMISTRY INTERNATIONAL, 8 (NA):1155-1165. [DOI] [Details]
Dervan, AG; Meshul, CK; Beales, M; McBean, GJ; Moore, C; Totterdell, S; Snyder, AK; Meredith, GE; (2004) 'Astroglial plasticity and glutamate function in a chronic mouse model of Parkinson's disease'. Experimental Neurology, 190 (1):145-156. [Details]
Berry, CB; McBean, GJ; (2003) 'An investigation into the role of calcium in the modulation of rat synaptosomal D-[H-3]aspartate transport by docosahexaenoic acid'. Brain Research, 973 (1):107-114. [Details]
Brennan, L; Hewage, C; Malthouse, JPG; McBean, GJ; (2003) 'An NMR study of alterations in [1-C-13]glucose metabolism in C6 glioma cells by gliotoxic amino acids'. Neurochemistry International, 42 (6):441-448. [Details]
Murphy, JEJ,Flynn, JJ,Cannon, DM,Guiry, PJ,McCormack, P,Baird, AW,McBean, GJ,Keenan, AK (2002) 'In vitro neuronal and vascular responses to 5-hydroxytryptamine: modulation by 4-methylthioamphetamine, 4-methylthiomethamphetamine and 3,4-methylenedioxymethamphetamine'. European Journal of Pharmacology, 444 (NA):61-67. [DOI] [Details]
Murphy, JEJ, McBean, GJ, Guiry, PJ, McCormack, P, Baird, AW, Keenan, AK, (2002) 'In vitro effects of (+/-)-4-methylthioamphetamine, (+/-)-4-methylthiomethamphetamine and (+/-)-MDMA on vascular responses to noradrenaline and phenylephrine'. British Journal of Pharmacology, 136 (NA). [Details]
McBean,G.J. (2002) 'Cerebral cystine uptake: a tale of two transporters'. Trends in Pharmacological Sciences, 23 (7):299-302. [Details]
Cannon, DM; Keenan, AK; Guiry, PJ; Buon, C; Baird, AW; McBean, GJ; (2001) 'In vitro neuronal and vascular responses to 5-HT in rats chronically exposed to MDMA'. British Journal of Pharmacology, 134 (7):1455-1460. [DOI] [Details]
Baird, AW, Moriarty, D, Guiry, P, McBean, GJ, Keenan, AK, (2001) '(+/-)-3,4 methylenedioxymethamphetamine (MDMA) stimulates electrogenic ion transport in rat colonic mucosa in vitro'. British Journal of Pharmacology, 134 (NA). [Details]
Murphy, JEJ, Cannon, DM, Guiry, P, McCormack, P, Baird, AW, McBean, GJ, Keenan, AK, (2001) 'A comparison of the in vitro effects of (+/-)-4-methylthioamphetamine and (+/-)-MDMA on 5-HT re-uptake in the brain and on vascular responses to 5-HT'. British Journal of Pharmacology, 134 (NA). [Details]
Flynn, J, McBean, GJ, (2000) 'Kinetic and pharmacological analysis of L-[S-35]cystine transport into rat brain synaptosomes'. Neurochemistry International, 36 (6):513-521. [Details]
