Research
- Research Programmes
- Researchers
- Postdoctoral & Research Fellows
- Featured Researchers
- Conway Fellows
- Conway Clinical Associate Fellows
- Conway Fellows (A-Z)
- Professor Mohamed Al-Rubeai
- Professor Alan Baird
- Dr. John Baugh
- Dr. Orina Belton
- Dr. Oliver Blacque
- Professor Billy Bourke
- Professor David Brayden
- Dr. Lorraine Brennan
- Professor Geraldine Butler
- Dr. Gerard Cagney
- Professor Dolores J. Cahill
- Professor Sean Callanan
- Dr. Marguerite Clyne
- Dr. John Crean
- Dr. Paul Crossey
- Professor Mark Crowe
- Professor Seamas Donnelly
- Professor Michael (Joe) Duffy
- Professor Jim Egan
- Professor Guiliano Elia
- Professor Paul Engel
- Professor Alex Evans
- Dr. Paul Evans
- Dr. Neil Ferguson
- Professor Oliver Fitzgerald
- Professor William Gallagher
- Professor Declan Gilheany
- Professor Catherine Godson
- Professor Stephen Gordon
- Professor Andrew Green
- Professor Patrick Guiry
- Dr. Jana Haase
- Dr. Chandralal Hewage
- Professor Des Higgins
- Professor Suzanne Jarvis
- Professor Michael Keane
- Dr. Breandan Kennedy
- Professor Boris Kholodenko
- Professor Therese Kinsella
- Professor Ulla Knaus
- Professor Walter Kolch
- Professor. Gil Lee
- Professor Brendan Loftus
- Professor Pat Lonergan
- Professor David MacHugh
- Dr. Patricia Maguire
- Professor Kevin Malone
- Professor J.Paul.G Malthouse
- Professor Finian Martin
- Dr. Margaret Mc Gee
- Professor Fionnuala McAuliffe
- Dr. Gethin McBean
- Dr. Amanda McCann
- Dr. Edward McKone
- Professor Paul McLoughlin
- Dr. Hilary McMahon
- Dr. Tara McMorrow
- Professor Walter McNicholas
- Professor Wim Meijer
- Dr. Anika Mostaert
- Professor Grace Mulcahy
- Dr. Keith Murphy
- Dr. Evelyn Murphy
- Dr. Jarlath Nally
- Professor Phillip Newsholme
- Dr. Jens Nielsen
- Dr. Peter O'Brien
- Dr. Kevin O'Connor
- Dr. John O'Connor
- Professor Ronan O'Connell
- Dr. Tadhg O'Croinin
- Dr. James O'Gara
- Professor Donal F. O'Shea
- Professor Stefan Oscarson
- Dr. Francesca Paradisi
- Professor William Powderly
- Professor Prem Puri
- Professor Ciaran Regan
- Professor Helen Roche
- Professor Pauline Rudd
- Professor Dimitri Scholz
- Dr. Noreen Sheehy
- Professor Denis Shields
- Professor Jeremy Simpson
- Dr. Albert Smolenski
- Dr. Matthias Tacke
- Professor Cormac Taylor
- Dr. Emma Teeling
- Professor Douglas Veale
- Professor Dominic Walsh
- Professor William Watson
- Professor Matthias Wilm
- Dr. Xiangming Zhu
- Core Technologies
Dr Tara McMorrow BSc PhD
Contact Details
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Biography:
2008-Present: Conway Fellow, UCD Conway Institute 2005-Present: Lecturer in Pharmacology, UCD School of Biomolecular and Biomedical Science, UCD Conway Institute 2002-2008: Conway Investigator, UCD Conway Institute 2002-2004: Special Lecturer and DMMC Senior Research Fellow, Dept. of Pharmacology, UCD Conway Institute 2000-2002: Conway Senior Research Fellow, Dept. of Pharmacology, UCD |
Research Interests
| Our research involves the study of kidney fibrosis and end-stage renal disease. The incidence of end stage renal disease (ESRD) is rising at a rate of 8-10% per annum. While the initiating factors of the disease may vary, tubulo-interstitial fibrosis is a keMolecular and Cellular Biology of Renal Fibrosis. Our research involves the study of kidney fibrosis and end-stage renal disease. The incidence of end stage renal disease (ESRD) is rising at a rate of 8-10% per annum. While the initiating factors of the disease may vary, tubulo-interstitial fibrosis is a key event and indicates a likelihood of progression to ESRD. Therapeutic strategies to halt the progression to ESRD are very limited mainly because of a lack of understanding of the mechanisms involved in tubulo-interstitial fibrosis. Molecular and Cellular Biology of Renal Fibrosis We believe that a process known as epithelial-mesenchymal transition (EMT), whereby epithelial cells become more fibroblast-like, may be involved in the development