Dr. Matthias Tacke | UCD Conway

Research

Dr Matthias Tacke PhD

Contact Details

Title	Conway Fellow
Address	Conway Institute of Biomolecular & Biomedical Research
Telephone:	+353 1 7168428
Email:	ei.dcu@ekcat.saihttam

Title	Senior Lecturer
Address	School of Chemistry & Chemical Biology Science Centre Belfield Dublin 4
Telephone:	Ext. 8428
Email:	ei.dcu@ekcat.saihttam

Biography:

1987 Diplom in Chemistry, University of Münster, Germany
1990 Ph.D. in Inorganic Chemistry, University of Münster
1990 Postdoctoral Associate, University of München, Germany
1991 Postdoctoral Associate, University of Amsterdam, The Netherlands
1992-1996 Habilitation in Inorganic Chemistry, University of Karlsruhe, Germany
1996-2004 College Lecturer, Department of Chemistry, University College Dublin
May 1997 Habilitation Colloquium, University of Karlsruhe
Since 2002 Conway Fellow
Since 2005 Senior Lecturer, UCD School of Chemistry and Chemical Biology
2006-2007 Chairman of CESAR-AWO (Central European Society for Anticancer Drug Research)
Autumn 2007 Visiting Professor at the ENSCP in Paris with Prof. Dr. Gerard Jaouen
Oct. 2009 Winner of the CESAR Prize 2009 for Translational Anticancer Research

Research Interests

My research group is interested in synthesising novel carbene-metal antibiotics and titanocene anticancer drugs in order to evaluate them biologically in cell tests and mouse models. Additionally we want to get an insight into the mechanism of action from a biological and chemical point of view. The targets for our titanocenes are breast and renal cell cancer, while the carbene-metal antibiotics are to be developed into resistance-breaking antibiotics targeting difficult bacteria like MRSA.

Book Chapters

M. Hogan, M. Tacke; (2010) 'Titanocenes - Cytotoxic and Anti-Angiogenic Chemotherapy Against Advanced Renal-Cell Cancer' In: G. Jaouen, N. Metzler-Nolte (eds). Topics in Organometallic Chemistry, Volume 32: Medicinal Organometallic Chemistry. Heidelberg: Springer. [Details]

M. Tacke; (1997) 'The Main Group Carbonyls RLi-CO and R2Si-CO: An Ab Initio Study ' In: N. Auner, J. Weis (eds). Organosilicon Chemistry III, From Molecules to Materials, VCH-Wiley, Weinheim. [Details]

M. Tacke, P. Sparrer, R. Teuber, H.-J. Stadter, F. Schuster; (1996) 'A Novel Liquid Xenon IR Cell Constructed from a Silicon Single Crystal' In: N. Auner, J. Weis (eds). Organosilicon Chemistry II, From Molecules to Materials, VCH Verlagsgesellschaft, Weinheim. [Details]

M. Tacke, Ch. Klein, D. J. Stufkens, A. Oskam, P. Jutzi, E. A. Bunte; (1994) 'Complexes of Decamethylsilicocene: Cp2*Si(CO) and Cp2*Si(N2) ' In: N. Auner, J. Weis (eds). Organosilicon Chemistry, From Molecules to Materials VCH Verlagsgesellschaft, Weinheim . [Details]

Peer Reviewed Journals

L. Kaps, B. Biersack, H. Müller-Bunz, K. Mahal, J. Münzner, M. Tacke, T. Mueller, R. Schobert; (2012) 'Gold(I)-NHC complexes of antitumoral diarylimidazoles: structures, cellular uptake routes and anticancer activities'. Journal of Inorganic Biochemistry, 106 (1):52-58.

[DOI] [Details]

L. Kater, J. Claffey, M. Hogan, P. Jesse, B. Kater, S. Strauß, M. Tacke, A. Prokop; (2012) 'The role of the intrinsic FAS pathway in Titanocene Y apoptosis: The mechanism of overcoming multiple drug resistance in malignant leukemia cells'. Toxicology in Vitro, 26 (1):119-124.

[DOI] [Details]

F. Hackenberg, A. Deally, G. Lally, S. Malenke, H. Müller-Bunz, F. Paradisi, S. Patil, D. Quaglia, M. Tacke; (2012) 'Novel non-symmetrically p-benzyl-substituted (benz)imidazole N-heterocyclic carbene-silver(I) acetate complexes - synthesis and biological evaluation'. International Journal of Inorganic Chemistry, Article ID 121540 (13 pages).

[DOI] [Details]

C. M. Dowling, S. Cuffe, M. Tacke, A. Deally, M. Hogan, J. M. Fitzpatrick, R. W. G. Watson; (2012) 'Manipulating the ability of novel titanocene analogues to induce apoptosis in castrate-resistant prostate cancer cells'. Letters in Drug Design & Discovery, 9 (3):226-233.

[Details]

A. Deally, F. Hackenberg, G. Lally, M. Tacke (2012) 'Synthesis and biological evaluation of achiral indole-substituted titanocene dichloride derivatives'. International Journal of Medicinal Chemistry, Article ID 905981 .

[DOI] [Details]

