Professor Catherine Godson

Research

Professor Catherine Godson BSC, PHD

Contact Details

Title	Professor, Director Diabetes Research Centre
Address	School of Medicine & Medical Science Diabetes Research Centre, Conway Institute University College Dublin Belfield Dublin 4
Telephone:	353-1-716-6731
Email:	ei.dcu@nosdog.enirehtac

Biography:

Research Interests

Microvascular complications of diabetes and TGF signalling networks
Mammalian cell signal transduction
The resolution of inflammatory responses

Work in our laboratory focuses on understanding signal transduction processes implicated in disease states such as inflammation and diabetes. We are particularly interested in understanding the mechanisms underlying the resolution of inflammation. It is increasingly appreciated that the resolution of inflammation is a dynamically regulated process. Whereas inflammation is appropriate to effective host defence, in several chronic disease including the arthritides, atherosclerosis and colitis, chronic inflammation persists contributing to the pathology of these conditions. The resolution of inflammation does not merely reflect the dissipation of proinflammatory signals but the active generation of anti-inflammatory mediators, which included the lipoxins.

RESEARCH FUNDING:
Principal Investigator on the following Grants (1998-2007)
2007-2013 Science Foundation Ireland Investigator Award, Molecular Mechanisms of the Initiation, Progression and Potential Regression of Diabetic Kidney Disease. Total value €7.5 m; €3.5 m (SFI) and €3.7m (industrial partners)
2003-2006: Wellcome Trust Project Grant: Characterization of IHG-1, a novel diabetic nephroropathy-associated gene product, which amplifies TGF- induced signalling
2003-2006: Irish Research Council for Science Engineering and Technology PhD Project Grant: Resolving Inflammation through Endogenous Mediators: An investigation of the potential of lipoxin receptor agonists to stimulate macrophage phagocytosis of apoptotic cells
2002-2005: Health Research Board Project Grant: Antifibrotic potential of lipoxins in renal disease.
2002-2007: Health Research Board Program Grant: Lipoxins, lipid-derived mediators that promote the resolution of inflammation
2001-2004: Health Research Board Project Grant: Functional proteomics of lipoxin-stimulated macrophages.
2000-2003: Health Research Project Grant: Leukotriene, lipoxin and PDGF receptor cross talk in renal mesangial cells.
2001-2002 Mater College Grant: Macrophage transcriptional responses in inflammation
2000-2001: Mater College Grant: Differential gene expression in glomerular hypertension
1999-2002: Health Research Board Project Grant: Lipoxin-induced gene expression in macrophages.
1998-2001: Health Research Board Project Grant: Cloning and characterization of endothelial lipoxin receptors.
1998: UCD President's Research Award.
1998: Health Research Board -Wellcome Trust Equipment Grant.

Sponsor for fellowships:
2004-2007: Health Research Board Postdoctoral Fellowship to Dr. Rosemary Kane: The role of the BMP-4 antagonist ventroptin in diabetic retinopathy
2001-2004: Health Research Board Postdoctoral Fellowship to Dr John Crean: CTGF as a therapeutic target in diabetic nephropathy.
1998-2000: Health Research Board Clinical Research Fellowship to Dr. Michael Clarkson: Expression of the lipoxin A4 receptor in experimental and human glomerulonephritis
1998; 1999,2000,2001 Health Research Board Summer Student Scholarships

Coinvestigator on the following grants:
2005-2008 Science Foundation Ireland Research Frontiers Programme
2004-2009 EU Framework 6: Eicosanox Programme Grant; Work Programme Leader
2004-2007 Science Foundation Ireland Research Frontiers Programme: Mechanisms of M. tuberculosis-induced macrophage apoptosis in the host response.
2000: Health Research Board Equipment Grant.
2000-2002 Conway Institute Postdoctoral Fellowship. Differential gene expression in fibrosis and unilateral ureteric obstruction
2000-2002: Conway Institute Postdoctoral Fellowship. Thromboxane-Lipoxin Receptor cross-talk in renal mesangial cells.
2000-2002 Conway Institute Postdoctoral Fellowship. TGF- signal transduction via the SMAD family.
1999-2002: Wellcome Trust Project Grant 'Lipoxin biosynthesis and bioactions in glomerulonephritis'.
1999-2001: Enterprise Ireland Strategic Grant. ‘Identification of Novel Diagnostic Markers and Therapeutic Targets by Suppression Subtractive Hybridisation'.
1997-2000: Health Research Board Unit Grant - Differential Gene Expression in Diabetic Glomerulosclerosis
1998: Health Research Board Equipment Grant.
1998-2000: Enterprise Ireland Strategic Grant: 'Pre-clinical development of a novel class of anti-inflammatory drugs based on synthetic lipoxin analogues'
1998-2002: EU Concerted Action Grant: Chronic inflammation leading to scarring, the major mechanism for kidney failure

Research Projects

Sponsor : Higher Education Authority (HEA)
Title : Biomedical Sciences Network
Start Date / End Date : 01-OCT-09 / 31-MAR-12

Sponsor : University College Dublin Foundation Ltd.
Title : Gremlin in renal fibrosis
Start Date / End Date : 01-SEP-09 / 30-AUG-10

Sponsor : The Wellcome Trust (WT)
Title : Biomedical Vacation Scholarship for Daniel Regan-Komito
Start Date / End Date : 21-JUN-10 / 20-AUG-10

Sponsor : Boehringer Ingelheim Pharmaceuticals Inc
Title : Boehringer Ingelheim Pharmaceuticals Inc Research Project
Start Date / End Date : 01-NOV-09 / 30-NOV-10

Sponsor : Irish Research Council for Science Engineering and Technology (IRCSET)
Title : Diabetic complications: a failure to resolve inflammation?
Start Date / End Date : 01-OCT-09 / 30-SEP-12

Sponsor : Health Research Board (HRB) Title : An investigation of the potential of lipoxin A4 and novel synthetic lipoxin of inflammatory arthritis Start Date / End Date : 01-OCT-09 / 01-MAR-12
Sponsor : Health Research Board (HRB) Title : Investigation of the role of ROS in the regulation and function of IHG-1, a novel mediator of fibrosis Start Date / End Date : 01-NOV-09 / 30-APR-13
Sponsor : Compugen Ltd Title : Efficiency and potency of two peptides in in vitro assays in human macrophages Start Date / End Date : 15-JUN-09 / 15-OCT-09
Sponsor : Science Foundation Ireland (SFI) Title : Genome-Wide Association Studies of Diabetic Nephropathy Start Date / End Date : 01-SEP-09 / 01-SEP-13
Sponsor : Bayer Schering Pharma AG, Germany Title : Mechanism of action of LX analogues Start Date / End Date : 01-MAR-09 / 30-JUN-09
Sponsor : Science Foundation Ireland (SFI) Title : Micro-RNA Regulation of Gene Expression in Diabetic Nephropathy Start Date / End Date : 01-JAN-09 / 31-DEC-09
Sponsor : Science Foundation Ireland (SFI) Title : In vitro transgenic models of renal diseas Start Date / End Date : 01-MAR-08 / 28-FEB-09
Sponsor : University College Dublin (UCD) Title : Top-up funding Start Date / End Date : 01-JUL-08 / 30-JUN-11
Sponsor : Science Foundation Ireland (SFI) Title : Genome-Wide Association Studies of Diabetic Nephropathy Start Date / End Date : 01-OCT-08 / 31-DEC-08
Sponsor : HEA/PRTLI Cycle 4 Grant Title : Biomedical Sciences Network Start Date / End Date : 01-JUL-08 / 30-JUN-11
Sponsor : Irish Research Council for Science Engineering and Technology (IRCSET) Title : Lipoxins: modulators of diabetic kidney disease? Start Date / End Date : 01-OCT-07 / 30-SEP-10
Sponsor : Science Foundation Ireland (SFI) Title : The molecular mechanisms underlying the initiation progression and potential regression of diabetic kidney disease Start Date / End Date : 01-MAR-07 / 31-DEC-12
Sponsor : European Commission FP6 Title : Eicosanoids and Nitric Oxide: Mediators of Cardiovascular, Cerebral & Neoplastic Diseases (EICOSANOX) Start Date / End Date : 01-FEB-05 / 31-JAN-10
Sponsor : Wellcome Trust, UK Title : Characterisation of IHG-1, a novel diabetic-associated gene product, which amplifies TGF B-induced signalling Start Date / End Date : 01-FEB-04 / 31-JAN-07
Sponsor : Science Foundation Ireland (SFI) Title : Women in Irish Science and Engineering Research Institute Planning Grant Start Date / End Date : 29-JUN-05 / 29-SEP-05
Sponsor : Science Foundation Ireland (SFI) Title : Ulysses Inaugural Medal (Dr. Phillip Sharp) Start Date / End Date : 10-MAR-05 / 11-MAR-05
Sponsor : Health Research Board (HRB) Title : The role of ventroptin, a BMP antagonist, in diabetic retinopathy Start Date / End Date : 01-OCT-04 / 30-SEP-07
Sponsor : Atlantic Philanthropies, USA Title : Funding for Dr. Peter Doran (Bioinformatics and Human Genomics Unit) Start Date / End Date : 01-SEP-03 / 30-AUG-08
Sponsor : Irish Research Council for Science Engineering and Technology (IRCSET) Title : Annexun - 1 stimulated phagocytosis Start Date / End Date : 01-OCT-03 / 31-MAR-07
Sponsor : Health Research Board (HRB) Title : An investigation of the potential antifibrotic actions of lipoxins in renal cells Start Date / End Date : 01-OCT-02 / 30-SEP-05
Sponsor : Health Research Board (HRB) Title : Identification of molecular drivers of diabetic athenosclenosis through complementary analysis of differential gene expression in vascular smooth muscle cells. Start Date / End Date : 01-JUL-02 / 30-JUN-04
Sponsor : Health Research Board (HRB) Title : Lipoxins: Lipid-derived mediators that promote resolution of Inflammation. Start Date / End Date : 01-JUL-02 / 01-OCT-07
Sponsor : Health Research Board (HRB) Title : Functional proteomics of lipocin - stimulated macroimages Start Date / End Date : 01-OCT-01 / 30-SEP-04
Sponsor : Health Research Board (HRB) Title : Connective tissue growth factor: a putative therapeutic target in Type 1 diabetes over a period of three years. Start Date / End Date : 01-JUL-01 / 30-JUN-02
Sponsor : Health Research Board (HRB) Title : Evaluation of the therapeutic potential and mechanisms of action of the Lipoxins in experimental ischaemic acute renal failure with special emphasis on tubule epithelial cell transcriptemic responses. Start Date / End Date : 01-JUL-01 / 03-JUN-03
Sponsor : Health Research Board (HRB) Title : Microinjection equipment Start Date / End Date : 01-FEB-01 / 31-JAN-02
Sponsor : Higher Education Authority (HEA) Title : Research Unit 4 - project 3 Proteomics Start Date / End Date : 01-NOV-00 / 31-OCT-03
Sponsor : Higher Education Authority (HEA) Title : Research Unit 4 Project 1 Polymorphisins Start Date / End Date : 01-NOV-00 / 31-OCT-03
Sponsor : Higher Education Authority (HEA) Title : Research Unit 2 Project 1 Lipoxin Start Date / End Date : 01-NOV-00 / 31-OCT-03
Sponsor : Higher Education Authority (HEA) Title : Research Unit 1 - project 2 (Dr. Geraldine McCarthy) Start Date / End Date : 01-NOV-00 / 31-OCT-03
Sponsor : Health Research Board (HRB) Title : Hypoxia Dual Chamber System Start Date / End Date : 01-NOV-00 / 08-NOV-00
Sponsor : Health Research Board (HRB) Title : Lipoxin, Leukotriene and PDGF receptor crorss-talk in renal mesangial cells Start Date / End Date : 01-OCT-00 / 30-SEP-03
Sponsor : The Wellcome Trust (WT) Title : Lipoxins: Lipid mediators that promote resolution of glomerulonephritis and other inflammatory diseases Start Date / End Date : 01-DEC-99 / 01-NOV-03
Sponsor : Health Research Board (HRB) Title : Molecular Basis for Glomerulosclerosis in Diabetic Nephropathy Start Date / End Date : 01-OCT-97 / 30-SEP-01
Sponsor : Health Research Board (HRB) Title : Lipoxin mediated gene expression in macrophages Start Date / End Date : 01-OCT-99 / 30-SEP-02
Sponsor : Health Research Board (HRB) Title : Identification of susceptibility genes for progressive renal disease by combined differential gene expression, gene association and genetic linkage approaches Start Date / End Date : 01-OCT-99 / 30-SEP-02
Sponsor : Health Research Board (HRB) Title : Diabetic Nephropathy Research Unit Equipment Grant Start Date / End Date : 01-JAN-99 / 31-JAN-99
Sponsor : Irish Heart Foundation Title : Lipoxin modulation of tissue factor gene expression Start Date / End Date : 01-JAN-99 / 31-DEC-99
Sponsor : Centre for Molecular Inflammation & Vascular Research Ltd Title : Lipoxin-stimulated phagocytosis of apoptotic neutrophils by macrophage Start Date / End Date : 01-OCT-98 / 30-OCT-01
Sponsor : Centre for Molecular Inflammation & Vascular Research Ltd Title : The suppressors of Cytokine Signaling (SOCS) proteins as an Endogenous Regulators or Inflammation and Host Defence Start Date / End Date : 01-OCT-98 / 30-OCT-01
Sponsor : Health Research Board (HRB) Title : No Project title to migrate. Start Date / End Date : 01-JUL-98 / 01-JUL-20
Sponsor : Health Research Board (HRB) Title : No Project title to migrate. Start Date / End Date : 01-OCT-98 / 31-OCT-01
Sponsor : Scios Nova Inc, USA Title : No Project title to migrate. Start Date / End Date : 01-JUN-97 / 09-AUG-97
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Book Chapters

Serhan, CN and Godson, C; (2010) 'pp 69-92' In: Lipid Mediators of Regeneration In: Regenerative Nephrology. Elsevier Academic Press: Elsevier Academic Press. [Details]

Ryan A, Sadlier, DM and Godson C Animal models of glomerulonphritis. In Fundamentals of Inflammation, Serhan, Ward and Gilroy (Eds.) Cambridge University Press, In press 2009; (2010) 'Animal models of glomerulonphritis' In: Fundamentals of Inflammation. NY: Cambridge University Press. [Details]

Maderna, P Godson,C ; (2007) 'Beyond inflammation: Lipoxins; resolution of inflammation and regulation of fibrosis' In: Rossi, Adriano; Sawatzky, Deborah A. (Eds.) (eds). The Resolution of Inflammation. Series: Progress in Inflammation Research. *: Birkhäuser. [Details]

Peer Reviewed Journals

Borgeson,E Dochery, NG Murphy,M Rodgers,K Ryan, A O¿Sullivan, T Guiry,P Goldschmeding, R Higgins DF and Godson, C. ; (2011) 'Lipoxin A4 and benzo-Lipoxin A4 attenuate experimental renal fibrosis. FASEB J'. . [Details]

