Dr. John Baugh | UCD Conway

Research

Dr John Andrew Baugh BSc, PhD

Book Chapters:

J.A. Baugh (2007) 'Gene Structure and Functional MIF Polymorphisms in Respiratory Disease' In: Richard Bucala (eds). MIF: A Most Interesting Factor. Singapore: World Scientific. [Details]

Peer Reviewed Journals:

Collier, P,Watson, CJ,Voon, V,Phelan, D,Jan, A,Mak, G,Martos, R,Baugh, JA,Ledwidge, MT,McDonald, KM (2011) 'Can emerging biomarkers of myocardial remodelling identify asymptomatic hypertensive patients at risk for diastolic dysfunction and diastolic heart failure?'. European Journal of Heart Failure, 13 :1087-1095. [DOI] [Details]

Watson, CJ,Ledwidge, MT,Phelan, D,Collier, P,Byrne, JC,Dunn, MJ,McDonald, KM,Baugh, JA (2011) 'Proteomic Analysis of Coronary Sinus Serum Reveals Leucine-Rich alpha 2-Glycoprotein as a Novel Biomarker of Ventricular Dysfunction and Heart Failure'. Heart, 4 :188-126. [DOI] [Details]

Martos, R,Baugh, J,Ledwidge, M,O'Loughlin, C,Murphy, NF,Conlon, C,Patle, A,Donnelly, SC,McDonald, K (2009) 'Diagnosis of heart failure with preserved ejection fraction: improved accuracy with the use of markers of collagen turnover'. European Journal of Heart Failure, 11 :191-197. [DOI] [Details]

Watson JA, Watson CJ, McCann A, Baugh J (2010) 'Epigenetics, the epicenter of the hypoxic response'. Epigenetics : official journal of the DNA Methylation Society, 5 (4):293-296. [Details]

Watson, JA,Watson, CJ,McCrohan, AM,Woodfine, K,Tosetto, M,McDaid, J,Gallagher, E,Betts, D,Baugh, J,O'Sullivan, J,Murrell, A,Watson, RWG,McCann, A (2009) 'Generation of an epigenetic signature by chronic hypoxia in prostate cells'. Gene, 18 (NA):3594-3604. [DOI] [Details]

Mak, GJ,Ledwidge, MT,Watson, CJ,Phelan, DM,Dawkins, IR,Murphy, NF,Patle, AK,Baugh, JA,McDonald, KM (2009) 'Natural History of Markers of Collagen Turnover in Patients With Early Diastolic Dysfunction and Impact of Eplerenone'. Journal of the American College of Cardiology, 54 :1674-1682. [DOI] [Details]

