Dr. Jarlath Nally | UCD Conway

Research

Dr Jarlath Nally BSc, PhD

Contact Details

Title	College Lecturer
Address	School of Veterinary Medicine Veterinary Science Centre Belfield Dublin 4
Telephone:	Ext. 6182
Email:	ei.dcu@yllan.htalraj

Biography:

Jarlath Nally graduated from University College Dublin with a first class honours degree in Zoology in 1995. In 1996 he was awarded a Maxwell and Muriel Gluck Fellowship at the University of Kentucky and in 2001 he completed his Ph.D. in Veterinary Science (Molecular Microbiology and Immunology) with Prof. John F. Timoney, Keeneland Professor of Infectious Diseases. During his Ph.D., he worked on molecular mechanisms of microbial pathogens, including the spirochete Leptospira and Group C Streptococci. His research received several awards, including, for immunology, Outstanding Graduate Student Presentation Award 2000 from the American College of Veterinary Microbiologists. In 2001, Dr. Nally joined the laboratory of Dr. Michael A. Lovett, Chief of the Division of Infectious Diseases, in the Department of Medicine at the University of California, Los Angeles. His research focused on understanding pathogenic mechanisms of the zoonotic disease Leptospirosis (Weil's disease) during acute and chronic infection and in particular, the severe pulmonary form of leptospirosis. As a postdoctoral fellow, he was awarded a Ruth L. Kirschstein National Research Service Award from the National Institute's of Health. In 2005, Dr. Nally returned to Ireland to accept the President of Ireland Young Researcher Award from Science Foundation Ireland. He is currently a Lecturer in the School of Agriculture, Food Science and Veterinary Sciences Centre at UCD. He has authored publications in several scientific journals including, The American Journal of Pathology, Infection and Immunity, Vaccine, Proteomics, Lancet Infectious Diseases, and Veterinary Immunology and Immunopathology.

Research Interests

Molecular mechanisms and immunopathogenesis of bacterial pathogens using the tools of proteomics and animal models of disease.

Peer Reviewed Journals

Bonilla-Santiago, R., Nally, J.E.; (2011) 'Rat model of chronic leptospirosis'. current protocols in microbiology, Chapter 12 (Unit 12E.3). [Details]

Marques, P.X., O' Donovan, J., Williams, E.J., Gutierrez, J., Worrall, S., McElroy, M., Proctor, A., Brady, C., Sammin, D., Bassett, H., Buxton, D., Maley, S., Markey, B.K., Nally, J.E; (2011) 'Detection of Toxoplasma gondii antigens reactive with antibodies from serum, amniotic, and allantoic fluids from experimentally infected pregnant ewes'. Veterinary Parasitology, . [Details]

Gutierrez, J., Williams, E.J., O'Donovan, J., Brady, C., Proctor, A.F., Marques, P.X., Worrall, S., Nally, J.E., McElroy, M., Bassett, H.F., Sammin, D.J., Markey, B.K.; (2011) 'Monitoring clinical outcomes, pathological changes and shedding of Chlamydophila abortus following experimental challenge of periparturient ewes utilizing the natural route of infection'. Veterinary Microbiology, 147 :119-126. [DOI] [Details]

Worrall, S., Sammin, D.J., Bassett, H.F., Reid, C.R., Gutierrez, J., Marques, P.X., Nally, J.E., O'Donovan, J., Williams, E.J., Proctor, A., Markey, B.K.; (2011) 'Interferon-gamma expression in trophoblast cells in pregnant ewes challenged with Chlamydophila abortus'. JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 90 (2):214-219. [DOI] [Details]

Jarlath E. Nally, Avril M. Monahan, Ian S. Miller, Ruben Bonilla-Santiago, Puneet Souda, and Julian P. Whitelegge; (2011) 'Comparative Proteomic Analysis of Differentially Expressed Proteins in the Urine of Reservoir Hosts of Leptospirosis'. PLoS ONE, . [Details]