Hickey, F Corcoran, J Docherty NG, Griffin, B Bhreathnach, U Furlong, F Martin, F Godson, C and Murphy, M ; (2011) 'IHG-1 regulates mitochondrial biogenesis through stabilisation of PGC-1α J Am Soc Nephrol 2011, in press'. . [Details]

Rooney, B,O'Donovan, H,Gaffney, A,Browne, M,Faherty, N,Curran, SP,Sadlier, D,Godson, C,Brazil, DP,Crean, J; (2011) 'CTGF/CCN2 activates canonical Wnt signalling in mesangial cells through LRP6: Implications for the pathogenesis of diabetic nephropathy'. FEBS letters, 585 :531-538. [DOI] [Details]

Borgeson, E,Docherty, NG,Murphy, M,Rodgers, K,Ryan, A,O'Sullivan, TP,Guiry, PJ,Goldschmeding, R,Higgins, DF,Godson, C; (2011) 'Lipoxin A(4) and benzo-lipoxin A(4) attenuate experimental renal fibrosis'. FASEB Journal, 25 :2967-2979. [DOI] [Details]

O'Donovan HC, Hickey F, Brazil DP, Kavanagh DH, Oliver N, Martin F, Godson C, Crean J.; (2011) 'Connective tissue growth factor antagonizes transforming growth factor-β1/Smad signalling in renal mesangial cells'. Biochem J, . [Details]