of kidney fibrosis. EMT is a physiological process during embryo development but in the adult can play a fundamental role in the early stages of transformation, invasion and metastasis of cancer cells. This process involves the loss of epithelial cell markers such as E-cadherin and the increase in mesenchymal markers such as alpha-smooth muscle actin. We are using DNA microarray analysis to determine specific gene changes in cell culture models of renal fibrosis, including EMT models. Renal Pharmacology and Toxicology We are also interested in the development of models of renal cell injury, including the investigation of the role of immunosuppressant agents in renal fibrosis through the application of genomics and proteomics techniques. Studies on differentially regulated genes and proteins provide insights not only into immunosuppressant-induced renal fibrosis, but also into the molecular mechanisms underlying EMT in other contexts, including tumour biology and fibrosis of other organs. Further examination of differentially regulated genes may lead to the identification of novel genes and potential adjunct therapies. The major focus of our research is providing new models to develop our understanding of the mechanisms of nephrotoxicity and kidney damage, with the aim of identifying new therapeutic targets and strategies. Research Funding EU SFI MRCG-HRB Enterprise Ireland IRCSET UCD Seed Funding American Cystinosis Foundation |
Research Projects
| Sponsor : University College Dublin (UCD) Title : M.Sc. project Supervision TMcM Start Date / End Date : 09-MAY-12 / 10-MAY-13 |
| Sponsor : Cystinosis Foundation Title : Role of nitric oxide in the kidney proximal tubular dysfunction associated with the Fanconi Syndrome in cystinosis Start Date / End Date : 30-JAN-12 / 30-JAN-13 |
| Sponsor : European Chemical Industry Council (CEFIC) Title : Mechanism-based characteristics of systemic toxicity for Repdose database substances employing in vitro toxicogenomics Start Date / End Date : 01-FEB-11 / 31-JAN-14 |
| Sponsor : EC Framework Title : Systems biology towards novel chronic kidney disease diagnosis and treatment (SysKID) Start Date / End Date : 01-JAN-10 / 31-DEC-14 |
| Sponsor : Cystinosis Foundation Ireland Title : Molecular mechanisms of muscle myopathy and pancreatic beta cell dysfunction associated with cystinosis: Determination of optimal approaches for cell protection Start Date / End Date : 01-SEP-10 / 31-AUG-13 |
| Sponsor : Irish Research Council for Science Engineering and Technology (IRCSET) Title : Identifying the mechanisms of microalbuminuria and novel therapeutic targets in kidney disease Start Date / End Date : 01-SEP-09 / 31-AUG-11 |
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| Sponsor : University College Dublin (UCD) Title : Identification of Blomarkers in Kidney Disease Development using a Metabolomics Approach Start Date / End Date : 26-MAY-08 / 01-DEC-09 |
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| Sponsor : Science Foundation Ireland (SFI) Title : Mechanisms and Potential Gene Targets in Immune Mediated Epithelial-Mesenchymal Transdifferentiation. Start Date / End Date : 01-OCT-04 / 31-MAR-08 |
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| Sponsor : Health Research Board (HRB) Title : Gene regulation and mechanism of epithelial-mesenchymal transdifferentiation (EMT) in a cyclosporine A-induced model. Start Date / End Date : 01-OCT-03 / 30-SEP-06 |
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Recent Postgraduates
| Postgraduate Students: |
Current Postgraduate Students
| Ismael Obaidi, Doctor of Philosophy (PhD) - Thesis Supervisor |
| Jennifer Slyne, Doctor of Philosophy (PhD) - Thesis Supervisor |
| Helena Frain, Doctor of Philosophy (PhD) - Thesis Supervisor |
Book Chapters
| O¿Connell S, Nolan S, Slattery C, Ryan MP, McMorrow T. (2012) 'The role of Transglumatinase in Kidney Disease' In: Fibronectin and Disease. Croatia: Intech. [Details] |