O¿Donovan J., Proctor A., Gutierrez J., Worrall S., Nally J., Marques P. X., Brady C., McElroy M., Sammin D., Buxton D., Maley S. , Bassett H., Markey B.; (2011) 'Distribution of lesions in ovine foetal brains following experimental infection of pregnant sheep with Toxoplasma gondii'. Veterinary Pathology, . [Details]
Marga G. A. Goris, Jiri F. P. Wagenaar, Rudy A. Hartskeerl, Eric C. M. van Gorp, Simone Schuller, Avril M. Monahan, Jarlath E. Nally, Tom van der Poll, Cornelis van ¿t Veer; (2011) 'Potent Innate Immune Response to Pathogenic Leptospira in Human Whole Blood'. PLoS ONE, . [Details]
Michael P. Mullen, Niamh Forde, Mervyn H. Parr, Michael G. Diskin, Dermot G. Morris, Jarlath E. Nally, Alexander C.O. Evans and Mark A. Crowe.; (2011) 'Alterations in systemic concentrations of progesterone during the early luteal phase affect RBP4 expression in the bovine uterus'. Reproduction Fertility and Development, . [Details]
Marques, P.X., O'Donovan, J., Souda, P., Gutierrez, J., Williams, E.J., Worrall, S., McElroy, M., Proctor, A.,Brady, C.,Sammin, D.,Basset, H., Whitelegge, J.P., Markey, B.K., Nally, J.E.; (2011) 'Amniotic and allantoic fluids from experimentally infected sheep contain immunoglobulin specific for Chlamydophila abortus'. Veterinary Immunology and Immunopathology, 140 :1-9. [DOI] [Details]
Juvet, F., Schuller, S., O'Neill, E.J., O'Neill, P.A., Nally, J.E.; (2011) 'Urinary shedding of spirochaetes in a dog with acute leptospirosis despite treatment'. Veterinary Record, 168 . [DOI] [Details]
Challa, S,Nally, JE,Jones, C,Sheoran, AS; (2011) 'Passive immunization with Leptospira LPS-specific agglutinating but not non-agglutinating monoclonal antibodies protect guinea pigs from fatal pulmonary hemorrhages induced by serovar Copenhageni challenge'. Vaccine, 29 :4431-4434. [DOI] [Details]
Sayers, G,Marques, PX,Evans, NJ,O'Grady, L,Doherty, ML,Carter, SD,Nally, JE; (2009) 'Identification of Spirochetes Associated with Contagious Ovine Digital Dermatitis'. Journal of Clinical Microbiology, 47 (NA):1199-1201. [DOI] [Details]
Mullane, N., O'Gaora, P., Nally, J. E., Iversen, C., Whyte, P., Wall, P. G., Fanning, S., ; (2008) 'Molecular analysis of the Enterobacter sakazakii O-antigen gene locus'. Applied and Environmental Microbiology, 74 (12):3783-3794. [DOI] [Details]
Fanning S, Healy B, Cooney S, O'Brien S, Iversen C, Whyte P, Nally J, Callanan JJ, ; (2010) 'Cronobacter (Enterobacter sakazakii): an opportunistic foodborne pathogen'. Foodborne Pathogens and Disease, 7 (4):339-350. [DOI] [Details]
Rojas P, Monahan AM, Schuller S, Miller IS, Markey BK, Nally JE.; (2010) 'Detection and quantification of leptospires in urine of dogs: a maintenance host for the zoonotic disease leptospirosis'. European Journal for Clinical Microbiology and Infectious diseases, . [Details]
J. Gutierrez, J. O¿Donovan, E. Williams, A. Proctor, C. Brady, P.X. Marques, S. Worrall, J.E. Nally, M. McElroy, H. Bassett, D. Sammin, D. Buxton, S. Maley, and B.K. Markey; (2010) 'Detection and quantification of Toxoplasma gondii in ovine maternal and foetal tissues from experimentally infected pregnant ewes using real-time PCR'. Veterinary Parasitology, . [Details]
Marques P.X., Puneet Souda, O¿ Donovan J., Gutierrez J., Williams E.J., Worrall S., McElroy M., Proctor A., Brady C., Sammin, D., Basset, H., Julian P. Whitelegge, Markey B.E. and Nally J.E.; (2010) 'Identification of immunologically relevant proteins of Chlamydophila abortus using sera from experimentally infected pregnant ewes'. Clinical Vaccine and Immunology, 17 (8):1278-1281. [Details]
Jorge Gutierrez, Erin J Williams, Jim O¿Donovan, Colm Brady, Aisling F Proctor, Patricia X Marques, Sheila Worrall, Jarlath Nally, M. McElroy, Hugh F Bassett, Donal J Sammin, and Bryan K Markey.; (2010) 'Monitoring clinical outcomes, pathological changes and shedding of Chlamydophila abortus following experimental challenge of periparturient ewes utilizing the natural route of infection'. Veterinary Microbiology, . [Details]