Nyhan, KC,Faherty, N,Murray, G,Cooey, LB,Godson, C,Crean, JK,Brazil, DP; (2010) 'Jagged/Notch signalling is required for a subset of TGF beta 1 responses in human kidney epithelial cells'. Cell, 1803 :1386-1395. [DOI] [Details]
Borgeson, E,Godson, C; (2010) 'Molecular Circuits of Resolution in Renal Disease'. THESCIENTIFICWORLDJOURNAL, 10 :1370-1385. [DOI] [Details]
Borgeson E, Godson C.; (2010) 'Molecular circuits of resolution in renal disease'. Scientific World Journal, 10 :1370-1385. [Details]
Nyhan KC, Faherty N, Murray G, Cooey LB, Godson C, Crean JK, Brazil DP.; (2010) 'Jagged/Notch signalling is required for a subset of TGFBeta1 responses in human kidney epithelial cells'. Biochima Et Biophysica Acta - Molecular Cell Research, 1803 :1386-1395. [Details]
Brennan EP, Ehrich M, Brazil DP, Crean JK, Murphy M, Sadlier DM, Martin F, Godson C, van den Boom D, Maxwell AP, Savage DA.; (2010) 'DNA methylation profiling in cell models of diabetic nephropathy'. Epigenetics : official journal of the DNA Methylation Society, 16 (5). [Details]
Rooney B, O'Donovan, H., Browne, M., Gaffney, A., Curran, SP., Brazil, DP. Godson, C., Sadlier, D and Crean, JK. ; (2010) 'CTGF/CCN2 activates canonical Wnt signaling in mesangial cells through LRP6; implications for the pathogenesis of diabetic nephropathy'. European journal of biochemistry / FEBS, . [Details]
Maderna P, Cottell DC, Toivonen T, Dufton N, Dalli J, Perretti M, Godson C. ; (2010) 'FPR2/ALX receptor expression and internalization are critical for lipoxin A4 and annexin-derived peptide-stimulated phagocytosis'. FASEB Journal, . [Details]
Ryan A, Godson C. ; (2010) 'Lipoxins: regulators of resolution'. CURRENT OPINION IN PHARMACOLOGY, 10 (2):166-172. [Details]
Duffy CD, Maderna P, McCarthy C, Loscher CE, Godson C, Guiry PJ; (2010) 'Synthesis and Biological Evaluation of Pyridine-Containing Lipoxin A(4) Analogues'. Chemmedchem, 5 (4):517-522. [Details]
Walsh DW, Godson C, Brazil DP, Martin F.; (2010) 'Extracellular BMP-antagonist regulation in development and disease: tied up in knots'. Trends in cell biology, 20 (5):244-256. [Details]
Maderna P and Godson C; (2009) 'Lipoxins: Resolutionary Road'. British Journal of Pharmacology, 158 (4):947-959. [Details]
Maderna P and Godson C; (2009) 'Lipoxins: Resolutionary Road'. British Journal of Pharmacology, 158 (4):947-959. [Details]
Ryan, A.,Murphy, M.,Godson, C.,Hickey, F. B.; (2009) 'Diabetes mellitus and apoptosis: inflammatory cells'. Apoptosis, 14 (1212):1435-501435. [Details]
Brennan EP, Ehrich M, Brazil DP, Crean JK, Murphy M, Sadlier DM, Martin F,Godson C, McKnight AJ, van den Boom D, Maxwell AP, Savage DA. ; (2009) 'Comparative analysis of DNA methylation profiles in peripheral blood leukocytes versus lymphoblastoid cell lines'. Epigenetics : official journal of the DNA Methylation Society, 1 (4). [Details]
Baker, N.,O'Meara, S. J.,Scannell, M.,Maderna, P.,Godson, C.; (2009) 'Lipoxin A4: anti-inflammatory and anti-angiogenic impact on endothelial cells'. J Immunol, 182 (66):3819-263819. [Details]
Roxburgh, S. A.,Kattla, J. J.,Curran, S. P.,O'Meara, Y. M.,Pollock, C. A.,Goldschmeding, R.,Godson, C.,Martin, F.,Brazil, D. P.; (2009) 'Allelic depletion of grem1 attenuates diabetic kidney disease'. Diabetes, 58 (77):1641-501641. [Details]
Maderna, P.,Godson, C.; (2009) 'Lipoxins: resolutionary road'. Br J Pharmacol, 158 (44):947-59947. [Details]
Connolly, M,Marrelli, A,Blades, M,McCormick, J,Maderna, P,Godson, C,Mullan, R,FitzGerald, O,Bresnihan, B,Pitzalis, C,Veale, DJ,Fearon, U; (2010) 'Acute Serum Amyloid A Induces Migration, Angiogenesis, and Inflammation in Synovial Cells In Vitro and in a Human Rheumatoid Arthritis/SCID Mouse Chimera Model'. J IMMUNOL, 184 :6427-6437. [DOI] [Details]
Duffy, CD,Maderna, P,McCarthy, C,Loscher, CE,Godson, C,Guiry, PJ; (2010) 'Synthesis and Biological Evaluation of Pyridine-Containing Lipoxin A(4) Analogues'. Chemmedchem, 5 :517-522. [DOI] [Details]
Godson C, Decker Y, McBean G, ; (2009) 'Lipoxin A4 inhibits IL-1beta-induced IL-8 and ICAM-1 expression in 1321N1 human astrocytoma cells'. American Journal of Physiology-Cell Physiology, 296 (6):1-7. [DOI] [Details]
Hickey FB, Ryan A, Murphy M, Godson C, ; (2009) 'Diabetes mellitus and apoptosis: inflammatory cells'. Apoptosis, . [DOI] [Details]
Godson C, Maderna P, Baker N, O'Meara SJ, Scannell M, ; (2009) 'Lipoxin A4: anti-inflammatory and anti-angiogenic impact on endothelial cells'. Immunology, 182 (6):3819-3826. [DOI] [Details]
Brennan, EP,Ehrich, M,Brazil, DP,Crean, JK,Murphy, M,Sadlier, DM,Martin, F,Godson, C,McKnight, AJ,van den Boom, D,Maxwell, AP,Savage, DA; (2009) 'Comparative analysis of dna methylation profiles in peripheral blood leukocytes versus lymphoblastoid cell lines'. Gene, 4 :159-164. [Details]
Baker, N,O'Meara, SJ,Scannell, M,Maderna, P,Godson, C; (2009) 'Lipoxin A(4): Anti-Inflammatory and Anti-Angiogenic Impact on Endothelial Cells'. J IMMUNOL, 182 :3819-3826. [Details]
Decker, Y,McBean, G,Godson, C; (2009) 'Lipoxin A(4) inhibits IL-1 beta-induced IL-8 and ICAM-1 expression in 1321N1 human astrocytoma cells'. Cell, 296 :1420-1427. [DOI] [Details]
Godson C, Murphy M, Crean J, Brazil DP, Sadlier D, Martin F, ; (2008) 'Regulation and consequences of differential gene expression in diabetic kidney disease'. Biochemical Society Transactions, Pt 5 (NA):941-945. [DOI] [Details]
O'Meara, S. J., Rodgers, K., Godson, C., ; (2008) 'Lipoxins: update and impact of endogenous pro-resolution lipid mediators'. Reviews of Physiology, Biochemistry and Pharmacology, Vol 160, 160 :47-69. [Details]
Kane, R., Godson, C., O'Brien, C., ; (2008) 'Chordin-like 1, a bone morphogenetic protein-4 antagonist, is upregulated by hypoxia in human retinal pericytes and plays a role in regulating angiogenesis'. Molecular Vision, 14 (135):1138-1148. [Details]
Godson C, Murphy M, Crean J, Brazil DP, Sadlier D, Martin F, ; (2008) 'Regulation and consequences of differential gene expression in diabetic kidney disease'. Biochemical Society Transactions, 36 (Pt 5):941-945. [DOI] [Details]
. Kattla JJ, Carew R, Godson C and Brazil DP ; (2008) 'TGF b 1-mediated activation of Protein kinase B/Akt is important for epithelial-mesenchymal transition in vitro and in vivo'. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, . [Details]
Martin F, McArdle E, McMahon R, Schmid H, Kretzler M, Droguett A, Mezzano S, Brady HR, Furlong F, Godson C, Murphy M, Docherty NG, Griffin B, Howlin J, ; (2008) 'IHG-1 amplifies TGF-beta1 signaling and is increased in renal fibrosis'. J AM SOC NEPHROL, 9 (NA):1672-1680. [DOI] [Details]
Murphy M, Crean JK, Brazil DP, Sadlier D, Martin F and Godson C ; (2008) 'Regulation and consequences of differential gene expression in diabetic kidney disease'. Biochem J, 36 :941-945. [Details]
Martin F, McArdle E, McMahon R, Schmid H, Kretzler M, Droguett A, Mezzano S, Brady HR, Furlong F, Godson C, Murphy M, Docherty NG, Griffin B, Howlin J, ; (2008) 'IHG-1 amplifies TGF-beta1 signaling and is increased in renal fibrosis'. J AM SOC NEPHROL, 19 (9):1672-1680. [DOI] [Details]
O'Brien C, Kane R, Godson C, ; (2008) 'Chordin-like 1, a bone morphogenetic protein-4 antagonist, is upregulated by hypoxia in human retinal pericytes and plays a role in regulating angiogenesis'. Molecular Vision, 14 :1138-1148. [Details]
Brazil DP, Kattla JJ, Carew RM, Heljic M, Godson C, ; (2008) 'Protein kinase B/Akt activity is involved in renal TGF-beta1-driven epithelial-mesenchymal transition in vitro and in vivo'. American Journal of Physiology-Renal Physiology, 295 (1):1-25. [DOI] [Details]
Decker, Y., Mc Bean, G., Godson, C., ; (2008) 'Anti-inflammatory effects of Lipoxin A4 in human 1321N1 astrocytoma cells'. Journal of Neuroimmunology, 197 (2):168-168. [Details]
Martin F, McArdle E, McMahon R, Schmid H, Kretzler M, Droguett A, Mezzano S, Brady HR, Furlong F, Godson C, Murphy M, Docherty NG, Griffin B, Howlin J, ; (2008) 'IHG-1 amplifies TGF-beta1 signaling and is increased in renal fibrosis'. J AM SOC NEPHROL, 9 (NA):1672-1680. [DOI] [Details]
Kane, R,Godson, C,O'Brien, C; (2008) 'Chordin-like 1, a bone morphogenetic protein-4 antagonist, is upregulated by hypoxia in human retinal pericytes and plays a role in regulating angiogenesis'. Molecular Vision, 14 :1138-1148. [Details]
Kattla, JJ,Carew, RM,Heljic, M,Godson, C,Brazil, DP; (2008) 'Protein kinase B/Akt activity is involved in renal TGF-beta 1-driven epithelial-mesenchymal transition in vitro and in vivo'. American Journal of Physiology-Renal Physiology, 295 :215-225. [DOI] [Details]
Murphy, M,Docherty, NG,Griffin, B,Howlin, J,McArdle, E,McMahon, R,Schmid, H,Kretzler, M,Droguett, A,Mezzano, S,Brady, HR,Furlong, F,Godson, C,Martin, F; (2008) 'IHG-1 amplifies TGF-beta 1 signaling and is increased in renal fibrosis'. Journal of the American Society of Nephrology, 19 (NA):1672-1680. [DOI] [Details]
Kattla, J. J., Carew, R. M., Heljic, M., Godson, C., Brazil, D. P., ; (2008) 'Protein kinase B/Akt activity is involved in renal TGF-beta 1-driven epithelial-mesenchymal transition in vitro and in vivo'. American Journal of Physiology-Renal Physiology, 295 (1):215-225. [Details]
Scannell, M, Flanagan, MB, Destefani, A, Wynne, KJ, Cagney, G, Godson, C, Maderna, P, ; (2007) 'Annexin-1 and peptide derivatives are released by apoptotic cells and stimulate phagocytosis of apoptotic neutrophils by macrophages'. J IMMUNOL, 178 :4595-4605. [Details]
Mitchell D, O'Meara SJ, Gaffney A, Crean JK, Kinsella BT, Godson C.; (2007) 'The Lipoxin A4 Receptor Is Coupled to SHP-2 Activation:implications for regulation of receptor tyrosine kinases'. Journal of Biological Chemistry, 282 (21):15606-15618. [Details]
O'Sullivan, TP,Vallin, KSA,Shah, STA,Fakhry, J,Maderna, P,Scannell, M,Sampaio, ALF,Perretti, M,Godson, C,Guiry, PJ; (2007) 'Aromatic lipoxin A(4) and lipoxin B-4 analogues display potent biological activities'. Journal of medicinal chemistry, 50 (NA):5894-5902. [DOI] [Details]
Scannell, M,Flanagan, MB,Destefani, A,Wynne, KJ,Cagney, G,Godson, C,Maderna, P; (2007) 'Annexin-1 and peptide derivatives are released by apoptotic cells and stimulate phagocytosis of apoptotic neutrophils by macrophages'. J IMMUNOL, 178 :4595-4605. [Details]
Mitchell, D,O'Meara, SJ,Gaffney, A,Crean, JKG,Kinsella, BT,Godson, C; (2007) 'The lipoxin A(4) receptor is coupled to SHP-2 activation - Implications for regulation of receptor tyrosine kinases'. J BIOL CHEM, 282 :15606-15618. [DOI] [Details]
Scannell M, Flanagan MB, deStefani A, Wynne KJ, Cagney G, Godson C, Maderna P.; (2007) 'Annexin-1 and peptide derivatives are released by apoptotic cells and stimulate phagocytosis of apoptotic neutrophils by macrophages'. Journal of Immunology, 178 (7):4595-4605. [Details]
O'Sullivan, T. P.,Vallin, K. S.,Shah, S. T.,Fakhry, J.,Maderna, P.,Scannell, M.,Sampaio, A. L.,Perretti, M.,Godson, C.,Guiry, P. J.; (2007) 'Aromatic Lipoxin A(4) and Lipoxin B(4) Analogues Display Potent Biological Activities'. J Med Chem, . [Details]
Mitchell, DM., Gaffney, A., Crean, JK., Kinsella, BT. and Godson C; (2007) 'The lipoxin A4 receptor is coupled to SHP-2 activation; implications for regulating growth factor receptor signalling'. Journal of Biological Chemistry, . [Details]
Maderna P, Scannell M, Flanagan MB, deStefani A, Wynne KJ, Cagney G, Godson C, ; (2007) 'Annexin-1 and peptide derivatives are released by apoptotic cells and stimulate phagocytosis of apoptotic neutrophils by macrophages'. Immunology, 178 (7):4595-4605. [Details]
Guiry PJ, O'Sullivan TP, Vallin KS, Shah ST, Fakhry J, Maderna P, Scannell M, Sampaio AL, Perretti M, Godson C, ; (2007) 'Aromatic lipoxin A4 and lipoxin B4 analogues display potent biological activities'. Journal of medicinal chemistry, 24 (NA):5894-5902. [DOI] [Details]
Cummins, EP; Berra, E; Comerford, KM; Ginouves, A; Fitzgerald, KT; Seeballuck, F; Godson, C; Nielsen, JE; Moynagh, P; Pouyssegur, J; Taylor, CT; ; (2006) 'Prolyl hydroxylase-1 negatively regulates I kappa B kinase-beta, giving insight into hypoxia-induced NF kappa B activity'. Proceedings of the National Academy of Sciences of the United States of America, 103 (48):18154-18159. [Details]
Cummins, EP; Berra, E; Comerford, KM; Ginouves, A; Fitzgerald, KT; Seeballuck, F; Godson, C; Nielsen, JE; Moynagh, P; Pouyssegur, J; Taylor, CT; ; (2006) 'Prolyl hydroxylase-1 negatively regulates I kappa B kinase-beta, giving insight into hypoxia-induced NF kappa B activity'. Proceedings of the National Academy of Sciences of the United States of America, 103 (48):18154-18159. [Details]
Reville, K; Crean, JK; Vivers, S; Dransfield, I; Godson, C; ; (2006) 'Lipoxin A(4) redistributes myosin IIA and Cdc42 in macrophages: Implications for phagocytosis of apoptotic leukocytes'. Immunology, 176 (3):1878-1888. [Details]
Crean, JK; Furlong, F; Mitchell, D; McArdle, E; Godson, C; Martin, F; ; (2006) 'Connective tissue growth factor/CCN2 stimulates actin disassembly through Akt/protein kinase B-mediated phosphorylation and cytoplasmic translocation of p27(Kip-1)'. FASEB Journal, 20 (10). [Details]
Crean, JK; Furlong, F; Mitchell, D; McArdle, E; Godson, C; Martin, F; ; (2006) 'Connective tissue growth factor/CCN2 stimulates actin disassembly through Akt/protein kinase B-mediated phosphorylation and cytoplasmic translocation of p27(Kip-1)'. FASEB Journal, 20 (10). [Details]
Reville, K,Crean, JK,Vivers, S,Dransfield, I,Godson, C; (2006) 'Lipoxin A(4) redistributes myosin IIA and Cdc42 in macrophages: Implications for phagocytosis of apoptotic leukocytes'. J IMMUNOL, 176 :1878-1888. [Details]
Crean, JK,Furlong, F,Mitchell, D,McArdle, E,Godson, C,Martin, F; (2006) 'Connective tissue growth factor/CCN2 stimulates actin disassembly through Akt/protein kinase B-mediated phosphorylation and cytoplasmic translocation of p27(Kip-1)'. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 20 . [DOI] [Details]
Cummins, EP,Berra, E,Comerford, KM,Ginouves, A,Fitzgerald, KT,Seeballuck, F,Godson, C,Nielsen, JE,Moynagh, P,Pouyssegur, J,Taylor, CT; (2006) 'Prolyl hydroxylase-1 negatively regulates I kappa B kinase-beta, giving insight into hypoxia-induced NF kappa B activity'. Proceedings of the National Academy of Sciences of the United States of America, 103 :18154-18159. [DOI] [Details]
Crean, J.K., Furlong, F., Mitchell, D., McArdle E., Godson, C. and Martin, F.; (2006) 'Connective Tissue Growth Factor [CTGF]/CCN2 stimulates actin disassembly through Akt/protein kinase B (PKB) mediated phosphorylation and cytoplasmic translocation of p27Kip-1'. FASEB JOURNAL, 20 :1712-1714. [Details]