F. Hackenberg, G. Lally, H. Müller-Bunz, F. Paradisi, D. Quaglia, W. Streciwilk, M. Tacke (2012) 'Novel symmetrically p-benzyl-substituted 4,5-diaryl-imidazole N-heterocyclic carbene-silver(I) acetate complexes ¿ synthesis and biological evaluation'. Journal of Organometallic Chemistry, 717 :123-134. [DOI] [Details]
U. Olszewski, A. Deally, M. Tacke, G. Hamilton (2012) 'Alterations of Phosphoproteins in NCI-H526 Small Cell Lung Cancer Cells involved in Cytotoxicity of Cisplatin and Titanocene Y'. Neoplasia, 14 (9):813-822. [DOI] [Details]
I. Fichtner, D. Behrens, J. Cinatl jr., M. Michaelis, L. C. Sanders, R. Hilger, B. N. Kennedy, A. L. Reynolds, F. Hackenberg, G. Lally, Susan Quinn, I. McRae, M. Tacke (2012) 'In Vitro and In Vivo Investigations into the Carbene Silver Acetate Anticancer Drug Candidate SBC1'. Letters in Drug Design & Discovery, 9 (9):815-822. [Details]
A. Deally, F. Hackenberg, G. Lally, H. Müller-Bunz, M. Tacke; (2012) 'Synthesis and preliminary cytotoxicity studies of achiral silyl-substituted titanocene dichloride derivatives'. Organometallics, 31 (16):5782-5790. [DOI] [Details]
S. Patil, A. Deally, B. Gleeson, H. Müller-Bunz, F. Paradisi, M. Tacke; (2011) 'Novel Benzyl-Substituted N-Heterocyclic Carbene¿Silver Acetate Complexes: Synthesis, Cytotoxicity and Antibacterial Studies'. Metallomics, 3 :74-88. [Details]
S. Cuffe, C. M. Dowling, J. Claffey, C. Pampillón, M. Hogan, J. M. Fitzpatrick, M. P. Carty, M. Tacke, R. W. G. Watson; (2011) 'Effects of Titanocene Dichloride Derivatives on Prostate Cancer Cells, Specifically DNA Damage Induced Apoptosis'. Prostate, 71 :111-124. [Details]
A. Deally, B. Gleeson, H. Müller-Bunz, S. Patil, D. F. O¿Shea, M. Tacke; (2011) 'Novel Achiral Indole-Functionalised Titanocenes: Synthesis and Preliminary Cytotoxicity Studies'. Journal of Organometallic Chemistry, 696 :1072-1083. [Details]
S. Patil, A. Deally, B. Gleeson, F. Hackenberg, H. Müller-Bunz, F. Paradisi, M. Tacke; (2011) 'Synthesis, Cytotoxicity and Antibacterial Studies of Novel Symmetrically and Non-Symmetrically p-Nitrobenzyl-Substituted N-Heterocyclic Carbene-Silver(I) Acetate Complexes'. ZAAC, 637 :386-396. [Details]
S. Patil, M. Tacke; (2011) 'NHC-Silver(I) Acetates as Bioorganometallic Anticancer and Antibacterial Drugs'. Insights into Coordination, Bioinorganic and Applied Inorganic Chemistry, :555-566. [Details]
J. Zagerman, A. Deally, N. Metzler-Nolte, H. Müller-Bunz, D. Wallis, M. Tacke; (2011) 'Towards Protein-Substituted Titanocene Anticancer Drugs'. Polyhedron, 30 :2387-2390. [Details]
R. A. Hilger, D. Alex, A. Deally, B. Gleeson, M. Tacke; (2011) 'Titanocene Y and Vanadocene Y: Platinum Resistance-Breaking Cytotoxic and DNA-Targeting Anticancer Drug Candidates'. Letters in Drug Design & Discovery, 8 (10):904-910. [Details]
S. Patil, A. Deally, F. Hackenberg, L. Kaps, H. Müller-Bunz, R. Schobert, M. Tacke; (2011) 'Novel Benzyl- or 4-Cyanobenzyl-Substituted N-Heterocyclic (Bromo)(carbene)silver(I) and (Carbene)(chloro)gold(I) Complexes: Synthesis and Preliminary Cytotoxicity Studies'. Helvetica Chimica Acta, 94 :1551-1562. [Details]
I. Fichtner, D. Behrens, J. Claffey, A. Deally, S. Patil, H. Weber, M. Tacke; (2011) 'The Antiangiogenic and Antitumoral Activity of Titanocene Y* in vivo'. Letters in Drug Design & Discovery, 8 (4):302-307. [Details]
L. M. Menéndez Méndez, A. Deally, D. F. O'Shea, M. Tacke; (2011) 'Synthesis and Cytotoxicity Studies of Azaindole-Substituted Titanocenes'. Heterotam Chemistry, 22 (2):148-157. [Details]
U. Olszewski, J. Claffey, M. Hogan, M. Tacke, R. Zeillinger, P. Bednarski, G. Hamilton; (2011) 'Anticancer activity and mode of action of titanocene C'. Investigational New Drugs, 29 :607-614. [Details]
S. Patil, J. Claffey, A. Deally, B. Gleeson, M. Hogan, L. M. Menéndez Méndez, H. Müller-Bunz, F. Paradisi, M. Tacke; (2010) 'Synthesis, Cytotoxicity and Antibacterial Studies of p-Methoxybenzyl-Substituted and Benzyl-Substituted N-Heterocyclic Carbene-Silver Complexes'. European Journal of Inorganic Chemistry, :1020-1031. [Details]
M. Hogan, B. Gleeson, M. Tacke; (2010) 'Synthesis and Preliminary Cytotoxicity Studies of Achiral Indolyl-Substituted Titanocenes'. Organometallics, 29 :1032-1040. [Details]
S. Eger, T. A. Immel, J. Claffey, H. Müller-Bunz, M. Tacke, U. Groth, T. Huhn; (2010) 'Titanocene difluorides with improved cytotoxic activity'. Inorganic Chemistry, 49 :1292-1294. [Details]
A. Erxleben, J. Claffey, M. Tacke; (2010) 'Binding and hydrolysis studies of antitumoural titanocene dichloride and Titanocene Y with phosphate diesters'. Journal of Inorganic Biochemistry, 104 :390-396. [Details]
I. Fichtner, D. Behrens, J. Claffey, A. Deally, B. Gleeson, M. Hogan, H. Weber, M. Tacke; (2010) 'Antitumor Activity of Vanadocene Y and its Selenocyanate Derivative in Xenografted CAKI-1 Tumors in Mice'. Journal of Organometallic Chemistry, 695 :1175-1181. [Details]