| C. Slattery, H. Cassidy, O. Johsnton, M.P.Ryan and T.McMorrow (2012) 'Mechanisms of calcineurin inhibitor nephrotoxicity in chronic allograft injury' In: Chronic Kidney Disease and Renal Transplantation. India: Research Signpost. [Details] |
| McMorrow T., Campbell E., Slattery C., Ryan M.P.; (2008) 'Altered gene expression and molecular Mechanisms modulating epithelial-mesenchymal transition in human renal epithelial cells' In: Paul J Higgins (eds). Human Epithelial Tumor Cell Plasticity: Implications for Cancer Progression and Metastasis. India: Research Signpost. [Details] |
Peer Reviewed Journals
| Radford R, Slattery C, Jennings P, Blaque O, Pfaller W, Gmuender H, Van Delft J, Ryan MP, McMorrow T. (2012) 'Carcinogens induce loss of the primary cilium in human renal proximal tubular epithelial cells independently of effects on the cell cycle'. American Journal of Physiology-Renal Physiology, . [Details] |
| Martin-Martin N, Slattery C, McMorrow T, Ryan MP. (2011) 'TGF-β1 mediates sirolimus and cyclosporine A-induced alteration of barrier function in renal epithelial cells via a noncanonical ERK1/2 signaling pathway'. American Journal of Physiology-Renal Physiology, . [Details] |
| O'Connell S, Slattery C, Ryan MP, McMorrow T. (2012) 'Sirolimus enhances cyclosporine a-induced cytotoxicity in human renal glomerular mesangial cells'. Journal of transplantation, . [Details] |
| imonciel A, Wilmes A, Aschauer L, Radford R, Bloch KM, McMorrow T, Pfaller W, van Delft JH, Slattery C, Ryan MP, Lock EA, Jennings P. (2012) 'Oxidative stress induced by potassium bromate exposure results in altered tight junction protein expression in renal proximal tubule cells'. Archives of Toxicology, . [Details] |
| Cassidy H, Radford R, Slyne J, O'Connell S, Slattery C, Ryan MP, McMorrow T. (2012) 'The role of MAPK in drug-induced kidney injury'. Journal of transplantation, . [Details] |
| O'Connell S, Tuite N, Slattery C, Ryan MP, McMorrow T. (2012) 'Cyclosporine A-induced oxidative stress in human renal mesangial cells: a role for ERK 1/2 MAPK signaling'. Toxicological sciences : an official journal of the Society of Toxicology, . [Details] | |||||||||
| Jennings P, Weiland C, Limonciel A, Bloch KM, Radford R, Aschauer L, McMorrow T, Wilmes A, Pfaller W, Ahr HJ, Slattery C, Lock EA, Ryan MP, Ellinger-Ziegelbauer H. (2012) 'Transcriptomic alterations induced by Ochratoxin A in rat and human renal proximal tubular in vitro models and comparison to a rat in vivo model'. Archives of Toxicology, . [Details] | |||||||||
| Martin-Martin N, Dan Q, Amoozadeh Y, Waheed F, McMorrow T, Ryan MP, Szászi K. (2012) 'RhoA and Rho kinase mediate cyclosporine A and sirolimus-induced barrier tightening in renal proximal tubular cells'. International Journal of Biochemistry & Cell Biology, . [Details] | |||||||||
| O'Connell S, Slattery C, Ryan MP, McMorrow T.; (2011) 'Identification of novel indicators of cyclosporine A nephrotoxicity in a CD-1 mouse model'. Toxicology & Applied Pharmacology, 252 (2):201-210. [Details] | |||||||||
| Johnston O, Cassidy H, O'Connell S, O'Riordan A, Gallagher W, Maguire PB, Wynne K, Cagney G, Ryan MP, Conlon PJ, McMorrow T.; (2011) 'Identification of β2-microglobulin as a urinary biomarker for chronic allograft nephropathy using proteomic methods'. Proteomics Clinical Applications, 5 (7-8):422-431. [Details] | |||||||||
| J. K. Ellis, T. J. Athersuch, R. Cavill, R. Radford, C. Slattery, T. McMorrow, M. P. Ryan, T. M.D. Ebbels, H. Keun; (2011) 'Metabolic Response to Low Level Toxicant Exposure in a Novel Renal Tubule'. Molecular BioSystems, 7 (1):247-257. [Details] | |||||||||
| J. Lynch, S. Nolan, C. Slattery, R. Feighery, M.P. Ryan, T. McMorrow; (2010) 'High-Mobility Group Box Protein 1: A Novel Mediator of Inflammatory-Induced Renal Epithelial-Mesenchymal Transition'. American Journal of Nephrology, 32 (6):590-602. [Details] | |||||||||
