Dr. Tara McMorrow | UCD Conway

Research

Dr Tara McMorrow BSc PhD

Book Chapters:

McMorrow T., Campbell E., Slattery C., Ryan M.P. (2008) 'Altered gene expression and molecular Mechanisms modulating epithelial-mesenchymal transition in human renal epithelial cells' In: Paul J Higgins (eds). Human Epithelial Tumor Cell Plasticity: Implications for Cancer Progression and Metastasis. India: Research Signpost. [Details]

Peer Reviewed Journals:

O'Connell S, Slattery C, Ryan MP, McMorrow T. (2011) 'Identification of novel indicators of cyclosporine A nephrotoxicity in a CD-1 mouse model'. Toxicology & Applied Pharmacology, 252 (2):201-210. [Details]

Johnston O, Cassidy H, O'Connell S, O'Riordan A, Gallagher W, Maguire PB, Wynne K, Cagney G, Ryan MP, Conlon PJ, McMorrow T. (2011) 'Identification of β2-microglobulin as a urinary biomarker for chronic allograft nephropathy using proteomic methods'. Proteomics Clinical Applications, 5 (7-8):422-431. [Details]

J. K. Ellis, T. J. Athersuch, R. Cavill, R. Radford, C. Slattery, T. McMorrow, M. P. Ryan, T. M.D. Ebbels, H. Keun (2011) 'Metabolic Response to Low Level Toxicant Exposure in a Novel Renal Tubule'. Molecular BioSystems, 7 (1):247-257. [Details]

J. Lynch, S. Nolan, C. Slattery, R. Feighery, M.P. Ryan, T. McMorrow (2010) 'High-Mobility Group Box Protein 1: A Novel Mediator of Inflammatory-Induced Renal Epithelial-Mesenchymal Transition'. American Journal of Nephrology, 32 (6):590-602. [Details]

Martin-Martin N, Ryan G, McMorrow T, Ryan MP (2010) ''Sirolimus and cyclosporine A alter barrier function in renal proximal tubular cells through stimulation of ERK1/2 signaling and claudin-1 expression'. American Journal of Physiology-Renal Physiology, 293 (3):672-682. [Details]

H Cassidy, O Johnston, L Brennan, A O Riordan, P Conlon, MP Ryan, T Mc Morrow (2010) 'Metabolomic Analysis of Human(HOMO SAPIENS) Immunosuppressant Nephropathy Post Renal Transplantation'. IRISH J MED SCI, 7 . [Details]