Cummins, EP; Berra, E; Comerford, KM; Ginouves, A; Fitzgerald, KT; Seeballuck, F; Godson, C; Nielsen, JE; Moynagh, P; Pouyssegur, J; Taylor, CT; ; (2006) 'Prolyl hydroxylase-1 negatively regulates I kappa B kinase-beta, giving insight into hypoxia-induced NF kappa B activity'. Proceedings of the National Academy of Sciences of the United States of America, 103 (48):18154-18159. [Details]
Crean, JK; Furlong, F; Mitchell, D; McArdle, E; Godson, C; Martin, F; ; (2006) 'Connective tissue growth factor/CCN2 stimulates actin disassembly through Akt/protein kinase B-mediated phosphorylation and cytoplasmic translocation of p27(Kip-1)'. FASEB Journal, 20 (10). [Details]
Martin F, Crean JK, Furlong F, Mitchell D, McArdle E, Godson C, ; (2006) 'Connective tissue growth factor/CCN2 stimulates actin disassembly through Akt/protein kinase B-mediated phosphorylation and cytoplasmic translocation of p27(Kip-1)'. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 10 (NA):1712-1714. [DOI] [Details]
Leonard, MO; Godson, C; Brady, HR; Taylor, CT; ; (2005) 'Potentiation of glucocorticoid activity in hypoxia through induction of the glucocorticoid receptor'. Immunology, 174 (4):2250-2257. [Details]
Kane, R,Stevenson, L,Godson, C,Stitt, AW,O'Brien, C; (2005) 'Gremlin gene expression in bovine retinal pericytes exposed to elevated glucose'. British Journal of Ophthalmology, 89 :1638-1642. [DOI] [Details]
Crean, JK; Furlong, F; O'Leary, R; Mc Ardle, E; Godson, C; Martin, F; ; (2005) 'CTGF induces actin disassembly in mesangial cells through PI3 kinase mediated phosphorylation and cytoplasmic translocation of p27/kip-1 on serine 10 and subsequent downregulation of RhoA activity'. FASEB Journal, 19 (4):814-814. [Details]
Dolan, V; Murphy, M; Sadlier, D; Lappin, D; Doran, P; Godson, C; Martin, F; O'Meara, Y; Schmid, H; Henger, A; Kretzler, M; Droguett, A; Mezzano, S; Brady, HR; ; (2005) 'Expression of gremlin, a bone morphogenetic protein antagonist, in human diabetic nephropathy'. American Journal of Kidney Diseases, 45 (6):1034-1039. [Details]
Dolan, V; Murphy, M; Sadlier, D; Lappin, D; Doran, P; Godson, C; Martin, F; O'Meara, Y; Schmid, H; Henger, A; Kretzler, M; Droguett, A; Mezzano, S; Brady, HR; ; (2005) 'Expression of gremlin, a bone morphogenetic protein antagonist, in human diabetic nephropathy'. American Journal of Kidney Diseases, 45 (6):1034-1039. [Details]
Dolan, V; Murphy, M; Sadlier, D; Lappin, D; Doran, P; Godson, C; Martin, F; O'Meara, Y; Schmid, H; Henger, A; Kretzler, M; Droguett, A; Mezzano, S; Brady, HR; ; (2005) 'Expression of gremlin, a bone morphogenetic protein antagonist, in human diabetic nephropathy'. American Journal of Kidney Diseases, 45 (6):1034-1039. [Details]
Kane, R; Stevenson, L; Godson, C; Stitt, AW; O'Brien, C; ; (2005) 'Gremlin gene expression in bovine retinal pericytes exposed to elevated glucose'. British Journal of Ophthalmology, 89 (12):1638-1642. [Details]
Browne, JG, Kane, R, Godson, C, Cotter, TG, O'Brien, CJ, ; (2005) 'Glucose induction of apoptosis in human retinal pericytes'. Investigative Ophthalmology &Amp; Visual Science, 46 (NA). [Details]
Sadlier, DM, Ouyang, X, McMahon, B, Mu, W, Ohashi, R, Rodgers, K, Murray, D, Nakagawa, T, Godson, C, Doran, P, Brady, HR, Johnson, RJ, ; (2005) 'Microarray and bioinformatic detection of novel and established genes expressed in experimental anti-Thy1 nephritis'. Kidney International, 68 (6):2542-2561. [Details]
Leonard, MO,Godson, C,Brady, HR,Taylor, CT; (2005) 'Potentiation of glucocorticoid activity in hypoxia through induction of the glucocorticoid receptor'. J IMMUNOL, 174 :2250-2257. [Details]
Maderna, P,Yona, S,Perretti, M,Godson, C; (2005) 'Modulation of phagocytosis of apoptotic neutrophils by supernatant from dexamethasone-treated macrophages and annexin-derived peptide AC(2-26)'. J IMMUNOL, 174 :3727-3733. [Details]
Dolan, V,Murphy, M,Sadlier, D,Lappin, D,Doran, P,Godson, C,Martin, F,O'Meara, Y,Schmid, H,Henger, A,Kretzler, M,Droguett, A,Mezzano, S,Brady, HR; (2005) 'Expression of gremlin, a bone morphogenetic protein antagonist, in human diabetic nephropathy'. American journal of kidney diseases : the official journal of the National Kidney Foundation, 45 :1034-1039. [DOI] [Details]
Rodgers, K,McMahon, B,Mitchell, D,Sadlier, D,Godson, C; (2005) 'Lipoxin A(4) modifies platelet-derived growth factor-induced profibrotic gene expression in human renal mesangial cells'. The Journal of pathology, 167 :683-694. [Details]
Sadlier, DM,Ouyang, X,McMahon, B,Mu, W,Ohashi, R,Rodgers, K,Murray, D,Nakagawa, T,Godson, C,Doran, P,Brady, HR,Johnson, RJ; (2005) 'Microarray and bioinformatic detection of novel and established genes expressed in experimental anti-Thy1 nephritis'. Kidney International, 68 :2542-2561. [Details]
Brady HR, Dolan V, Murphy M, Sadlier D, Lappin D, Doran P, Godson C, Martin F, O'Meara Y, Schmid H, Henger A, Kretzler M, Droguett A, Mezzano S, ; (2005) 'Expression of gremlin, a bone morphogenetic protein antagonist, in human diabetic nephropathy'. American journal of kidney diseases : the official journal of the National Kidney Foundation, 45 (6):1034-1039. [Details]
Sadlier, D. M.,Ouyang, X.,McMahon, B.,Mu, W.,Ohashi, R.,Rodgers, K.,Murray, D.,Nakagawa, T.,Godson, C.,Doran, P.,Brady, H. R.,Johnson, R. J.; (2005) 'Microarray and bioinformatic detection of novel and established genes expressed in experimental anti-Thy1 nephritis'. Kidney Int, 68 (6):2542-61. [Details]
Sadlier, D. M.Sadlier, D. M.,Ouyang, X.Ouyang, X.,McMahon, B.McMahon, B.,Mu, W.Mu, W.,Ohashi, R.Ohashi, R.,Rodgers, K.Rodgers, K.,Murray, D.Murray, D.,Nakagawa, T.Nakagawa, T.,Godson, C.Godson, C.,Doran, P.Doran, P.,Brady, H. R.Brady, H. R.,Johnson, R. J.Johnson, R. J.; (2005) 'Microarray and bioinformatic detection of novel and established genes expressed in experimental anti-Thy1 nephritis'. Kidney InternationalKidney InternationalKidney International, 68 (66):2542-25612542. [Details]
Brady HR, Dolan V, Murphy M, Sadlier D, Lappin D, Doran P, Godson C, Martin F, O'Meara Y, Schmid H, Henger A, Kretzler M, Droguett A, Mezzano S, ; (2005) 'Expression of gremlin, a bone morphogenetic protein antagonist, in human diabetic nephropathy'. American journal of kidney diseases : the official journal of the National Kidney Foundation, 45 (6):1034-1039. [Details]
Johnson RJ, Sadlier DM, Ouyang X, McMahon B, Mu W, Ohashi R, Rodgers K, Murray D, Nakagawa T, Godson C, Doran P, Brady HR, ; (2005) 'Microarray and bioinformatic detection of novel and established genes expressed in experimental anti-Thy1 nephritis'. Kidney International, 68 (6):2542-2561. [DOI] [Details]
Maderna P, Godson C.; (2005) 'Taking insult from injury: lipoxins and lipoxin receptor agonists and'. Prostaglandins, Leukotrienes & Essential Fatty Acids, 73 (3-4):179-187. [Details]
Brady HR, Dolan V, Murphy M, Sadlier D, Lappin D, Doran P, Godson C, Martin F, O'Meara Y, Schmid H, Henger A, Kretzler M, Droguett A, Mezzano S, ; (2005) 'Expression of gremlin, a bone morphogenetic protein antagonist, in human diabetic nephropathy'. American journal of kidney diseases : the official journal of the National Kidney Foundation, 6 (NA):1034-1039. [Details]
Sadlier, DM; Ouyang, X; McMahon, B; Mu, W; Ohashi, R; Rodgers, K; Murray, D; Nakagawa, T; Godson, C; Doran, P; Brady, HR; Johnson, RJ; ; (2005) 'Microarray and bioinformatic detection of novel and established genes expressed in experimental anti-Thy1 nephritis'. Kidney International, 68 (6):2542-2561. [Details]
Dolan, V.,Murphy, M.,Sadlier, D.,Lappin, D.,Doran, P.,Godson, C.,Martin, F.,O'Meara, Y.,Schmid, H.,Henger, A.,Kretzler, M.,Droguett, A.,Mezzano, S.,Brady, H. R.; (2005) 'Expression of gremlin, a bone morphogenetic protein antagonist, in human diabetic nephropathy'. Am J Kidney Dis, 45 (6):1034-9. [Details]
Maderna P, Yona S, Perretti M, Godson C. ; (2005) 'Modulation of phagocytosis of apoptotic neutrophils by supernatant from dexamethasone-treated macrophages and annexin-derived peptide Ac(2-26)'. Journal of Immunology, 174 (6):3727-3733. [Details]
Leonard, M. O.,Godson, C.,Brady, H. R.,Taylor, C. T.; (2005) 'Potentiation of glucocorticoid activity in hypoxia through induction of the glucocorticoid receptor'. J Immunol, 174 (4):2250-7. [Details]
Leonard MO, Godson C, Brady HR, Taylor CT; (2005) 'Potentiation of glucocorticoid activity in hypoxia through induction of the glucocorticoid receptor'. Journal of Immunology, 174 (4):2250-2257. [Details]
Crean, J. K.,Furlong, F.,Finlay, D.,Mitchell, D.,Murphy, M.,Conway, B.,Brady, H. R.,Godson, C.,Martin, F.; (2004) 'Connective tissue growth factor [CTGF]/CCN2 stimulates mesangial cell migration through integrated dissolution of focal adhesion complexes and activation of cell polarization'. Faseb J, 18 (13):1541-3. [Details]
Crean JK, Furlong F, Finlay D, Mitchell D, Conway B, Brady HR, Godson C, Martin F.; (2004) 'Connective tissue growth factor [CTGF]/CCN2 stimulates mesangial cell migration through integrated dissolution of focal adhesion complexes and activation of cell polarization'. FASEB JOURNAL, 18 . [Details]
Ohse, T,Ota, T,Kieran, N,Godson, C,Yamada, K,Tanaka, T,Fujita, T,Nangaku, M; (2004) 'Modulation of interferon-induced genes by lipoxin analogue in anti-glomerular basement membrane nephritis'. J AM SOC NEPHROL, 15 :919-927. [DOI] [Details]
Kieran, NE,Maderna, P,Godson, C; (2004) 'Lipoxins: Potential anti-inflammatory, proresolution, and antifibrotic mediators in renal disease'. Kidney International, 65 :1145-1154. [Details]
Mitchell, D,Rodgers, K,Hanly, J,McMahon, B,Brady, HR,Martin, F,Godson, C; (2004) 'Lipoxins inhibit Akt/PKB activation and cell cycle progression in human mesangial cells'. The Journal of pathology, 164 :937-946. [Details]
Crean, JK,Furlong, F,Finlay, D,Mitchell, D,Conway, B,Brady, HR,Godson, C,Martin, F; (2004) 'Connective tissue growth factor [CTGF]/CCN2 stimulates mesangial cell migration through integrated dissolution of focal adhesion complexes and activation of cell polarization'. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 18 . [DOI] [Details]
Mitchell, D; Rodgers, K; Hanly, J; McMahon, B; Brady, HR; Martin, F; Godson, C; ; (2004) 'Lipoxins inhibit Akt/PKB activation and cell cycle progression in human mesangial cells'. American Journal of Pathology, 164 (3):937-946. [Details]
Crean, JK; Furlong, F; Finlay, D; Mitchell, D; Conway, B; Brady, HR; Godson, C; Martin, F; ; (2004) 'Connective tissue growth factor [CTGF]/CCN2 stimulates mesangial cell migration through integrated dissolution of focal adhesion complexes and activation of cell polarization'. FASEB Journal, 18 (11). [Details]
Kieran N. Maderna P, Godson C. ; (2004) 'Lipoxins: potential anti-inflammatory, pro-resolution and anti-fibrotic mediators in renal disease'. Kidney International, 65 (4):1145-1154. [Details]
Mitchell, D.,Rodgers, K.,Hanly, J.,McMahon, B.,Brady, H. R.,Martin, F.,Godson, C.; (2004) 'Lipoxins inhibit Akt/PKB activation and cell cycle progression in human mesangial cells'. Am J Pathol, 164 (3):937-46. [Details]
Martin F, Crean JK, Furlong F, Finlay D, Mitchell D, Murphy M, Conway B, Brady HR, Godson C, ; (2004) 'Connective tissue growth factor [CTGF]/CCN2 stimulates mesangial cell migration through integrated dissolution of focal adhesion complexes and activation of cell polarization'. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 13 (NA):1541-1543. [DOI] [Details]
Gallagher, J.,Howlin, J.,McCarthy, C.,Murphy, E. P.,Bresnihan, B.,FitzGerald, O.,Godson, C.,Brady, H. R.,Martin, F.; (2003) 'Identification of Naf1/ABIN-1 among TNF-alpha-induced expressed genes in human synoviocytes using oligonucleotide microarrays'. FEBS Lett, 551 (1-3):8-12. [Details]
Goh, J.,Godson, C.,Brady, H. R.,Macmathuna, P.; (2003) 'Lipoxins: pro-resolution lipid mediators in intestinal inflammation'. Gastroenterology, 124 (4):1043-54. [Details]
Higgins, D. F.,Lappin, D. W.,Kieran, N. E.,Anders, H. J.,Watson, R. W.,Strutz, F.,Schlondorff, D.,Haase, V. H.,Fitzpatrick, J. M.,Godson, C.,Brady, H. R.; (2003) 'DNA oligonucleotide microarray technology identifies fisp-12 among other potential fibrogenic genes following murine unilateral ureteral obstruction (UUO): modulation during epithelial-mesenchymal transition'. Kidney Int, 64 (6):2079-91. [Details]
Kieran, N. E.,Doran, P. P.,Connolly, S. B.,Greenan, M. C.,Higgins, D. F.,Leonard, M.,Godson, C.,Taylor, C. T.,Henger, A.,Kretzler, M.,Burne, M. J.,Rabb, H.,Brady, H. R.; (2003) 'Modification of the transcriptomic response to renal ischemia/reperfusion injury by lipoxin analog'. Kidney Int, 64 (2):480-92. [Details]
Leonard, M. O.,Cottell, D. C.,Godson, C.,Brady, H. R.,Taylor, C. T.; (2003) 'The role of HIF-1 alpha in transcriptional regulation of the proximal tubular epithelial cell response to hypoxia'. J Biol Chem, 278 (41):40296-304. [Details]
Gallagher J, Howlin J, Mc Carthy C, Murphy E, Bresnihan B, FitzGerald O, Godson C, Brady HR and Finian Martin.; (2003) 'Identification of Naf1/ABIN-1 among TNF-alpha-induced expressed genes in human synoviocytes using oligonucleotide microarrays'. FEBS Letters, 551 :8-12. [Details]
Brady HR, Kieran NE, Doran PP, Connolly SB, Greenan MC, Higgins DF, Leonard M, Godson C, Taylor CT, Henger A, Kretzler M, Burne MJ, Rabb H, ; (2003) 'Modification of the transcriptomic response to renal ischemia/reperfusion injury by lipoxin analog'. Kidney International, 64 (2):480-492. [DOI] [Details]
Duffy, TN; Fearon, U; Godson, C; Brady, H; Bresnihan, B; Veale, D; FitzGerald, O; ; (2003) 'Profibrotic mRNA is preferentially expressed in bone forming arthritis'. Arthritis and Rheumatism, 48 (9):602-602. [Details]
Leonard MO, Cottell DC, Godson C, Brady HR, Taylor CT. ; (2003) 'The role of HIF-1 alpha in transcriptional regulation of the proximal tubular epithelial cell response to hypoxia'. Journal of Biological Chemistry, 278 (41):40298-40304. [Details]
Maderna P, Godson C.; (2003) 'Phagocytosis of apoptotic cells and the resolution of inflammation'. Biochimica Et Biophysica Acta, 1639 (3):141-151. [Details]
Gallagher, J,Howlin, J,McCarthy, C,Murphy, EP,Bresnihan, B,FitzGerald, O,Godson, C,Brady, HR,Martin, F; (2003) 'Identification of Naf1/ABIN-1 among TNF-alpha-induced expressed genes in human synoviocytes using oligonucleotide microarrays'. FEBS Letters, 551 (NA):8-12. [DOI] [Details]
Brady HR, Higgins DF, Lappin DW, Kieran NE, Anders HJ, Watson RW, Strutz F, Schlondorff D, Haase VH, Fitzpatrick JM, Godson C, ; (2003) 'DNA oligonucleotide microarray technology identifies fisp-12 among other potential fibrogenic genes following murine unilateral ureteral obstruction (UUO): modulation during epithelial-mesenchymal transition'. Kidney International, 64 (6):2079-2091. [DOI] [Details]
Kieran, NE; Doran, PP; Connolly, SB; Greenan, MC; Higgins, DF; Leonard, M; Godson, C; Taylor, CT; Henger, A; Kretzler, M; Burne, MJ; Rabb, H; Brady, HR; ; (2003) 'Modification of the transcriptomic response to renal ischemia/reperfusion injury by lipoxin analog'. Kidney International, 64 (2):480-492. [Details]