Timothy R. Crother and Jarlath E. Nally; (2008) 'Analysis of Bacterial Membrane Proteins Produced During Mammalian Infection Using Hydrophobic Antigen Tissue Triton Extraction (HATTREX)'. current protocols in microbiology, . [Details]
Nally JE, Monahan AM, Callanan JJ, ; (2008) 'Proteomic analysis of Leptospira interrogans shed in urine of chronically infected hosts'. Infection and Immunity, 76 (11):4952-4958. [DOI] [Details]
Nally, J.E., Whitelegge, J.P. and Carroll, J.A.; (2007) 'Proteomic strategies to elucidate pathogenic mechanisms of spirochetes'. Proteomics Clinical Applications, 1 (9):1185-1197. [Details]
Nally JE, Monahan AM, Callanan JJ, ; (2009) 'Review paper: Host-pathogen interactions in the kidney during chronic leptospirosis'. Veterinary Pathology, 5 (NA):792-799. [DOI] [Details]
Nally JE, Monahan AM, Miller IS, ; (2009) 'Leptospirosis: risks during recreational activities'. Journal of Applied Microbiology, 107 (3):707-716. [DOI] [Details]
Nally, JE, Whitelegge, JP, Bassilian, S, Blanco, DR, Lovett, MA, ; (2007) 'Characterization of the outer membrane Proteome of Leptospira interrogans expressed during acute lethal infection'. Infection and Immunity, 75 (2):766-773. [Details]
JE Nally, E Chow, MC Fishbein, DR Blanco, MA Lovett; (2005) 'Changes in Lipopolysaccharide O Antigen Distinguish Acute versus Chronic Leptospira interrogans Infections'. INFECTION AND IMMUNITY, 73 (6):3251-3260. [Details]
JE Nally, JP Whitelegge, R Aguilera, MM Pereira, DR Blanco, MA Lovett; (2005) 'Purification and proteomic analysis of outer membrane vesicles from a clinical isolate of Leptospira interrogans serovar Copenhageni'. PROTEOMICS, :144-152. [Details]
JE Nally, MC Fishbein, DR Blanco, MA Lovett; (2005) 'Lethal Infection of C3H/HeJ and C3H/SCID Mice with an Isolate of Leptospira interrogans Serovar Copenhageni'. INFECTION AND IMMUNITY, 73 (10):7014-7017. [Details]
JE Nally, C Chantranuwat, XY Wu, MC Fishbein, MM Pereira, JJ Pereira da Silva, DR Blanco, MA Lovett; (2004) 'Alveolar Septal Deposition of Immunoglobulin and Complement Parallels Pulmonary Hemorrhage in a Guinea Pig Model of Severe Pulmonary Leptospirosis'. AMERICAN JOURNAL OF PATHOLOGY, 164 :1115-1127. [Details]
S. Artiushin, J. F. Timoney, J. Nally and A. Verma.; (2004) 'A Host-Inducible Immunogenic Sphingomyelinase-like Protein (Lk73.5) of Leptospira interrogans'. INFECTION AND IMMUNITY, 72 (2):742-749. [Details]
A. Bharti, J. Nally, J. Ricaldi, M. Matthias, M. Diaz, M. Lovett, P. Levett, R. Gilman, M. Willig, E. Gotuzzo; (2003) 'Leptospirosis: a zoonotic disease of global importance'. The Lancet Infectious Diseases, :757-771. [Details]
J.P. Whitelegge, S.P. Gomez, R. Roberson, W. Vermass, T.R. Crother, C. Champion, J.E. Nally, D.R. Blanco, M. Lovett, J. Miller and K. Faull; (2002) 'Identification of Proteins and Intact Mass Measurements in Proteomics'. Applied Genomics and Proteomics, 1 (2):85-94. [Details]
J.E. Nally, JF Timoney, B Stevenson; (2001) 'Temperature-Regulated Protein Synthesis by Leptospira interrogans'. INFECTION AND IMMUNITY, 69 (1):400-404. [Details]
J.E. Nally, S Artiushin, JF Timoney; (2001) 'Molecular Characterization of Thermoinduced Immunogenic Proteins Qlp42 and Hsp15 of Leptospira interrogans'. INFECTION AND IMMUNITY, 69 (12):7616-7624. [Details]
J.E. Nally, Artiushin, S., Sheoran, A.S., Burns, P.J., Simon, B., Gilley, R.M., Gibson, J., Sullivan, S., and Timoney, J.F; (2000) 'Induction of Mucosal and Systemic Antibody Specific for SeMF3 of Streptococcus equi by Intranasal Vaccination Using a Sucrose Acetate Isobutyrate Based Delivery System'. VACCINE, 19 (4-5):500-505. [Details]
Sheoran, A.S., Nally, J.E., Donahue, J.M., Smith, B.J., and Timoney, J.F. ; (2000) 'Antibody Isotype Responses in Sera of Equine Fetuses Aborted Due to Leptospira interrogans Serovar Pomona Type kennewicki Infection'. VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 77 (3-4):301-309. [Details]
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Honours and Awards