B. Gleeson, J. Claffey, M. Hogan, H. Müller-Bunz, D. Wallis, M. Tacke; (2010) 'Novel Benzyl-Substituted Molybdocene Anticancer Drugs'. Inorganica Chimica Acta, 363 :1831-1836. [Details]
J. Claffey, H. Müller-Bunz, M. Tacke; (2010) 'Benzyl-Substituted Titanocene Dichloride Anticancer Drugs: From Lead to Hit'. Journal of Organometallic Chemistry, 695 :2105-2117. [Details]
J. Claffey, A. Deally, B. Gleeson, S. Patil, M. Tacke; (2010) 'Synthesis and Cytotoxicity Studies of Novel Anion-Exchanged Titanocene Y Derivatives'. Applied Organometallic Chemistry, 24 :675-679. [Details]
M. Hogan, M. Tacke; (2010) 'Titanocenes - Cytotoxic and Anti-Angiogenic Chemotherapy Against Advanced Renal-Cell Cancer'. Topics in Organometallic Chemistry: Medicinal Organometallic Chemistry, 32 :119-140. [Details]
S. Patil, K. Dietrich, A. Deally, B. Gleeson, H. Müller-Bunz, F. Paradisi, M. Tacke; (2010) 'Synthesis, Cytotoxicity and Antibacterial Studies of Novel Symmetrically and Non-Symmetrically Methyl Benzoate-Substituted N-Heterocyclic Carbene-Silver Acetate Complexes'. Helvetica Chimica Acta, 93 :2347-2364. [Details]
B. Gleeson, S. Patil, A. Deally, H. Müller-Bunz, M. Tacke; (2010) 'Novel Achiral Aryl-Substituted Vanadocenes: Synthesis and Preliminary Cytotoxicity Studies'. Australian Journal of Chemistry, 63 :1514-1520. [Details]
B. Gleeson, M. Hogan, H. Müller-Bunz, M. Tacke; (2010) 'Synthesis and Preliminary Cytotoxicity Studies of Indole-Substituted Vanadocenes'. Transition Metal Chemistry, 35 :973-983. [Details]
S. Patil, A. Deally, B. Gleeson, H. Müller-Bunz, F. Paradisi, M. Tacke; (2010) 'Synthesis, Cytotoxicity and Antibacterial Studies of Symmetrically and Non-Symmetrically Benzyl- or p-Cyanobenzyl-Substituted N-Heterocyclic Carbene-Silver Complexes'. Applied Organometallic Chemistry, 24 :781-793. [Details]
A. Deally, J. Claffey, B. Gleeson, M. Hogan, H. Müller-Bunz, S. Patil, D. O'Shea, M. Tacke; (2010) 'Synthesis and Preliminary Cytotoxicity Studies of Achiral Pyrrolyl-Substituted Titanocenes'. Polyhedron, 29 (12):2445-2453. [Details]
M. Hogan, B. Gleeson, M. Tacke; (2010) 'The Cytotoxicity of Titanocene Y against CAKI-1 Cells: An In Vitro Formulation Study'. Letters in Drug Design & Discovery, 7 (5):310-317. [Details]
D. Wallis, J. Claffey, B. Gleeson, M. Hogan, H. Müller-Bunz, M. Tacke; (2009) 'Novel Zirconocene Anticancer Drugs?'. Journal of Organometallic Chemistry, 694 :828-833. [Details]
A. Vessières, M.-A. Plamont, C. Cabestaing, J. Claffey, S. Dieckmann, M. Hogan, H. Müller-Bunz, K. Strohfeldt, M. Tacke; (2009) 'Proliferative and Antiproliferative Effects of Titanium- and Iron-Based Metallocene Anticancer Drugs'. Journal of Organometallic Chemistry, 694 :874-879. [Details]
B. Gleeson, J. Claffey, M. Hogan, H. Müller-Bunz, D. Wallis, M. Tacke; (2009) 'Novel Benzyl-Substituted Vanadocene Anticancer Drugs'. Journal of Organometallic Chemistry, 694 :1369-1374. [Details]
J. Claffey, A. Deally, B. Gleeson, M. Hogan, L. M. Menéndez Méndez, H. Müller-Bunz, D. Wallis, S. Patil, M. Tacke; (2009) 'Pseudo-Halide Derivatives of Titanocene Y: Synthesis and Cytotoxicity Studies'. Metallomics, 1 :511-517. [Details]
B. Gleeson, J. Claffey, A. Deally, M. Hogan, L. M. Menéndez Méndez, H. Müller-Bunz, S. Patil, D. Wallis, M. Tacke; (2009) 'Synthesis and Cytotoxicity Studies of Fluorinated Derivatives of Vanadocene Y'. European Journal of Inorganic Chemistry, :2804-2810. [Details]
M. Hogan, M. Tacke; (2009) 'Bioorganometallic Chemistry: A Key To New Chemotherapy?'. Insights into Coordination, Bioinorganic and Applied Inorganic Chemistry, :403-412. [Details]
J. Claffey, B. Gleeson, M. Hogan, H. Müller-Bunz, D. Wallis, M. Tacke (2008) 'Fluorinated Derivatives of Titanocene Y: Synthesis and Cytotoxicity Studies'. European Journal of Inorganic Chemistry, :4074-4082. [Details]
M. Hogan, J. Cotter, J. Claffey, B. Gleeson, D. Wallis, D. O¿Shea, M. Tacke; (2008) 'Synthesis and Cytotoxicity Studies of New Dimethylamino-Functionalised and Azaindole-Substituted Titanocene Anticancer Agents'. Helvetica Chimica Acta, 91 (9):1787-1797. [DOI] [Details]
I. Fichtner, J. Claffey, B. Gleeson, M. Hogan, D. Wallis, H. Weber, M. Tacke; (2008) 'Antitumor Activity of Oxali-Titanocene Y in Xenografted Caki-1 Tumors in Mice'. Letters in Drug Design & Discovery, 5 (8):489-493. [DOI] [Details]
J. Claffey, M. Hogan, H. Müller-Bunz, C. Pampillón, M. Tacke; (2008) 'Oxali-Titanocene Y: A Potent Anticancer Drug'. Chemmedchem, 3 :729-731. [Details]
Strohfeldt, K., Tacke, M., ; (2008) 'Bioorganometallic fulvene-derived titanocene anti-cancer drugs'. Chemical Society Reviews, 37 (6):1174-1187. [Details]
Pampillon, C., Claffey, J., Hogan, M., Tacke, M., ; (2008) 'Novel achiral titanocene anti-cancer drugs synthesised from bis-N,N-dimethylamino fulvene and lithiated heterocyclic compounds'. Biometals, 21 (2):197-204. [Details]