| Martin-Martin N, Ryan G, McMorrow T, Ryan MP; (2010) ''Sirolimus and cyclosporine A alter barrier function in renal proximal tubular cells through stimulation of ERK1/2 signaling and claudin-1 expression'. American Journal of Physiology-Renal Physiology, 293 (3):672-682. [Details] | |||||||||
| H Cassidy, O Johnston, L Brennan, A O Riordan, P Conlon, MP Ryan, T Mc Morrow ; (2010) 'Metabolomic Analysis of Human(HOMO SAPIENS) Immunosuppressant Nephropathy Post Renal Transplantation'. IRISH J MED SCI, 7 . [Details] | |||||||||
| Jennings P, Aydin S, Bennett J, McBride R, Weiland C, Tuite N, Gruber LN, Perco P, Gaora PO, Ellinger-Ziegelbauer H, Ahr HJ, Kooten CV, Daha MR, Prieto P, Ryan MP, Pfaller W, McMorrow T; (2009) 'Inter-laboratory comparison of human renal proximal tubule (HK-2) transcriptome alterations due to Cyclosporine A exposure and medium exhaustion'. Toxicology in Vitro, 23 (3):486-499. [Details] | |||||||||
| Feighery, R., Maguire, P., Ryan, M. R., McMorrow, T., ; (2008) 'A proteomic approach to immune-mediated epithelial-mesenchymal transition'. Proteomics Clinical Applications, 2 (7-8):1110-1117. [Details] | |||||||||
| Nee, L,O'Connell, S,Nolan, S,Ryan, MP,McMorrow, T; (2008) 'Nitric Oxide Involvement in TNF-alpha and IL-1 beta-Mediated Changes in Human Mesangial Cell MMP-9 and TIMP-1'. Nephron. Experimental nephrology, 110 (NA):59-66. [DOI] [Details] | |||||||||
| Slattery, C., Ryan, M. P., McMorrow, T., ; (2008) 'Protein kinase C beta overexpression induces fibrotic effects in human proximal tubular epithelial cells'. International Journal of Biochemistry & Cell Biology, 40 (10):2218-2229. [Details] | |||||||||
| O'Riordan A, Johnston O, McMorrow T, Wynne K, Maguire P, Hegarty JE, McCormick A, Watson AJ, Cagney G, Gallagher WM, Ryan MR; (2008) 'Identification of Apolipoprotein AI as a serum biomarker of chronic kidney disease in liver transplant recipients, using proteomic techniques'. Proteomics Clinical Applications, 2 (9):1338-1348. [Details] | |||||||||
| Nee, L,Tuite, N,Ryan, MP,McMorrow, T; (2007) 'TNF-alpha and IL-1beta-mediated regulation of MMP-9 and TIMP-1 in human glomerular mesangial cells'. Nephron. Experimental nephrology, 107 :73-86. [DOI] [Details] | |||||||||
| Slattery, C; McMorrow, T; Ryan, MP; ; (2006) 'Overexpression of E2A proteins induces epithelial-mesenchymal transition in human renal proximal tubular epithelial cells suggesting a potential role in renal fibrosis'. FEBS Letters, 580 (17):4021-4030. [Details] | |||||||||
| Slattery, C., Campbell, E., McMorrow, T., Ryan, M.P.; (2005) 'Cyclosporine A-induced renal fibrosis: a role for epithelial-mesenchymal transition'. AMERICAN JOURNAL OF PATHOLOGY, 167 (2):395-407. [Details] | |||||||||
| Nee, LE,McMorrow, T,Campbell, E,Slattery, C,Ryan, MP; (2004) 'TNF-alpha and IL-1 beta-mediated regulation of MMP-9 and TIMP-1 in renal proximal tubular cells'. Kidney International, 66 :1376-1386. [Details] | |||||||||
| Gillemans, N,McMorrow, T,Tewari, R,Wai, AWK,Burgtorf, C,Drabek, D,Ventress, N,Langeveld, A,Higgs, D,Tan-Un, K,Grosveld, F,Philipsen, S; (2003) 'Functional and comparative analysis of globin loci in pufferfish and humans'. Blood, 101 :2842-2849. [DOI] [Details] | |||||||||
| Feldman, G., Kiely, B., Martin, N., Ryan, G., McMorrow, T., Ryan, M.P.; (2007) 'Role for TGF-Beta in cyclosporine-induced modulation of renal epithelial barrier function'. Journal of the American Society of Nephrology, 18 (6):1662-1671. [Details] | |||||||||
| Slattery C, Ryan MP, McMorrow T.; (2007) 'E2A proteins: Regulators of cell phenotype in normal physiology and disease'. International Journal of Biochemistry & Cell Biology, doi:10.1016/j.biocel.2007.05.014 . [Details] | |||||||||
| Campbell, E., Slattery, C., Tuite, N., Nolan, S., Leonard, M., Ryan, M.P. and McMorrow, T.; (2006) 'RNA Interference: a novel alternative approach in nephrotoxicity studies'. ALTEX, 23 :406-409. [Details] | |||||||||
