Professor Brendan Loftus

Research

Professor Brendan Loftus BSc PhD

Peer Reviewed Journals:

Weissenmayer BA, Prendergast JG, Lohan AJ, Loftus BJ (2011) 'Sequencing Illustrates the Transcriptional Response of Legionella pneumophila during Infection and Identifies Seventy Novel Small Non-Coding RNAs'. PLoS ONE, .

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Tong P, Prendergast JG, Lohan AJ, Farrington SM, Cronin S, Friel N, Bradley DG, Hardiman O, Evans A, Wilson JF, Loftus B. (2010) 'Sequencing and analysis of an Irish human genome'. Genome Biology, .

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Edwards, C. J.Edwards, C. J.,Magee, D. A.Magee, D. A.,Park, S. D.Park, S. D.,McGettigan, P. A.McGettigan, P. A.,Lohan, A. J.Lohan, A. J.,Murphy, A.Murphy, A.,Finlay, E. K.Finlay, E. K.,Shapiro, B.Shapiro, B.,Chamberlain, A. T.Chamberlain, A. T.,Richards, M. B.Richards, M. B.,Bradley, D. G.Bradley, D. G.,Loftus, B. J.Loftus, B. J.,Machugh, D. E.Machugh, D. E. (2010) 'A complete mitochondrial genome sequence from a mesolithic wild aurochs (Bos primigenius)'. PLoS ONEPLoS ONEPLoS ONE, 5 (22).

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McGivney BA, McGettigan PA, Browne JA, Evans AC, Fonseca RG, Loftus BJ, Lohan A, MacHugh DE, Murphy BA, Katz LM, Hill EW. (2010) 'Characterization of the equine skeletal muscle transcriptome identifies novel functional responses to exercise training'. BMC Genomics, 11 .

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Nene V, Wortman JR, Lawson D, Haas B, Kodira C, Tu ZJ, Loftus B et al (2007) 'Genome Sequence of Aedes aegypti, a Major Arbovirus Vector'. Science, 316 :1718-1723. [Details]

Lobo NF, Campbell KS, Thaner D, Debruyn B, Koo H, Gelbart WM, Loftus BJ, Severson DW, Collins FH. (2007) 'Analysis of 14 BAC sequences from the Aedes aegypti genome: a benchmark for genome annotation and assembly'. Genome Biology, 8 (5). [Details]