Weber, H., Claffey, J., Hogan, M., Pampillon, C., Tacke, M., ; (2008) 'Analyses of Titanocenes in the spheroid-based cellular angiogenesis assay'. Toxicology in Vitro, 22 (2):531-534. [Details]
B. Gleeson, J. Claffey, D. Ertler, M. Hogan, H. Müller-Bunz, F. Paradisi, D. Wallis, M. Tacke; (2008) 'Novel Organotin Antibacterial and Anticancer Drugs'. Polyhedron, 27 (18):3619-3624. [DOI] [Details]
M. Tacke; (2008) 'The Interaction of Titanocene Y with Double-Stranded DNA: A Computational Study'. Letters in Drug Design & Discovery, 5 (5):332-335. [DOI] [Details]
Pampillon, C., Claffey, J., Strohfeldt, K., Tacke, M., ; (2008) 'Synthesis and cytotoxicity studies of new dimethylamino-functionalised and aryl-substituted titanocene anti-cancer agents'. European Journal of Medicinal Chemistry, 43 (1):122-128. [Details]
Dowling, C. M., Claffey, J., Cuffe, S., Fichtner, I., Pampillon, C., Sweeney, N. J., Strohfeldt, K., Watson, R. W. G., Tacke, M., ; (2008) 'Antitumor activity of Titanocene Y in xenografted PC3 tumors in mice'. Letters in Drug Design & Discovery, 5 (2):141-144. [Details]
Hogan, M., Claffey, J., Pampillon, C., Tacke, M., ; (2008) 'Synthesis and cytotoxicity studies of new morpholino-functionalised and N-heteroaryl-substituted titanocene anticancer drugs'. Medicinal Chemistry, 4 (2):91-99. [Details]
Claffey, J., Hogan, M., Muller-Bunz, H., Pampillon, C., Tacke, M., ; (2008) 'Synthesis and cytotoxicity studies of methoxy benzyl substituted titanocenes'. Journal of Organometallic Chemistry, 693 (3):526-536. [Details]
M. Hogan, J. Claffey, E. Fitzpatrick, T. Hickey, C. Pampillon, M. Tacke; (2008) 'Synthesis and Cytotoxicity Studies of Titanocene C Analogues'. Metal-Based Drugs, . [DOI] [Details]
Sweeney, N.J., Claffey, J., Muller-Bunz, H., Pampillon, C., Strohfeldt, K., Tacke, M. ; (2007) 'The synthesis and cytotoxic evaluation of a series of benzodioxole substituted titanocenes'. Applied Organometallic Chemistry, 21 (2):57-65. [Details]
I. Fichtner, J. Bannon, A. O¿Neill, C. Pampillón, N. J. Sweeney, K. Strohfeldt, R. W. G. Watson, M. Tacke, M. M. Mc Gee (2007) 'Substituted Titanocenes Induce Caspase-dependent Apoptosis in Human Epidermoid Carcinoma Cells In Vitro and Exhibit Anti-tumour Activity In Vivo'. British Journal of Cancer, 97 (9):1234-1241. [DOI] [Details]
Hogan, M., Claffey, J. Pampillón, C., Watson, R. W. G., Tacke, M. ; (2007) 'Synthesis and Cytotoxicity Studies of New Dimethylamino-Functionalized and Azole-Substituted Titanocene Anti-Cancer Drugs'. Organometallics, 26 (10):2501-2506. [DOI] [Details]
Pampillón, C. Sweeney, N. J., Strohfeldt, K., Tacke, M. ; (2007) 'Synthesis and Cytotoxicity Studies of New Dimethylamino-Functionalised and Heteroaryl-Substituted Titanocene Anti-Cancer Drugs'. Journal of Organometallic Chemistry, 692 (11):2153-2159. [DOI] [Details]
Oberschmidt, O., Hanauske, A.-R., Pampillón, C., Strohfeldt, K., Sweeney,N. J., Tacke, M. ; (2007) 'Antiproliferative Activity of Titanocene Y against Tumor Colony Forming Units'. ANTI-CANCER DRUG, 18 (3):317-321. [DOI] [Details]
Pampillón, C., Claffey, J., Hogan, M., Tacke, M. (2007) 'Morpholino-Functionalized and Heteroaryl-Substituted Titanocene Anticancer Drugs: Synthesis and Cytotoxicity Studies'. ZAAC, 633 (10):1695-1700. [DOI] [Details]
Müller-Bunz, H., Dix, I., Lou, Y., Pampillón, C., Strohfeldt, K., Sweeney, N. J., Tacke, M. ; (2007) 'A series of novel 6-aryl fulvenes: Impact of substitution on the phenyl ring, characterised by X-Ray crystallography'. Zeitschrift Fur Kristallographie, 222 (7):376-882. [DOI] [Details]
Pampillón, C., Claffey, J., Hogan, M., Strohfeldt, K., Tacke, M. ; (2007) 'Synthesis and Cytotoxicity Studies of New Dimethylamino-Functionalised and Indolyl-Substituted Titanocene Anti-Cancer Drugs'. Transition Metal Chemistry, 32 (4):434-441. [DOI] [Details]
Beckhove, P., Hanauske, A.-R., Oberschmidt, O., Pampillón, C., Schirrmacher, V., Sweeney, N. J., Strohfeldt, K., Tacke, M. ; (2007) 'Antitumor Activity of Titanocene Y in Freshly Explanted Human Breast Tumors and in Xenografted MCF-7 Tumors in Mice'. ANTI-CANCER DRUG, 18 (3):311-315. [DOI] [Details]
T. Hickey, J. Claffey, E. Fitzpatrick, M. Hogan, C. Pampillón, M. Tacke; (2007) 'Dimethylamino-Functionalised and N-Heteroaryl-Substituted Titanocene Anticancer Drugs: Synthesis and Cytotoxicity Studies'. Investigational New Drugs, 25 (5):425-433. [DOI] [Details]
K. Strohfeldt, H. Müller-Bunz, C. Pampillón, M. Tacke; (2007) 'Proliferative and Antiproliferative Effects in Substituted Titanocene Anticancer Drugs'. Transition Metal Chemistry, 32 (7):971-980. [DOI] [Details]
Valadares, MC; Ramos, AL; Rehmann, FJK; Sweeney, NJ; Strohfeldt, K; Tacke, M; Queiroz, MLS; ; (2006) 'Antitumour activity of [1,2-di(cyclopentadienyl)-1,2-di(p-N,N-dimethylaminophenyl)-ethanediyl] titanium dichloride in xenografted Ehrlich's ascites tumour'. European Journal of Pharmacology, 534 (1-3):264-270. [Details]