Duffy, TN; Fearon, U; Godson, C; Brady, H; Bresnihan, B; Veale, D; FitzGerald, O; ; (2003) 'Profibrotic mRNA is preferentially expressed in bone forming arthritis'. Arthritis and Rheumatism, 48 (9):602-602. [Details]
Kieran, NE; Doran, PP; Connolly, SB; Greenan, MC; Higgins, DF; Leonard, M; Godson, C; Taylor, CT; Henger, A; Kretzler, M; Burne, MJ; Rabb, H; Brady, HR; ; (2003) 'Modification of the transcriptomic response to renal ischemia/reperfusion injury by lipoxin analog'. Kidney International, 64 (2):480-492. [Details]
Leonard, MO; Godson, C; Brady, HR; Taylor, CT; ; (2003) 'Involvement of HIF-1 alpha in hypoxia mediated alterations in human proximal tubular epithelial cell transcription'. Journal of the American Society of Nephrology, 14 (NA):24-24. [Details]
Leonard, MO; Cottell, DC; Godson, C; Brady, HR; Taylor, CT; ; (2003) 'The role of HIF-1 alpha in transcriptional regulation of the proximal tubular epithelial cell response to hypoxia'. Journal of Biological Chemistry, 278 (41):40296-40304. [Details]
Murphy, M; Curtin, D; Dolan, V; Hensey, C; Kretzler, M; Schlondorff, D; Godson, C; Brady, HR; Martin, F; ; (2003) 'IHG-1 enhances TGF-beta-induced transcriptional activation and its expression is increased in diabetic nephropathy'. Journal of the American Society of Nephrology, 14 (NA):127-128. [Details]
Kieran, NE; Doran, PP; Connolly, SB; Greenan, MC; Higgins, DF; Leonard, M; Godson, C; Taylor, CT; Henger, A; Kretzler, M; Burne, MJ; Rabb, H; Brady, HR; ; (2003) 'Modification of the transcriptomic response to renal ischemia/reperfusion injury by lipoxin analog'. Kidney International, 64 (2):480-492. [Details]
Duffy, TN; Fearon, U; Godson, C; Brady, H; Bresnihan, B; Veale, D; FitzGerald, O; ; (2003) 'Profibrotic mRNA is preferentially expressed in bone forming arthritis'. Arthritis and Rheumatism, 48 (9):602-602. [Details]
Duffy, TN; Fearon, U; Godson, C; Brady, H; Bresnihan, B; Veale, D; FitzGerald, O; ; (2003) 'Profibrotic mRNA is preferentially expressed in bone forming arthritis'. Arthritis and Rheumatism, 48 (9):602-602. [Details]
Higgins, DF,Lappin, DWP,Kieran, NE,Anders, HJ,Watson, RWG,Strutz, F,Schlondorff, D,Haase, VH,Fitzpatrick, JM,Godson, C,Brady, HR; (2003) 'DNA oligonucleotide microarray technology identifies fisp-12 among other potential fibrogenic genes following murine unilateral ureteral obstruction (UUO): Modulation during epithelial-mesenchymal transition'. Kidney International, 64 :2079-2091. [Details]
Leonard, MO,Cottell, DC,Godson, C,Brady, HR,Taylor, CT; (2003) 'The role of HIF-1 alpha in transcriptional regulation of the proximal tubular epithelial cell response to hypoxia'. J BIOL CHEM, 278 :40296-40304. [DOI] [Details]
Kieran, NE,Doran, PP,Connolly, SB,Greenan, MC,Higgins, DF,Leonard, M,Godson, C,Taylor, CT,Henger, A,Kretzler, M,Burne, MJ,Rabb, H,Brady, HR; (2003) 'Modification of the transcriptomic response to renal ischemia/reperfusion injury by lipoxin analog'. Kidney International, 64 :480-492. [Details]
Crean, JKG; Finlay, D; Murphy, M; Moss, C; Godson, C; Martin, F; Brady, HR; ; (2002) 'The role of p42/44 MAPK and protein kinase B in connective tissue growth factor induced extracellular matrix protein production, cell migration, and actin cytoskeletal rearrangement in human mesangial cells'. Journal of Biological Chemistry, 277 (46):44187-44194. [Details]
Leonard, MO; Hannan, K; Burne, MJ; Lappin, DWP; Doran, P; Coleman, P; Stenson, C; Taylor, CT; Daniels, F; Godson, C; Petasis, NA; Rabb, H; Brady, HR; ; (2002) '15-Epi-16-(para-fluorophenoxy)-lipoxin A(4)-methyl ester, a synthetic analogue of 15-epi-lipoxin A(4), is protective in experimental ischemic acute renal failure'. Journal of the American Society of Nephrology, 13 (6). [Details]
Crean, JKG; Finlay, D; Martin, F; Godson, C; Brady, HR; ; (2002) 'The role of p42/44 MAPK and protein kinase B in connective tissue growth factor induced extracellular matrix protein production, cell migration and actin cytoskeletal rearrangement in human mesangial cells'. Journal of the American Society of Nephrology, 13 (NA):87-87. [Details]
Crean, JKG; Finlay, D; Murphy, M; Moss, C; Godson, C; Martin, F; Brady, HR; ; (2002) 'The role of p42/44 MAPK and protein kinase B in connective tissue growth factor induced extracellular matrix protein production, cell migration, and actin cytoskeletal rearrangement in human mesangial cells'. Journal of Biological Chemistry, 277 (46):44187-44194. [Details]
Lappin, DWP; Mullally, A; Kairaitis, L; Wang, YP; Godson, C; Harris, DCH; Brady, HR; Doran, PP; ; (2002) 'Temporal patterns of gene expression in adriamycin-induced nephrosis'. Journal of the American Society of Nephrology, 13 (NA):117-117. [Details]
Kieran, NE; Connolly, SB; Greenan, MC; Higgins, D; Burne, MJ; Godson, C; Doran, PP; Rabb, H; Brady, HR; ; (2002) 'The transcriptomic response to renal ischemia-reperfusion injury and its modification by lipoxin A4 analogue FphO-15-RLXA4-Me'. Journal of the American Society of Nephrology, 13 (NA):120-120. [Details]
Lappin, DWP; Doran, P; Godson, C; Brady, HR; ; (2002) 'Gene responses to hyperglycaemia'. Experimental Nephrology, 10 (2):120-129. [Details]
Higgins, DF; Lappin, DWP; Isaka, Y; Watson, RW; Godson, C; Imai, E; Fitzpatrick, JM; Brady, HR; ; (2002) 'Transcriptomic responses underpinning renal tubulointerstitial fibrosis as identified by DNA oligonucleotide microarray technology'. Journal of the American Society of Nephrology, 13 (NA):560-560. [Details]
Leonard, M. O.,Hannan, K.,Burne, M. J.,Lappin, D. W.,Doran, P.,Coleman, P.,Stenson, C.,Taylor, C. T.,Daniels, F.,Godson, C.,Petasis, N. A.,Rabb, H.,Brady, H. R.; (2002) '15-Epi-16-(para-fluorophenoxy)-lipoxin A(4)-methyl ester, a synthetic analogue of 15-epi-lipoxin A(4), is protective in experimental ischemic acute renal failure'. J Am Soc Nephrol, 13 (6):1657-62. [Details]
Clarkson, M. R.,Murphy, M.,Gupta, S.,Lambe, T.,Mackenzie, H. S.,Godson, C.,Martin, F.,Brady, H. R.; (2002) 'High glucose-altered gene expression in mesangial cells. Actin-regulatory protein gene expression is triggered by oxidative stress and cytoskeletal disassembly'. J Biol Chem, 277 (12):9707-12. [Details]
Clarkson, M., Murphy, M., Gupta, S., Mackenzie, H.S., Godson, C., Martin F., Brady, H.R. ; (2002) 'High glucose-altered gene expression in mesangial cells. Actin-regulatory protein gene expression is triggered by oxidative stress and cytoskeletal disassembly'. Journal of Biological Chemistry, 277 (12):9707-9712. [Details]
Leonard MO, Hannan K, Burne MJ, Lappin DW, Doran P, Coleman P, Stenson C, Taylor CT, Daniels F, Godson C, Petasis NA, Rabb H, Brady HR.; (2002) '15-Epi-16-(para-fluorophenoxy)-lipoxin A(4)-methyl ester, a synthetic analogue of 15-epi-lipoxin A(4), is protective in experimental ischemic acute renal failure'. Journal of the American Society of Nephrology, 13 (6):1657-1662. [Details]
Clarkson, MR, Murphy, M, Gupta, S, Lambe, T, Mackenzie, HS, Godson, C, Martin, F, Brady, HR, ; (2002) 'High glucose-altered gene expression in mesangial cells - Actin-regulatory protein gene expression is triggered by oxidative stress and cytoskeletal disassembly'. J BIOL CHEM, 277 (12):9707-9712. [Details]
Brady HR, Crean JK, Finlay D, Murphy M, Moss C, Godson C, Martin F, ; (2002) 'The role of p42/44 MAPK and protein kinase B in connective tissue growth factor induced extracellular matrix protein production, cell migration, and actin cytoskeletal rearrangement in human mesangial cells'. J BIOL CHEM, 46 (NA):44187-44194. [DOI] [Details]
Maderna, P, Cottell, DC, Berlasconi, G, Petasis, NA, Brady, HR, Godson, C, ; (2002) 'Lipoxins induce actin reorganization in monocytes and macrophages but not in neutrophils - Differential involvement of Rho GTPases'. American Journal of Pathology, 160 (6):2275-2283. [Details]
Godson C, McMahon B, Mitchell D, Shattock R, Martin F, Brady HR, ; (2002) 'Lipoxin, leukotriene, and PDGF receptors cross-talk to regulate mesangial cell proliferation'. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 13 (NA):1817-1819. [DOI] [Details]
McMahon, B.,Mitchell, D.,Shattock, R.,Martin, F.,Brady, H. R.,Godson, C.; (2002) 'Lipoxin, leukotriene, and PDGF receptors cross-talk to regulate mesangial cell proliferation'. Faseb J, 16 (13):1817-9. [Details]
Crean, J. K.,Finlay, D.,Murphy, M.,Moss, C.,Godson, C.,Martin, F.,Brady, H. R.; (2002) 'The role of p42/44 MAPK and protein kinase B in connective tissue growth factor induced extracellular matrix protein production, cell migration, and actin cytoskeletal rearrangement in human mesangial cells'. J Biol Chem, 277 (46):44187-94. [Details]
Crean JK, Finlay D, Murphy M, Moss C, Godson C, Martin F, Brady HR; (2002) 'The role of p42/44 MAPK and protein kinase B in connective tissue growth factor induced extracellular matrix protein production, cell migration, and actin cytoskeletal rearrangement in human mesangial cells'. Journal of Biological Chemistry, 27 (46):44187-44194. [Details]
Maderna P, Cottell DC, Berlasconi G, Petasis NA, Brady HR, Godson C.; (2002) 'Lipoxins induce actin reorganization in monocytes and macrophages but not in neutrophils: differential involvement of rho GTPases'. American Journal of Pathology, 160 (6):2275-2283. [Details]
Stenson, C.,Mitchell, S.,Lappin, D.,Brady, H. R.,Godson, C.; (2002) 'Biphasic regulation of leukocyte trafficking by lipoxins'. Adv Exp Med Biol, 507 :543-9. [Details]
Mitchell, S.,Thomas, G.,Harvey, K.,Cottell, D.,Reville, K.,Berlasconi, G.,Petasis, N. A.,Erwig, L.,Rees, A. J.,Savill, J.,Brady, H. R.,Godson, C.; (2002) 'Lipoxins, aspirin-triggered epi-lipoxins, lipoxin stable analogues, and the resolution of inflammation: stimulation of macrophage phagocytosis of apoptotic neutrophils in vivo'. J Am Soc Nephrol, 13 (10):2497-507. [Details]
Lappin, D. W.,Doran, P.,Godson, C.,Brady, H. R.; (2002) 'Gene responses to hyperglycaemia'. Exp Nephrol, 10 (2):120-9. [Details]
Maderna, P.,Cottell, D. C.,Berlasconi, G.,Petasis, N. A.,Brady, H. R.,Godson, C.; (2002) 'Lipoxins induce actin reorganization in monocytes and macrophages but not in neutrophils: differential involvement of rho GTPases'. Am J Pathol, 160 (6):2275-83. [Details]
Kieran, NE; Connolly, SB; Greenan, MC; Higgins, D; Burne, MJ; Godson, C; Doran, PP; Rabb, H; Brady, HR; ; (2002) 'The transcriptomic response to renal ischemia-reperfusion injury and its modification by lipoxin A4 analogue FphO-15-RLXA4-Me'. Journal of the American Society of Nephrology, 13 (NA):120-120. [Details]
McMahon, B,Mitchell, D,Shattock, R,Martin, F,Brady, HR,Godson, C; (2002) 'Lipoxin, leukotriene, and PDGF receptors cross-talk to regulate mesangial cell proliferation'. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 16 . [DOI] [Details]
Crean, JKG,Finlay, D,Murphy, M,Moss, C,Godson, C,Martin, F,Brady, HR; (2002) 'The role of p42/44 MAPK and protein kinase B in connective tissue growth factor induced extracellular matrix protein production, cell migration, and actin cytoskeletal rearrangement in human mesangial cells'. J BIOL CHEM, 277 :44187-44194. [DOI] [Details]
Leonard, MO; Hannan, K; Burne, MJ; Lappin, DWP; Doran, P; Coleman, P; Stenson, C; Taylor, CT; Daniels, F; Godson, C; Petasis, NA; Rabb, H; Brady, HR; ; (2002) '15-Epi-16-(para-fluorophenoxy)-lipoxin A(4)-methyl ester, a synthetic analogue of 15-epi-lipoxin A(4), is protective in experimental ischemic acute renal failure'. Journal of the American Society of Nephrology, 13 (6). [Details]
Maderna, P,Cottell, DC,Berlasconi, G,Petasis, NA,Brady, HR,Godson, C; (2002) 'Lipoxins induce actin reorganization in monocytes and macrophages but not in neutrophils - Differential involvement of Rho GTPases'. The Journal of pathology, 160 :2275-2283. [Details]
Leonard, MO,Hannan, K,Burne, MJ,Lappin, DWP,Doran, P,Coleman, P,Stenson, C,Taylor, CT,Daniels, F,Godson, C,Petasis, NA,Rabb, H,Brady, HR; (2002) '15-Epi-16-(para-fluorophenoxy)-lipoxin A(4)-methyl ester, a synthetic analogue of 15-epi-lipoxin A(4), is protective in experimental ischemic acute renal failure'. J AM SOC NEPHROL, 13 . [DOI] [Details]
Clarkson, MR,Murphy, M,Gupta, S,Lambe, T,Mackenzie, HS,Godson, C,Martin, F,Brady, HR; (2002) 'High glucose-altered gene expression in mesangial cells - Actin-regulatory protein gene expression is triggered by oxidative stress and cytoskeletal disassembly'. J BIOL CHEM, 277 :9707-9712. [DOI] [Details]
Higgins, DF; Lappin, DWP; Isaka, Y; Watson, RW; Godson, C; Imai, E; Fitzpatrick, JM; Brady, HR; ; (2002) 'Transcriptomic responses underpinning renal tubulointerstitial fibrosis as identified by DNA oligonucleotide microarray technology'. Journal of the American Society of Nephrology, 13 (NA):560-560. [Details]
Mitchell, S,Thomas, G,Harvey, K,Cottell, D,Reville, K,Berlasconi, G,Petasis, NA,Erwig, L,Rees, AJ,Savill, J,Brady, HR,Godson, C; (2002) 'Lipoxins, aspirin-triggered epi-lipoxins, lipoxin stable analogues, and the resolution of inflammation: Stimulation of macrophage phagocytosis of apoptotic neutrophils in vivo'. J AM SOC NEPHROL, 13 :2497-2507. [DOI] [Details]
Crean JK, Lappin D, Godson C, Brady HR; (2001) 'Connective tissue growth factor: an attractive therapeutic target in fibrotic renal disease'. Expert Opin. Ther. Targets, 5 (4):519-530. [Details]
Goh, J., Baird, A.W., O'Keane, C., Watson, R.W., Cottell, D., Bernasconi, G., Petasis, N.A., Godson, C., Brady H.R., and MacMathuna; (2001) 'Lipoxin A(4) and aspirin-triggered 15-epi-lipoxin A(4) antagonize TNF-alpha-stimulated neutrophil-enterocyte interactions in vitro and attenuate TNF-alpha-induced chemokine release and colonocyte apoptosis in human intestinal mucosa ex vivo'. Immunology, 167 :2772-2780. [Details]
Goh, J.,Baird, A. W.,O'Keane, C.,Watson, R. W.,Cottell, D.,Bernasconi, G.,Petasis, N. A.,Godson, C.,Brady, H. R.,MacMathuna, P.; (2001) 'Lipoxin A(4) and aspirin-triggered 15-epi-lipoxin A(4) antagonize TNF-alpha-stimulated neutrophil-enterocyte interactions in vitro and attenuate TNF-alpha-induced chemokine release and colonocyte apoptosis in human intestinal mucosa ex vivo'. J Immunol, 167 (5):2772-80. [Details]
McMahon, B,Mitchell, S,Brady, HR,Godson, C; (2001) 'Lipoxins: revelations on resolution'. Trends in Pharmacological Sciences, 22 :391-395. [Details]
McMahon, R; Murphy, M; Gardiner, C; Godson, C; Martin, F; Brady, HR; ; (2001) 'Gremlin inhibits DNA synthesis and proliferation in human mesangial cells by a BMP independent mechanism'. British Journal of Pharmacology, 134 (NA). [Details]
McMahon, R; Murphy, M; Gardiner, C; Godson, C; Martin, F; Brady, HR; ; (2001) 'Gremlin inhibits DNA synthesis and proliferation in human mesangial cells by a BMP independent mechanism'. British Journal of Pharmacology, 134 (NA). [Details]
