Professor Ciaran Regan

Research

Professor Ciaran Regan BSc PhD DSc

Books:

Regan CM (2000) 'Intoxicating Minds'. : Weidenfeld and Nicolson. [Details]

Book Chapters:

Regan C, de Souza I, Gallagher H (2004) 'The impact of chemical residues: the case of polychlorinated biphenyls (PCBs)' In: Pesticide, Veterinary and other residues in food. Cambridge: Woodhead Publishing Ltd. [Details]

Murphy KJ, Gallagher HC, Regan CM (2002) 'Learning-induced modulation of neural cell adhesion molecule polysialylation state as a biomarker of prior inorganic lead exposure during the early postnatal period' In: Biomarkers of Environmentally Associated Disease: Technologies, Concepts, and Perspectives. USA: CRC Press/Lewis Publishers. [Details]

Murphy K.J., Gallagher H.C. and Regan C.M. (2002) 'Learning-induced modulation of neural cell adhesion molecule polysialylation state as a biomarker of prior inorganic lead exposure during the early postnatal period' In: In: Eds. Wilson S.H. and Suk W.A. Lewis Publishers, CRC Press (eds). Biomarkers of Environmentally associated Disease: Technologies, Concepts, and Perspectives. [Details]

Ng K, ODowd B, Regan CM (1998) 'Astrocytic involvement in learning' In: (Laming, P., Sykova, E., Reichenbach, A., Hatton, G and Bauer, H., Eds.) Cambridge University Press (eds). Glial cells and their role in behaviour. [Details]

Murphy KJ, Fox GB, OConnell AW, Regan CM (1997) 'Time-limited roles for cell adhesion molecule-mediated neuroplastic events in the commitment of memory to long term storage' In: (Teelken AW, Korf J, Eds.) Plenum Publishing Corp., New York (eds). 'Neurochemistry: Cellular, Molecular, and Clinical Aspects'. [Details]

Murphy KJ, Fox G.B., O'Connell AW, Regan CM (1997) 'Time-limited roles for cell adhesion molecule-mediated neuroplastic events in the commitment of memory to long term storage' In: Teelken A.W. and Korf J (eds). Neurochemistry: Cellular, Molecular, and Clinical Aspects. New York: Plenum Publishing Corp. [Details]

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Peer Reviewed Journals:

Foley, AG,Murphy, KJ,Regan, CM (2008) 'INTRAVENTRICULAR INFUSIONS OF ANTI-NCAM PSA IMPAIR THE PROCESS OF CONSOLIDATION OF BOTH AVOIDANCE CONDITIONING AND SPATIAL LEARNING PARADIGMS IN WISTAR RATS'. Neuroscience, 157 (NA):813-820. [DOI] [Details]

McKee AG, Loscher JS, O'Sullivan NC, Chadderton N, Palfi A, Batti L, Sheridan GK, O'Shea S, Moran M, McCabe O, Fernández AB, Pangalos MN, O'Connor JJ, Regan CM, O'Connor WT, Humphries P, Farrar GJ, Murphy KJ (2010) 'AAV-mediated chronic over-expression of SNAP-25 in adult rat dorsal hippocampus impairs memory-associated synaptic plasticity'. Journal of Neurochemistry, 112 :991-1004. [Details]

Cassidy AW, Mulvany SK, Pangalos MN, Murphy KJ, Regan CM (2010) 'Developmental emergence of reelin deficits in the prefrontal cortex of Wistar rats reared in social isolation'. Neuroscience, 166 :377-385. [Details]

Freir DB, Fedriani R, Scully D, Smith IM, Selkoe DJ, Walsh DM, Regan CM (2010) 'Aβ oligomers inhibit synapse remodelling necessary for memory consolidation'. Neurobiology of Aging, . [Details]

Murphy KJ, ter Horst JPF, Cassidy AW, DeSouza IEJ, Morgunova M, Li C, Connole LM, O'Sullivan NC, Loscher JS, Brady AT, Rombach N, Connellan J, McGettigan PA, Scully D, Fedriani R, Lukasz B, Moran MP, McCabe OM, Wantuch CM, Hughes ZA, Mulvany SK, Higgins DG, Pangalos MN, Marquis KL, William T. O'Connor WT, Ring RH, von Schack D, Regan CM (2010) 'Temporal dysregulation of cortical gene expression in the isolation reared Wistar rat'. Journal of Neurochemistry, 113 :601-614. [Details]