Kevill, K. A., Bhandari, V., Kettunen, M., Leng, L., Fan, J., Mizue, Y., Dzuira, J. D., Reyes-Mugica, M., McDonald, C. L., Baugh, J. A., O'Connor, C. L., Aghai, Z. H., Donnelly, S. C., Bazzy-Asaad, A., Bucala, R. J., (2008) 'A role for macrophage migration inhibitory factor in the neonatal respiratory distress syndrome'. Immunology, 180 (1):601-608. [Details]
Armstrong, M. E., Gantier, M., Li, L. L., Chung, W. Y., McCann, A., Baugh, J. A., Donnelly, S. C., (2008) 'Small interfering RNAs induce macrophage migration inhibitory factor production and proliferation in breast cancer cells via a double-stranded RNA-dependent protein kinase-dependent mechanism'. Immunology, 180 (11):7125-7133. [Details]
Baugh JA, Byrne JD, (2008) 'The significance of nanoparticles in particle-induced pulmonary fibrosis'. McGill journal of medicine : MJM : an international forum for the advancement of medical sciences by students, 11 (1):43-50. [Details]
Gantier, MP,Baugh, JA,Donnelly, SC (2007) 'Nuclear transcription of long hairpin RNA triggers innate immune responses'. Cytokine, 27 :789-797. [DOI] [Details]
Martos, R; Baugh, J; Ledwidge, M; O'Loughlin, C; Conlon, C; Patle, A; Donnelly, SC; McDonald, K; (2007) 'Diastolic heart failure - Evidence of increased myocardial collagen turnover linked to diastolic dysfunction'. Circulation, 115 (7):888-895. [Details]
Govender, P.,Baugh, J. A.,Pennington, S. R.,Dunn, M. J.,Donnelly, S. C. (2007) 'Role of proteomics in the investigation of pulmonary fibrosis'. Expert Rev Proteomics, 4 (3):379-88. [Details]
Plant, BJ,Ghani, S,O'Mahony, MJ,Morgan, L,O'Connor, CM,Morgan, K,Baugh, JA,Donnelly, SC (2007) 'Sarcoidosis and MIF gene polymorphism: a case-control study in an Irish population'. EUR RESPIR J, 29 :325-329. [DOI] [Details]
Baugh, JA; Gantier, M; Li, L; Byrne, A; Buckley, A; Donnelly, SC; (2006) 'Dual regulation of macrophage migration inhibitory factor (MIF) expression in hypoxia by CREB and HIF-1'. Biochemical and Biophysical Research Communications, 347 (4):895-903. [Details]
Martos, R; Patle, A; Baugh, J; Ledwidge, M; Loughlin, CO; Conlon, C; Donnelly, S; Mc Donald, K; (2006) 'The role of myocardial fibrotic markers in detecting different stages of diastolic dysfunction in a hypertensive population'. European Heart Journal, 27 (NA):300-300. [Details]
Plant, B.J., Ghani, S., O'mahony, M.J., Morgan, L., O'connor, C.M., Morgan, K., Baugh, J.A. Donnelly, S.C. (2006) 'Sarcoidosis and a MIF gene polymorphism: a case-control study in an Irish Population'. EUROPEAN RESPIRATORY JOURNAL, . [Details]
Plant, BJ; Gallagher, CG; Bucala, R; Baugh, JA; Chappell, S; Morgan, L; O'Connor, CM; Morgan, K; Donnelly, SC; (2005) 'Cystic fibrosis, disease severity, and a macrophage migration inhibitory factor polymorphism'. American Journal of Respiratory and Critical Care Medicine, 172 (11):1412-1415. [Details]
Mizue, Y; Ghani, S; Leng, L; McDonald, C; Kong, P; Baugh, J; Lane, SJ; Craft, J; Nishihira, J; Donnelly, SC; Zhu, Z; Bucala, R; (2005) 'Role for macrophage migration inhibitory factor in asthma'. Proceedings of the National Academy of Sciences of the United States of America, 102 (40):14410-14415. [Details]
Martos, R; Baugh, J; O'Loughlin, C; Ledwidge, M; Donnelly, S; McDonald, K; (2005) 'Diastolic heart failure is associated with elevated serum markers of collagen turnover'. European Heart Journal, 26 (NA):602-602. [Details]
Plant, BJ; Baugh, JA; Chappell, S; Morgan, L; Keatings, V; O'Connor, C; Morgan, K; Donnelly, SC; (2004) 'The role of a macrophage migration inhibitory factor (MIF) functional polymorphism in chronic obstructive pulmonary disease'. Thorax, 59 (1):69-69. [Details]
Baugh, JA; Donnelly, SC; (2003) 'Macrophage migration inhibitory factor: a neuroendocrine modulator of chronic inflammation'. Journal of Endocrinology, 179 (1):15-23. [Details]
Leng, L,Metz, CN,Fang, Y,Xu, J,Donnelly, S,Baugh, J,Delohery, T,Chen, YB,Mitchell, RA,Bucala, R (2003) 'MIF signal transduction initiated by binding to CD74'. Experimental Medicine, 197 :1467-1476. [DOI] [Details]