Goh, J,Baird, AW,O'Keane, C,Watson, RWG,Cottell, D,Bernasconi, G,Petasis, NA,Godson, C,Brady, HR,MacMathuna, P; (2001) 'Lipoxin A(4) and aspirin-triggered 15-epi-lipoxin A(4) antagonize TNF-alpha-stimulated neutrophil-enterocyte interactions in vitro and attenuate TNF-alpha-induced chemokine release and colonocyte apoptosis in human intestinal mucosa ex vivo'. J IMMUNOL, 167 :2772-2780. [Details]
Goh, J; Baird, AW; O'Keane, C; Watson, RWG; Cottell, D; Bernasconi, G; Petasis, NA; Godson, C; Brady, HR; MacMathuna, P; ; (2001) 'Lipoxin A(4) and aspirin-triggered 15-epi-lipoxin A(4) antagonize TNF-alpha-stimulated neutrophil-enterocyte interactions in vitro and attenuate TNF-alpha-induced chemokine release and colonocyte apoptosis in human intestinal mucosa ex vivo'. Immunology, 167 (5):2772-2780. [Details]
Goh, J; Baird, AW; O'Keane, C; Watson, RWG; Cottell, D; Bernasconi, G; Petasis, NA; Godson, C; Brady, HR; MacMathuna, P; ; (2001) 'Lipoxin A(4) and aspirin-triggered 15-epi-lipoxin A(4) antagonize TNF-alpha-stimulated neutrophil-enterocyte interactions in vitro and attenuate TNF-alpha-induced chemokine release and colonocyte apoptosis in human intestinal mucosa ex vivo'. Immunology, 167 (5):2772-2780. [Details]
Freeman JE., Godson C., and Kinsella, BT.; (2001) 'An investigation of thromboxane A2 and lipoxin A4 signalling in primary human mesangial cells'. BRITISH JOURNAL OF PHARMACOLOGY, . [Details]
Crean, J. K.,Lappin, D.,Godson, C.,Brady, H. R.; (2001) 'Connective tissue growth factor: an attractive therapeutic target in fibrotic renal disease'. Expert Opin Ther Targets, 5 (4):519-530. [Details]
McMahon, B.,Mitchell, S.,Brady, H. R.,Godson, C.; (2001) 'Lipoxins: revelations on resolution'. Trends Pharmacol Sci, 22 (8):391-5. [Details]
Freeman JE, Godson C & Kinsella BT.; (2001) 'An investigation into thromboxane A2 and lipoxin A4 signalling in primary human mesangial cells'. British Journal of Pharmacology, 134 . [Details]
Maderna P, Godson C, Hannify G, Murphy M, Brady HR.; (2000) 'Influence of lipoxin A(4) and other lipoxygenase-derived eicosanoids on tissue factor expression'. American Journal of Physiology and Cell Physiology, 279 (4):c945-c953. [Details]
Godson, C.,Mitchell, S.,Harvey, K.,Petasis, N. A.,Hogg, N.,Brady, H. R.; (2000) 'Cutting edge: lipoxins rapidly stimulate nonphlogistic phagocytosis of apoptotic neutrophils by monocyte-derived macrophages'. J Immunol, 164 (4):1663-7. [Details]
Lappin, D. W.,Hensey, C.,McMahon, R.,Godson, C.,Brady, H. R.; (2000) 'Gremlins, glomeruli and diabetic nephropathy'. Curr Opin Nephrol Hypertens, 9 (5):469-72. [Details]
Godson, C.,Brady, H. R.; (2000) 'Lipoxins: novel anti-inflammatory therapeutics?'. Curr Opin Investig Drugs, 1 (3):380-5. [Details]
McMahon, B.,Stenson, C.,McPhillips, F.,Fanning, A.,Brady, H. R.,Godson, C.; (2000) 'Lipoxin A4 antagonizes the mitogenic effects of leukotriene D4 in human renal mesangial cells. Differential activation of MAP kinases through distinct receptors'. J Biol Chem, 275 (36):27566-75. [Details]
McMahon, R.,Murphy, M.,Clarkson, M.,Taal, M.,Mackenzie, H. S.,Godson, C.,Martin, F.,Brady, H. R.; (2000) 'IHG-2, a mesangial cell gene induced by high glucose, is human gremlin. Regulation by extracellular glucose concentration, cyclic mechanical strain, and transforming growth factor-beta1'. J Biol Chem, 275 (14):9901-4. [Details]
Maderna, P.,Godson, C.,Hannify, G.,Murphy, M.,Brady, H. R.; (2000) 'Influence of lipoxin A(4) and other lipoxygenase-derived eicosanoids on tissue factor expression'. Am J Physiol Cell Physiol, 279 (4):C945-53. [Details]
Brady HR, McMahon R, Murphy M, Clarkson M, Taal M, Mackenzie HS, Godson C, Martin F, ; (2000) 'IHG-2, a mesangial cell gene induced by high glucose, is human gremlin. Regulation by extracellular glucose concentration, cyclic mechanical strain, and transforming growth factor-beta1'. J BIOL CHEM, 14 (NA):9901-9904. [Details]
Godson, C, Mitchell, S, Harvey, K, Petasis, NA, Hogg, N, Brady, HR, ; (2000) 'Cutting edge: Lipoxins rapidly stimulate nonphlogistic phagocytosis of apoptotic neutrophils by monocyte-derived macrophages'. J IMMUNOL, 164 (4):1663-1667. [Details]
Maderna, P; Godson, C; Hannify, G; Murphy, M; Brady, HR; ; (2000) 'Influence of lipoxin A(4) and other lipoxygenase-derived eicosanoids on tissue factor expression'. American Journal of Physiology-Cell Physiology, 279 (4):945-953. [Details]
McMahon, R,Murphy, M,Clarkson, M,Taal, M,Mackenzie, HS,Godson, C,Martin, F,Brady, HR; (2000) 'IHG-2, a mesangial cell gene induced by high glucose, is human gremlin - Regulation by extracellular glucose concentration, cyclic mechanical strain, and transforming growth factor-beta 1'. J BIOL CHEM, 275 :9901-9904. [Details]
McMahon, B,Stenson, C,McPhillips, F,Fanning, A,Brady, HR,Godson, C; (2000) 'Lipoxin A(4) antagonizes the mitogenic effects of leukotriene D-4 in human renal mesangial cells - Differential activation of MAP kinases through distinct receptors'. J BIOL CHEM, 275 :27566-27575. [Details]
Maderna, P,Godson, C,Hannify, G,Murphy, M,Brady, HR; (2000) 'Influence of lipoxin A(4) and other lipoxygenase-derived eicosanoids on tissue factor expression'. Cell, 279 :945-953. [Details]
Lappin, DWP; Hensey, C; McMahon, R; Godson, C; Brady, HR; ; (2000) 'Gremlins, glomeruli and diabetic nephropathy'. Current Opinion in Nephrology and Hypertension, 9 (5):469-472. [Details]
Goh, J; Baird, AW; Watson, WR; Godson, C; O'Keane, C; Brady, HR; MacMathuna, P; ; (2000) 'Lipoxins attenuate TNF-A-induced apoptosis in human colonic mucosa'. Gastroenterology, 118 (4):806-806. [Details]
McMahon, R; Murphy, M; Clarkson, M; Taal, M; Mackenzie, HS; Godson, C; Martin, F; Brady, HR; ; (2000) 'IHG-2, a mesangial cell gene induced by high glucose, is human gremlin - Regulation by extracellular glucose concentration, cyclic mechanical strain, and transforming growth factor-beta 1'. Journal of Biological Chemistry, 275 (14):9901-9904. [Details]
McMahon, R; Murphy, M; Clarkson, M; Taal, M; Mackenzie, HS; Godson, C; Martin, F; Brady, HR; ; (2000) 'IHG-2, a mesangial cell gene induced by high glucose, is human gremlin - Regulation by extracellular glucose concentration, cyclic mechanical strain, and transforming growth factor-beta 1'. Journal of Biological Chemistry, 275 (14):9901-9904. [Details]
Murphy, M,Godson, C,Cannon, S,Kato, S,Mackenzie, HS,Martin, F,Brady, HR; (1999) 'Suppression subtractive hybridization identifies high glucose levels as a stimulus for expression of connective tissue growth factor and other genes in human mesangial cells'. J BIOL CHEM, 274 :5830-5834. [Details]
Maderna, P,Coleman, P,Godson, C,O'Meara, YM,Brady, HR; (1999) 'Serum from hemodialysis patients inhibits basal and cytokine-stimulated tissue factor expression in vitro'. J AM SOC NEPHROL, 10 :2403-2406. [Details]
Maher, LJ; Skelly, MM; Godson, C; Brady, HR; Baird, AW; ; (1999) 'Lipoxin A(4) inhibits mast cell stimulation in rat colon in vitro'. Gastroenterology, 116 (4):905-905. [Details]
Murphy, M.,Godson, C.,Cannon, S.,Kato, S.,Mackenzie, H. S.,Martin, F.,Brady, H. R.; (1999) 'Suppression subtractive hybridization identifies high glucose levels as a stimulus for expression of connective tissue growth factor and other genes in human mesangial cells'. J Biol Chem, 274 (9):5830-4. [Details]
Diamond, P.,McGinty, A.,Sugrue, D.,Brady, H. R.,Godson, C.; (1999) 'Regulation of leukocyte trafficking by lipoxins'. Clin Chem Lab Med, 37 (3):293-7. [Details]
Maderna, P.,Coleman, P.,Godson, C.,O'Meara, Y. M.,Brady, H. R.; (1999) 'Serum from hemodialysis patients inhibits basal and cytokine-stimulated tissue factor expression in vitro'. J Am Soc Nephrol, 10 (11):2403-6. [Details]
Clarkson, M. R.,Gupta, S.,Murphy, M.,Martin, F.,Godson, C.,Brady, H. R.; (1999) 'Connective tissue growth factor: a potential stimulus for glomerulosclerosis and tubulointerstitial fibrosis in progressive renal disease'. Curr Opin Nephrol Hypertens, 8 (5):543-8. [Details]
Maderna P, Coleman P, Godson C, O'Meara YM, Brady HR.; (1999) 'Serum from hemodialysis patients inhibits basal and cytokine-stimulated tissue factor expression in vitro'. Journal of the American Society of Nephrology, 10 (11):2403-2406. [Details]
Murphy, M., Godson, C., Cannon, S., Kato, S., Mackenzie, H.S., Martin, F., Brady, H.R. ; (1999) 'Suppression subtraction hybridization identifies high glucose levels as a stimulus for expression of connective tissue growth factor and other genes in human mesangial cells'. Journal of Biological Chemistry, 274 :5830-5834. [Details]
Brady HR, Maderna P, Coleman P, Godson C, O'Meara YM, ; (1999) 'Serum from hemodialysis patients inhibits basal and cytokine-stimulated tissue factor expression in vitro'. Journal of the American Society of Nephrology, 10 (11):2403-2406. [Details]
Brady HR, Murphy M, Godson C, Cannon S, Kato S, Mackenzie HS, Martin F, ; (1999) 'Suppression subtractive hybridization identifies high glucose levels as a stimulus for expression of connective tissue growth factor and other genes in human mesangial cells'. J BIOL CHEM, 9 (NA):5830-5834. [Details]
Murphy, M; Godson, C; Cannon, S; Martin, F; Brady, HR; ; (1999) 'Connective tissue growth factor expression in human mesangial cells exposed to high glucose'. FASEB Journal, 13 (4):37-37. [Details]
Bosio, PM; Cannon, S; Godson, C; McKenna, PJ; O'Herlihy, C; Conroy, R; McCann, H; Sugrue, D; Brady, HR; ; (1999) 'Hyperdynamic circulation and elevated plasma levels of soluble p-selectin precede the development of peripheral vasoconstriction and hypertension in women destined to develop pre-eclampsia'. Kidney International, 55 (6):2581-2581. [Details]
Clarkson, MR; Gupta, S; Murphy, M; Martin, F; Godson, C; Brady, HR; ; (1999) 'Connective tissue growth factor: a potential stimulus for glomerulosclerosis and tubulointerstitial fibrosis in progressive renal disease'. Current Opinion in Nephrology and Hypertension, 8 (5):543-548. [Details]
Murphy, M; Godson, C; Cannon, S; Martin, F; Brady, HR; ; (1999) 'Connective tissue growth factor expression in human mesangial cells exposed to high glucose'. Kidney International, 55 (6):2585-2585. [Details]
Murphy, M; Godson, C; Martin, F; Brady, HR; ; (1999) 'Gene expression in cultured human mesangial cells in response to extracellular glucose as assessed by suppressive subtractive hybridization'. Kidney International, 55 (6):2585-2585. [Details]
Clarkson, MR; Gupta, S; Murphy, M; Martin, F; Godson, C; Brady, HR; ; (1999) 'Connective tissue growth factor: a potential stimulus for glomerulosclerosis and tubulointerstitial fibrosis in progressive renal disease'. Current Opinion in Nephrology and Hypertension, 8 (5):543-548. [Details]
Clarkson, M. R.,McGinty, A.,Godson, C.,Brady, H. R.; (1998) 'Leukotrienes and lipoxins: lipoxygenase-derived modulators of leukocyte recruitment and vascular tone in glomerulonephritis'. Nephrol Dial Transplant, 13 (12):3043-51. [Details]
Clarkson, MR,McGinty, A,Godson, C,Brady, HR; (1998) 'Leukotrienes and lipoxins: lipoxygenase-derived modulators of leukocyte recruitment and vascular tone in glomerulonephritis'. Nephrology Dialysis Transplantation, 13 :3043-3051. [Details]
Godson, C.,Ryan, M. P.,Brady, H. R.,Bourke, S.,FitzGerald, M. X.; (1988) 'Acute hypomagnesaemia complicating the treatment of meconium ileus equivalent in cystic fibrosis'. Scand J Gastroenterol Suppl, 143 :148-50. [Details]
Godson, C.,Ryan, M. P.,O'Halloran, D.,Bourke, S.,Brady, H. R.,FitzGerald, M. X.; (1988) 'Investigation of aminoglycoside nephrotoxicity in cystic fibrosis patients'. Scand J Gastroenterol Suppl, 143 :70-3. [Details]
GODSON, C, RYAN, MP, BRAYDEN, D, BRADY, HB, FITZGERALD, MX, ; (1986) 'INVESTIGATION OF MAGNESIUM STATUS IN PATIENTS WITH CYSTIC-FIBROSIS'. Irish Journal of Medical Science, 155 (4):133-134. [Details]
GODSON, C, BRAYDEN, D, BRADY, HR, WALLEY, T, FITZGERALD, MX, RYAN, MP, ; (1985) 'PREVALENCE AND CAUSES OF MAGNESIUM-DEFICIENCY IN AMBULATORY AND HOSPITALIZED-PATIENTS WITH CYSTIC-FIBROSIS'. Journal of The American College of Nutrition, 4 (3):370-370. [Details]
Mitchell, D. O'Meara,S. Gaffney,A. Crean, JKG Kinsella, BT and Godson C ; (2007) 'The lipoxin A4 receptor is coupled to SHP-2 activation; implications for regulation of receptor tyrosine kinases'. Journal of Biological Chemistry, 282 (21):15606-15618. [Details]
Kieran NE Maderna P and Godson C. ; (2004) 'Lipoxins: potential anti-inflammatory, proresolution, and antifibrotic mediators in renal disease'. Kidney International, 65 (4):1145-1154. [Details]
Clarkson, MR; McGinty, A; Godson, C; Brady, HR; ; (1998) 'Leukotrienes and lipoxins: lipoxygenase-derived modulators of leukocyte recruitment and vascular tone in glomerulonephritis'. Nephrology Dialysis Transplantation, 13 (12):3043-3051. [Details]
Murphy, M; McGinty, A; Godson, C; ; (1998) 'Protein kinases C: potential targets for intervention in diabetic nephropathy'. Current Opinion in Nephrology and Hypertension, 7 (5):563-570. [Details]
Reville, K; Crean, JK; Vivers, S; Dransfield, I; Godson, C; ; (2006) 'Lipoxin A(4) redistributes myosin IIA and Cdc42 in macrophages: Implications for phagocytosis of apoptotic leukocytes'. Immunology, 176 (3):1878-1888. [Details]
Cummins, EP; Berra, E; Comerford, KM; Ginouves, A; Fitzgerald, KT; Seeballuck, F; Godson, C; Nielsen, JE; Moynagh, P; Pouyssegur, J; Taylor, CT; ; (2006) 'Prolyl hydroxylase-1 negatively regulates I kappa B kinase-beta, giving insight into hypoxia-induced NF kappa B activity'. Proceedings of the National Academy of Sciences of the United States of America, 103 (48):18154-18159. [Details]
Rodgers, K; Mitchell, D; O'Meara, S; Godson, C; ; (2006) 'Lipoxins: Potential anti-fibtrotic agents in models of inflammation'. Prostaglandins &Amp; Other Lipid Mediators, 79 (1-2):168-168. [Details]
Kane, R; Stevenson, L; Godson, C; Stitt, AW; O'Brien, C; ; (2005) 'Gremlin gene expression in bovine retinal pericytes exposed to elevated glucose'. British Journal of Ophthalmology, 89 (12):1638-1642. [Details]
Dolan, V; Murphy, M; Sadlier, D; Lappin, D; Doran, P; Godson, C; Martin, F; O'Meara, Y; Schmid, H; Henger, A; Kretzler, M; Droguett, A; Mezzano, S; Brady, HR; ; (2005) 'Expression of gremlin, a bone morphogenetic protein antagonist, in human diabetic nephropathy'. American Journal of Kidney Diseases, 45 (6):1034-1039. [Details]
Maderna, P; Yona, S; Perretti, M; Godson, C; ; (2005) 'Modulation of phagocytosis of apoptotic neutrophils by supernatant from dexamethasone-treated macrophages and annexin-derived peptide AC(2-26)'. Immunology, 174 (6):3727-3733. [Details]
Leonard, MO; Godson, C; Brady, HR; Taylor, CT; ; (2005) 'Potentiation of glucocorticoid activity in hypoxia through induction of the glucocorticoid receptor'. Immunology, 174 (4):2250-2257. [Details]