Cassidy AW, Mulvany SK, Pangalos MN, Murphy KJ, Regan CM (2010) 'Reduced reelin protein synthesis in ventral hippocampus of isolation reared Wistar rats accompanies impaired avoidance conditioning'. Behavioural Brain Research, 213 (1):130-134. [DOI] [Details]

Regan CM, Foley AG, Hirst WD, Gallagher HC, Barry C, Hagan JJ, Upton N, Walsh FS, Hunter AJ, (2008) 'The selective 5-HT(6) receptor antagonists SB-271046 and SB-399885 potentiate NCAM PSA immunolabeling of dentate granule cells, but not neurogenesis, in the hippocampal formation of mature Wistar rats'. Neuropharmacology, 8 (NA):1166-1174. [DOI] [Details]
Regan CM, Foley AG, Prendergast A, Barry C, Scully D, Upton N, Medhurst AD, (2009) 'H3 receptor antagonism enhances NCAM PSA-mediated plasticity and improves memory consolidation in odor discrimination and delayed match-to-position paradigms'. Neuropsychopharmacology, 34 (12):2585-2600. [DOI] [Details]
Regan CM, Conboy L, Foley AG, O'Boyle NM, Lawlor M, Gallagher HC, Murphy KJ, (2009) 'Curcumin-induced degradation of PKC delta is associated with enhanced dentate NCAM PSA expression and spatial learning in adult and aged Wistar rats'. Biochemical Pharmacology, 77 (7):1254-1265. [DOI] [Details]
ter Horst, J. P. F., Loscher, J. S., Pickering, M., Regan, C. M., Murphy, K. J., (2008) 'Learning-associated regulation of polysialylated neural cell adhesion molecule expression in the rat prefrontal cortex is region-, cell type- and paradigm-specific'. European Journal of Neuroscience, 28 (3):419-427. [Details]
Shankar, G. M., Li, S. M., Mehta, T. H., Garcia-Munoz, A., Shepardson, N. E., Smith, I., Brett, F. M., Farrell, M. A., Rowan, M. J., Lemere, C. A., Regan, C. M., Walsh, D. M., Sabatini, B. L., Selkoe, D. J., (2008) 'Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory'. Nature Medicine, 14 (8):837-842. [Details]
O'Sullivan NC, McGettigan PA, Sheridan GK, Pickering M, Conboy L, O'Connor JJ, Moynagh PN, Higgins DG, Regan CM, Murphy KJ (2007) 'Temporal change in gene expression in the rat dentate gyrus following passive avoidance learning'. Journal of Neurochemistry, 101 :1085-1098. [Details]
Medhurst AD, Briggs MA, Bruton G, Calver AR, Chessell I, Crook B, Davis JB, Davis RP, Foley AG, Heslop T, Hirst WD, Medhurst SJ, Oceipka S, Ray A, Regan CM, Sargent B, Schogger J, Stean TO, Trail BK, Upton N, Wald JA, White T, Wilson DM, Orlek B (2007) 'Structurally novel histamine H3 receptor antagonists GSK207040 and GSK334429 improve scopolamine-induced memory impairment and capsaicin-induced secondary allodynia'. Biochemical Pharmacology, 73 :1182-1194. [Details]
Conboy L, Seymour CM, Monopoli MP, O'Sullivan NC, Murphy KJ, Regan CM (2007) 'Notch signalling becomes transiently attenuated during long term memory consolidation in adult Wistar rats'. Neurobiology of Learning and Memory, 88 :342-351. [Details]
Medhurst AD, Atkins AR, Beresford IJ, Brackenborough K, Michael Briggs MA, Calver AR, Cilia J, Cluderay JE, Crook B, Davis JB, Davis RK, Davis RP, Dawson LA, Foley AG, Gartlon J, Gonzalez MI, Heslop T, Hirst W, Jennings C, Jones DNC, Lacroix LP, Martyn A, Ociepka S, Ray A, Regan CM, Roberts JC, Schogger J, Southam E, Stean TO, Trail BK, Upton N, Wadsworth G, Wald JA, White T, Witherington J, Woolley ML, Worby A, Wilson DM (2007) 'GSK189254 - a novel H3 receptor antagonist that binds to histamine H3 receptors in Alzheimer's Disease brain and improves cognitive performance in preclinical models'. Journal of Pharmacology and Experimental Therapeutics, 321 :1032-1045. [Details]
