Dr. Neil Ferguson | UCD Conway

Research

Dr Neil Ferguson PhD

Book Chapters:

Ferguson, N. & Fersht, A. R. (2008) 'Phi value analysis of protein folding transition states' In: Lutz, S. & Theo, U (eds). Protein Engineering Handbook. Germany: Wiley-VCH Verlag GmbH. [Details]

Peer Reviewed Journals:

Chi, CN,Bach, A,Engstrom, A,Stromgaard, K,Lundstrom, P,Ferguson, N,Jemth, P (2011) 'Biophysical Characterization of the Complex between Human Papillomavirus E6 Protein and Synapse-associated Protein 97'. Journal of Biological Chemistry, 286 :3597-3606. [DOI] [Details]

O'Nuallain, B,Freir, DB,Nicoll, AJ,Risse, E,Ferguson, N,Herron, CE,Collinge, J,Walsh, DM (2010) 'Amyloid beta-Protein Dimers Rapidly Form Stable Synaptotoxic Protofibrils'. Journal of Neuroscience, 30 :14411-14419. [DOI] [Details]

Freund, SMV,Johnson, CM,Jaulent, AM,Ferguson, N (2008) 'Moving towards High-Resolution Descriptions of the Molecular Interactions and Structural Rearrangements of the Human Hepatitis B Core Protein'. Journal of Molecular Biology, 384 :1301-1313. [DOI] [Details]

Chi, C., Bach, A., Engstrom, A., Stromgaard, K., Lundstrom, P., Ferguson, N. & Jemth, P. (2011) 'Biophysical characterization of the complex between human papillomavirus E6 protein and synapse associated protein 97'. Journal of Biological Chemistry, 286 :3597-3606. [Details]

O'Nuallain, B., Freir, D., Nicoll, A. Risse, E., Ferguson, N., Herrron, C., Collinge, J. & Walsh, D. (2010) 'Abeta dimers rapidly form synaptotoxic protofibrils'. Journal of Neuroscience, 30 :14411-14419. [Details]

Arbely, E., Rutherford, T. J., Neuweiler, H., Sharpe, T. D., Ferguson, N. & Fersht, A. R. (2010) 'Carboxly pKa values and acid denaturation of BBL'. Journal of molecular biology, 403 :313-327. [Details]