Jennings P, Aydin S, Bennett J, McBride R, Weiland C, Tuite N, Gruber LN, Perco P, Gaora PO, Ellinger-Ziegelbauer H, Ahr HJ, Kooten CV, Daha MR, Prieto P, Ryan MP, Pfaller W, McMorrow T (2009) 'Inter-laboratory comparison of human renal proximal tubule (HK-2) transcriptome alterations due to Cyclosporine A exposure and medium exhaustion'. Toxicology in Vitro, 23 (3):486-499. [Details]
Feighery, R., Maguire, P., Ryan, M. R., McMorrow, T., (2008) 'A proteomic approach to immune-mediated epithelial-mesenchymal transition'. Proteomics Clinical Applications, 2 (7-8):1110-1117. [Details]
Nee, L,O'Connell, S,Nolan, S,Ryan, MP,McMorrow, T (2008) 'Nitric Oxide Involvement in TNF-alpha and IL-1 beta-Mediated Changes in Human Mesangial Cell MMP-9 and TIMP-1'. Nephron. Experimental nephrology, 110 (NA):59-66. [DOI] [Details]
Slattery, C., Ryan, M. P., McMorrow, T., (2008) 'Protein kinase C beta overexpression induces fibrotic effects in human proximal tubular epithelial cells'. International Journal of Biochemistry & Cell Biology, 40 (10):2218-2229. [Details]
O'Riordan A, Johnston O, McMorrow T, Wynne K, Maguire P, Hegarty JE, McCormick A, Watson AJ, Cagney G, Gallagher WM, Ryan MR (2008) 'Identification of Apolipoprotein AI as a serum biomarker of chronic kidney disease in liver transplant recipients, using proteomic techniques'. Proteomics Clinical Applications, 2 (9):1338-1348. [Details]
Nee, L,Tuite, N,Ryan, MP,McMorrow, T (2007) 'TNF-alpha and IL-1beta-mediated regulation of MMP-9 and TIMP-1 in human glomerular mesangial cells'. Nephron. Experimental nephrology, 107 :73-86. [DOI] [Details]
Slattery, C; McMorrow, T; Ryan, MP; (2006) 'Overexpression of E2A proteins induces epithelial-mesenchymal transition in human renal proximal tubular epithelial cells suggesting a potential role in renal fibrosis'. FEBS Letters, 580 (17):4021-4030. [Details]
Slattery, C., Campbell, E., McMorrow, T., Ryan, M.P. (2005) 'Cyclosporine A-induced renal fibrosis: a role for epithelial-mesenchymal transition'. AMERICAN JOURNAL OF PATHOLOGY, 167 (2):395-407. [Details]
Nee, LE,McMorrow, T,Campbell, E,Slattery, C,Ryan, MP (2004) 'TNF-alpha and IL-1 beta-mediated regulation of MMP-9 and TIMP-1 in renal proximal tubular cells'. Kidney International, 66 :1376-1386. [Details]
Nee, LE; McMorrow, T; Campbell, E; Slattery, C; Ryan, MP; (2004) 'TNF-alpha and IL-1 beta-mediated regulation of MMP-9 and TIMP-1 in renal proximal tubular cells'. Kidney International, 66 (4):1376-1386. [Details]
Gillemans, N,McMorrow, T,Tewari, R,Wai, AWK,Burgtorf, C,Drabek, D,Ventress, N,Langeveld, A,Higgs, D,Tan-Un, K,Grosveld, F,Philipsen, S (2003) 'Functional and comparative analysis of globin loci in pufferfish and humans'. Blood, 101 :2842-2849. [DOI] [Details]
Feldman, G., Kiely, B., Martin, N., Ryan, G., McMorrow, T., Ryan, M.P. (2007) 'Role for TGF-Beta in cyclosporine-induced modulation of renal epithelial barrier function'. Journal of the American Society of Nephrology, 18 (6):1662-1671. [Details]
Slattery C, Ryan MP, McMorrow T. (2007) 'E2A proteins: Regulators of cell phenotype in normal physiology and disease'. International Journal of Biochemistry & Cell Biology, doi:10.1016/j.biocel.2007.05.014 . [Details]
Campbell, E., Slattery, C., Tuite, N., Nolan, S., Leonard, M., Ryan, M.P. and McMorrow, T. (2006) 'RNA Interference: a novel alternative approach in nephrotoxicity studies'. ALTEX, 23 :406-409. [Details]
Nee, LE; McMorrow, T; Campbell, E; Slattery, C; Ryan, MP; (2004) 'TNF-alpha and IL-1 beta-mediated regulation of MMP-9 and TIMP-1 in renal proximal tubular cells'. Kidney International, 66 (4):1376-1386. [Details]
