| Fan, Y., Murphy, T.B., Byrne, J., Brennan, L., Fitzpatrick, J. and Watson, R.W.G. (2011) 'Applying Random Forests to identify biomarker panels in serum 2D-DIGE data for the detection and staging of prostate cancer'. Journal of Proteome Research, 10 (3):1361-1373. [DOI] [Details] |
| Nyamundanda, G., Brennan, L and Gormley, I.C. (2010) 'Probabilistic principal component analysis for metabolomic data'. BMC Bioinformatics, 11 (571). [DOI] [Details] |
| Bender K, Walsh S, Evans AC, Fair T, Brennan L (2010) 'Metabolite concentrations in follicular fluid may explain differences in fertility between heifers and lactating cows'. Reproduction (Cambridge, England), 139 (6):1047-1055. [DOI] [Details] |
| Bender, K,Walsh, S,Evans, ACO,Fair, T,Brennan, L (2010) 'Metabolite concentrations in follicular fluid may explain differences in fertility between heifers and lactating cows'. Reproduction, 139 :1047-1055. [DOI] [Details] |
| Kandil, S,Brennan, L,McBean, GJ (2010) 'Glutathione depletion causes a JNK and p38(MAPK)-mediated increase in expression of cystathionine-gamma-lyase and upregulation of the transsulfuration pathway in C6 glioma cells'. NEUROCHEMISTRY INTERNATIONAL, 56 :611-619. [DOI] [Details] |
| Carmody, S,Brennan, L (2010) 'Effects of pentylenetetrazole-induced seizures on metabolomic profiles of rat brain'. NEUROCHEMISTRY INTERNATIONAL, 56 :340-344. [DOI] [Details] |
| Wallace M, Hashim YZ, Wingfield M, Culliton M, McAuliffe F, Gibney MJ, Brennan L, (2010) 'Effects of menstrual cycle phase on metabolomic profiles in premenopausal women'. Human Reproduction, 25 (4):949-956. [DOI] [Details] |
| 2. Scalbert A, Brennan L, Fiehn O, Hankemeier T, Kristal BS, van Ommen B, Pujos-Guillot E, Verheij E, Wishart D, Wopereis S. (2009) 'Mass-spectrometry-based metabolomics in nutrition ¿ Current limitations and recommendations'. metabolomics, . [Details] |
| 4. Baccini M, Bachmaier EM, Biggeri A, Boekschoten MV, Bouwman FG, Brennan L, Caesar R, Cinti S, Coort SL, Crosley K, Daniel H, Drevon CA, Duthie S, Eijssen L, Elliott RM, van Erk M, Evelo C, Gibney M, Heim C, Horgan GW, Johnson IT, Kelder T, Kleemann R, Kooistra T, van Iersel MP, Mariman EC, Mayer C, McLoughlin G, Müller M, Mulholland F, van Ommen B, Polley AC, Pujos-Guillot E, Rubio-Aliaga I, Roche HM, de Roos B, Sailer M, Tonini G, Williams LM, de Wit N; For the NuGO PPS Team. (2008) 'The NuGO proof of principle study package: a collaborative research effort of the European Nutrigenomics Organisation'. Genes & Nutrition, 3 . [Details] |
| McClenaghan NH, Scullion SM, Mion B, Hewage C, Malthouse JP, Flatt PR, Newsholme P, Brennan L, (2008) 'Prolonged L-alanine exposure induces changes in metabolism, Ca2+ handling and desensitization of insulin secretion in clonal pancreatic beta-cells'. Clinical Science, . [DOI] [Details] |
| Turner DL, Paixa̿o VB, Salgueiro CA, Brennan L, Reid GA, Chapman SK, (2008) 'The Solution Structure of a Tetraheme Cytochrome from Shewanella frigidimarina Reveals a Novel Family Structural Motif'. Biochemistry, . [DOI] [Details] |
| Brennan L, (2008) 'Session 2: Personalised nutrition. Metabolomic applications in nutritional research'. The Proceedings of the Nutrition Society, 67 (4):404-408. [DOI] [Details] |
| Jin Y, Brennan L, (2008) 'Effects of homocysteine on metabolic pathways in cultured astrocytes'. Neurochemistry International, 52 (8):1410-1415. [DOI] [Details] |
| Walsh, M. C., Brennan, L., Pujos-Guillot, E., Sebedio, J. L., Scalbert, A., Fagan, A., Higgins, D. G., Gibney, M. J., (2007) 'Influence of acute phytochemical intake on human urinary metabolomic profiles'. American Journal of Clinical Nutrition, 86 (6):1687-1693. [Details] |
| Newsholme, P., Bender, K., Kiely, A., Brennan, L., (2007) 'Amino acid metabolism, insulin secretion and diabetes'. Biochemical Society Transactions, 35 :1180-1186. [Details] |