| McMorrow, T,Gaffney, MM,Slattery, C,Campbell, E,Ryan, MP; (2005) 'Cyclosporine A induced epithelial-mesenchymal transition in human renal proximal tubular epithelial cells'. Nephrology Dialysis Transplantation, 20 :2215-2225. [DOI] [Details] | |||||||||
| Nee, LE; McMorrow, T; Campbell, E; Slattery, C; Ryan, MP; ; (2004) 'TNF-alpha and IL-1 beta-mediated regulation of MMP-9 and TIMP-1 in renal proximal tubular cells'. Kidney International, 66 (4):1376-1386. [Details] | |||||||||
| Campbell, E., Slattery, C., McMorrow, T., Ryan, M.P. ; (2004) 'Role of RAP GTPases in TGF-B Mediated Epithelial-Mesenchymal Transition'. Journal of the American Society of Nephrology, 15 . [Details] | |||||||||
| Gillemans, N; McMorrow, T; Tewari, R; Wai, A; Burgtorf, C; Drabek, D; Ventress, N; Langeveld, A; Higgs, D; Tan-Un, K; Grosveld, F; Philipsen, S; ; (2003) 'Comparative analysis of globin loci in pufferfish and man suggests a common origin of vertebrate globin loci and reveals a novel mammalian globin locus'. Blood Cells Molecules and Diseases, 31 (1):161-161. [Details] | |||||||||
| Slattery, C; McMorrow, T; Watson, A; Ryan, MP; ; (2002) 'Cyclosporin A-induced renal fibrosis: A genomic and functional investigation'. Journal of the American Society of Nephrology, 13 (NA):120-120. [Details] | |||||||||
| Campbell, E; McMorrow, T; Watson, AJ; Ryan, MP; ; (2002) 'Differential gene expression in a renal model of TGF-beta mediated epithelial-mesenchymal transformation: Implications for tubular interstitial fibrosis'. Journal of the American Society of Nephrology, 13 (NA):544-544. [Details] | |||||||||
| Lynch, J., McMorrow, T., Ryan, M.P. ; (2004) 'Mechanisms of Immune Mediated Epithelial - Mesenchymal Transition (EMT) in Human Renal Proximal Tubular Cells: A Role for HMGB-1'. Journal of the American Society of Nephrology, 15 . [Details] | |||||||||
| Nee, L; McMorrow, T; Ryan, MP; ; (2001) 'Signalling pathways involved in the regulation of MMP-9 (gelatinase B) and TIMP-1 by renal proximal tubular cells in response to TNF alpha and IL-1 beta'. British Journal of Pharmacology, 134 (NA). [Details] | |||||||||
| Nathwani, SM; McMorrow, T; Tuite, N; Dempsey, M; Ryan, MP; ; (2001) 'Pathways involved in cisplatin-induced apoptosis in renal tubular epithelial LLC-PK1 cells'. British Journal of Pharmacology, 134 (NA). [Details] | |||||||||
| J. Flint, C. Tufarelli, J. Peden, K. Clark, R.J. Daniels, R. Hardison, W. Miller, S. Philipsen, K.C. Tan-Un, T. McMorrow, J. Frampton, B.P. Alter, A.M. Frischauf, D.R. Higgs.; (2001) 'Comparative genome analysis delimits a chromosomal domain and identifies key regulatory elements in the alpha globin cluster'. Human Molecular Genetics, 10 (4):371-382. [Details] | |||||||||
| T. McMorrow, A. van den Wijngaard, T. Trimborn, , P. Fraser, M. van Lohuizen, T. Jenuwein, M. Djabali, S. Philipsen, F. Grosveld and E. Milot.; (2000) 'Transcriptional activation of the b-globin locus by transcription factors and chromatin modifiers'. Embo Journal, 19 :4986-4996. [Details] | |||||||||
| R. Calzolari, T. McMorrow, N. Yannoutsos, A. Langeveld and F. Grosveld.; (1999) 'Deletion of a region that is a candidate for the difference between the deletion forms of hereditary persistence of fetal hemoglobin and db-thalassemia affects g- but not b-globin gene expression'. Embo Journal, 18 :949-958. [Details] | |||||||||
| F. Grosveld, E. De Boer, N. Dillon, J. Gribnau, T. McMorrow, E. Milot, T. Trimborn, M. Wijgerde and P. Fraser; (1998) 'The dynamics of globin gene expression and position effects'. Novartis Foundation Symposium, 214 :67-86. [Details] | |||||||||
| T. McMorrow, A. Wagner, T. Harte and F. Gannon; (1997) 'Isolation and developmental expression of the non-Bohr beta-globin cDNA from Atlantic Salmon'. Gene, 189 :183-188. [Details] | |||||||||
| T. McMorrow, A. Wagner, F. Deryckere and F. Gannon.; (1996) 'Structural Organization and Sequence Analysis of the Globin Locus in Atlantic Salmon'. Dna and Cell Biology, 15 :407-414. [Details] | |||||||||