Hirst, WD; Stean, TO; Rogers, DC; Sunter, D; Pugh, P; Moss, SF; Bromidge, SM; Riley, G; Smith, DR; Bartlett, S; Heidbreder, CA; Atkins, AR; Lacroix, LP; Dawson, LA; Foley, AG; Regan, CM; Upton, N; (2006) 'SB-399885 is a potent, selective 5-HT6 receptor antagonist with cognitive enhancing properties in aged rat water maze and novel object recognition models'. EUROPEAN JOURNAL OF PHARMACOLOGY, 553 (1-3):109-119. [Details]
Murphy, KJ; Foley, AG; O'Connell, AW; Regan, CM; (2006) 'Chronic exposure of rats to cognition enhancing drugs produces a neuroplastic response identical to that obtained by complex environment rearing'. Neuropsychopharmacology, 31 (1):90-100. [Details]
Conboy, L., Murphy, K.J. Regan, C.M. (2005) 'APP expression in the hippocampal dentate gyrus modulates during memory consolidation'. Journal of Neurochemistry, 5 :1677-1688. [Details]
Foley, AG; Murphy, KJ; Regan, CM; (2005) 'Complex-environment rearing prevents prenatal hypoxia-induced deficits in hippocampal cellular mechanisms necessary for memory consolidation in the adult Wistar rat'. Journal of Neuroscience Research, 82 (2):245-254. [Details]
Conboy, L; Murphy, KJ; Regan, CM; (2005) 'Amyloid precursor protein expression in the rat hippocampal dentate gyrus modulates during memory consolidation'. Neurochemistry, 95 (6):1677-1688. [Details]
Sandi C, Merino JJ, Cordero MI, Kruyt ND, Regan CM, Murphy KJ (2004) 'Neurobiological and Endocrine Correlates of Individual Differences in Spatial Learning Ability'. Learning Memory, 11 :244-252. [Details]
Foley AG, Murphy KJ, Regan CM (2004) 'Pentyl-4-yn-valproic acid reverses age-associated memory impairment in the Wistar rat. '. Neurobiology of Aging, 25 :539-546. [Details]
Foley AG, Murphy KJ, Hirst WD, Gallagher HC, Hagan JJ, Upton N, Walsh FS, Regan CM (2004) 'The 5-HT6 receptor antagonist SB-271046 reverses scopolamine-disrupted consolidation of a passive avoidance task and ameliorates spatial task deficits in aged rats'. Neuropsychopharmacology, 29 :93-100. [Details]
Gallagher HC, Bacon CL, Odumeru OA, Gallagher KF, Fitzpatrick T, Regan CM (2004) 'Valproate activates phosphodiesterase-mediated cAMP degradation relevance to C6 glioma G1 phase progression'. Neurotoxicology and Teratology, 26 :73-81. [Details]
O' Loinsigh ED, Gherardini LM, Gallagher HC, Foley AG, Murphy KJ, Regan CM (2004) 'Differential enantioselective effects of pentyl-4-yn-valproate on spatial learning in the rat, and neurite outgrowth and cyclin D3 expression in vitro'. Journal of Neurochemistry, 88 :370-379. [Details]
Foley, AG; Gallagher, HC; Murphy, KJ; Regan, CM; (2004) 'Pentyl-4-yn-valproic acid reverses age-associated memory impairment in the Wistar rat'. Neurobiology of Aging, 25 (4):539-546. [Details]
Foley, AG; Murphy, KJ; Hirst, WD; Gallagher, HC; Hagan, JJ; Upton, N; Walsh, FS; Regan, CM; (2004) 'The 5-HT6 receptor antagonist SB-271046 reverses scopolamine-disrupted consolidation of a passive avoidance task and ameliorates spatial task deficits in aged rats'. Neuropsychopharmacology, 29 (1):93-100. [Details]
Sandi, C; Merino, JJ; Cordero, MI; Kruyt, ND; Murphy, KJ; Regan, CM; (2003) 'Modulation of hippocampal NCAM polysialylation and spatial memory consolidation by fear conditioning'. Biological Psychiatry, 54 (6):599-607. [Details]