Campbell, E., Slattery, C., McMorrow, T., Ryan, M.P. (2004) 'Role of RAP GTPases in TGF-B Mediated Epithelial-Mesenchymal Transition'. Journal of the American Society of Nephrology, 15 . [Details]
Gillemans, N; McMorrow, T; Tewari, R; Wai, A; Burgtorf, C; Drabek, D; Ventress, N; Langeveld, A; Higgs, D; Tan-Un, K; Grosveld, F; Philipsen, S; (2003) 'Comparative analysis of globin loci in pufferfish and man suggests a common origin of vertebrate globin loci and reveals a novel mammalian globin locus'. Blood Cells Molecules and Diseases, 31 (1):161-161. [Details]
Slattery, C; McMorrow, T; Watson, A; Ryan, MP; (2002) 'Cyclosporin A-induced renal fibrosis: A genomic and functional investigation'. Journal of the American Society of Nephrology, 13 (NA):120-120. [Details]
Campbell, E; McMorrow, T; Watson, AJ; Ryan, MP; (2002) 'Differential gene expression in a renal model of TGF-beta mediated epithelial-mesenchymal transformation: Implications for tubular interstitial fibrosis'. Journal of the American Society of Nephrology, 13 (NA):544-544. [Details]
Lynch, J., McMorrow, T., Ryan, M.P. (2004) 'Mechanisms of Immune Mediated Epithelial - Mesenchymal Transition (EMT) in Human Renal Proximal Tubular Cells: A Role for HMGB-1'. Journal of the American Society of Nephrology, 15 . [Details]
Nee, L; McMorrow, T; Ryan, MP; (2001) 'Signalling pathways involved in the regulation of MMP-9 (gelatinase B) and TIMP-1 by renal proximal tubular cells in response to TNF alpha and IL-1 beta'. British Journal of Pharmacology, 134 (NA). [Details]
Nathwani, SM; McMorrow, T; Tuite, N; Dempsey, M; Ryan, MP; (2001) 'Pathways involved in cisplatin-induced apoptosis in renal tubular epithelial LLC-PK1 cells'. British Journal of Pharmacology, 134 (NA). [Details]
J. Flint, C. Tufarelli, J. Peden, K. Clark, R.J. Daniels, R. Hardison, W. Miller, S. Philipsen, K.C. Tan-Un, T. McMorrow, J. Frampton, B.P. Alter, A.M. Frischauf, D.R. Higgs. (2001) 'Comparative genome analysis delimits a chromosomal domain and identifies key regulatory elements in the alpha globin cluster'. Human Molecular Genetics, 10 (4):371-382. [Details]
T. McMorrow, A. van den Wijngaard, T. Trimborn, , P. Fraser, M. van Lohuizen, T. Jenuwein, M. Djabali, S. Philipsen, F. Grosveld and E. Milot. (2000) 'Transcriptional activation of the b-globin locus by transcription factors and chromatin modifiers'. Embo Journal, 19 :4986-4996. [Details]
R. Calzolari, T. McMorrow, N. Yannoutsos, A. Langeveld and F. Grosveld. (1999) 'Deletion of a region that is a candidate for the difference between the deletion forms of hereditary persistence of fetal hemoglobin and db-thalassemia affects g- but not b-globin gene expression'. Embo Journal, 18 :949-958. [Details]
F. Grosveld, E. De Boer, N. Dillon, J. Gribnau, T. McMorrow, E. Milot, T. Trimborn, M. Wijgerde and P. Fraser (1998) 'The dynamics of globin gene expression and position effects'. 214 :67-86. [Details]
T. McMorrow, A. Wagner, T. Harte and F. Gannon (1997) 'Isolation and developmental expression of the non-Bohr beta-globin cDNA from Atlantic Salmon'. Gene, 189 :183-188. [Details]
T. McMorrow, A. Wagner, F. Deryckere and F. Gannon. (1996) 'Structural Organization and Sequence Analysis of the Globin Locus in Atlantic Salmon'. Dna and Cell Biology, 15 :407-414. [Details]
F. Deryckere, L. Byrnes, A. Wagner, T. McMorrow and F. Gannon. (1995) 'Salmon HNF1: cDNA Sequence, Evolution, Tissue Specificity and Binding to the Salmon Serum Albumin Promoter'. Journal of Molecular Biology, 247 :1-10. [Details]
A. Wagner, F. Deryckere, T. McMorrow and F. Gannon. (1994) 'Tail-to-Tail Organization of the Atlantic Salmon Alpha- and Beta- globin genes'. Journal of Molecular Evolution, 38 :28-35. [Details]
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Conference Publications:

H Cassidy, J Slyne, O Johnston , L Brennan , A O¿Riordan, P Conlon, MP Ryan, T McMorrow (2011) Metabolomic Profiling Of Chronic Allograft Nephropathy (CAN) Resulting From Immunosuppressant Therapies In Post Renal Transplantation Patients HUPO 10th World Congress Geneva, Switzerland, , 03-SEP-11 - 07-SEP-11 [Details]

Robert Radford, Craig Slattery, Michael Ryan, Tara McMorrow (2010) Deciliation of Kidney Epithelial Cells Is an Early marker of Carcinogenic Effects American Society of Cell Biology [Details]

H. Cassidy, O. Johnston, L. Brennan, A. O'Riordan, P. Conlon, M.P. Ryan and T. McMorrow (2010) Metabolomic Analysis in Immunosuppressant Nephropathy Irish Nephrological Society Conference, Dublin, Ireland [Details]

H. Cassidy, O. Johnston, L. Brennan, A. O'Riordan, P. Conlon, M.P. Ryan and T. McMorrow (2010) Metabolomic Analysis of Human Immunosuppressant Nephropathy Post Renal Transplantation . In: Irish Journal of Medical Science eds. Proceedings of the Royal Academy of Medicine in Ireland Dublin, Ireland, [Details]