Mendoza, O; Tacke, M; ; (2006) 'Cocondensation reactions of heterocyclic aromatic compounds with lithium, calcium and magnesium atoms at 77 K'. Journal of Organometallic Chemistry, 691 (6):1110-1116. [Details]
C. Pampillon, N. J. Sweeney, K. Strohfeldt, M. Tacke (2006) 'Diheteroarylmethyl substituted titanocenes: A novel class of possible anti-cancer drugs'. Inorganica Chimica Acta, 359 (12):3969-3975. [DOI] [Details]
Pampillon, C; Mendoza, O; Sweeney, NJ; Strohfeldt, K; Tacke, M; ; (2006) 'Diarylmethyl substituted titanocenes: Promising anti-cancer drugs'. Polyhedron, 25 (10):2101-2108. [Details]
Cuffe, L; MacElroy, JMD; Tacke, M; Kozachok, M; Mooney, DA; ; (2006) 'The development of nanoporous membranes for separation of carbon dioxide at high temperatures'. Journal of Membrane Science, 272 (1-2):6-10. [Details]
M. Tacke, R. Leyden, L. P. Cuffe (2006) 'Reactions of Methyllithium with CO and CNMe: Theoretical Study'. International Journal of Quantum Chemistry, 106 (3):692-696. [DOI] [Details]
O'Connor, K; Gill, C; Tacke, M; Rebmann, FJK; Strohfeldt, K; Sweeney, N; Fitzpatrick, JM; Watson, RWG; ; (2006) 'Novel titanocene anti-cancer drugs and their effect on apoptosis and the apoptotic pathway in prostate cancer cells'. Apoptosis, 11 (7):1205-1214. [Details]
K. Strohfeldt, H. Müller-Bunz, C. Pampillón, N. J. Sweeney, M. Tacke (2006) 'Glycol methyl ether and glycol amine substituted titanocenes as antitumor agents'. European Journal of Inorganic Chemistry, :4621-4628. [DOI] [Details]
N. Sweeney, W. M. Gallagher, H. Müller-Bunz, C. Pampillón, K. Strohfeldt, M. Tacke (2006) 'Heteroaryl Substituted Titanocenes as Potential Anti-Cancer Drugs'. Journal of Inorganic Biochemistry, 100 (9):1479-1486. [DOI] [Details]
I. Fichtner, C. Pampillón, N. J. Sweeney, K. Strohfeldt, M. Tacke (2006) 'Anti-tumor activity of Titanocene Y in xenografted Caki-1 tumors in mice'. ANTI-CANCER DRUG, 17 (3):333-336. [Details]
O. Mendoza, H. Müller-Bunz, M. Tacke (2005) 'Cocondensation Reactions of Nitrogen-Containing Heterocycles with Lithium Atoms at 77 K'. Journal of Organometallic Chemistry, 690 (14):3357-3365. [Details]
Oberschmidt, O; Hanauske, AR; Rehmann, FJK; Strohfeldt, K; Sweeney, N; Tacke, M; ; (2005) 'Activity of [1,2-di(cyclopentadienyl)-1,2-di(p-N,N-domethylaminophenyl)-ethanediyl] titanium dichloride against tumor colony-forming units'. ANTI-CANCER DRUG, 16 (10):1071-1073. [Details]
Kelter, G; Sweeney, NJ; Strohfeldt, K; Fiebig, HH; Tacke, M; ; (2005) 'In-vitro anti-tumor activity studies of bridged and unbridged benzyl-substituted titanocenes'. ANTI-CANCER DRUG, 16 (10):1091-1098. [Details]
Mendoza, O; Cuffe, LP; Rehmann, FJK; Tacke, M; ; (2005) 'The cocondensation reaction of lithium atoms and anisole: an experimental and theoretical study of the reaction pathway'. Journal of Organometallic Chemistry, 690 (6):1511-1522. [Details]
N. J. Sweeney, O. Mendoza, H. Müller-Bunz, C. Pampillón, F.J.K. Rehmann, K. Strohfeldt, M. Tacke (2005) 'Novel benzyl substituted titanocene anti-cancer drugs'. Journal of Organometallic Chemistry, 690 (21-22):4537-4544. [DOI] [Details]
F. J. K. Rehmann, A. J. Rous, O. Mendoza, N. J. Sweeney, K. Strohfeldt, W. M. Gallagher, M. Tacke (2005) 'A trimethoxyphenyl substituted ansa-titanocene: A possible anti-cancer drug'. Polyhedron, 24 (11):1250-1255. [DOI] [Details]
Rehmann, FJK; Cuffe, LP; Mendoza, O; Rai, DK; Sweeney, N; Strohfeldt, K; Gallagher, WM; Tacke, M; ; (2005) 'Heteroaryl substituted ansa-titanocene anti-cancer drugs derived from fulvenes and titanium dichloride'. Applied Organometallic Chemistry, 19 (3):293-300. [Details]
M. Tacke, L. T. Allen, L. P. Cuffe, W. M. Gallagher, Y. Lou, O. Mendoza, H. Müller-Bunz, F.-J. K. Rehmann, N. Sweeney (2004) 'Novel Titanocene Anti-Cancer Drugs Derived from Fulvenes and Titanium Dichloride'. Journal of Organometallic Chemistry, 689 (13):2242-2249. [DOI] [Details]
M. Tacke, L. P. Cuffe, W. M. Gallagher, Y. Lou, O. Mendoza, H. Müller-Bunz, F.-J. K. Rehmann, N. Sweeney (2004) 'Methoxy-phenyl Substituted Ansa-Titanocenes as Potential Anti-Cancer Drugs Derived from Fulvenes and Titanium Dichloride'. Journal of Inorganic Biochemistry, 98 (12):1987-1994. [DOI] [Details]
M. Tacke, O. Mendoza, FJK Rehmann, LP Cuffe; (2004) 'Cocondensation Reactions of Five-Membered Heterocycles with Lithium Atoms at 77 K'. European Journal of Inorganic Chemistry, (22):4525-4532. [Details]
Tacke, M, Leyden, R, Cuffe, LP, ; (2004) 'A DFT study of the reactions of tetrameric and hexameric methyllithium with CO and CNMe'. Journal of Molecular Structure-Theochem, 684 (1-3):211-215. [Details]
S. Fox, J. Dunne, M. Tacke, J. F. Gallagher (2004) 'Novel derivatives of ansa-titanocenes procured from 6-phenylfulvene: a combined experimental and theoretical study'. Inorganica Chimica Acta, 357 (1):225-234. [DOI] [Details]
