Professor Cormac Taylor

Research

Professor Cormac Taylor B.Sc., Ph.D.

Contact Details

Title	Associate Professor
Address	School of Medicine & Medical Science Conway Institute Belfield Dublin 4
Telephone:	Ext. 6732
Email:	ei.dcu@rolyat.camroc

Biography:

2006 - present Associate Professor, School of Medicine & Medical Science, UCD
2001 - 2006 College Lecturer (Research), UCD Conway Institute
1996 - 2001 Research fellow, Brigham & Women's Hospital & Harvard Medical School, USA
1992 - 1996 Ph.D. , Dept. Pharmacology, University College Dublin.

Research Interests

Current research is directed towards expanding our understanding of the mechanisms by which hypoxia regulates transcriptional events in epithelial cells. Specifically, we are interested in the regulation of global gene expression in response to hypoxia and the modification of transcriptional regulators which underlies the induction of such events.

Research Projects

Sponsor : Johnson & Johnson Pharmaceutical Research & Development, LLC (J&JPRD)
Title : Oral hydroxylase inhibitors in colitis
Start Date / End Date : 01-JUL-10 / 01-JUL-13

Sponsor : University College Dublin (UCD)
Title : EU COST meeting support
Start Date / End Date : 01-SEP-10 / 01-DEC-10

Sponsor : AstraZeneca Pharmaceuticals Ltd., Ireland
Title : Obesity and Obstructive Sleep Apnoea: Cardiovascular, Metabolic and Inflammatory Association
Start Date / End Date : 01-JUL-09 / 30-JUN-11

Sponsor : Johnson & Johnson Pharmaceutical Research & Development, LLC (J&JPRD)
Title : Testing PHD inhibitors
Start Date / End Date : 01-JUL-09 / 31-DEC-09

Sponsor : Irish Research Council for Science Engineering and Technology (IRCSET)
EU - European Regional Development Fund (ERDF)
Title : Novel drug delivery strategies in inflammatory Bowel Disease
Start Date / End Date : 13-OCT-08 / 12-OCT-11

Sponsor : Irish Research Council for Science Engineering and Technology (IRCSET) Title : Impact of hypoxia on antibiotic resistance in Pseudomonas aeruginosa: Implications for therapeutic approaches in cystic fibrosis Start Date / End Date : 01-OCT-08 / 30-SEP-11
Sponsor : University College Dublin (UCD) Title : In vivo models of hypoxic lung disease Start Date / End Date : 26-MAY-08 / 01-DEC-09
Sponsor : Science Foundation Ireland (SFI) Title : To investigate a role for hydroxylases in hypoxia-regulated inflammatory processes Start Date / End Date : 01-DEC-07 / 30-MAY-12
Sponsor : Science Foundation Ireland (SFI) Title : Pgcl and Insulin sensitivity Start Date / End Date : 01-NOV-06 / 31-OCT-07
Sponsor : Science Foundation Ireland (SFI) Title : Consolidated Imaging Laboratory Start Date / End Date : 01-DEC-04 / 31-MAY-05
Sponsor : Science Foundation Ireland (SFI) Title : Impact of hypoxia on cAMP - dependent pro-inflammatory gene expression in epithelial cells. Start Date / End Date : 01-AUG-02 / 31-JAN-08
Sponsor : The Wellcome Trust (WT) Title : The role of creb in hypoxia elicited gene transcription Start Date / End Date : 01-APR-01 / 31-MAR-05
Sponsor : University College Dublin (UCD) Title : Drug resistance in cancer Start Date / End Date : 01-OCT-06 / 30-SEP-07
Sponsor : Science Foundation Ireland (SFI) Title : Impact of hypoxia on cAMP-dependent pro-inflammatory gene expression in epithelial cells Start Date / End Date : 01-SEP-05 / 31-AUG-07
Sponsor : Science Foundation Ireland (SFI) Title : The role of mitochondria in signalling pathways activated in neuronal hypoxia Start Date / End Date : 01-JUL-06 / 30-SEP-09
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Peer Reviewed Journals

Taylor CT, Cummins EP; (2011) 'Regulation of gene expression by carbon dioxide'. The Journal of physiology, 589 (Pt 4):797-803. [DOI] [Details]

Bruning U, Cerone L, Neufeld Z, Fitzpatrick SF, Cheong A, Scholz CC, Simpson DA, Leonard MO, Tambuwala MM, Cummins EP, Taylor CT ; (2011) 'MicroRNA-155 Promotes Resolution of Hypoxia-Inducible Factor-1{alpha} Activity During Prolonged Hypoxia''. Molecular Cell Biology, 31 . [DOI] [Details]

