Dr. John Crean | UCD Conway

Research

Dr John Crean B.Sc., M.Sc., Ph.D.

Book Chapters:

Crean, JK., Brady, HR and Rabb, H. (2004) 'Cell-cell and cell matrix interactions' In: Barry Brenner (eds). The Kidney. Philadelphia: Saunders, Elsevier. [Details]

Peer Reviewed Journals:

O'Donovan HC, Hickey F, Brazil DP, Kavanagh DH, Oliver N, Martin F, Godson C, Crean J. (2011) 'Connective tissue growth factor antagonizes transforming growth factor-β1/Smad signalling in renal mesangial cells'. Biochem J, . [Details]

C. O'Donovan, Fionnuala Hickey, Derek P. Brazil, Noelynn Oliver, Finian Martin, Catherine Godson, and John Crean (2011) 'Cross talk between connective tissue growth factor and transforming growth factor-Beta1 via interaction with the type III TGF-Beta receptor modulates mesangial cell behavior with pathogenic implications for diabetic nephropathy'. Biochem J, . [Details]

Kavanagh DH, Savage DA, Patterson CC, McKnight AJ, Crean JK (2011) 'Association Analysis of Canonical Wnt Signalling Genes in Diabetic Nephropathy'. PLoS ONE, 6 (8). [Details]

Smith, J. Meehan, M., Crean J. and McCann A (2011) 'Alpha T-catenin (CTNNA3); A gene in the hand is worth two in the nest'. Cellular and Molecular Life Sciences, 68 (15):2493-2498. [Details]

Browne, JG., Ho, SL., Kadare, SJ., Kane, R., Oliver, N., Clark, AF., O'Brien, CJ., Crean, JK. (2010) 'The Effect Of CTGF On Trabecular Meshwork Cells And The Implications For Pseudoexfoliative Syndrome'. IOVS, . [Details]

Rooney B, O'Donovan, H., Browne, M., Gaffney, A., Curran, SP., Brazil, DP. Godson, C., Sadlier, D and Crean, JK. (2010) 'CTGF/CCN2 activates canonical Wnt signaling in mesangial cells through LRP6; implications for the pathogenesis of diabetic nephropathy'. European journal of biochemistry / FEBS, . [Details]