Rodgers, K; McMahon, B; Mitchell, D; Sadlier, D; Godson, C; ; (2005) 'Lipoxin A(4) modifies platelet-derived growth factor-induced profibrotic gene expression in human renal mesangial cells'. American Journal of Pathology, 167 (3):683-694. [Details]
Browne, JG; Kane, R; Godson, C; Cotter, TG; O'Brien, CJ; ; (2005) 'Glucose induction of apoptosis in human retinal pericytes'. Investigative Ophthalmology &Amp; Visual Science, 46 (NA). [Details]
Sadlier, DM; Ouyang, X; McMahon, B; Mu, W; Ohashi, R; Rodgers, K; Murray, D; Nakagawa, T; Godson, C; Doran, P; Brady, HR; Johnson, RJ; ; (2005) 'Microarray and bioinformatic detection of novel and established genes expressed in experimental anti-Thy1 nephritis'. Kidney International, 68 (6):2542-2561. [Details]
Crean, JK; Furlong, F; O'Leary, R; Mc Ardle, E; Godson, C; Martin, F; ; (2005) 'CTGF induces actin disassembly in mesangial cells through PI3 kinase mediated phosphorylation and cytoplasmic translocation of p27/kip-1 on serine 10 and subsequent downregulation of RhoA activity'. FASEB Journal, 19 (4):814-814. [Details]
Maderna, P; Godson, C; ; (2005) 'Taking insult from injury: Lipoxins and lipoxin receptor agonists and phagocytosis of apoptotic cells'. Prostaglandins Leukotrienes and Essential Fatty Acids, 73 (3-4):179-187. [Details]
McMahon, B; Godson, C; ; (2004) 'Lipoxins: endogenous regulators of inflammation'. American Journal of Physiology-Renal Physiology, 286 (2):189-201. [Details]
Crean, JK; Furlong, F; Finlay, D; Mitchell, D; Conway, B; Brady, HR; Godson, C; Martin, F; ; (2004) 'Connective tissue growth factor [CTGF]/CCN2 stimulates mesangial cell migration through integrated dissolution of focal adhesion complexes and activation of cell polarization'. FASEB Journal, 18 (11). [Details]
Mitchell, D; Rodgers, K; Hanly, J; McMahon, B; Brady, HR; Martin, F; Godson, C; ; (2004) 'Lipoxins inhibit Akt/PKB activation and cell cycle progression in human mesangial cells'. American Journal of Pathology, 164 (3):937-946. [Details]
Browne, JG; Kane, R; Godson, C; Cotter, TG; O'Brien, CJ; ; (2004) 'Mechanism of pericyte apoptosis following glucose exposure'. Investigative Ophthalmology &Amp; Visual Science, 45 (NA):88-88. [Details]
Kieran, NE; Doran, PP; Connolly, SB; Greenan, MC; Higgins, DF; Leonard, M; Godson, C; Taylor, CT; Henger, A; Kretzler, M; Burne, MJ; Rabb, H; Brady, HR; ; (2003) 'Modification of the transcriptomic response to renal ischemia/reperfusion injury by lipoxin analog'. Kidney International, 64 (2):480-492. [Details]
Duffy, TN; Fearon, U; Godson, C; Brady, H; Bresnihan, B; Veale, D; FitzGerald, O; ; (2003) 'Profibrotic mRNA is preferentially expressed in bone forming arthritis'. Arthritis and Rheumatism, 48 (9):602-602. [Details]
Maderna, P; Godson, C; ; (2003) 'Phagocytosis of apoptotic cells and the resolution of inflammation'. Biochimica Et Biophysica Acta-Molecular Basis of Disease, 1639 (3):141-151. [Details]
Kane, R; Godson, C; Brady, HR; O'Brien, C; ; (2003) 'Differential gene expression in human retinal pericytes in response to glucose and hypoxia'. Investigative Ophthalmology &Amp; Visual Science, 44 (NA):395-395. [Details]
Ohse, T; Ota, T; Kieran, N; Godson, C; Yamada, K; Tanaka, T; Fujita, T; Nangaku, M; ; (2003) 'Modulation of interferon-induced genes by lipoxin analogue in Anti-GBM nephritis'. Journal of the American Society of Nephrology, 14 (NA):635-635. [Details]
Mitchell, DM; Rodgers, K; Petasis, NA; Brady, HR; Godson, C; ; (2003) 'Lipoxins modulate Akt/PKB activation and cell cycle progression in mesangial cells'. Journal of the American Society of Nephrology, 14 (NA):340-340. [Details]
Murphy, M; Curtin, D; Dolan, V; Hensey, C; Kretzler, M; Schlondorff, D; Godson, C; Brady, HR; Martin, F; ; (2003) 'IHG-1 enhances TGF-beta-induced transcriptional activation and its expression is increased in diabetic nephropathy'. Journal of the American Society of Nephrology, 14 (NA):127-128. [Details]
Reville, K; Brady, HR; Godson, C; ; (2003) 'Functional proteomics of lipoxin-stimulated macrophage function'. Journal of the American Society of Nephrology, 14 (NA):87-87. [Details]
McMahon, B; Rodgers, K; Mitchell, D; Brady, HR; Godson, C; ; (2003) 'Lipoxin A(4) modulation of platelet-derived growth factor-induced transcriptional responses in human renal mesangial cells'. Journal of the American Society of Nephrology, 14 (NA):62-62. [Details]
Leonard, MO; Godson, C; Brady, HR; Taylor, CT; ; (2003) 'Involvement of HIF-1 alpha in hypoxia mediated alterations in human proximal tubular epithelial cell transcription'. Journal of the American Society of Nephrology, 14 (NA):24-24. [Details]
Leonard, MO; Cottell, DC; Godson, C; Brady, HR; Taylor, CT; ; (2003) 'The role of HIF-1 alpha in transcriptional regulation of the proximal tubular epithelial cell response to hypoxia'. Journal of Biological Chemistry, 278 (41):40296-40304. [Details]
Goh, J; Godson, C; Brady, HR; MacMathuna, P; ; (2003) 'Lipoxins: Pro-resolution lipid mediators in intestinal inflammation'. Gastroenterology, 124 (4):1043-1054. [Details]
Crean, JKG; Finlay, D; Murphy, M; Moss, C; Godson, C; Martin, F; Brady, HR; ; (2002) 'The role of p42/44 MAPK and protein kinase B in connective tissue growth factor induced extracellular matrix protein production, cell migration, and actin cytoskeletal rearrangement in human mesangial cells'. Journal of Biological Chemistry, 277 (46):44187-44194. [Details]
Lappin, DWP; Doran, P; Godson, C; Brady, HR; ; (2002) 'Gene responses to hyperglycaemia'. Experimental Nephrology, 10 (2):120-129. [Details]
Leonard, MO; Hannan, K; Burne, MJ; Lappin, DWP; Doran, P; Coleman, P; Stenson, C; Taylor, CT; Daniels, F; Godson, C; Petasis, NA; Rabb, H; Brady, HR; ; (2002) '15-Epi-16-(para-fluorophenoxy)-lipoxin A(4)-methyl ester, a synthetic analogue of 15-epi-lipoxin A(4), is protective in experimental ischemic acute renal failure'. Journal of the American Society of Nephrology, 13 (6). [Details]
Stenson, C; Mitchell, S; Lappin, D; Brady, HR; Godson, C; ; (2002) 'Biphasic regulation of leukocyte trafficking by lipoxins'. Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 5, 507 (NA):543-549. [Details]
Mitchell, S; Thomas, G; Harvey, K; Cottell, D; Reville, K; Berlasconi, G; Petasis, NA; Erwig, L; Rees, AJ; Savill, J; Brady, HR; Godson, C; ; (2002) 'Lipoxins, aspirin-triggered epi-lipoxins, lipoxin stable analogues, and the resolution of inflammation: Stimulation of macrophage phagocytosis of apoptotic neutrophils in vivo'. Journal of the American Society of Nephrology, 13 (10):2497-2507. [Details]
Higgins, DF; Lappin, DWP; Isaka, Y; Watson, RW; Godson, C; Imai, E; Fitzpatrick, JM; Brady, HR; ; (2002) 'Transcriptomic responses underpinning renal tubulointerstitial fibrosis as identified by DNA oligonucleotide microarray technology'. Journal of the American Society of Nephrology, 13 (NA):560-560. [Details]
Kieran, NE; Connolly, SB; Greenan, MC; Higgins, D; Burne, MJ; Godson, C; Doran, PP; Rabb, H; Brady, HR; ; (2002) 'The transcriptomic response to renal ischemia-reperfusion injury and its modification by lipoxin A4 analogue FphO-15-RLXA4-Me'. Journal of the American Society of Nephrology, 13 (NA):120-120. [Details]
McMahon, B; Mitchell, D; Shattock, R; Martin, F; Brady, HR; Godson, C; ; (2002) 'Lipoxin, leukotriene, and PDGF receptors cross-talk to regulate mesangial cell proliferation'. FASEB Journal, 16 (13). [Details]
Leonard, MO; Cottell, D; Godson, C; Brady, HR; Taylor, CT; ; (2002) 'Gene expression profile clustering of proximal tubule epithelial cells in hypoxia and reoxygenation'. Journal of the American Society of Nephrology, 13 (NA):118-118. [Details]
Crean, JKG; Finlay, D; Martin, F; Godson, C; Brady, HR; ; (2002) 'The role of p42/44 MAPK and protein kinase B in connective tissue growth factor induced extracellular matrix protein production, cell migration and actin cytoskeletal rearrangement in human mesangial cells'. Journal of the American Society of Nephrology, 13 (NA):87-87. [Details]
Lappin, DWP; Mullally, A; Kairaitis, L; Wang, YP; Godson, C; Harris, DCH; Brady, HR; Doran, PP; ; (2002) 'Temporal patterns of gene expression in adriamycin-induced nephrosis'. Journal of the American Society of Nephrology, 13 (NA):117-117. [Details]
Mitchell, DM; Hanly, J; Petasis, NA; Brady, HR; Godson, C; ; (2002) 'The lipoxin A(4) receptor is coupled to antiproliferative responses'. Journal of the American Society of Nephrology, 13 (NA):85-85. [Details]
McMahon, B; Mitchell, S; Brady, HR; Godson, C; ; (2001) 'Lipoxins: revelations on resolution'. Trends in Pharmacological Sciences, 22 (8):391-395. [Details]
Goh, J; Baird, AW; O'Keane, C; Watson, RWG; Cottell, D; Bernasconi, G; Petasis, NA; Godson, C; Brady, HR; MacMathuna, P; ; (2001) 'Lipoxin A(4) and aspirin-triggered 15-epi-lipoxin A(4) antagonize TNF-alpha-stimulated neutrophil-enterocyte interactions in vitro and attenuate TNF-alpha-induced chemokine release and colonocyte apoptosis in human intestinal mucosa ex vivo'. Immunology, 167 (5):2772-2780. [Details]
McMahon, R; Murphy, M; Gardiner, C; Godson, C; Martin, F; Brady, HR; ; (2001) 'Gremlin inhibits DNA synthesis and proliferation in human mesangial cells by a BMP independent mechanism'. British Journal of Pharmacology, 134 (NA). [Details]
Freeman, JE; Godson, C; Kinsella, BT; ; (2001) 'An investigation into thromboxane A(2) and lipoxin A(4) signalling in primary human mesangial cells'. British Journal of Pharmacology, 134 (NA). [Details]
Maderna, P; Brady, HR; Godson, C; ; (2001) 'Lipoxins induce reorganisation of the actin cytoskeleton in monocyte-derived macrophages: The role of RhoA'. British Journal of Pharmacology, 134 (NA). [Details]
Lappin, DWP; Hensey, C; McMahon, R; Godson, C; Brady, HR; ; (2000) 'Gremlins, glomeruli and diabetic nephropathy'. Current Opinion in Nephrology and Hypertension, 9 (5):469-472. [Details]
Goh, J; Baird, AW; Watson, WR; Godson, C; O'Keane, C; Brady, HR; MacMathuna, P; ; (2000) 'Lipoxins attenuate TNF-A-induced apoptosis in human colonic mucosa'. Gastroenterology, 118 (4):806-806. [Details]
McMahon, B; Stenson, C; Brady, HR; Godson, C; ; (2000) 'Lipoxin A4 modulates Leukotriene D4-induced mitogenesis in renal mesangial cells'. FASEB Journal, 14 (8):1346-1346. [Details]
Diamond, P; McGinty, A; Jiao, QS; Murphy, B; Godson, C; Sugrue, D; McCann, H; Brady, HR; ; (2000) 'Expression of suppressors of cytokine signalling (SOCS) in experimental cardiac transplant rejection'. Journal of the American College of Cardiology, 35 (2):221-221. [Details]
McMahon, R; Murphy, M; Clarkson, M; Taal, M; Mackenzie, HS; Godson, C; Martin, F; Brady, HR; ; (2000) 'IHG-2, a mesangial cell gene induced by high glucose, is human gremlin - Regulation by extracellular glucose concentration, cyclic mechanical strain, and transforming growth factor-beta 1'. Journal of Biological Chemistry, 275 (14):9901-9904. [Details]
McMahon, B; Stenson, C; McPhillips, F; Fanning, A; Brady, HR; Godson, C; ; (2000) 'Lipoxin A(4) antagonizes the mitogenic effects of leukotriene D-4 in human renal mesangial cells - Differential activation of MAP kinases through distinct receptors'. Journal of Biological Chemistry, 275 (36):27566-27575. [Details]
Maderna, P; Godson, C; Hannify, G; Murphy, M; Brady, HR; ; (2000) 'Influence of lipoxin A(4) and other lipoxygenase-derived eicosanoids on tissue factor expression'. American Journal of Physiology-Cell Physiology, 279 (4):945-953. [Details]
Maderna, P; Coleman, P; Godson, C; O'Meara, YM; Brady, HR; ; (1999) 'Serum from hemodialysis patients inhibits basal and cytokine-stimulated tissue factor expression in vitro'. Journal of the American Society of Nephrology, 10 (11):2403-2406. [Details]
Murphy, M; Godson, C; Cannon, S; Martin, F; Brady, HR; ; (1999) 'Connective tissue growth factor expression in human mesangial cells exposed to high glucose'. FASEB Journal, 13 (4):37-37. [Details]
Mitchell, S; Harvey, K; Fokin, VV; Petasis, NA; Godson, C; Brady, HR; ; (1999) 'Lipoxins stimulate macrophage phagocytosis of apoptotic neutrophils'. FASEB Journal, 13 (4):557-557. [Details]
Clarkson, MR; Gupta, S; Murphy, M; Martin, F; Godson, C; Brady, HR; ; (1999) 'Connective tissue growth factor: a potential stimulus for glomerulosclerosis and tubulointerstitial fibrosis in progressive renal disease'. Current Opinion in Nephrology and Hypertension, 8 (5):543-548. [Details]
Mitchell, S; Harvey, K; Fokin, VV; Petasis, NA; Godson, C; Brady, HR; ; (1999) 'Lipoxins stimulate macrophages to phagocytose apoptotic neutrophils'. Kidney International, 55 (6):2574-2574. [Details]
Maderna, P; Coleman, P; Godson, C; O'Meara, YM; Brady, HR; ; (1999) 'Haemodialysis serum inhibits endothelial cell (EC) expression of tissue factor (TF)'. Kidney International, 55 (6):2575-2575. [Details]
McMahon, B; McPhillips, F; Fanning, A; Brady, HR; Godson, C; ; (1999) 'Modulation of mesangial cell MAP kinase activities by leukotrien D-4 and lipoxin A(4)'. Kidney International, 55 (6):2578-2578. [Details]
Maderna, P; Chanyaputhipong, P; Petasis, NA; Godson, C; Brady, HR; ; (1999) 'Protein kinase C-dependent stereospecific regulation of endothelial cell tissue factor gene expression by lipoxins'. Kidney International, 55 (6):2578-2579. [Details]
Bosio, PM; Cannon, S; Godson, C; McKenna, PJ; O'Herlihy, C; Conroy, R; McCann, H; Sugrue, D; Brady, HR; ; (1999) 'Hyperdynamic circulation and elevated plasma levels of soluble p-selectin precede the development of peripheral vasoconstriction and hypertension in women destined to develop pre-eclampsia'. Kidney International, 55 (6):2581-2581. [Details]
Clarkson, M; Cannon, S; Godson, C; Jones, D; Horan, J; Mulkerrin, E; Brady, HR; ; (1999) 'Pathophysiology of hyperkalaemia in elderly patients'. Kidney International, 55 (6):2582-2582. [Details]
Murphy, M; Godson, C; Martin, F; Brady, HR; ; (1999) 'Gene expression in cultured human mesangial cells in response to extracellular glucose as assessed by suppressive subtractive hybridization'. Kidney International, 55 (6):2585-2585. [Details]
Murphy, M; Godson, C; Cannon, S; Martin, F; Brady, HR; ; (1999) 'Connective tissue growth factor expression in human mesangial cells exposed to high glucose'. Kidney International, 55 (6):2585-2585. [Details]
Diamond, P; McGinty, A; Sugrue, D; Brady, HR; Godson, C; ; (1999) 'Regulation of leukocyte trafficking by lipoxins'. Clinical Chemistry and Laboratory Medicine, 37 (3):293-297. [Details]
Maher, LJ; Skelly, MM; Godson, C; Brady, HR; Baird, AW; ; (1999) 'Lipoxin A(4) inhibits mast cell stimulation in rat colon in vitro'. Gastroenterology, 116 (4):905-905. [Details]
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Conference Publications

