Dr. Margaret Mc Gee | UCD Conway

Research

Dr Margaret McGee PhD

Peer Reviewed Journals:

O'Connor AE, Mc Gee MM, Likar Y, Ponomarev V, Callanan JJ, O'shea DF, Byrne AT, Gallagher WM (2011) 'Mechanism of cell death mediated by a BF(2) -chelated tetraaryl-azadipyrromethene photodynamic therapeutic: Dissection of the apoptotic pathway in vitro and in vivo'. INT J CANCER, . [DOI] [Details]

Bannon, JH,Fichtner, I,O'Neill, A,Pampillon, C,Sweeney, NJ,Strohfeldt, K,Watson, RW,Tacke, M,Mc Gee, MM (2007) 'Substituted titanocenes induce caspase-dependent apoptosis in human epidermoid carcinoma cells in vitro and exhibit antitumour activity in vivo'. British Journal of Cancer, 97 :1234-1241. [DOI] [Details]

Bannon JH, Mc Gee MM. (2009) 'Understanding the role of aneuploidy in tumorigenesis'. BIOCHEMICAL SOCIETY TRANSACTIONS, 37 ((Pt 4):):910-913. [Details]

Bane FT, Bannon JH, Pennington SR, Campiani G, Williams DC, Zisterer DM, Mc Gee MM, (2009) 'The microtubule-targeting agents, PBOX-6 and paclitaxel, induce nuclear-cytoplasmic redistribution of the peptidyl prolyl isomerases, cyclophilin A and pin1, in malignant haematopoietic cells'. Journal of Pharmacology and Experimental Therapeutics, 329 :38-47. [DOI] [Details]

McGrath, L.B., Onnis, V., Campiani, G., Zisterer, D.M., Williams, D.C., and Mc Gee, M.M. (2006) 'Caspase-activated DNase (CAD)-independent oligonucleosomal DNA fragmentation in chronic myeloid leukaemia cells: requirement for chymotrypsin-like serine protease activity and a Mn2+-dependent acidic endonuclease'. Apoptosis, 11 (9):1473-1489. [Details]

Mc Gee, M.M., Gemma, S., Ramunno,A., Zisterer, D.M., Fattorusso, C., Catalanotti, B., Butini, S., Fiorini, I., Claudio, P., Cucco, C., Novellino, E., Nacci, V., Williams, D.C., Campiani, G. (2005) 'Pyrrolo[1,5]benzoxa(thia)zepines as a New Class of Potent Apoptotic Agents. Biological Studies and Identification of an Intracellular Location of their Drug Target'. J Med Chem, 48 (13):4367-4377. [Details]

Mc Gee MM, Greene LM, Ledwidge S, Campiani G, Nacci V, Lawler M, Williams DC, Zisterer DM. (2004) 'Selective induction of apoptosis by the pyrrolo-1,5-benzoxazepine 7-[[dimethylcarbamoyl]oxy]-6-(2-naphthyl)pyrrolo-[2,1-d] (1,5)-benzoxazepine (PBOX-6) in Leukemia cells occurs via the c-Jun NH2-terminal kinase-dependent phosphorylation and inactivation of Bcl-2 and Bcl-XL'. Journal of Pharmacology and Experimental Therapeutics, 310 (3):1084-1095. [Details]
Mulligan, J.M., Greene, L.M., Mc Gee M.M , Onnis, V., Campiani, G.,Lawler, M., Williams, D.C., Zisterer D.M. (2006) 'Identification of tubulin as the molecular target of pro-apoptotic pyrrolo-1,5-benzoxazepines'. MOLECULAR PHARMACOLOGY, 70 (1):60-70. [Details]
Mc Gee, M.M., Campiani, G., Ramunno, A., Nacci, V., Lawler, M., Williams, D.C. & Zisterer, DM. (2002) 'Activation of the c-Jun NH2 terminal kinase (JNK) signaling pathway is essential during PBOX-6-induced apoptosis in chronic myelogenous leukemia (CML) cells'. Journal of Biological Chemistry, 227 (21):18383-18389. [Details]
Mc Gee, M.M., Hyland, E., Campiani, G., Ramunno, A., Nacci, V. & Zisterer D.M. (2002) 'Caspase-3 is not essential for DNA fragmentation in MCF-7 cells during apoptosis induced by the pyrrolo-1,5-benzoxazepine, PBOX-6'. Febs Letters, 515 (1-3):66-70. [Details]
Mc Gee, M.M., Campiani, G., Ramunno, A., Fattorusso, C., Nacci, V., Lawler, M., Williams, D.C. & Zisterer, D.M. (2001) 'Pyrrolo-1,5-benzoxazepines induce apoptosis in chronic myelogenous leukemia (CML) cells by bypassing the apoptotic suppressor bcr-abl'. Journal of Pharmacology and Experimental Therapeutics, 296 (1):31-40. [Details]
Zisterer, D.M., Mc Gee, M.M., Campiani, G., Ramunno, A., Fattorusso, C., Nacci, V., Lawler, M. & Williams, D.C. (2001) 'Pyrrolo-1,5-benzoxazepines: a new class of apoptotic agents'. Biochemical Society Transactions, 29 (6):704-706. [Details]
Marangolo, M., Mc Gee, M.M., Tipton, K.F., Williams, D.C. & Zisterer, D.M. (2001) 'Oxidative stress induces apoptosis in C6-Glioma cells: Involvement of mitogen-activated protein kinase and nuclear factor kappa B'. Neurotoxicity Res, (3):397-409. [Details]
Glasgow, GM; McGee, MM; Tarbatt, CJ; Mooney, DA; Sheahan, BJ; Atkins, GJ; (1998) 'The Semliki Forest virus vector induces p53-independent apoptosis'. Journal of General Virology, 79 (NA):2405-2410. [Details]
Glasgow, G.M., Mc Gee, M.M., Sheahan, B.J. & Atkins, G.J. (1997) 'Death mechanisms in cultured cells infected by Semliki Forest virus'. Journal of General Virology, 78 (pt 7):1559-1563. [Details]
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