J. P. Dunne, M. Bockmeyer, M. Tacke; (2003) 'Cocondensation Reactions of Substituted Aromatic Compounds with Lithium Atoms at 77 K'. European Journal of Inorganic Chemistry, :458-466. [Details]
J. P. Dunne, M. Tacke; (2003) 'Aryl Calcium Hydrides as Precursors to Alkoxides and Aryloxides of Calcium'. European Journal of Inorganic Chemistry, :1416-1425. [Details]
S. Fox, J. P. Dunne, R. Dronskowski, D. Schmitz, M. Tacke; (2002) 'Synthesis and Structural Characterisation of a Novel Chiral ansa-Cobaltocenium Hexafluorophospate'. European Journal of Inorganic Chemistry, :3039-3046. [Details]
J. P. Dunne, S. Fox, M. Tacke (2001) 'A DFT Study on Structures of Aryl Calcium Hydrides in Donor Solvents'. Journal of Molecular Structure-Theochem, 543 :157-166. [Details]
M. Tacke, J. P. Dunne, S. Fox, G. Linti, R. Teuber (2001) 'The Synthesis, X-Ray, and DFT Structure of the free ansa-Cyclopentadiene Ligand C5H5CMe2CMe2C5H5'. Journal of Molecular Structure, 570 :197-202. [Details]
M. Tacke, S. Fox, L. Cuffe, J. D. Dunne, F. Hartl, T. Mahabiersing (2001) 'Reduction of Substituted Fulvenes Studied by Spectro-Electrochemistry and Ab Initio Theory'. Journal of Molecular Structure-Theochem, 559 :331-339. [Details]
M. Tacke, J. P. Dunne, I. El-Gamati, S. Fox, A. Rous, L. P. Cuffe (1999) 'Matrix effect found in the reaction of GaCl with HCl: application of the Onsager model to describe interactions between matrices and matrix isolated species'. Journal of Molecular Structure, 477 (1-3):221-224. [DOI] [Details]
M. Tacke (1998) 'Carbonyl and Benzene Complexes of Lithium: Transition-Metal-Like Behaviour of Lithium in Organolithium Compounds'. European Journal of Inorganic Chemistry, (5):537-541. [Details]
M. Tacke, R. Teuber; (1997) 'Direct Synthesis of Isopropylcyclopentadienyl M(I) Compounds of Ga, Tl, Mn and Cu via Metal Vapor Cocondensation and their Spectroscopic Characterization'. Journal of Molecular Structure, 408 :507-512. [Details]
R. Teuber, G. Linti, M. Tacke; (1997) 'The X-Ray Structure of Fe(fulvene)2: The Missing Link in the Direct Synthesis of ansa- and Cpi-Metallocenes (Cpi = C5H4CHMe2)'. Journal of Organometallic Chemistry, 545-546 :105-110. [Details]
M. Tacke, Ch. Tacke, D. J. Stufkens, A. Oskam, J. M. de Wolf, J. Teuben, G. Luinstra; (1997) 'IR Spectroscopic Investigations in Reactions between Unsaturated Titanium Complexes and CO or N2 in Liquid Xenon or Heptane'. Journal of Molecular Structure, 408/409 :499-505. [Details]
M. Tacke (1996) 'The Mechanism of the Activation of Aromatic Hydrocarbons with Lithium Atoms: Spectroscopic Results and their Ab Initio Interpretation'. Chemische Berichte, 129 :1369-1371. [Details]
M. Tacke (1995) 'Selective Activation of Aromatic C-H Bonds with Lithium Atoms at 77 K'. Chemische Berichte, 128 :91-92. [Details]
M. Tacke, P. Sparrer, R. Teuber, H.-J. Stadter, F. Schuster; (1995) 'A Novel Liquid Xenon IR Cell Constructed from a Silicon Single Crystal '. Journal of Molecular Structure, 349 :251-252. [Details]
M. Tacke (1995) 'The Reaction of RLi Species with CO and Isonitriles: IR Spectroscopic Investigations in Liquid Xenon and Ab Initio Calculations of the Intermediates'. Chemische Berichte, 128 :1051-1053. [Details]
M. Tacke; (1994) 'Direct Synthesis of ansa-Metallocenes of Tin and Lead via Metal Vapor Cocondensation '. Organometallics, 13 :4124-4125. [Details]
M. Tacke, Ch. Klein, D. J. Stufkens, A. Oskam, P. Jutzi, E. A. Bunte (1993) 'Complexes of Decamethylsilicocene: Cp2Si(CO) and Cp2Si(N2)'. ZAAC, 619 :865-868. [Details]
J. Kroner, H. Noeth, K. Polborn, H. Stolpmann, M. Tacke, M.Thomann; (1993) '(Di-tert.-butylphosphanylimino)-(tetramethylpiperidino)boran: ein BNP-1,3-Dipol'. Chemische Berichte, 126 :1995-2002. [Details]
Ch. Klein, H. Noeth, M. Tacke, M. Thomann; (1993) 'Dimere und trimere Aminoalane mit inverser Brueckenfunktion'. Angewandte Chemie-International Edition in English, 32 :886-888. [Details]
M. Tacke, Ch. Klein, D. J. Stufkens, A. Oskam (1993) 'Photochemistry of Cp2Ti(CO)2 and Cp2Ti(N3)2 in solid matrices and in solution at low temperature'. Journal of Organometallic Chemistry, 444 :75-81. [Details]
M. Tacke, H. Kreienkamp, L. Plaggenborg, H. Schnoeckel; (1991) 'GaCl: Ein roter metastabiler Festkoerper'. ZAAC, 604 :35-38. [Details]
C. Dohmeier, C. Robl, M. Tacke, H. Schnoeckel; (1991) 'The Tetrameric Aluminium (I) Compound [AlCp]4'. Angewandte Chemie-International Edition in English*, 30 :564-565. [Details]
R. Koeppe, M. Tacke, H. Schnoeckel; (1991) 'Infrarotspektroskopischer Nachweis von monomeren HGaCl2 in festem Argon'. ZAAC, 605 :35-41. [Details]
R. Ahlrichs, M. Haeser, H. Schnoeckel, M. Tacke; (1989) 'Aluminium-Olefin Bonds in Dimeric 1.4.-Dichloro-1.4.-Dialumina-2.5.-Cyclohexadiene'. Chemical Physics Letters, 154 :104-110. [Details]
M. Tacke, H. Schnoeckel; (1989) 'Metastable AlCl as a Solid and in Solution'. Inorganic Chemistry, 28 :2895-2896. [Details]
Hide