Browne, M., Faherty, N.1, Xu, L., Oliver, N., Brazil, D. , Godson, C. and Crean, J. ; (2010) Connective Tissue Growth Factor (CTGF) causes Cdc42 activation and altered actin binding protein expression in the glomerular podocyte J Am Soc Nephrol [Details]

Rooney B, Gaffney, A., Godson, C., Sadlier, D and Crean, JK.; (2010) CTGF/CCN2 activates canonical Wnt signaling in mesangial cells through LRP6; implications for the pathogenesis of diabetic nephropathy J Am Soc Nephrol [Details]

O'Donovan, H. 1, Xu, L.3, Oliver, N.3, Godson, C.2, and Crean, JK; (2010) CTGF/CCN2 and TGFBeta Superfamily signalling: Implications for therapeutic intervention J Am Soc Nephrol [Details]

Godson C, Murphy M, Crean J, Brazil DP, Sadlier D, Martin F, ; (2008) Biochemical Society transactions Regulation and consequences of differential gene expression in diabetic kidney disease , pp.941-945 [DOI] [Details]

Shah, S.T. A., O'Sullivan, T.P., Maderna, P., Godson, C. Guiry, P.J.; (2005) The total synthesis of novel lipoxin A4 analogues for biological evaluation UCD Conway Festival of Research [Details]

Shah, S.T. A., O'Sullivan, T.P., Maderna, P., Godson, C. Guiry, P.J.; (2005) The total synthesis of novel lipoxin A4 analogues for biological evaluation Recent Advances in Synthesis and Chemical Biology IV [Details]
Shah, S.T. A., O'Sullivan, T.P., Maderna, P., Godson, C. Guiry, P.J.; (2005) The total synthesis of novel lipoxin A4 analogues for biological evaluation Recent Advances in Synthesis and Chemical Biology IV [Details]
Shah, S.T. A., O'Sullivan, T.P., Maderna, P., Godson, C. and Guiry, P.J.; (2005) The total synthesis of novel lipoxin A4 analogues for biological evaluation Recent Advances in Synthesis and Chemical Biology IV [Details]
Shah, S.T. A., O'Sullivan, T.P., Maderna, P., Godson, C. Guiry, P.J.; (2005) The total synthesis of novel lipoxin A4 analogues for biological evaluation UCD Conway Festival of Research [Details]
Shah, S.T. A., O'Sullivan, T.P., Maderna, P., Godson, C. Guiry, P.J.; (2005) The total synthesis of novel lipoxin A4 analogues for biological evaluation UCD Conway Festival of Research [Details]
Murphy, M; Curtin, D; Dolan, V; Hensey, C; Kretzler, M; Schlondorff, D; Godson, C; Brady, HR; Martin, F; ; (2003) JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY IHG-1 enhances TGF-beta-induced transcriptional activation and its expression is increased in diabetic nephropathy , pp.127-128 [Details]
Freeman JE., Godson C., and Kinsella, BT.; (2001) An investigation of thromboxane A2 and lipoxin A4 signalling in primary human mesangial cells Conway Institute of Biomolecular and Biomedical Research Festival of Research University College Dublin, [Details]
Freeman JE., McMahon, B., Godson C., and Kinsella, BT.; (2001) Characterisation of thromboxane A2 and lipoxin A4 signalling in human mesangial cells Irish Nephrological Society AGM Royal College of Physicians of Ireland, [Details]
Freeman JE., Godson C., and Kinsella, BT.; (2001) An investigation of thromboxane A2 and lipoxin A4 signalling in primary human mesangial cells British Pharmacological Society Dublin, [Details]
Shah, S. T. A.; O'Sullivan, T. P.; Maderna, P.; Godson, C.; Guiry, P. J.; (2005) The total synthesis of novel lipoxin A4 analogues for biological evaluation UCD Conway Festival of Research [Details]
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Abstract

Decker Y., McBean G. and Godson C.; (2008) Anti-inflammatory effects of lipoxin A4 in human 1321N1 astrocytoma cells. J. Neuroimmunol. 197, p168: Abstract [Details]

Presentation

Crean JK, Finlay D, Godson C, Martin F, Brady HR; (2002) Connective Tissue Growth Factor induces adhesion, contraction and cytoskeletal rearrangement in human mesangial cells: the role of Erk and Rho Kinases. Presentation [Details]

Crean JK, Finlay D, Martin F, Godson C, Brady HR; (2002) The role of p42/44 MAPK and protein kinase B in connective tissue growth factor induced extracellular matrix protein production, cell migration and actin cytoskeletal rearrangement in human mesangial cells. Presentation [Details]

Honours and Awards

Year: 1984.
Title: Cystic Fibrosis Association Postgraduate Research Scholarship

Year: 1987.
Title: Young Investigator Award, Third International. Symposium on Nephrotoxicity

Year: 1989.
Title: University of California Cancer Research Coordinating Committee Post-Doctoral Fellowship

Year: 1990.
Title: American Heart Association Postdoctoral Fellowship

Year: 1992.
Title: University of Geneva Postdoctorante Award

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Associations

Association: Wellcome Trust Physiological Sciences Review Panel , Function/Role: Member

Association: Health Research Board, Ireland , Function/Role: Member

Association: Editorial Board of Molecular Pharmacology , Function/Role: Member

Association: Irish Government¿s Chief Science Adviser¿s SWOT Analysis 2005, Function/Role: Member

Association: Wellcome Trust, National Kidney Research Fund (UK), National Institutes of Health, Function/Role: Grant reviewer

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Patents

Patent PCT /IE 00/0026 : Identification of genes having a role in the presentation of diabetic nephropathy

Conference Contributions

Freeman JE., Godson C., and Kinsella, BT.; An investigation of thromboxane A2 and lipoxin A4 signalling in primary human mesangial cells. [Oral Presentation], Conway Institute of Biomolecular and Biomedical Research Festival of Research, University College Dublin, May 2002, * .

Brazil, DP., Kattla, JJ., Moran, RM., Roxburgh SR., Murphy M., Hemmings BA., Godson, C.; European Association for the Study of Diabetes (EASD). [Poster Presentation], European Association for the Study of Diabetes (EASD), Athens, Greece .

Kattla, JK, Roxburgh, SA, Godson C, Brazil, DP.; American Society of Nephrology. [Poster Presentation], American Society of Nephrology, Philadelphia, USA .

Freeman JE., Godson C., and Kinsella, BT.; An investigation of thromboxane A2 and lipoxin A4 signalling in primary human mesangial cells. Conway Institute of Biomolecular and Biomedical Research Festival of Research, University College Dublin, September 2001, .

Catherine GODSON; (2008) Lipoxin receptors and signal transduction. [Invited Lecture], European Conference on Lipid Mediators, Vallodolid, Spain , 12-JUN-08 - 14-JUN-08.

Catherine GODSON; (2008) FPRL Receptor Workshop. [Invited Lecture], fPRL-1 expression and bioactions in the resolution of inflammation, London June 2008, London June 2008 , 12-JUN-08 - 12-JUN-08.
Invited Speaker ; (2008) Diabetes and the kidney. Lipoxins, macrophages and diabetic nephropathy,. [Invited Lecture], International Society of Nephrology Nexus Symposium:, Dublin , 28-JUN-08 - 30-JUN-08.
Godson, C.; (2005) The thrill of biomedical discovery: new targets and markers in diabetic kidney disease. [Invited Oral Presentation], BA Festival of Science, Dublin , 01-JAN-05.
Godson, C.; (2005) Lipoxins and Annexin'1 regulate macrophage phagocytosis of apoptotic leukocytes. [Invited Oral Presentation], Gordon Research Conference, Phagocytic Clearance of Apoptotic Leukocytes, Connecticut , 01-JAN-05.
Godson, C.; (2005) Invited Speaker: Taking insult from injury: lipoxins pro-resolution, anti-fibrotic mediators in renal disease. [Invited Oral Presentation], International Conference on Eicosanoid Biology, San Francisco , 01-JAN-05.
Godson, C.; (2006) Invited Speaker: Monocyte-Endothelial Interactions. [Invited Oral Presentation], ISN Forefronts in Nephrology: Endothelial Biology and Renal Disease, Palisades New York , 01-MAR-06.
Godson, C.; (2006) Molecular mechanisms in the pathogenesis of diabetic nephropathy. [Keynote Address], European Renal Cell Study Group International Meeting, Dublin , 01-MAR-06.
Godson, C.; (2006) Phagocytosis of apoptotic cells in the resolution of inflammation. [Keynote Address], International Society of Histochemistry Annual Meeting, Stressa, Italy , 01-SEP-06.
Godson, C.; (2006) Resolvyx, Boston. [Invited Lecture], Resolvyx, Boston, Boston , 01-MAR-06.
Godson, C.; (2004) Berlex BioSciences. [Invited Lecture], Berlex BioSciences, Richmond, CA , 01-JAN-04.
Godson, C.; (2003) CellTech Ltd. [Invited Lecture], CellTech Ltd, Cambridge , 01-JAN-03.
Godson, C.; (2004) William Harvey Research Institute. [Invited Lecture], William Harvey Research Institute, Queen Mary College, London , 01-JAN-04.
Godson, C.; (2002) BioSciences Institute, University College Cork. [Invited Lecture], BioSciences Institute, University College Cork, UCC , 01-JAN-02.
Godson, C.; (2004) A Genomics Approach to Understanding the Pathogenesis of Diabetic Nephropathy. [Invited Oral Presentation], American Society of Nephrology Annual Meeting, St. Louis , 01-JAN-04.
Godson, C.; (2003) Regression of fibrosis, the physicians holy grail. [Chaired Session], American Society of Nephrology Annual Meeting, San Diego , 01-JAN-03.
Godson, C.; (2007) Panellist, Today's Research, Tomorrow's Prosperity: Commercializing University Research Symposium. [Other], Today's Research, Tomorrow's Prosperity: Commercializing University Research Symposium, University of Toronto , 01-MAY-07.
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Committees

Committee : HRB Board Member

Committee : Wellcome Trust Physiological Sciences Review Committee

Committee : European Medical Research Council Board Member

Committee : Dublin Chamber Knowledge Economy Committee

Committee : Health Research Board Ireland, Molecular and Cell Biology Committee

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Education

Year 1988 Institution: University College Dublin
Qualification: PhD Subject:

Year 1984 Institution: University College Dublin
Qualification: BSc Subject:

Consultancy

Client: : Abbott Laboratories

Client: : GE Life Sciences

Client: : GSK, Greenford

Client: : Boehringer-Ingelheim, Germany

Client: : Resolvyx, Boston

Other Activities

Invited reviewer for J. Biol.Chem, Proc. Natl.Acad Sci USA, J. Immunol., Science, J. Am. Soc. Nephrol , Eur J. Biochem. Kid. Intl.

EXTERNAL EXAMINER:
University of Utrecht (2007), University of Warwick (2004), Trinity College Dublin (2005)

Internal Collaborators

Professor Finian Martin
Conway Institute, UCD
http://www.ucd.ie/conway/cv_64.html

Professor Pat Guiry
CSCB, UCD

Prof. Cormac Taylor
Conway Institute, UCD
http://www.ucd.ie/conway/cv_38.html

External Collaborators

Prof Mauro Perretti
William Harvey Research Institute
London

Prof AP Maxwell
Queens University
Belfast
N Ireland

Dr James Tobin

Cardiovascular and Metabolic Diseases

Wyeth

Cambridge, MA

Dr Jesper Haeggesstrom

Karolinska Institute

Stockholm

Sweden
Dr David Savage
Queens University
Belfast
N Ireland

Dr Jim Tobin
Cardiovascular and Metabolic Disease
Wyeth
Cambridge MA

Dr Ji-Ming Wang
Chemokine Receptor Lab
NCI
Fredricksburg, MD

Dr Joel Hirschhorn and Dr Jose Flores
Broad Institute
MIT
Boston, MA

Teaching Interests

Recent Postgraduates

Blaithin McMahon PhD - Liposxin A4 and leukotriene D4 receptors in the regulation of glomerular inflammation 2002
Siobhan Mitchell PhD - Lipoxin mediated macrophage phagocytosis in the resolution of inflammation 2002
David Lappin PhD - A functional genomics investigation of diabetic nephropathy 2003
Michael Clarkson MD - Actin cytoskeletal dysfunction in the pathogenesis of diabetic nephropathy 2004
Derick Mitchell PhD - Receptor cross talk in the regulation of mesangial cell function 2004
Keira Reville PhD - Molecular mechganisms regulating lipoxin-stimulated phagocytosis of apoptotic leukocytes 2005
Susan Connolly PhD - An integrated functional genomics and bioinformativc approach to the study of cardiovascular disease 2005
Eoin Cummins PhD - Novel insights into NF-kB mediated responses to hypoxia 2007
Karen Rodgers PhD - Anti fibrotic actions of lipoxins in models of renal disease 2007
Michael Scannell PhD- Pleiotropic lipoxin receptor agonists and the reolution of inflammation 2007
Jayesh Kattla PhD- Molecular mechanisms of tubulointerstitial fibrosis in diabetic nephropathy 2007
Yann Decker- expected completion Summer 2008
Emma Borgeson- expected completion Autumn 2010
Aidan Ryan- expected completion Autumn 2010

Current Postgraduate Students

Karen Nolan, Doctor of Philosophy (PhD) - Thesis Supervisor

Karin Borgeson, Doctor of Philosophy (PhD) - Thesis Supervisor

Aidan Ryan, Doctor of Philosophy (PhD) - Thesis Supervisor