Foley AG, Rønn LCR, Murphy KJ, Regan CM (2003) 'Distribution of polysialylated neural cell adhesion molecule in the rat septal nuclei and septohippocampal pathway Transient increase of polysialylated cells in sub-triangular septal zone during memory consolidation'. Journal of Neuroscience Research, 74 :807-817. [Details]
Foley, AG; Hedigan, K; Roullet, P; Moricard, Y; Murphy, KJ; Sara, SJ; Regan, CM; (2003) 'Consolidation of memory for odour-reward association requires transient polysialylation of the neural cell adhesion molecule in the rat hippocampal dentate gyrus'. Journal of Neuroscience Research, 74 (4):570-576. [Details]
Foley AG, K Hedigan, Roullet P, Sara SJ, Murphy KJ, Regan CM (2003) 'Consolidation of odour-reward associative memory involves neural cell adhesion molecule polysialylation-mediated synaptic plasticity within the rodent hippocampus'. Journal of Neuroscience Research, 74 :570-576. [Details]
Walmod PS, Berezin A, Gallagher HC, Gravemann U, Lepekhin EA, Belman V, Nau H, Regan CM, Berezin V, Bock E (2002) 'Automated in vitro screening of teratogens'. Toxicology and Applied Pharmacology, 181 :1-15. [Details]
Walmod, PS; Berezin, A; Gallagher, HC; Gravemann, U; Lepekhin, EA; Belman, V; Bacon, CL; Nau, H; Regan, CM; Berezin, V; Bock, E; (2002) 'Automated in vitro screening of teratogens'. Toxicology and Applied Pharmacology, 181 (1):1-15. [Details]
Bacon, C.L., Gallagher, H.C., Haughey, J.C., and Regan, C.M. (2002) 'The anti-proliferative action of valproate is associated with aberrant expression and nuclear translocation of cyclin D3 during the C6 glioma G1 phase'. Journal of Neurochemistry, 83 :12-19. [Details]
Walmod, P.S., Berezin, A., Gallagher, H.C., Gravemann, U., Lepekhin, E.A., Belman, V., Nau, H., Regan, C.M., Berezin, V., and Bock, E. (2002) 'Automated in vitro screening of teratogens'. Toxicology and Applied Pharmacology, 181 :1-15. [Details]
Prag, S., Lepekhin, E.A., Kolkova, K., Hartmann-Petersen, R., Kawa, A., Walmod, P.S., Belman, V., Gallagher, H.C., Berezin, V., Bock, E., and Pedersen, N. (2002) 'NCAM regulates cell motility'. Journal of Cell Science, 115 :283-292. [Details]
Bacon CL, Gallagher HC, Haughey JC, Regan CM (2002) 'Anti-proliferative action of valproate is associated with aberrant expression and nuclear translocation of cyclin D3 during the C6 glioma G1 phase'. Neurochemistry, 83 :12-19. [Details]
Murphy, KJ; Fox, GB; Foley, AG; Gallagher, HC; O'Connell, A; Griffin, AM; Nau, H; Regan, CM; (2001) 'Pentyl-4-yn-valproic acid enhances both spatial and avoidance learning, and attenuates age-related NCAM-mediated neuroplastic decline within the rat medial temporal lobe'. Neurochemistry, 78 (4):704-714. [Details]
Gallagher HC, Murphy KJ, Foley AG, Regan CM (2001) 'Protein kinase C delta regulates neural cell adhesion molecule polysialylation state in the rat brain'. Neurochemistry, 77 :425-434. [Details]
Gallagher, H.C., Murphy, K.J., Foley, A.G., and Regan, C.M. (2001) 'Protein kinase C delta regulates neural cell adhesion molecule polysialylation state in the rat brain'. Neurochemistry, 77 :425-434. [Details]
Murphy, K.J., Fox, G.B., Foley, A.G., Gallagher, H.C., OConnell, A., Griffin, A.-M., Nau, H., and Regan, C.M. (2001) 'Pentyl-4-yn-valproic acid analogue enhances both spatial and avoidance learning and attenuates age-related NCAM-mediated neuroplastic decline within the medial temporal lobe'. Neurochemistry, 78 :704-714. [Details]
Haughey, J; Bacon, CL; Gallagher, HC; Regan, CM; (2001) 'Modulation of cyclin protein expression during the C6 glioma G1 phase by the anticonvulsant valproate'. British Journal of Pharmacology, 134 (NA). [Details]