Show All

Other Journals

P. Genova-Kalou, T. Barkina, D. Ignatova, A. Toshev, M. Tacke (2009) 'Inhibition of Herpes Simplex Virus Type 1 Infection by Some Selected Antitumor Titanium-Based Coordination Compounds' Biotechnology & Biotechnological Equipment 23 (2) :507-510.

[Details]

M. Tacke ; (1997) 'Selektive C-H-Aktivierung mit Lithiumatomen: Kryochemische Synthese und spektroskopische Aufklaerung' GIT Fachz. Lab 41 :133-135. [Details]

Conference Publications

Dowling, C. M., Cuffe, S., Gill, C., Tacke, M., Fitzpatrick, J. M., Watson, R. W. G., ; (2008) European Urology Supplements Effects of docetaxel and novel titanocene analogues on cell death in prostate cancer following downregulation of Id-1 and the IAPS , pp.276-276 [Details]

Cuffe, S., Dowling, C., Gill, C., Tacke, M., Fitzpatrick, J. M., Carty, M. P., Watson, R. W. G., ; (2008) Ejc Supplements Novel titanocene analogues induce apoptosis in prostate cancer epithelial cells by initiating a DNA damage response , pp.29-29 [Details]

Dissertations/Theses

M.Tacke; (1996) Ungewoehnliche Wege zur Metall-Kohlenstoff-Bindung. Dissertations/Theses [Details]

M. Tacke; (1990) Solid and Dissolved AlCl and GaCl: Spectroscopic and Chemical Investigations. Dissertations/Theses [Details]

M. Tacke; (1987) Cryochemistry of AlCl with Alkynes and Aromatic Compounds. Dissertations/Theses [Details]

Associations

Association: GDCh (German Chemical Society), Function/Role: Member

Association: EFB (European Federation of Biotechnology), Function/Role: Member

Association: CESAR (Central European Society of Anti Cancer Drug Research), Function/Role: Member of the anti cancer drug synthesis section

Association: COST D20 working group D20/0001/00 "Design of novel, innovative metal anticancer drugs", Function/Role: Member

Conference Contributions

Tacke M (2005) Novel Titanocene Anti-Cancer Drugs. [Oral Presentation], CESAR SYMPOSIUM 2005: Novel Approaches for the Discovery and the Development of Anticancer Agents, Vienna, Austria , 08-SEP-05 - 09-SEP-05.

Tacke M; (2005) Novel Titanocene Anti-Cancer Drugs. [Invited Oral Presentation], CESAR SYMPOSIUM 2005 Novel Approaches for the Discovery and the Development of Anticancer Agents, University of Vienna, Austria , 07-JUL-05 - 09-JUL-05.

Mendoza O, Strohfeldt K, Rehmann F-J, Sweeney N, Pampillon C, Rous A, Mueller-Bunz H, Tacke M; (2005) Unusual Ways to the Lithium Carbon Bond Novel Benzyl Substituted Titanocene Anti-Cancer Drugs Novel Ansa-Titanocene Anti-Cancer Drugs. [Oral Presentation], 57th Irish Universities Chemistry Research Colloquium, Maynooth , 22-JUN-05 - 24-JUN-05.

Tacke M, Strohfeldt K, Rehmann F-J, Sweeney N, Mendoza O, Pampillon C, Rous A, Mueller-Bunz H; (2005) Novel Benzyl Substituted Titanocene Anti-Cancer Drugs Novel Ansa-Titanocene Anti-Cancer Drugs. [Poster Presentation], Chemical Biology Interface Meeting, Royal College of Surgeons in Ireland , 13-MAY-05 - 13-MAY-05.

Tacke, M; (2005) Novel Titanocene Anti-Cancer Drugs. [Invited Lecture], MedChem Europe 2005, Berlin, Germany , 12-APR-05 - 14-APR-05.