| F. Deryckere, L. Byrnes, A. Wagner, T. McMorrow and F. Gannon.; (1995) 'Salmon HNF1: cDNA Sequence, Evolution, Tissue Specificity and Binding to the Salmon Serum Albumin Promoter'. Journal of Molecular Biology, 247 :1-10. [Details] | |||||||||
| A. Wagner, F. Deryckere, T. McMorrow and F. Gannon.; (1994) 'Tail-to-Tail Organization of the Atlantic Salmon Alpha- and Beta- globin genes'. Journal of Molecular Evolution, 38 :28-35. [Details] | |||||||||
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Conference Publications
| H Cassidy, J Slyne, O Johnston , L Brennan , A O¿Riordan, P Conlon, MP Ryan, T McMorrow ; (2011) Metabolomic Profiling Of Chronic Allograft Nephropathy (CAN) Resulting From Immunosuppressant Therapies In Post Renal Transplantation Patients HUPO 10th World Congress Geneva, Switzerland, , 03-SEP-11 - 07-SEP-11 [Details] |
| Robert Radford, Craig Slattery, Michael Ryan, Tara McMorrow; (2010) Deciliation of Kidney Epithelial Cells Is an Early marker of Carcinogenic Effects American Society of Cell Biology [Details] |
| H. Cassidy, O. Johnston, L. Brennan, A. O'Riordan, P. Conlon, M.P. Ryan and T. McMorrow ; (2010) Metabolomic Analysis in Immunosuppressant Nephropathy Irish Nephrological Society Conference, Dublin, Ireland [Details] |
| H. Cassidy, O. Johnston, L. Brennan, A. O'Riordan, P. Conlon, M.P. Ryan and T. McMorrow ; (2010) Metabolomic Analysis of Human Immunosuppressant Nephropathy Post Renal Transplantation . In: Irish Journal of Medical Science eds. Proceedings of the Royal Academy of Medicine in Ireland Dublin, Ireland, [Details] |
| Bloch K., Lock E.A., Jennings P., Limonciel A., Aschauer L., Boei J., Radford R., McMorrow T., Slattery C., Ryan M.P.; (2009) Cytotoxicity Studies With Two Renal Carcinogens In Human And Rat Renal Tubule Epithelial Cells In Vitro Toxicology Society Meeting, Liverpool, United Kingdom Liverpool, United Kingdom, [Details] |
| Radford R., Ryan M.P., McMorrow T.; (2008) Development of Renal Cell Culture Models of Carcinogenesis within the E.U. CarcinoGENOMICS Project: Analysis of Epithelial Mesenchymal Transition (EMT) Induction American Society of Nephrology [Details] | |||||||||
| Martin N., Ryan G.E., McMorrow T., Ryan M.P.; (2008) Molecular Mechanisms of Immunosuppressant-Induced Alteration of Barrier Function in Renal Proximal Tubular Cells American Society of Nephrology [Details] | |||||||||
| Bennett J., Ryan M.P., McMorrow T.; (2008) Molecular Mechanisms of Immunosuppressive Agents in Human Renal Proximal Tubular Cells American Society of Nephrology [Details] | |||||||||
| Bennett, J., Ryan, M.P. and McMorrow, T.; (2007) Diiferential effects of Immunosuppressive agents in human renal proximal tubular cells . In: J.Am. Soc. Nephrol eds. American Society of Nephrology [Details] | |||||||||
| Feighery, R., Ryan, M.P. and McMorrow, T.; (2007) Proteomic Approaches to Immune-Mediated Epithelial Mesenchymal Transition (EMT) in Renal Disease . In: J. Am. Soc. Nephrol eds. American Society of Nephrology [Details] | |||||||||
| Nolan S, Ryan MP, McMorrow T.; (2006) Implications of increased expression of tissue transglutaminase in immune-mediated renal EMT American Society of Nephrology [Details] | |||||||||
| Johnston O, Conlon PJ, McMorrow T, O'Riordan A, Gallagher W, Maguire P, Wynne K, Cagney G, and Ryan MP.; (2006) Urinary B2-microglobulin as a novel potential biomarker for chronic allograft nephropathy American Society of Nephrology [Details] | |||||||||
| O' Riordan A, McMorrow T, Johnston O, Gallagher W, Maguire P, Cagney G, Hegarty J, McCormick A, Watson AJ and Ryan MP.; (2006) Using SELDI-TOF-MS Apo A1 is a serum biomarker of chronic kidney disease, post orthotopic liver transplantation American Society of Nephrology [Details] | |||||||||
| O'Connell S, McMorrow T, Ryan MP; (2006) Evidence for EMT in a CsA induced model of renal fibrosis American Society of Nephrology [Details] | |||||||||
| Slattery, C., McMorrow, T. and Ryan, M.P.; (2005) The role of PKC-beta in cyclosporine A-induced tubulointerstitial fibrosis American Society of Nephrology Philadelphia, USA, , 09-NOV-05 - 13-NOV-05 [Details] | |||||||||
