Professor Boris Kholodenko is widely recognised and respected as an academic leader in the field of systems biology and predictive models of cellular functions (www.cellnetworks.org/).

Boris Kholodenko has brought a wealth of expertise in the modelling biological systems and a unique understanding of design of experimental biological measurements informed by mathematical models. His appointment to SBI will bring together the cell and molecular biology strengths based at UCD Conway Institute and Remedi, NUIG with the applied mathematics and modelling strengths based at UCD CASL. Boris Kholodenko has a wide network of international collaborators, which will also enhance the strategic drive for the development of SBI.

Boris Kholodenko graduated (with the distinction of summa cum laude) and received a Ph.D. in Biophysics from the Moscow Institute of Physics and Technology, Russia. Most recently Dr. Kholodenko was employed at the faculty of Thomas Jefferson University in Philadelphia, Pennsylvania, USA, where he was a Professor and Director of Computational Cell Biology. He developed the first systems biology model of the epidermal-growth-factor receptor signalling pathway, a novel principle for mechanistic modeling, referred to as a domain-oriented framework, discovered a novel systematic approach to unravel interaction 'maps' in signaling and gene networks from experimental data on steady-state and temporal responses to perturbations, predicted the existence of intracellular gradients of signaling activities that control both the living circuitry and cell communication and showed intricate dynamic behaviours of signalling systems in space and time including oscillations, bistability and travelling waves of phosphorylation signals.