Gallagher, HC; Murphy, KJ; Foley, AG; Regan, CM; (2001) 'Protein kinase C delta regulates neural cell adhesion molecule polysialylation state in the rat brain'. Neurochemistry, 77 (2):425-434. [Details]
Murphy, K.J., Lynch, M.A., and Regan, C.M. (2001) 'Neuroplastic events required for LTP and avoidance learning are impaired by opiate addiction'. British Journal of Pharmacology, 134 . [Details]
Haughey, J., Bacon, C.L., Gallagher, H.C., and Regan, C.M. (2001) 'Modulations of cyclin protein expression during the C6 glioma G1 phase by the anticonvulsant valproate'. British Journal of Pharmacology, 134 . [Details]
OConnell, A.W., Fox, G.B., Kjøller, C., Gallagher, H., Murphy, K.J., Kelly, J., and Regan, C.M. (2001) 'Anti-ischemic and cognition-enhancing properties of NNC-711, a -aminobutyric acid reuptake inhibitor'. European Journal of Pharmacology, 424 :37-44. [Details]
Fox, G.B., Kjøller, C., Murphy, K.J., and Regan, C.M. (2001) 'The modulations of NCAM polysialylation state that follow transient global ischaemia are brief on neurons but enduring on glia'. Journal of Neuropathology and Experimental Neurology, 60 :132-140. [Details]
Mulvany, S., Murphy, K.J., and Regan, C.M. (2001) 'Cerebellar NCAM polysialylation is preserved in a discrete banded pattern in the adult Wistar rat'. Irish Journal of Medical Science, . [Details]
Conboy, L., and Regan, C.M. (2001) 'Proteins aberrant in Alzheimers disease modulate their expression during memory consolidation in the hippocampal dentate gyrus of adult Wistar rats'. Irish Journal of Medical Science, . [Details]
O'Connell, AW; Fox, GB; Kjoller, C; Gallagher, HC; Murphy, KJ; Kelly, J; Regan, CM; (2001) 'Anti-ischemic and cognition-enhancing properties of NNC-711, a gamma-aminobutyric acid reuptake inhibitor'. European Journal of Pharmacology, 424 (1):37-44. [Details]
O¡¦Connell AW, Fox GB, Kjøller C, Gallagher H, Murphy KJ, Kelly J, Regan CM ( (2001) 'Anti-ischemic and cognition-enhancing properties of NNC-711, a ×-aminobutyric acid reuptake inhibitor'. European Journal of Pharmacology, 424 :37-44. [Details]
Murphy KJ, Fox GB, Foley AG, Gallagher HC, OConnell A, Griffin A-M, Nau H, Regan CM (2001) 'Pentyl-4-yn-valproic acid analogue enhances both spatial and avoidance learning and attenuates age-related NCAM-mediated neuroplastic decline within the medial temporal lobe'. Neurochemistry, 78 :704-714. [Details]
O'Connell C, Gallagher HC, O'Malley A, Bourke M, Regan CM (2000) 'CREB phosphorylation coincides with transient synapse formation in the rat hippocampal dentate gyrus following avoidance learning'. Neural Plasticity, 7 :279-289. [Details]
Foley, AG; Ellenbroek, BA; Lubbers, LJ; Cools, AR; Regan, CM; (2000) 'Complex environment rearing reverses neuroplastic deficits in the perinatal period'. European Journal of Neuroscience, 12 (NA):295-295. [Details]
Soares, S; Gallagher, HC; Gallagher, K; Regan, CM; Nothias, F; (2000) 'Correlation between expression of 14-3-3E and NCAM polysialylation in the hypothalamo-neurohypophysial system during lactation'. European Journal of Neuroscience, 12 (NA):274-274. [Details]
Merino, JJ; Murphy, KJ; Cordero, MI; Kruyt, ND; Venero, C; Regan, C; Sandi, C; (2000) 'PSA-NCAM modulation by contextual fear conditioning'. European Journal of Neuroscience, 12 (NA):254-254. [Details]