Hams E, Saunders SP, Cummins EP, O'Connor A, Tambuwala MT, Gallagher WM, Byrne A, Campos-Torres A, Moynagh PM, Jobin C, Taylor CT, Fallon PG; (2011) 'The hydroxylase inhibitor dimethyloxallyl glycine attenuates endotoxic shock via alternative activation of macrophages and IL-10 production by B1 cells'. Shock, . [Details]

Walmsley, SR,Chilvers, ER,Thompson, AA,Vaughan, K,Marriott, HM,Parker, LC,Shaw, G,Parmar, S,Schneider, M,Sabroe, I,Dockrell, DH,Milo, M,Taylor, CT,Johnson, RS,Pugh, CW,Ratcliffe, PJ,Maxwell, PH,Carmeliet, P,Whyte, MKB; (2011) 'Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice'. The Journal of clinical investigation, 121 :1053-1063. [DOI] [Details]

Fitzpatrick, S. F., Tambuwala, M. M., Bruning, U., Schaible, B., Scholz, C. C., Byrne, A., O'Connor, A., Gallagher, W. M., Lenihan, C. R., Garvey, J. F., Howell, K., Fallon, P. G., Cummins, E. P., and Taylor, C. T. ; (2011) 'An intact canonical NF-kB pathway is required for inflammatory gene expression in pesponse to hypoxia'. Journal of Immunology, 186 (2):1091-1096. [Details]