Bloch K., Lock E.A., Jennings P., Limonciel A., Aschauer L., Boei J., Radford R., McMorrow T., Slattery C., Ryan M.P. (2009) Cytotoxicity Studies With Two Renal Carcinogens In Human And Rat Renal Tubule Epithelial Cells In Vitro Toxicology Society Meeting, Liverpool, United Kingdom Liverpool, United Kingdom, [Details]

Radford R., Ryan M.P., McMorrow T. (2008) Development of Renal Cell Culture Models of Carcinogenesis within the E.U. CarcinoGENOMICS Project: Analysis of Epithelial Mesenchymal Transition (EMT) Induction American Society of Nephrology [Details]

Martin N., Ryan G.E., McMorrow T., Ryan M.P. (2008) Molecular Mechanisms of Immunosuppressant-Induced Alteration of Barrier Function in Renal Proximal Tubular Cells American Society of Nephrology [Details]
Bennett J., Ryan M.P., McMorrow T. (2008) Molecular Mechanisms of Immunosuppressive Agents in Human Renal Proximal Tubular Cells American Society of Nephrology [Details]
Bennett, J., Ryan, M.P. and McMorrow, T. (2007) Diiferential effects of Immunosuppressive agents in human renal proximal tubular cells . In: J.Am. Soc. Nephrol eds. American Society of Nephrology [Details]
Feighery, R., Ryan, M.P. and McMorrow, T. (2007) Proteomic Approaches to Immune-Mediated Epithelial Mesenchymal Transition (EMT) in Renal Disease . In: J. Am. Soc. Nephrol eds. American Society of Nephrology [Details]
Nolan S, Ryan MP, McMorrow T. (2006) Implications of increased expression of tissue transglutaminase in immune-mediated renal EMT American Society of Nephrology [Details]
Johnston O, Conlon PJ, McMorrow T, O'Riordan A, Gallagher W, Maguire P, Wynne K, Cagney G, and Ryan MP. (2006) Urinary B2-microglobulin as a novel potential biomarker for chronic allograft nephropathy American Society of Nephrology [Details]
O' Riordan A, McMorrow T, Johnston O, Gallagher W, Maguire P, Cagney G, Hegarty J, McCormick A, Watson AJ and Ryan MP. (2006) Using SELDI-TOF-MS Apo A1 is a serum biomarker of chronic kidney disease, post orthotopic liver transplantation American Society of Nephrology [Details]
O'Connell S, McMorrow T, Ryan MP (2006) Evidence for EMT in a CsA induced model of renal fibrosis American Society of Nephrology [Details]
Slattery, C., McMorrow, T. and Ryan, M.P. (2005) The role of PKC-beta in cyclosporine A-induced tubulointerstitial fibrosis American Society of Nephrology Philadelphia, USA, , 09-NOV-05 - 13-NOV-05 [Details]
Johnston, O., O'Riordan, A., McMorrow, T., Gallagher, W., Walshe, J.J., Conlon, P.J. and Ryan, M.P. (2005) Optimizing proteomic profile analysis in chronic renal transplant recipients American Society of Nephrology Philadelphia, USA, , 09-NOV-05 - 13-NOV-05 [Details]
O' Riordan, A., McMorrow, T., Johnston, O., Gallagher, W., Watson, A.J. and Ryan, M.P. (2005) Proteome analysis and biomarker discovery in calcineurin inhibitor nephrotoxicity post liver transplantation American Society of Nephrology Philadelphia, USA, , 09-NOV-05 - 13-NOV-05 [Details]
McMorrow, T., Campbell, E., Slattery, C., Tuite, N. and Ryan, M.P. (2005) RNA interference: A novel alternative approach in nephrotoxicity studies 5th World Congress of Alternatives to Animal experimentation Berlin, Germany, , 21-AUG-05 - 25-AUG-05 [Details]
Davey, L., McMorrow, T. and Ryan, M.P. (2005) Differential effects of immunosuppressive agents in human renal proximal tubular cells American Society of Nephrology Philadelphia, USA, , 09-NOV-05 - 13-NOV-05 [Details]
Johnston, O., O'Riordan, A., McMorrow, T., Gallagher, W., Walshe, J.J., Conlon, P.J. and Ryan, M.P. (2005) Optimizing proteomic profile analysis in chronic renal transplant recipients American Society of Nephrology Philadelphia, USA, , 09-NOV-05 - 13-NOV-05 [Details]
Tuite, N.M., McMorrow, T. and Ryan, M.P. (2005) Gene expression patterns in human mesangial cells in response to cyclosporine A American Society of Nephrology Dublin, Ireland, , 09-NOV-05 - 13-NOV-05 [Details]
Slattery, C., McMorrow, T. and Ryan, M.P. (2005) The role of PKC-beta in cyclosporine A-induced tubulointerstitial fibrosis American Society of Nephrology Philadelphia, USA, , 09-NOV-05 - 13-NOV-05 [Details]
Davey, L., McMorrow, T. and Ryan, M.P. (2005) Differential effects of immunosuppressive agents in human renal proximal tubular cells American Society of Nephrology Philadelphia, USA, , 09-NOV-05 - 13-NOV-05 [Details]
McMorrow, T., Campbell, E., Slattery, C., Tuite, N. and Ryan, M.P. (2005) RNA interference: A novel alternative approach in nephrotoxicity studies 5th World Congress of Alternatives to Animal experimentation Berlin, Germany, , 21-AUG-05 - 25-AUG-05 [Details]
O' Riordan, A., McMorrow, T., Johnston, O., Gallagher, W., Watson, A.J. and Ryan, M.P. (2005) Proteome analysis and biomarker discovery in calcineurin inhibitor nephrotoxicity post liver transplantation American Society of Nephrology Philadelphia, USA, , 09-NOV-05 - 13-NOV-05 [Details]
McMorrow T, Campbell E, Slattery C, Tuite N and Ryan MP. (2005) RNA interference: A novel alternative approach in nephrotoxicity studies World Congress on Alternatives to Animals [Details]
Tuite NM, McMorrow T and Ryan MP. (2005) Gene expression patterns in human mesangial cells in response to cyclosporine A American Society of Nephrology Las Vegas, Nevada, USA, , 26-JUN-06 - 29-JUN-06 [Details]
Campbell, E., McMorrow, T. and Ryan, M.P. (2004) Role of Rap GTPases in TGF-beta mediated epithelial mesenchymal transition American Society of Nephrology [Details]
Slattery, C., McMorrow, T. and Ryan, M.P. (2004) Cyclosporine A-induced epithelial mesenchymal transition: a role for PKC-beta American Society of Nephrology [Details]
Lynch,J., McMorrow, T. and Ryan, M.P. (2004) Mechanisms of immune mediated epithelial mesenchymal transition in human renal proximal tubular cells American Society of Nephrology [Details]
Campbell, E; McMorrow, T; Watson, AJ; Ryan, MP; (2002) Differential gene expression in a renal model of TGF-beta mediated epithelial-mesenchymal transformation: Implications for tubular interstitial fibrosis American Society of Nephrology [Details]
Gaffney, M; McMorrow, T; Slattery, C; Watson, A; Brady, H; Ryan, MP; (2002) Cyclosporine A-induced transdifferentiation in renal tubular epithelial cells: Implications for renal fibrosis American Society of Nephrology [Details]
Slattery, C; McMorrow, T; Watson, A; Ryan, MP; (2002) Cyclosporin A-induced renal fibrosis: A genomic and functional investigation American Society of Nephrology , pp.120-120 [Details]
Nathwani, SM; McMorrow, T; Tuite, N; Dempsey, M; Ryan, MP; (2001) Pathways involved in cisplatin-induced apoptosis in renal tubular epithelial LLC-PK1 cells British Pharmacological Society [Details]
Nee, L; McMorrow, T; Ryan, MP; (2001) Signalling pathways involved in the regulation of MMP-9 (gelatinase B) and TIMP-1 by renal proximal tubular cells in response to TNF alpha and IL-1 beta British Pharmacological Society [Details]
Nee, L; McMorrow, T; Ryan, MP; (2001) Cytokine receptors and signalling pathways in TNF-alpha American Society of Nephrology [Details]
Nathwani, SM; McMorrow, T; Tuite, N; Dempsey, M; Ryan, MP; (2001) Possible role of p53 in cisplatin-induced apoptosis in renal tubular epithelial LLC-PK1 cells American Society of Nephrology [Details]
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