Flynn, J, McBean, GJ, (1998) 'Characterisation of cystine transport in rat brain synaptosomes'. European Journal of Neuroscience, 10 (NA):352-352. [Details]
MCBEAN, GJ, DOORTY, KB, TIPTON, KF, KOLLEGGER, H, (1995) 'ALTERATION IN THE GLIAL-CELL METABOLISM OF GLUTAMATE BY KAINATE AND N-METHYL-D-ASPARTATE'. Toxicon, 33 (4):569-576. [Details]
TIPTON, KF, MCBEAN, GJ, DAVEY, SP, (1995) 'NEUROTOXINS AND NEURODEGENERATIVE DISEASES'. Neurochemistry, 65 (NA):65-65. [Details]
KOLLEGGER, H, MCBEAN, GJ, TIPTON, KF, (1993) 'REDUCTION OF STRIATAL N-METHYL-D-ASPARTATE TOXICITY BY INHIBITION OF NITRIC-OXIDE SYNTHASE'. BIOCHEM PHARMACOL, 45 (1):260-264. [Details]
KOLLEGGER, H, MCBEAN, GJ, TIPTON, KF, (1991) 'THE INHIBITION OF GLUTAMINE-SYNTHETASE IN RAT CORPUS STRIATUM INVITRO BY METHIONINE SULFOXIMINE INCREASES THE NEUROTOXIC EFFECTS OF KAINATE AND N-METHYL-D-ASPARTATE'. Neuroscience Letters, 130 (1):95-98. [Details]
McBean, GJ, Flynn, J, (2001) 'Molecular mechanisms of cystine transport'. Biochemical Society Transactions, 29 (NA):717-722. [Details]
Berry, CB, McBean, GJ, (2001) 'Structure activity relationships in the modulation of glutamate transport in synaptosomes and HEKGLT1 cells by fatty acids'. British Journal of Pharmacology, 134 (NA). [Details]
Flynn, J., and McBean, G.J. (2000) 'Kinetic and pharmacological analysis of L-[35S]cystine transport into rat brain synaptosomes'. Neurochemistry International, 36 :513-521. [Details]
Healy, J; Downes, A; McBean, GJ; (2000) 'Stimulation of synaptosomal D-[H-3]aspartate transport by substance P in rat brain'. Neuroscience Letters, 290 (2):113-116. [Details]
Healy, J., Downes, A., and McBean, G.J. (2000) 'Stimulation of synaptosomal D-[3H]aspartate transport by substance P in rat brain'. Neuroscience Letters, 290 :113-116. [Details]
De Souza, I.E.J., McBean, G.J. and Meredith, G.E. (1999) 'Chronic haloperidol treatment impairs glutamate transport in the rat striatum'. European Journal of Pharmacology, 382 :139-142. [Details]
De Souza, IEJ; McBean, GJ; Meredith, GE; (1999) 'Chronic haloperidol treatment impairs glutamate transport in the rat striatum'. European Journal of Pharmacology, 382 (2):139-142. [Details]
OByrne, MB; Tipton, KF; McBean, GJ; (1996) 'The effects of 1-methyl-4-phenylpyridinium ion on biogenic amine levels in rat substantia nigra'. Biochemical Society Transactions, 24 (1):62-62. [Details]
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Abstract