| Johnston, O., O'Riordan, A., McMorrow, T., Gallagher, W., Walshe, J.J., Conlon, P.J. and Ryan, M.P.; (2005) Optimizing proteomic profile analysis in chronic renal transplant recipients American Society of Nephrology Philadelphia, USA, , 09-NOV-05 - 13-NOV-05 [Details] | |||||||||
| O' Riordan, A., McMorrow, T., Johnston, O., Gallagher, W., Watson, A.J. and Ryan, M.P.; (2005) Proteome analysis and biomarker discovery in calcineurin inhibitor nephrotoxicity post liver transplantation American Society of Nephrology Philadelphia, USA, , 09-NOV-05 - 13-NOV-05 [Details] | |||||||||
| McMorrow, T., Campbell, E., Slattery, C., Tuite, N. and Ryan, M.P.; (2005) RNA interference: A novel alternative approach in nephrotoxicity studies 5th World Congress of Alternatives to Animal experimentation Berlin, Germany, , 21-AUG-05 - 25-AUG-05 [Details] | |||||||||
| Davey, L., McMorrow, T. and Ryan, M.P.; (2005) Differential effects of immunosuppressive agents in human renal proximal tubular cells American Society of Nephrology Philadelphia, USA, , 09-NOV-05 - 13-NOV-05 [Details] | |||||||||
| Johnston, O., O'Riordan, A., McMorrow, T., Gallagher, W., Walshe, J.J., Conlon, P.J. and Ryan, M.P.; (2005) Optimizing proteomic profile analysis in chronic renal transplant recipients American Society of Nephrology Philadelphia, USA, , 09-NOV-05 - 13-NOV-05 [Details] | |||||||||
| Tuite, N.M., McMorrow, T. and Ryan, M.P.; (2005) Gene expression patterns in human mesangial cells in response to cyclosporine A American Society of Nephrology Dublin, Ireland, , 09-NOV-05 - 13-NOV-05 [Details] | |||||||||
| Slattery, C., McMorrow, T. and Ryan, M.P.; (2005) The role of PKC-beta in cyclosporine A-induced tubulointerstitial fibrosis American Society of Nephrology Philadelphia, USA, , 09-NOV-05 - 13-NOV-05 [Details] | |||||||||
| Davey, L., McMorrow, T. and Ryan, M.P.; (2005) Differential effects of immunosuppressive agents in human renal proximal tubular cells American Society of Nephrology Philadelphia, USA, , 09-NOV-05 - 13-NOV-05 [Details] | |||||||||
| McMorrow, T., Campbell, E., Slattery, C., Tuite, N. and Ryan, M.P.; (2005) RNA interference: A novel alternative approach in nephrotoxicity studies 5th World Congress of Alternatives to Animal experimentation Berlin, Germany, , 21-AUG-05 - 25-AUG-05 [Details] | |||||||||
| O' Riordan, A., McMorrow, T., Johnston, O., Gallagher, W., Watson, A.J. and Ryan, M.P.; (2005) Proteome analysis and biomarker discovery in calcineurin inhibitor nephrotoxicity post liver transplantation American Society of Nephrology Philadelphia, USA, , 09-NOV-05 - 13-NOV-05 [Details] | |||||||||
| McMorrow T, Campbell E, Slattery C, Tuite N and Ryan MP.; (2005) RNA interference: A novel alternative approach in nephrotoxicity studies World Congress on Alternatives to Animals [Details] | |||||||||
| Tuite NM, McMorrow T and Ryan MP.; (2005) Gene expression patterns in human mesangial cells in response to cyclosporine A American Society of Nephrology Las Vegas, Nevada, USA, , 26-JUN-06 - 29-JUN-06 [Details] | |||||||||
| Campbell, E., McMorrow, T. and Ryan, M.P.; (2004) Role of Rap GTPases in TGF-beta mediated epithelial mesenchymal transition American Society of Nephrology [Details] | |||||||||
| Slattery, C., McMorrow, T. and Ryan, M.P.; (2004) Cyclosporine A-induced epithelial mesenchymal transition: a role for PKC-beta American Society of Nephrology [Details] | |||||||||
| Lynch,J., McMorrow, T. and Ryan, M.P.; (2004) Mechanisms of immune mediated epithelial mesenchymal transition in human renal proximal tubular cells American Society of Nephrology [Details] | |||||||||
| Campbell, E; McMorrow, T; Watson, AJ; Ryan, MP; ; (2002) Differential gene expression in a renal model of TGF-beta mediated epithelial-mesenchymal transformation: Implications for tubular interstitial fibrosis American Society of Nephrology [Details] | |||||||||