Brennan EP, Ehrich M, Brazil DP, Crean JK, Murphy M, Sadlier DM, Martin F, Godson C, van den Boom D, Maxwell AP, Savage DA. (2010) 'DNA methylation profiling in cell models of diabetic nephropathy'. Epigenetics : official journal of the DNA Methylation Society, 16 (5). [Details]
Nyhan KC, Faherty N, Murray G, Cooey LB, Godson C, Crean JK, Brazil DP. (2010) 'Jagged/Notch signalling is required for a subset of TGFBeta1 responses in human kidney epithelial cells'. Biochima Et Biophysica Acta - Molecular Cell Research, 1803 :1386-1395. [Details]
Brennan EP, Ehrich M, Brazil DP, Crean JK, Murphy M, Sadlier DM, Martin F,Godson C, McKnight AJ, van den Boom D, Maxwell AP, Savage DA. (2009) 'Comparative analysis of DNA methylation profiles in peripheral blood leukocytes versus lymphoblastoid cell lines'. Epigenetics : official journal of the DNA Methylation Society, 1 (4). [Details]
Godson C, Murphy M, Crean J, Brazil DP, Sadlier D, Martin F, (2008) 'Regulation and consequences of differential gene expression in diabetic kidney disease'. Biochemical Society Transactions, 36 (Pt 5):941-945. [DOI] [Details]
Mitchell, DM., Gaffney, A., Crean, JK., Kinsella, BT. and Godson C (2007) 'The lipoxin A4 receptor is coupled to SHP-2 activation; implications for regulating growth factor receptor signalling'. Journal of Biological Chemistry, . [Details]
Furlong, F., Crean, J.K., Murphy, M., O'Leary R., and Martin, F* (2007) 'Dysregulated Intracellular Signaling Impairs CTGF Stimulated Responses in Human Mesangial Cells Exposed to High Extracellular Glucose'. American Journal of Physiology, . [Details]
Crean, J.K., Furlong, F., Mitchell, D., McArdle E., Godson, C. and Martin, F. (2006) 'Connective Tissue Growth Factor [CTGF]/CCN2 stimulates actin disassembly through Akt/protein kinase B (PKB) mediated phosphorylation and cytoplasmic translocation of p27Kip-1'. FASEB JOURNAL, 20 :1712-1714. [Details]
Reville, K; Crean, JK; Vivers, S; Dransfield, I; Godson, C; (2006) 'Lipoxin A(4) redistributes myosin IIA and Cdc42 in macrophages: Implications for phagocytosis of apoptotic leukocytes'. Immunology, 176 (3):1878-1888. [Details]
Kirwan, RP; Fenerty, CH; Crean, J; Wordinger, RJ; Clark, AF; O'Brien, CJ; (2005) 'Influence of cyclical mechanical strain on extracellular matrix gene expression in human lamina cribrosa cells in vitro'. Molecular Vision, 11 (94-96):798-810. [Details]
Ho, SL; Dogar, GF; Wang, J; Crean, J; Wu, QD; Oliver, N; Weitz, S; Murray, A; Cleary, PE; O'Brien, C; (2005) 'Elevated aqueous humour tissue inhibitor of matrix metalloproteinase-1 and connective tissue growth factor in pseudoexfoliation syndrome'. British Journal of Ophthalmology, 89 (2):169-173. [Details]
Crean JK, Kirwan R, Finerty C and OBrien C (2004) 'Matrix metalloproteinase-2/type IV collagenase secretion in human lamina cribrosa cells is modulated by cyclical mechanical stretch and transforming growth factor-b1'. Journal of Glaucoma In Press . [Details]
Crean JK, Furlong F, Finlay D, Mitchell D, Conway B, Brady HR, Godson C, Martin F. (2004) 'Connective tissue growth factor [CTGF]/CCN2 stimulates mesangial cell migration through integrated dissolution of focal adhesion complexes and activation of cell polarization'. FASEB JOURNAL, 18 . [Details]
Kirwan, RP; Crean, JK; Clark, A; O'Brien, CJ; (2004) 'The effect of transforming growth factor beta-1 (TGF-beta 1) on gene expression profiles in lamina cribrosa cells from the human optic nerve head'. Investigative Ophthalmology &Amp; Visual Science, 45 (NA):408-408. [Details]
Kirwan, RP; Crean, JK; Fenerty, CH; Clark, AF; O'Brien, CJ; (2004) 'Effect of cyclical mechanical stretch and exogenous transforming growth factor-beta 1 on matrix metalloproteinase-2 activity in lamina cribrosa cells from the human optic nerve head'. Journal of Glaucoma, 13 (4):327-334. [Details]
Ho, S; Crean, J; Oliver, N; Klaus, S; O'Brien, C; (2003) 'Elevated aqueous humour tissue inhibitor of matrix metalloproteinase-1 and connective tissue growth factor in pseudoexfoliation syndrome'. Investigative Ophthalmology &Amp; Visual Science, 44 (NA):519-519. [Details]
Kirwan, RP; Crean, JK; Fenerty, C; Clark, AF; O'Brien, CJ; (2003) 'Differential gene expression in normal primary human lamina cribrosa cells exposed to cyclical mechanical stretch: A model for glaucomatous optic neuropathy'. Investigative Ophthalmology &Amp; Visual Science, 44 (NA):295-295. [Details]
Crean JK, Finlay D, Murphy M, Moss C, Godson C, Martin F, Brady HR (2002) 'The role of p42/44 MAPK and protein kinase B in connective tissue growth factor induced extracellular matrix protein production, cell migration, and actin cytoskeletal rearrangement in human mesangial cells'. Journal of Biological Chemistry, 27 (46):44187-44194. [Details]
Crean JK, Lappin D, Godson C, Brady HR (2001) 'Connective tissue growth factor: an attractive therapeutic target in fibrotic renal disease'. Expert Opin. Ther. Targets, 5 (4):519-530. [Details]
Devlin, HC; Crean, J; Fenerty, C; Clark, AF; O'Brien, C; (2001) 'Effects of mechanical stretch on the expression of MMPs and TIMPs by trabecular meshwork cells'. Investigative Ophthalmology &Amp; Visual Science, 42 (4):140-140. [Details]
O'Brien, CJ; Fenerty, CH; Crean, JKG; Clark, AF; (2001) 'Production of matrix metalloprotease-2 by glauomatous and non-glaucomatous optic nerve astrocytes'. Investigative Ophthalmology &Amp; Visual Science, 42 (4):511-511. [Details]
Crean JK, Duance VC, Sims TJ, Avery N, Smith S, Menage J, Eisenstein SM, Roberts S. (1998) 'Changes in collagen cross-linking in degenerative disc disease and scoliosis'. Spine Journal, 23 (23):2545-2551. [Details]
Crean JK, Roberts S, Eisenstein S and Duance V C (1997) 'Matrix metalloproteinases in the human intervertebral disc: role in disc degeneration and scoliosis'. Spine Journal, 22 (24):2877-2884. [Details]
Crean JK, Roberts S, Eisenstein S and Duance V C (1995) 'Matrix metalloproteinase levels in diseased human intervertebral disc'. Journal of Bone Joint Surgery, 3 :260-263. [Details]
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Other Journals:

Crean JK, Roberts S, Eisenstein SM and Duance VC (1995) 'Matrix metalloproteinase levels in diseased human intervertebral disc' Arthritis and Rheumatism Research Communications(Lumbar Spine Disorders) 10 :38-40. [Details]

Conference Publications:

O'Donovan, H. 1, Xu, L.3, Oliver, N.3, Godson, C.2, and Crean, JK (2010) CTGF/CCN2 and TGFBeta Superfamily signalling: Implications for therapeutic intervention J Am Soc Nephrol [Details]

Rooney B, Gaffney, A., Godson, C., Sadlier, D and Crean, JK. (2010) CTGF/CCN2 activates canonical Wnt signaling in mesangial cells through LRP6; implications for the pathogenesis of diabetic nephropathy J Am Soc Nephrol [Details]

Browne, M., Faherty, N.1, Xu, L., Oliver, N., Brazil, D. , Godson, C. and Crean, J. (2010) Connective Tissue Growth Factor (CTGF) causes Cdc42 activation and altered actin binding protein expression in the glomerular podocyte J Am Soc Nephrol [Details]

Godson C, Murphy M, Crean J, Brazil DP, Sadlier D, Martin F, (2008) Biochemical Society transactions Regulation and consequences of differential gene expression in diabetic kidney disease , pp.941-945 [DOI] [Details]

Dissertations/Theses

Crean, J.K., (1998) The Collagenous Matrix of the Intervertebral Disc in Idiopathic Scoliosis and Other Degenerate Pathologies. Dissertations/Theses [Details]

Crean, J.K., (1993) Clot Lysis in the Upper Gastrointestinal Tract. Dissertations/Theses [Details]

Presentation

Crean JK, Finlay B, Conway B, Murphy M, Godson G, Brady HR, Martin, F (2003) CCN-2 (CTGF) induces actin rearrangement and mesangial cell motility: Involvement of RhoA and protein kinase C zeta. Presentation [Details]

Kirwan RP, Crean JK, Fenerty C, Clark AF, O'Brien.C (2003) Differential gene expression in normal primary human lamina cribrosa cells exposed to cyclical mechanical stretch: A model for glaucomatous optic neuropathy. Presentation [Details]

Ho S, Crean J, Oliver N, Klaus S, O'Brien C. (2003) Elevated aqueous humour tissue inhibitor of matrix metalloproteinase-1 and connective tissue growth factor in pseudoexfoliation syndrome. Presentation [Details]

Crean JK, Finlay D, Martin F, Godson C, Brady HR (2002) The role of p42/44 MAPK and protein kinase B in connective tissue growth factor induced extracellular matrix protein production, cell migration and actin cytoskeletal rearrangement in human mesangial cells. Presentation [Details]

Crean JK, Finlay D, Godson C, Martin F, Brady HR (2002) Connective Tissue Growth Factor induces adhesion, contraction and cytoskeletal rearrangement in human mesangial cells: the role of Erk and Rho Kinases. Presentation [Details]

Devlin HC, Crean J, Fenerty C, Clark AF, O'Brien C. (2001) Effects of mechanical stretch on the expression of MMPs and TIMPs by trabecular meshwork cells. Presentation [Details]

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O'Brien CJ, Fenerty CH, Crean JKG, Clark AF (2001) Production of matrix metalloprotease-2 by glauomatous and non-glaucomatous optic nerve astrocytes. Presentation [Details]
Crean JK, Roberts S, Avery N, Sims T, Bailey AJ and Duance, VC (1997) Structural and Functional implications of changes in collagen crosslinking in the human intervertebral disc. Presentation [Details]
Crean JK, Roberts S, Eisenstein SM and Duance VC. (1996) Turnover of the connective tissue matrix in diseased intervertebral disc. Presentation [Details]
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