Foley, AG; Hartz, BP; Gallagher, HC; Ronn, LCB; Berezin, V; Bock, E; Regan, CM; (2000) 'A synthetic peptide ligand of neural cell adhesion molecule (NCAM) IgI domain prevents NCAM internalization and disrupts passive avoidance learning'. Neurochemistry, 74 (6):2607-2613. [Details]
O'Leary, G; Bacon, CL; Odumeru, O; Fagan, C; Fitzpatrick, T; Gallagher, HC; Moriarty, DC; Regan, CM; (2000) 'Antiproliferative actions of inhalational anesthetics: comparisons to the valproate teratogen'. International Journal of Developmental Neuroscience, 18 (1):39-45. [Details]
Gallagher, HC; Odumeru, OA; Regan, CM; (2000) 'Regulation of neural cell adhesion molecule polysialylation state by cell-cell contact and protein kinase C delta'. Journal of Neuroscience Research, 61 (6):636-645. [Details]
O'Connell, C., Gallagher, H.C., O'Malley, A., Bourke, M., and Regan, C. (2000) 'CREB phosphorylation coincides with transient synapse formation in the rat hippocampal dentate gyrus following avoidance learning'. Neural Plasticity, 7 :279-289. [Details]
Fox GB, Kjøller C, Murphy KJ, Regan CM (2000) 'The modulations of NCAM polysialylation state that follow transient global ischaemia are brief on neurons'. Journal of Neuropathology and Experimental Neurology, 60 :132-140. [Details]
Fox GB, Fichera G, Barry T, O'Connell AW, Murphy KJ, Regan CM (2000) 'Consolidation of passive avoidance learning is associated with transiently increased polysialylated neuron number in layer II of the rat medial temporal cortex'. Journal of Neurobiology, 45 :135-141. [Details]
Gallagher HC, Odumeru OA, Regan CM (2000) 'Regulation of neural cell adhesion molecule polysialylation state by cell-cell contact and protein kinase C delta'. Journal of Neuroscience Research, 61 :636-645. [Details]
OMalley A, OConnell C, Murphy KJ, Regan CM (2000) 'Transient spine density increases in the mid-molecular layer of hippocampal dentate gyrus accompany consolidation of a spatial learning task in the rodent'. Neuroscience, 99 :229-232. [Details]
Foley AG, Hartz BP, Gallagher HC, Rønn LCB, Berezin V, Bock E, Regan CM (2000) 'A synthetic peptide ligand of NCAM Ig1 domain prevents NCAM internalization and disrupts passive avoidance learning'. Neurochemistry, 74 :2607-2613. [Details]
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Gallagher HC, De Souza IEJ, Regan CM (2004) 'The impact of chemical residues: the case of polychlorinated biphenyls (PCBs)' In: Watson D, Ed. Woodhead Publishing (eds). In Pesticides, Veterinary and other Residues in Food. [Details]
Regan CM (2004) 'Cell Adhesion Molecules' In: In (Riedel G, Blatt B, Eds.), Landes Bioscience (eds). Memories are Made of These: From Messengers to Molecules. [Details]
Murphy KJ, Gallagher HC, Regan CM (2002) 'Learning-induced modulation of neural cell adhesion molecule polysialylation state as a biomarker of prior inorganic lead exposure during the early postnatal period' In: CRC Press/Lewis Publishers (ISBN 156670-596-7) (eds). 'Biomarkers of Environmentally Associated Disease: Technologies, Concepts, and Perspectives'. [Details]
Regan CM (2002) 'From cellular mechanisms to the architecture of memory: Synapse formation during learning' In: (Calabrese P, Neugebauer A, Eds.), World Scientific (ISBN 981-238-170-8) (eds). 'Memory and Emotion'. [Details]
Regan CM (2002) 'From cellular mechanisms to the architecture of memory: Cell adhesion molecules and memory consolidation' In: (Calabrese P, Neugebauer A, Eds.), World Scientific (ISBN 981-238-170-8) (eds). 'Memory and Emotion'. [Details]
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