| Gaffney, M; McMorrow, T; Slattery, C; Watson, A; Brady, H; Ryan, MP; ; (2002) Cyclosporine A-induced transdifferentiation in renal tubular epithelial cells: Implications for renal fibrosis American Society of Nephrology [Details] | |||||||||
| Slattery, C; McMorrow, T; Watson, A; Ryan, MP; ; (2002) Cyclosporin A-induced renal fibrosis: A genomic and functional investigation American Society of Nephrology , pp.120-120 [Details] | |||||||||
| Nathwani, SM; McMorrow, T; Tuite, N; Dempsey, M; Ryan, MP; ; (2001) Pathways involved in cisplatin-induced apoptosis in renal tubular epithelial LLC-PK1 cells British Pharmacological Society [Details] | |||||||||
| Nee, L; McMorrow, T; Ryan, MP; ; (2001) Signalling pathways involved in the regulation of MMP-9 (gelatinase B) and TIMP-1 by renal proximal tubular cells in response to TNF alpha and IL-1 beta British Pharmacological Society [Details] | |||||||||
| Nee, L; McMorrow, T; Ryan, MP; ; (2001) Cytokine receptors and signalling pathways in TNF-alpha American Society of Nephrology [Details] | |||||||||
| Nathwani, SM; McMorrow, T; Tuite, N; Dempsey, M; Ryan, MP; ; (2001) Possible role of p53 in cisplatin-induced apoptosis in renal tubular epithelial LLC-PK1 cells American Society of Nephrology [Details] | |||||||||
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Honours and Awards
| Year: 2008. Title: UCD Seed Funding Award |
| Year: 2003. Title: Irish Nephrological Society/ Amgen Research Award |
Associations
| Association: Irish Society of Toxicology, Function/Role: Committee Member |
| Association: American Society of Nephrology, Function/Role: Member |
| Association: Irish Nephrological Society, Function/Role: Member |
Conference Contributions
| T. McMorrow (2011) Identification of Biomarkers of CsA Nephrotoxicity in an animal model. [Invited Lecture], Singapore Laboratory Animal Research Conference, Singapore , 12-DEC-11 - 15-DEC-11. |
| Tara McMorrow; (2011) Candidate Biomarkers from in vitro models. [Invited Lecture], SysKid Annual Meeting, Innsbruck, Austria , 26-JAN-11 - 28-JAN-11. |
| McMorrow, T.; (2005) RNA interference: a novel alternative approach in nephrotoxicity studies. [Invited Oral Presentation], 5th World Congress on Alternatives and Animal use in the Life Sciences, Berlin, Germany , 01-AUG-05. |
| McMorrow, T.; (2004) Use of RNAi to elucidate the role of gene expression in in vitro nephrotoxicity. [Invited Oral Presentation], Ecopa Science Initiative, Alicante, Spain , 01-OCT-04. |
| McMorrow, T.; (2002) Mechanisms of Immune-mediated Renal Epithelial-Mesenchymal Transdifferentiation. [Invited Oral Presentation], Irish Nephrological Society and the UK Nephrogenesis Group, Dublin, Ireland , 01-MAY-02. |
Employment
| Employer: Erasmus University, Rotterdam Position: EU Postdoctoral Research Fellow |
| Employer: UCD Position: Enterprise Ireland Postdoctoral Research Fellow |
| Employer: Conway Institute, UCD Position: Conway Postdoctoral Research Fellow |
| Employer: Conway Institute, UCD Position: DMMC Senior Research Fellow |
| Employer: UCD Position: Lecturer |
Education
| Year 1991 Institution: NUI Galway Qualification: BSc Subject: Microbiology and Genetics |
| Year 1995 Institution: NUI Galway Qualification: PhD Subject: Molecular Biology |
Internal Collaborators
| Prof. Michael Ryan Conway Investigator, School of Biomolecular and Biomedical Science, Conway Institute Dr. Lorraine Brennan, Conway Investigator and Lecturer in Nutritional Biochemistry School of Agriculture & Food Science Conway Institute Belfield Dublin 4 |
External Collaborators
| Dr. Roel Goldschmeding Dr Paul Jennings |
Modules Coordinated
| 201200 BMOL40110 Biomolecular & Biomed Science: Pre-masters Project |
| 201200 BIOC40190 Biochemistry: Business Plan Development |
| 201200 MICR40120 Microbiology: Facility Design |
| 201200 PHAR40060 Pharmacology: Advanced Renal Pharmacology |
| 201200 PHAR30010 Pharmacology: Chemotherapeutic agents |