Loftus, B. et al (2005) 'The genome of the protist parasite Entamoeba histolytica'. Nature, 433 (7028):865-868. [Details]
Loftus, B.J et al (2005) 'The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans'. Science, 307 (5713):1321-1324. [Details]
Graham Clark, Ibne Karim M. Ali, Mehreen Zaki, Brendan J. Loftus and Neil Hall. (2006) 'Unique organization of tRNA genes in the protistan parasite Entamoeba histolytica'. Molecular and Biochemical Parasitology, 146 (1):24-29. [Details]
Yumiko Saito-Nakano, Brendan J. Loftus, Neil Hall and Tomoyoshi Nozaki. (2005) 'The diversity of Rab GTPases in Entamoeba histolytica'. Experimental Parasitology, 10 (3):244-252. [Details]
Loftus, B.J., Hall, N. (2005) 'Entamoeba: still more to be learned from the genome'. Trends in Parasitology, 21 (10). [Details]
Anderson, I.J., Loftus, B.J. (2005) 'Entamoeba histolytica: Observations on metabolism based on the genome sequence'. Experimental Parasitology, 110 (3):173-177. [Details]
Iain J. Anderson, Russell F. Watkins, John Samuelson, David F. Spencer, Michael W. Gray, and Brendan J. Loftus. (2005) 'Gene discovery in the Acanthamoeba castellanii genome'. Protist, 156 (2):203-214. [Details]
Holt, R.A., et al (2002) 'The genome sequence of the malaria mosquito Anopheles gambiae'. Science, 298 (5591):129-49. [Details]
Nixon, J.E., Wang, A., Morrison, H.G., McArthur, A.G., Sogin, M.L., Loftus, B.J. and Samuelson, J. (2002) 'A spliceosomal intron in Giardia lamblia'. Proceedings of the National Academy of Sciences, 99 (6):3701-3705. [Details]
Loftus, B., Monks, E., Hanlon, J., Weavers, E., and Rogers, M. (1999) 'Prion protein genotypes of Suffolk-type sheep representative of natural scrapie in Ireland'. IRISH VETERINARY JOURNAL, 52 :81-85. [Details]
Haft, D.H., Loftus, B.J., Richardson, D.L., Yang, F., Eisen, J.A., Paulsen, I.T. and White, O. (2001) 'TIGRFAMs: a protein family resource for the functional identification of proteins'. Nucleic Acids Research, 29 (1):41-43. [Details]
Loftus, B; Rogers, M; (1997) 'Characterization of a prion protein (PrP) gene from rabbit; A species with apparent resistance to infection by prions'. Gene, 184 (2):215-219. [Details]
Tettelin, H et al (2001) 'Complete genome sequence of a virulent isolate of Streptococcus pneumoniae'. Science, 293 (5529):498-506. [Details]
Horvath, J.E., Viggiano, L., Loftus, B.J., Adams, M.D., Archidiacono, N., Rocchi, M. and Eichler, E.E. (2000) 'Molecular structure and evolution of an alpha satellite/nonalpha satellite junction at 16p11'. Human Molecular Genetics, 9 (1):113-123. [Details]
Loftus, B.J., Kim, U.J., Sneddon, V.P., Kalush, F., Brandon, R., Fuhrmann, J., Mason, T., Crosby, M.L., Barnstead, M., Cronin, L., Deslattes Mays, A., Cao, Y., Xu, R.X., Kang, H.L., Mitchell, S., Eichler, E.E., Harris, P.C., Venter, J.C. and Adams, M.D. (1999) 'Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q'. Genomics, 60 (3):295-308. [Details]
Klenk, H.P., et al (1997) 'The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus'. Nature, 390 (6658):364-370. [Details]
Tomb, J.F., et al (1997) 'The complete genome sequence of the gastric pathogen Helicobacter pylori'. Nature, 388 (6642):539-547. [Details]
Loftus B, Rogers M (1997) 'Characterization of a prion protein (PrP) gene from rabbit; a species with apparent resistance to infection by prions'. Gene, 184 (2):215-219. [Details]
Severson, D.W., Knudson, D.L., Soares, M.B., Loftus, B.J. (2004) 'Aedes aegypti genomics'. Insect Biochem Mol Biol, 34 (7):715-721. [Details]
Wang Z, Samuelson J, Clark CG, Eichinger D, Paul J, Van Dellen K, Hall N, Anderson I, Loftus B. (2003) 'Gene discovery in the Entamoeba invadens genome'. Molecular and Biochemical Parasitology, 129 (1):23-31. [Details]
Bruchhaus, I., Loftus, B.J., Hall, N. and Tannich, E. (2003) 'The Intestinal Protozoan Parasite Entamoeba histolytica Contains 20 Cysteine Protease Genes, of which only a small subset Is expressed during in vitro cultivation'. Eukaryotic Cell, 2 (3):501-509. [Details]
Nixon, J.E., Field, J., McArthur, A.G., Sogin, M.L., Yarlett, N., Loftus, B.J. and Samuelson, J. (2003) 'Iron-Dependent Hydrogenases of Entamoeba histolytica and Giardia lamblia: Activity of the Recombinant Entamoebic Enzyme and Evidence for Lateral Gene Transfer'. Biological Bulletin, 204 (1):1-9. [Details]
Van Dellen, K., Ghosh, S.K., Robbins, P.W., Loftus, B. and Samuelson, J. (2002) 'Entamoeba histolytica lectins contain unique 6-Cys or 8-Cys chitin-binding domains'. Infection and Immunity, 70 (6):3259-3263. [Details]
Loftus, B,Rogers, M (1997) 'Characterization of a prion protein (PrP) gene from rabbit; A species with apparent resistance to infection by prions'. Gene, 184 :215-219. [Details]
Loftus, B,Monks, E,Hanlon, J,Weavers, E,Rogers, M (1999) 'Prion protein genotypes of Suffolk-type sheep representative of natural scrapie in Ireland'. Irish Veterinary Journal, 52 :81-85. [Details]
Beck, D.L., Tanyuksel, M., Mackey, A.J., Haque, R., Trapaidze, N., Pearson, W.R., Loftus, B. and Petri, W.A. (2002) 'Entamoeba histolytica: sequence conservation of the Gal/GalNAc lectin from clinical isolates'. Experimental Parasitology, 101 (2-3):157-163. [Details]
Cheng, X.J., Hughes, M.A., Huston, C.D., Loftus, B., Gilchrist, C.A., Lockhart, L.A., Ghosh, S., Miller-Sims, V., Mann, B.J., Petri, W.A., Jr. and Tachibana, H. (2001) 'Intermediate subunit of the Gal/GalNAc lectin of Entamoeba histolytica is a member of a gene family containing multiple CXXC sequence motifs'. Infection and Immunity, 69 (9):5892-5898. [Details]
Loftus B, Monks E, Hanlon J, et al. (1999) 'Prion protein genotypes of Suffolk-type sheep representative of natural scrapie in Ireland'. Irish Veterinary Journal, 52 (2):81-85. [Details]
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Book Chapters:

Loftus, B. (2003) 'Genome sequencing, assembly and gene prediction in fungi' In: D. K. Arora and Khachatourians, G. G (eds). Fungal Genomics. *: Elsevier Science. [Details]

Mann, BJ, Loftus, BJ. (2002) 'The Molecular Biology and Pathogenicity of Entamoeba histolytica' In: Karen Joy Shaw (eds). Pathogen Genomics: Impact on Human Health. Totowa, NJ: Humana Press, Inc. [Details]

Conference Publications:

Forde N, McGettigan PA, Browne JA, Carter F, Loftus BJ, Roche JF, Lonergan P, Crowe MA, and Evans ACO (2009) Pregnancy specific endometrial gene expression at the initiation of conceptus elongation in cattle 42nd Annual meeting of the Society for the Study of Reproduction, Biology of Reproduction 81, Abstract 303 Pittsburgh, , 18-JUL-09 - 22-JUL-09 [Details]