| Brennan, L, Hewage, C, Malthouse, JPG, McClenaghan, NH, Flatt, PR, Newsholme, P, (2006) 'Investigation of the effects of sulfonylurea exposure on pancreatic beta cell metabolism'. FEBS Journal, 273 (22):5160-5168. [DOI] [Details] |
| Brennan, L, Alves, PM, Hewage, C, Malthouse, JPG, McBean, GJ, (2006) 'Impact of the gliotoxin L-serine-O-sulphate on cellular metabolism in cultured rat astrocytes'. Neurochemistry International, 48 (8):739-745. [Details] |
| Brennan, L, Corless, M, Hewage, C, Malthouse, JPG, McClenaghan, NH, Flatt, PR, Newsholme, P, (2003) 'C-13 NMR analysis reveals a link between L-glutamine metabolism, D-glucose metabolism and gamma-glutamyl cycle activity in a clonal pancreatic beta-cell line'. Diabetologia, 46 (11):1512-1521. [Details] |
| Brennan, L, Hewage, C, Malthouse, JPG, McBean, GJ, (2003) 'An NMR study of alterations in [1-C-13]glucose metabolism in C6 glioma cells by gliotoxic amino acids'. Neurochemistry International, 42 (6):441-448. [DOI] [Details] |
| Brennan, L, Shine, A, Hewage, C, Malthouse, JPG, Brindle, KM, McClenaghan, N, Flatt, PR, Newsholme, P, (2002) 'A nuclear magnetic resonance-based demonstration of substantial oxidative L-alanine metabolism and L-alanine-enhanced glucose metabolism in a clonal pancreatic beta-cell line - Metabolism of L-alanine is important to the regulation of insulin secretion'. Diabetes, 51 (6):1714-1721. [DOI] [Details] |
| Brennan, L, Shine, A, Hewage, C, Brindle, KM, Malthouse, JPG, McClenaghan, NH, Flatt, PR, Newsholme, P, (2001) 'A NMR study of glucose and alanine metabolism by the beta cell lines RINm5F and BRIN-BD11'. Diabetologia, 44 (NA):124-124. [Details] |
| Walsh, MC; Brennan, L; Malthouse, JPG; Roche, HM; Gibney, MJ; (2006) 'Effect of acute dietary standardization on the urinary, plasma, and salivary metabolomic profiles of healthy humans'. American Journal of Clinical Nutrition, 84 (3):531-539. [Details] |
| Brennan, L., Hewage, C., Malthouse, J.P.G., McClenaghan, N.H., Flatt, P.R., Newsholme, P. (2006) 'NMR analysis reveals prolonged sulphonylurea exposure impacts on the regulation of pancreatic beta-cell metabolism'. FEBS JOURNAL, . [Details] |
| Bender, K; Newsholme, P; Brennan, L; Maechler, P; (2006) 'The importance of redox shuttles to pancreatic beta-cell energy metabolism and function'. Biochemical Society Transactions, 34 (NA):811-814. [Details] |
| Byrne, JC; Brennan, L; Downes, MR; O'Donoghue, N; Fitzpatrick, JM; Dunn, MJ; Watson, RWG; Pennington, SR; (2006) 'A combined proteomic and metabolomic analysis of prostate cancer serum samples'. Molecular & Cellular Proteomics, 5 (10):71-71. [Details] |
| Patterson, S; Flatt, PR; Brennan, L; Newsholme, P; McClenaghan, NH; (2006) 'Detrimental actions of metabolic syndrome risk factor, homocysteine, on pancreatic beta-cell glucose metabolism and insulin secretion'. Journal of Endocrinology, 189 (2):301-310. [Details] |
| Messias, A.C., Aguiar, A.P., Brennan, L., Salgueiro, C.A., Saraiva, L.M. Xavier, A.V., Turner, D.L. (2006) 'Solution structure of tetrahaem ferricytochrome c3 from Desulfovibrio vulgaris (Hildenborough) and its K45Q mutant: the molecular basis of cooperativity'. Biochim Biophys Acta ¿Bioenergetics, 1757 :143-153. [Details] |
| Gibney, MJ; Walsh, M; Brennan, L; Roche, HM; German, B; van Ommen, B; (2005) 'Metabolomics in human nutrition: opportunities and challenges'. American Journal of Clinical Nutrition, 82 (3):497-503. [Details] |
| Newsholme, P; Brennan, L; Rubi, B; Maechler, P; (2005) 'New insights into amino acid metabolism, beta-cell function and diabetes'. Clinical Science, 108 (3):185-194. [Details] |
| Brennan, L., Hewage, C., Malthouse, J.P.G. & McBean, G.J. (2004) 'Gliotoxins disrupt alanine metabolism and glutathione production in C6 glioma cells: a 13C-NMR spectroscopic study'. NEUROCHEMISTRY, 2 :139-158. [Details] |
| Brennan, L., Hewage, C., Malthouse, J.P.G. & McBean, G.J. (2003) 'An NMR study of alerations in [1-13C]glucose metabolism in C6 glioma cells by gliotoxic amino acids'. Neurochemistry International, 42 :441-448. [Details] |