Dodson, C. A., Ferguson, N, Rutherford, T. J., Johnson, C. M., Freund, S. M. V. & Fersht, A. R. (2010) 'Engineering a two-helix bundle protein for folding studies'. Protein Engineering Design and Selection, 23 (5):357-364. [Details]
Neuweiler, H., Sharpe, T. D., Rutherford, T. J., Johnson, C. M., Allen, M. D., Ferguson, N. & Fersht, A. R. (2009) 'The folding mechanism of BBL: Plasticity of transition state structure observed within an ultrafast folding protein family'. Journal of Molecular Biology, 390 :1060-1073. [DOI] [Details]
Arbely, A., Rutherford, T. J., Sharpe, T. D., Ferguson, N. & Fersht, A. R. (2009) 'Downhill versus barrier-limited folding. 1. Energetic and structural basis for the perturbation of the protein BBL on protonation of a histidine of unusually low pKa'. Journal of Molecular Biology, 387 :986-992. [Details]
Neuweiler, H., Sharpe, T. D., Johnson, C. M., Teufel, D. P., Ferguson, N. & Fersht, A. R. (2009) 'Downhill versus barrier limited folding of BBL. 2. Mechanistic Insights from kinetics of folding monitored by independent tryptophan probes'. Journal of Molecular Biology, 387 :975-985. [Details]
Sharpe, T.D., Ferguson, N., Johnson, C. M. & Fersht, A.R. (2008) 'Conservation of Transition State Structure in Fast Folding Peripheral Subunit Binding Domains'. Journal of Molecular Biology, 383 :224-237. [DOI] [Details]
Becker, J., Ferguson, N., Flinders, J., Rossum, B-J., Fersht A. R. & Oschkinat, H. (2008) 'A sequential assignment procedure for proteins that have intermediate linewidths in MAS NMR spectra: Amyloid fibrils of human CA150.WW2'. Chembiochem, 9 :1946-1952. [Details]
Ferguson, N., Sharpe, T. D., Johnson, C. M., Schartau, P. J. & Fersht, A. R. (2007) 'Structural biology: Analysis of 'downhill' protein folding'. Nature, 445 (7129):1-1. [DOI] [Details]
Petrovich, M., Jonsson, A. L., Ferguson, N., Daggett, V. & Fersht, A. R. (2006) 'Phi-analysis at the experimental limits: mechanism of beta-hairpin formation'. Journal of Molecular Biology, 360 (4):865-881. [DOI] [Details]
Ferguson, N., Sharpe, T. D., Johnson, C.M. & Fersht, A. R. (2006) 'The transition state for folding of a peripheral subunit-binding domain contains robust and ionic-strength dependent characteristics'. Journal of Molecular Biology, 356 (5):1237-1247. [DOI] [Details]
Ferguson, N., Becker J., Tidow, H., Tremmel, S., Sharpe, T. D., Flinders, J. Berriman, J., Oschkinat, H. & Fersht, A. R (2006) 'General structural motifs of amyloid protofilaments'. Proceedings of the National Academy of Sciences, 103 :16248-16253. [Details]
Ferguson, N., Day, R., Johnson, C. M., Allen, M. D., Daggett, V., (2005) 'Simulation and experiment at high temperatures: ultrafast folding of a thermophilic protein by nucleation-condensation'. Journal of Molecular Biology, 347 (4):855-870. [DOI] [Details]
Ferguson, N., Sharpe, T. D., Schartau, P. J., Sato, S., Allen, M. D., Johnson, C. M., Rutherford, T. J.& Fersht, A R. (2005) 'Ultra-fast barrier-limited folding in the peripheral subunit-binding domain family'. Journal of Molecular Biology, 353 (2):427-446. [DOI] [Details]
Ferguson, N., Schartau, P. J., Sharpe, T. D., Sato, S. & Fersht, A. R. (2004) 'One-state downhill versus conventional protein folding'. Journal of Molecular Biology, 344 (2):295-301. [DOI] [Details]
Ferguson, N., Berriman, J., Petrovich, M., Sharpe, T. D., Finch, J. T., & Fersht, A. R. (2003) 'Rapid amyloid fiber formation from the fast-folding WW domain FBP28'. Proceedings of the National Academy of Sciences of the United States of America, 100 (17):9814-9819. [DOI] [Details]
Ferguson, N. & Fersht, A. R. (2003) 'Early events in protein folding'. Current opinion in structural biology, 13 (1):75-81. [Details]
Ferguson, N., Pires, J. R., Toepert, F., Johnson, C. M., Pan, Y. P., Volkmer-Engert R., Schneider-Mergener, J., Daggett, V., Oschkinat, H. & Fersht, A. R. (2001) 'Using flexible loop mimetics to extend phi-value analysis to secondary structure interactions'. Proceedings of the National Academy of Sciences of the United States of America, 98 (23):13008-13013. [DOI] [Details]
Ferguson, N., Johnson, C. M., Macias, M., Oschkinat, H. & Fersht, A. R. (2001) 'Ultrafast folding of WW domains without structured aromatic clusters in the denatured state'. Proceedings of the National Academy of Sciences of the United States of America, 98 (23):13002-13007. [DOI] [Details]
Ferguson, N., Li, W., Capaldi, A. P., Kleanthous, C. & Radford S. E, (2001) 'Using chimeric immunity proteins to explore the energy landscape for alpha-helical protein folding'. Journal of Molecular Biology, 307 (1):393-405. [DOI] [Details]
Ferguson, N., Capaldi, A. P., James, R., Kleanthous, C. & Radford, S. E. (1999) 'Rapid folding with and without populated intermediates in the homologous four-helix proteins Im7 and Im9'. Journal of Molecular Biology, 286 (5):1597-1608. [DOI] [Details]
Kleanthous, C., Kuhlmann, U. C., Pommer, A. J., Ferguson, N., Radford, S. E., Moore, G. R., James, R. & Hemmings, A. M. (1999) 'Structural and mechanistic basis of immunity towards endonuclease colicins'. Nature Structural Biology, 6 :295-297. [Details]
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