Year: 2005.
Title: President of Ireland Young Researcher Award

Year: 2003.
Title: Ruth L. Kirschenstein National Research Service Award, National Institutes of Health

Year: 2001.
Title: Commonwealth Research Award, University of Kentucky

Year: 2000.
Title: American College of Veterinary Microbiologists (Immunology Award); Outstanding Graduate Student Presentation

Year: 2000.
Title: Commonwealth Research Award, University of Kentucky

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Associations

Association: The Association for Veterinary Teaching and Research Work, Function/Role: Council

Association: Amercian Leptospirosis Research Conference, Function/Role: Member

Association: Society for Applied Microbiology, Function/Role: Member

Association: International Leptospirosis Society, Function/Role: Member

Association: American Society for Microbiology, Function/Role: Member

Committees

Committee : Infection Biology Graduate Research Education Programme

Committee : School Research Committee

Committee : School Postgraduate Education Committee

Committee : Research Strategy Committee

Employment

Employer: University College Dublin, Ireland
Position: Principal Investigator/Lecturer

Employer: University of California Los Angeles, CA, U.S.A.
Position: Postdoctoral Scholar

Employer: University of Kentucky, KY, U.S.A.
Position: Graduate Student

Education

Year 2001 Institution: University of Kentucky, KY, U.S.A.
Qualification: Ph.D. Subject: Veterinary Science (Molecular Microbiology and Immunology)

Year 1995 Institution: University College Dublin, Ireland
Qualification: B.Sc. (Hons) Subject: Zoology

Teaching Interests

VET40090 & VET40100; Module Coordinator, Current Concepts in Infection Biology A & B respectively; Graduate Students from the School of Agriculture, Food Science & Veterinary Medicine, the School of Medicine and the School of Biomolecular & Biomedical Science.
VET30030; Veterinary Microbiology; 3^rd year veterinary students, lectures, laboratory practicals and essay writing.
VET20180; Module Coordinator, Introduction to One Health - bridging human and veterinary medical sciences.
INFECTION BIOLOGY THEMATIC PHD; Development and implementation of the ¿Infection Biology¿ thematic PhD programme between the School of Agriculture, Food Science and Veterinary Medicine, the School of Medicine and the School of Biomolecular and Biomedical Science.
Additional teaching contributions; VET 40080; Advances in Infection Biology, ANSC30220 Equine Health & Husbandry.

Recent Postgraduates

Graduated Ph.D. students

Avril Monahan, December 2009: Proteomic characterization of Leptospira interrogans in the urine of chronically infected hosts.

Currently a postdoctoral scholar at the University of Veterinary Medicine, Vienna Austria

Patricia Marques, April, 2010: Pathogenic mechanisms of Chlamydophila abortus in an ovine model of experimental infection.

Currently a postdoctoral position at the University of Maryland, Baltimore, U.S.A.

Graduated M.Sc. students

Pablo Rojas, March 2010: Development of a Quantitative Real-Time PCR assay to detect pathogenic Leptospira in Canine Urine Samples in Ireland.

Will commence a Ph.D. in Berlin, Germany in October 2010.

Current Postgraduate Students

Simone Schuller, Doctor of Philosophy (PhD) - Thesis Supervisor

Ruben Bonilla Santiago, Doctor of Philosophy (PhD) - Thesis Supervisor

Modules Taught

201000 VET40100 Veterinary Medicine: Concepts Infection Biology B