| Broca, C; Brennan, L; Petit, P; Newsholme, P; Maechler, P; (2003) 'Mitochondria-derived glutamate at the interplay between branched-chain amino acid and glucose-induced insulin secretion'. FEBS Letters, 545 (2-3):167-172. [Details] |
| Brennan, L., Shine, A., Hewage, C., Brindle, K. M., Malthouse, J. P. G., McClenaghan, N. H., Flatt, P. R. & Newsholme, P. (2002) 'A NMR based demonstration of substantial oxidative L-alanine metabolism and L-alanine enhanced glucose metabolism in a clonal pancreatic b-cell line Metabolism of L-alanine is important to the regulation of insulin secretion'. Diabetes, 51 :1714-1721. [Details] |
| Pessanha, M., Brennan, L., Xavier, A. V., Cuthbertson, P. M., Reid, G. A., Chapman, S. K., Turner, D. L. & Salgueiro, C. A. (2001) 'NMR structure of the haem core of a novel tetrahaem cytochrome isolated from Shewanella frigidimarina: identification of the haem-specific axial ligands and order of oxidation'. FEBS Letters, 26 (489):8-13. [Details] |
| Chamberlin, S. G., Brennan, L., Puddicombe, S. M., Davies, D. E. & Turner, D. L. (2001) 'Solution structure of the mEGF/TGF aplha44-50 chimeric growth factor'. European Journal of Biochemistry, 268 :6247-6255. [Details] |
| Lamosa, P., Brennan, L., Vis, H., Turner, D. L. & Santos, H. (2001) 'NMR structure of Desulfovibrio giaga Rubredoxin: a model for studying stabilization by compatible solutes'. Extremophiles, 5 :303-311. [Details] |
| Brennan, L., Turner, D. L., Fareleira, P. & Santos, H. (2001) 'Solution structure of Methylophilus methylotrophus cytochrome c´´: Insights into the structural basis of haem-ligand detachment'. Journal of Molecular Biology, 308 :353-365. [Details] |
| Turner, D. L., Brennan, L. Messias, A. C., Teodoro, M. J. & Xavier, A. V. (2000) 'Correlation of empirical magnetic susceptibility tensors and structure in low-spin heme proteins'. European Journal of Biophysics, 29 :104-112. [Details] |
| Price, N. J., Brennan, L., Faria, T. Q., Vijgenboom, E., Canters, G. W., Turner, D. L. & Santos, H. (2000) 'High yield of Methylophilus methylotrophus cytochrome c´´ by coexpression with cytochrome c maturation gene cluster from Escherichia coli'. 20 :444-450. [Details] |
| Brennan, L., Turner, D. L., Messias, A. C., Teodoro, M. L., LeGall, J., Santos, H. S. & Xavier, A. V. (2000) 'Structural basis for the network of functional cooperativities in cytochrome c3 from Desulfovibrio gigas: Solution structures of the oxidised and reduced states'. Journal of Molecular Biology, 298 :61-82. [Details] |
| Ciampi, E., Furby, M. I. C., Brennan, L., Emsley, J. W., Lesage, A. & Emsley, L. (1999) 'The structure, conformation and orientational order of fluorinated liquid crystals determined from Carbon-13 NMR spectroscopy'. Liquid Crystals, 26 :109-125. [Details] |
| Turner, D. L., Brennan, L., Meyer, H. E., Lohaus, C., Siethoff, C., Costa, H. S., Gonzalez, B., Santos, H. & Suárez, J.E. (1999) 'Solution structure of plantaricin C, a novel lantibiotic'. European Journal of Biochemistry, 264 :833-839. [Details] |
| Turner, D. L., Brennan, L., Chamberlin, S. G., Louro, O. R. & Xavier, A. V. (1998) 'Determination of solution structures of paramagnetic proteins by NMR'. European Journal of Biophysics, 27 :367-375. [Details] |
| Louro, R. O., Correia, I. J., Brennan, L., Couthino, I. B., Xavier, A.V. & Turner, D. L. (1998) 'Electronic structure of low-spin ferric porphyrins: 13C NMR studies of the influence of axial ligand orientation'. Journal of American Chemical Society, 120 :13240-13247. [Details] |
| Brennan, L. & Turner, D. L. (1997) 'Paramagnetic NMR shifts in cyanoferricytochrome c: Investigation of thermal stability and deviations from Curie law behaviour'. Biochimica Et Biophysica Acta-Protein Structure and Molecular Enzymology, 1342 :1-12. [Details] |
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