McBean, G.J. (2010) The cystine glutamate exchanger and antioxidant defence in astrocytes. Abstract [Details]

Vines, A., Blanco Fernández, A., Rogers, C. and McBean, G. (2009) A flow cytometric method for continuous measurement of intracellular calcium. Abstract [Details]

Vines, A., McBean, G. and Blanco Fernández, A. (2009) A flow cytometric method for continuous measurement of intracellular calcium concentration. Abstract [Details]

Vines, A., McBean, G.J. and Blanco Fernández, A. (2009) A flow-cytometric method for continuous measurement of intracellular Ca2+ concentration. Abstract [Details]

Vines, A., Blanco Fernández, A., Rogers, C. and McBean, G. (2009) A flowcytometric method for continuous measurement of intracellular calcium. Abstract [Details]

Decker Y., McBean G. and Godson C. (2008) Anti-inflammatory effects of lipoxin A4 in human 1321N1 astrocytoma cells. J. Neuroimmunol. 197, p168: Abstract [Details]

Vines, A., Murphy, A. and McBean, G. (2008) Intracellular calcium store-dependent modulation of EAAC1-mediated glutamate transport in C6 glioma cells. . Abstract [Details]
Vines, A. and McBean, G. (2008) Calcium-mediated regulation of glutamate uptake in rat primary astrocytes. J. Neuroimmunol. 197, p169: Abstract [Details]
Matthaes, S. and McBean, G. (2008) The cystine-glutamate exchanger in 1321N1 astrocytoma cells. J. Neuroimmunol. 197, p168: Abstract [Details]
Matthaes, S. and McBean, G. (2008) The cystine-glutamate exchanger in human 1321N1 astrocytoma cells. Ir. J. Med. Sci. 177, S379: Abstract [Details]
Kandil S., Brennan L. and McBean G. (2008) Differential effects of two gliotoxins on glutathione content in rat C6 glioma cells. J. Neuroimmunol. 197, p169: Abstract [Details]
Kandil S., Brennan L. and McBean G. (2008) Gliotoxin-mediated decrease in GSH synthesis in C6 glioma cells. Ir. J. Med. Sci. 177, S370: Abstract [Details]
Montgomery, T., Guiry, P.J., Keenan, A.K. and McBean, G.J. (2007) Modulation of [3H]noradrenaline and [3H]serotonin transport by structural analogues of 3,4-methylendioxymethamphetamine (MDMA). International Society of Neurochemistry, Satellite Symposium on Drugs of Abuse, Merida, Mexico: Abstract [Details]
Montgomerty, T., Guiry, P., Keenan, A.K. and McBean, G.J. (2007) In vitro toxicity studies of MDMA analogues in PC12 cells. International Society for Neurochemistry. Satellite Symposium on Drugs of Abuse, Merida, Mexico: Abstract [Details]
Quinn, S.T., Nyhan, L., Guiry, P.J., Keenan, A.K. and McBean, G.J. (2005) Modulation of noradrenaline transport and release by 4-methylthioamphetamine in the rat aorta. International Society for Neurochemistry, Satellite Symposium on Drugs of Abuse, Venice, Italy: Abstract [Details]
Montgomery T.M., Guiry P., Keenan A. and McBean G. (2006) In vitro modulation of monoamine transport by structural analogues of 3.4-methylenedioxymethamphetamine. Abstract [Details]
Brennan L., Hewage C., Malthouse J. P. G. and McBean G. J. (2005) Metabolic disruptions caused by gliotoxic amino acids. Abstract [Details]
Quinn S. T., Guiry P. J., McBean G. J. and Keenan A. K. (2005) 4-MTA signalling in rat aortic rings: the role of the noradrenaline transporter. Abstract [Details]
Murphy A., Berry C. B., Hayes D. and McBean G. J. (2004) Fatty acid mediated regulation of glutamate transporters. Abstract [Details]
Quinn S. T., Guiry P., McBean G. J. and Keenan A. K. (2004) Involvement of noradrenaline in the contractile effect of 4-methylthioamphetamine on isolated rat aorta. Abstract [Details]
Dervan A. G., Beales M., Frederickson J., Meshul C. K., McBean G. J., Snyder A. K. and Meredith G. E. (2003) Chronic MPTP/probenecid treatment induces a significant gliosis but does not alter striatal glutamate levels or transport. Abstract [Details]
Hayes D., Berry C. B. and McBean G. J. (2003) Uptake of L-cystine by high affinity glutamate transporters over-expressed in HEK cells. Abstract [Details]
Murphy J. E. J., McBean G. J., Guiry P. J., McCormack P., Baird A. W. and Keenan A. K. (2002) In vitro effects of (±)-4-methylthioamphetamine, (±)-4-methylthiomethamphetamine and (±)-MDMA on vascular responses to noradrenaline and phenylephrine. Abstract [Details]
Baird A. W., Moriatry D., Guiry P., McBean G. J. and Keenan A. K. (2001) (±)-3,4-methylenedioxymethamphetamine (MDMA) stimulates electrogenic ion transport in rat colonic mucosa in vitro. Abstract [Details]
Berry C. B. and McBean G. J. (2001) Structure-activity relationships in the modulation of glutamate transport in synaptosomes and HEKGLT1 cells by fatty acids. Abstract [Details]
Murphy J. E. J., Cannon D. M., Guiry P., McCormack P., Baird A. W., McBean G. J. and Keenan A. K. (2001) A comparison of the in vitro effects of (±)MDMA and 4-methylthioamphetamine on 5-HT re-uptake in the brain and on vascular responses to 5-HT. Abstract [Details]
Cannon D., McBean G. J., Baird A. W. and Keenan A. K. (2001) The effects of MDMA on smooth muscle contraction in the rat. Abstract [Details]
Flynn J. and McBean G. J. (1998) Characterisation of cystine transport in rat brain synaptosomes. Abstract [Details]
O'Byrne M. B., Tipton K. F. and McBean G. J. (1996) The effects of 1-methyl-4-phenylpyridinium ion on biogenic amine levels in rat substantia nigra. Abstract [Details]
Tipton K. F., McBean G. J. and Davey G. P. (1995) Neurotoxins and neurodegenerative diseases. Abstract [Details]
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