Tacke M, Strohfeldt K, Rehmann F-J, Sweeney N, Mendoza O, Pampillon C; (2005) Novel Titanocene Anti-Cancer Drugs. [Invited Lecture], The Second International Conference of Pharmaceutical and Drug Industries Division, Cairo, Egypt , 07-MAR-05 - 09-MAR-05.
Tacke M, Strohfeldt, Rehmann F-J, Sweeney N, Mendoza O, Gallagher W, Pampillon C; (2004) Novel Titanocene Anti-Cancer Drugs. [Invited Oral Presentation], CESAR (Central European Society of Anti Cancer Drug Research) November Meeting, Frankfurt, Germany , 13-DEC-04 - 13-DEC-04.
Tacke M, Strohfeldt K, Rehmann F-J, Sweeney N, Mendoza O, Gallagher W, Pampillon C; (2004) Novel Titanocene Anti-Cancer Drugs. [Poster Presentation], CSCB Symposium Recent Advances in Synthesis & Chemical Biology III, Trinity College Dublin , 13-DEC-04 - 13-DEC-04.
Tacke M, Strohfeldt, Rehmann F-J, Sweeney N, Mendoza O, Gallagher W, Pampillon C; (2004) Novel Titanocene Anti-Cancer Drugs. [Poster Presentation], ERC RESEARCH SYMPOSIUM: COMMON MOLECULAR MECHANISMS IN INFLAMMATION AND MALIGNANCY, St. Vincent's University Hospital , 12-NOV-04 - 12-NOV-04.
Tacke M, Lou Y, Rehmann F-J, Sweeney N, Mendoza O, Cuffe L, Allen L, Gallagher W; (2004) Novel Titanocene Anti-Cancer Drugs. [Poster Presentation (Refereed)], Conway Research Festival 2004, University College Dublin , 11-SEP-04 - 11-SEP-04.
Tacke M, Lou Y, Rehmann F-J, Sweeney N, Mendoza O, Cuffe L, Allen L, Gallagher W; (2004) Novel Titanocene Anti-Cancer Drugs. [Invited Lecture], COST D20 Conference, Garmisch-Partenkirchen, Germany , 28-AUG-04 - 29-AUG-04.
Tacke M, Lou Y, Rehmann F-J, Sweeney N, Mendoza O, Cuffe L, Allen L, Gallagher W; (2004) Novel Titanocene Anti-Cancer Drugs. [Oral Presentation], Second International Symposium on Biorganometallic Chemistry, ISBOMC`04, Zuerich, Switzerland , 14-JUL-04 - 17-JUL-04.
Tacke M, Rehmann F-J, Mendoza O, Cuffe L,; (2004) The Cocondensation Reaction of Lithium Atoms and Anisole: A Theoretical Study of the Reaction Pathway. [Poster Presentation (Refereed)], Reaction Mechanisms VII, University College Dublin , 04-JUL-04 - 08-JUL-04.
Tacke M, Leyden R, Cuffe L; (2004) The Reaction of Methyllithium with CO and CNMe: A Theoretical Study. [Oral Presentation], Fifth European Conference on Computational Chemistry EUCO-CC5, La Londe les Maures, France , 15-JUN-04 - 20-JUN-04.
Tacke M, Lou Y, Rehmann F-J, Sweeney N, Mendoza O, Cuffe L, Allen L, Gallagher W; (2004) Novel Titanocene Anti-Cancer Drugs. [Invited Oral Presentation], CSCB Synthesis Workshop, CSCB, Department of Chemistry, UCD , 30-APR-04 - 30-APR-04.
Tacke M, Lou Y, Rehmann F-J, Sweeney N, Mendoza O, Cuffe L, Allen L, Gallagher W; (2004) Novel Titanocene Anti-Cancer Drugs. [Poster Presentation], IACR & ISMO Joint Cancer Reseach Meeting, Belfast , 23-APR-04 - 24-APR-04.
Tacke M, Lou Y, Rehmann F-J, Sweeney N, Mendoza O, Cuffe L, Allen L, Gallagher W; (2003) Synthesis of novel titanocenes as possible anti-cancer drugs. [Poster Presentation], CSCB Symposium, Royal College of Surgeons in Ireland (RSCI), Dublin , 12-DEC-03 - 12-DEC-03.
Tacke M., Lou Y., Rehmann F.-J., Sweeney N., Mendoza O., Cuffe L., Allen L.T., Gallagher W.M.; (2003) Synthesis of novel titanocenes as possible anti-cancer drugs. [Poster Presentation], St. Vincent`s Hospital Annual Research Symposium Common Molecular Mechanisms in Inflammation and Malignancy, St. Vincent`s Hospital, Dublin, Ireland , 21-NOV-03 - 21-NOV-03.
Tacke M; (2003) Novel Titanocene Anti-Cancer Drugs. [Invited Oral Presentation], CESAR (Central European Society of Anti Cancer Drug Research) November Meeting, Frankfurt am Main, Germany , 14-NOV-03 - 14-NOV-03.
Tacke M., Rehmann F.-J., Mendoza O., Dunne J.P.; (2003) C-H Activation in Donor Substituted Benzenes and Heterocycles. [Oral Presentation], ALKCHEM-3 (Third International Conference on the Chemistry of the Alkali and Alkaline Earth Metals), University of Wuerzburg, Germany , 28-SEP-03 - 02-OCT-03.
Tacke M., Lou Y., Rehmann F.-J., Sweeney N., Mendoza O., Cuffe L., Allen L.T., Gallagher W.M.; (2003) Synthesis of novel titanocenes as possible anti-cancer drugs. [Poster Presentation], Conway Research Festival 2003, Conway Institute, UCD, Belfield, Dublin 4, Ireland , 16-SEP-03 - 17-SEP-03.
Tacke M; (2003) CH Activation Using Metal Atoms. [Oral Presentation], 7.ICCRD (7th International Conference on Chemistry and its Role in Development), Sharm El-Sheikh, Egypt , 14-APR-03 - 17-APR-03.
Tacke M ; (2002) Unusual Ways to the Metal Carbon Bond. [Oral Presentation], 3.JICC (3rd Jordanian International Conference of Chemistry), Irbid, Jordan , 22-APR-02 - 26-APR-02.
Hide

Show All

Committees

Committee : Conway/CSCB Institute

Committee : European Federation of Biotechnology (EFB)

Committee : Central European Society for Anti-Cancer Research (CESAR)

Committee : COST D20

Internal Collaborators

Dr. Francesca Paradisi: Antibacterial testing of carbene-metal salts

Prof. Donal O'Shea: Synthesis of heterocycles as substituents for metallocene anticancer drugs

Prof. William Watson: Advanced biological anticancer testing of metallocenes

External Collaborators

Prof. Heinz-Herbert Fiebig, Dr. Iduna Fichtner, Dr. Ralf Hilger, Dr. Holger Weber, Prof. Rainer Schobert
CESAR (Central European Society of Anti-Cancer Research) network