Plant, BJ; Gallagher, CG; Baugh, JA; Plummer, S; Morgan, L; O'Connor, C; Morgan, K; Donnelly, SC; (2003) 'The role of a macrophage migration inhibitory factor (MIF) functional polymorphism in adult cystic fibrosis disease severity'. Thorax, 58 (NA):20-20. [Details]
Leng, L; Metz, CN; Fang, Y; Xu, J; Donnelly, S; Baugh, J; Delohery, T; Chen, YB; Mitchell, RA; Bucala, R; (2003) 'MIF signal transduction initiated by binding to CD74'. Experimental Medicine, 197 (11):1467-1476. [Details]
Baugh JA, Chitnis S, Donnelly SC, Monteiro J, Lin X, Plant BJ, Wolfe F, Gregersen PK, Bucala R. (2002) 'A functional promoter polymorphism in the macrophage migration inhibitory factor (MIF) gene associated with disease severity in rheumatoid arthritis'. Genes and Immunity, 3 (3):170-176. [Details]
Baugh JA, Bucala R. (2001) 'Mechanisms for modulating TNF alpha in immune and inflammatory disease'. Current Opinion in Drug Discovery and Development, 4 (5):635-650. [Details]
Mostad, SB,Jackson, S,Overbaugh, J,Reilly, M,Chohan, B,Mandaliya, K,Nyange, P,Ndinya-Achola, J,Bwayo, JJ,Kreiss, JK (1998) 'Cervical and vaginal shedding of human immunodeficiency virus type 1-infected cells throughout the menstrual cycle'. The Journal of infectious diseases, 178 :983-991. [Details]
Plant, BJ; Ghani, S; O'Mahony, MJ; Morgan, L; O'Connor, CM; Morgan, K; Baugh, JA; Donnelly, SC; (2007) 'Sarcoidosis and MIF gene polymorphism: a case-control study in an Irish population'. European Respiratory Journal, 29 (2):325-329. [Details]
Martos, R; Patle, A; Baugh, J; Ledwidge, M; Loughlin, CO; Conlon, C; Donnelly, S; Mc Donald, K; (2006) 'The role of myocardial fibrotic markers in detecting different stages of diastolic dysfunction in a hypertensive population'. European Heart Journal, 27 (NA):300-300. [Details]
Martos, R; Baugh, J; Ledwidge, M; Loughlin, CO; Conlon, C; Donnelly, S; Mc Donald, K; (2006) 'Elevated plasma markers of matrix metalloproteinases type 2 and 9 are independent predictors of diastolic heart failure'. European Heart Journal, 27 (NA):844-844. [Details]
Martos, R; Baugh, J; O'Loughlin, C; Ledwidge, M; Donnelly, S; McDonald, K; (2005) 'Diastolic heart failure is associated with elevated serum markers of collagen turnover'. European Heart Journal, 26 (NA):602-602. [Details]
Plant, BJ; Gallagher, CG; Bucala, R; Baugh, JA; Chappell, S; Morgan, L; O'Connor, CM; Morgan, K; Donnelly, SC; (2005) 'Cystic fibrosis, disease severity, and a macrophage migration inhibitory factor polymorphism'. American Journal of Respiratory and Critical Care Medicine, 172 (11):1412-1415. [Details]
Mizue, Y; Ghani, S; Leng, L; McDonald, C; Kong, P; Baugh, J; Lane, SJ; Craft, J; Nishihira, J; Donnelly, SC; Zhu, Z; Bucala, R; (2005) 'Role for macrophage migration inhibitory factor in asthma'. Proceedings of the National Academy of Sciences of the United States of America, 102 (40):14410-14415. [Details]
Geall, AJ; Baugh, JA; Loyevsky, M; Gordeuk, VR; Al-Abed, Y; Bucala, R; (2004) 'Targeting malaria with polyamines'. Bioconjugate Chemistry, 15 (6):1161-1165. [Details]
Pan JH, Lindholt JS, Sukhova GK, Baugh JA, Henneberg EW, Bucala R, Donnelly SC, Libby P, Metz C, Shi GP. (2003) 'Macrophage migration inhibitory factor is associated with aneurysmal expansion'. Journal of Vascular Surgery, 37 (3):628-635. [Details]
Leng, L; Metz, CN; Fang, Y; Xu, J; Donnelly, S; Baugh, J; Delohery, T; Chen, YB; Mitchell, RA; Bucala, R; (2003) 'MIF signal transduction initiated by binding to CD74'. Experimental Medicine, 197 (11):1467-1476. [Details]
O'Reilly, KMA; Baugh, JA; Plant, BJ; Fitzgerald, MX; Bucala, R; Donnelly, SC; (2002) 'Macrophage Migration Inhibitory Factor induces proliferation and has pro-fibrotic effects in primary human pulmonary fibroblasts'. Thorax, 57 (NA). [Details]
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Other Journals:

Byrne JD, Baugh JA (2008) 'The significance of nanoparticles in particle-induced pulmonary fibrosis' McGill Journal of Medicine 11 (1) :43-50. [Details]

Conference Publications:

Adamali HI, Baugh J, Fingerle-Rowson G, McLoughlin P, Donnelly SC (2008) Enzymatic actvity of macrophage inhibitory factor (MIF) regulates growth of pseudomonas aeruginosa (Pa): implications for therapeutic interventions in cystic fibrosis American Thoracic Society International Conference [Details]

Phelan, D, Watson, CJ, Donnelly, S, Ledwidge, M, Baugh, J, Mcdonald, K, (2007) EUR J HEART FAIL Transforming growth factor beta induces collagen type I and alpha smooth muscle actin production in human cardiac fibroblasts , pp.101-101 [Details]

Watson, CJ, Phelan, DMJ, Ledwidge, M, Donnelly, S, Mcdonald, K, Baugh, J, (2007) EUR J HEART FAIL Increased MMP2 activity following treatment of cardiac fibroblast with Angiotensin II, Alclosterone, Endothelin-1 and TGF beta , pp.101-101 [Details]

Byrne, A., Li, L., Gantier, M., Donnelly, S.C. Baugh, J.A. (2006) Hypoxia-Induced Fibroroliferation is Rho Dependent and Augmented by Macrophage Migration Inhibitory Factor (MIF) American Thoracic Society [Details]

Li, L., O'Reilly, KMA., Buckley, A., Byrne, A.B., McLaughlin, A.M., Kettunen, M.P, Govender, P., Baugh, J.A., Donnelly, S.C. (2006) Sarcoidosis Bronchoalveolar Lavage (BAL) Fluid Induces the Differentiation of Normal Human Primary Lung Fibroblasts into Myofibroblasts American Thoracic Society [Details]

Li, L., Byrne, A., O'Reilly, K.M.A., Donnelly S.C. Baugh, J.A. (2006) Macrophage Migration Inhibitory Factory (MFI) is an early growth response-1 (EGR-1) target gene in TGFb activated human lung fibroblasts American Thoracic Society [Details]

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Byrne, A., Li, L., Gantier, M., Buckley, A., O'Reilly, K., Donnelly, S.C. Baugh, J.A. (2006) Macrophage Migration Inhibitory Factor (MIF): A Hypoxia Regulated Mediator of Pulmonary Fibrosis Hypoxia and Development, Physiology and Disease (Keystone) [Details]
Kettunen, M., Brennan, L., Govender, P., Newsholme, P., Baugh, J.A. Donnelly S.C. (2006) 1H NMR Analysis of BAL Fluid as a Potential Prognostic Tool in Sarcoidosis American Thoracic Society [Details]
Martos, R., Baugh, J., Ledwidge, M., O'Loughlin, C., Conlon, C., Donnelly, S. McDonald, K. (2006) Elevated plasma markers of matrix metalloproteinases type 2 and 9 are independent predictors of diastolic heart failure Heart Failure Congress [Details]
Martos, R., Baugh, J., Ledwidge, M., Patle, A., O'Loughlin, C., Donnelly, S. McDonald, K. (2005) Brain natriuretic peptide levels correlate with indices of diastolic function and serum markers of increased collagen turnover Irish Cardiac Society [Details]
Martos, R., Baugh, J., Ledwidge, M., O'Loughlin, C., Donnelly, S. McDonald, K. (2005) Diastolic Heart failure is associated with elevated serum markers of collagen turnover Heart Failure Congress [Details]
Martos, R., Baugh, J., Ledwidge, M., O'Loughlin, C., Donnelly, S. McDonald, K. (2005) Diastolic Heart failure is associated with elevated serum markers of collagen turnover World Congress of Cardiology [Details]
Martos, R., Baugh, J., Ledwidge, M., O'Loughlin, C., Donnelly, S. McDonald, K. (2005) Diastolic Heart failure is associated with elevated serum markers of collagen turnover Irish Cardiac Society [Details]
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