Agbor TA, Cheong A, Comerford KM, Scholz CC, Bruning U, Clarke A, Cummins EP, Cagney G, Taylor CT; (2011) 'Small Ubiquitin-related Modifier (SUMO)-1 Promotes Glycolysis in Hypoxia'. Journal of Biological Chemistry, 286 :4718-4726. [DOI] [Details]
Taylor, CT,Moncada, S; (2010) 'Nitric Oxide, Cytochrome C Oxidase, and the Cellular Response to Hypoxia'. ARTERIOSCL THROM VAS, 30 :643-647. [DOI] [Details]
Taylor CT, Moncada S; (2010) 'Nitric oxide, cytochrome C oxidase, and the cellular response to hypoxia'. Arteriosclerosis, thrombosis, and vascular biology, 30 (4):643-647. [DOI] [Details]
Colgan, S.P. and Taylor, C.T. ; (2010) 'Hypoxia: an alarm signal during intestinal inflammation'. Journal of Gastroenterology and Hepatology, 7 (5):281-287. [Details]
Zhdanov, AV, Ward MW, Taylor CT, Souslova EA, Chudakov DM, Prehn JH, Papkovsky, DB; (2010) 'Extracellular Calcium Depletion Transiently Elevates Oxygen Consumption in Neurosecretory PC12 Cells through Activation of Mitochondrial Na+/Ca2+ Exchange'. Biochimica et biophysica acta, 1797 (9):1627-1637. [Details]
Taylor, CT & McElwain J; (2010) 'Ancient Atmospheres and the evolution of oxygen sensing in the HIF pathway'. 25 (5):272-279. [Details]
Schaible, B, Schaffer K & Taylor CT (; (2010) 'Hypoxia, Innate Immunity and infection in the lung'. Respiratory Physiology &Amp; Neurobiology, . [Details]
Ng CT, Biniecka, M., Kennedy, A., McCormick, K., FitzGerald, O., Bresnihan, B., Buggy, D., Taylor,C.T., O'Sullivan, J., Fearon, U., and Veale, D.J:; (2010) 'Synovial Tissue Hypoxia and Inflammation in vivo'. Annals of Rheumatic Diseases, 69 (7):1389-1395. [Details]
Kennedy A, Ng CT, Biniecka M, Saber J, Taylor C, O¿Sullivan J, Veale DJ, Fearon U.; (2010) 'Angiogenesis and Blood Vessel Stability in Inflammatory Synovial Tissue'. Arthritis and Rheumatism, 62 (3):711-721. [Details]
Ward JB, Lawlor K, Amu S, Taylor CT, Fallon PG, and Keely SJ. ; (2010) 'Hydroxylase Inhibition Attenuates Colonic Epithelial Secretory Function and Ameliorates Experimental Diarrhea'. FASEB Journal, . [Details]
Cummins EP, Oliver KM, Lenihan CR, Fitzpatrick SF, Bruning U, Scholz CC, Slattery S, Leonard MO, McLoughlin P and Taylor CT. ; (2010) 'NF-B links CO2 sensing to innate immunity and inflammation in mammalian cells'. Immunology, 185 (7):4439-4445. [Details]
Chua YL, Dufour E, Dassa EP, Rustin P, Jacobs HT, Taylor CT, Hagen T ; (2010) 'Stabilization of HIF-1{alpha} protein in hypoxia occurs independently of mitochondrial reactive oxygen species production'. Biological chemistry, 285 (41):31277-31284. [Details]
Zhdanov AV, Ogurtsov VI, Taylor CT, Papkovsky DB; (2010) 'Monitoring of cell oxygenation and responses to metabolic stimulation by intracellular oxygen sensing technique'. Integrative biology, 2 (9):443-451. [Details]
Tambuwala MM, Cummins EP, Lenihan CR, Kiss J, Stauch M, Scholz CC, Fraisl P, Lasitschka F, Mollenhauer M, Saunders SP, Maxwell PH, Carmeliet P, Fallon PG, Schneider M, Taylor CT; (2010) 'Loss of prolyl hydroxylase-1 protects against colitis through reduced epithelial cell apoptosis and increased barrier function'. Gastroenterology, . [Details]
Taylor, C. T.,Cummins, E. P.; (2009) 'The role of NF-kappaB in hypoxia-induced gene expression'. Ann N Y Acad Sci, 1177 :178-84178. [Details]
Batti L, Taylor CT, O'Connor JJ; (2010) 'Hydroxylase inhibition reduces synaptic transmission and protects against a glutamate-induced ischemia in the CA1 region of the rat hippocampus'. Neuroscience, 167 (4):1014-1024. [Details]
Oliver, K. M.,Taylor, C. T.,Cummins, E. P.; (2009) 'Hypoxia. Regulation of NFkappaB signalling during inflammation: the role of hydroxylases'. Arthritis Res Ther, 11 (11). [Details]
Eivers, S. S.,McGivney, B. A.,Fonseca, R. G.,MacHugh, D. E.,Menson, K.,Park, S. D.,Rivero, J. L.,Taylor, C. T.,Katz, L. M.,Hill, E. W.; 'Alterations in oxidative gene expression in equine skeletal muscle following exercise and training'. Physiol Genomics, 40 (22):83-9383. [Details]
McLoughlin P, Leonard MO, Howell K, Madden SF, Costello CM, Higgins DG, Taylor CT, ; (2008) 'Hypoxia selectively activates the CREB family of transcription factors in the in vivo lung'. American Journal of Respiratory and Critical Care Medicine, 9 (NA):977-983. [DOI] [Details]
Oliver, KM, Garvey, JF, Ng, CT, Veale, DJ, Fearon, U, Cummins, EP & Taylor, CT ; (2009) 'Hypoxia activates NF-kB-dependent gene expression through the canonical signaling pathway'. Antioxident Radox Signalling, . [Details]
Zaman, MB,Leonard, MO,Ryan, EJ,Nolan, NP,Hoti, E,Maguire, D,Mulcahy, H,Traynor, O,Taylor, CT,Hegarty, JE,Geoghegan, JG,O'Farrelly, C; (2007) 'Lower expression of Nrf2 mRNA in older donor livers: A possible contributor to increased ischemia-reperfusion injury?'. Planta, 84 :1272-1278. [DOI] [Details]
Taylor, C.E., D.D. Link and N.J. English; (2007) 'Methane Hydrate Research at NETL: Research to Make Methane Production from Hydrates a Reality'. J. Petrol. Sci. & Eng, 56 (1-3):186-191. [Details]
Leonard MO, Godson C, Brady HR, Taylor CT; (2005) 'Potentiation of glucocorticoid activity in hypoxia through induction of the glucocorticoid receptor'. Journal of Immunology, 174 (4):2250-2257. [Details]
Samuel M, Aderogba K, Dutt N, Lambert JS, Taylor C.; (2007) 'A hat trick of ulcerating pathogens in a single genital lesion'. International Journal of Std and Aids, 18 (1):65-66. [Details]
Comerford, KM,Leonard, MO,Cummins, EP,Fitzgerald, KT,Beullens, M,Bollen, M,Taylor, CT; (2006) 'Regulation of protein phosphatase 1 gamma activity in hypoxia through increased interaction with NIPP1: Implications for cellular metabolism'. Cell, 209 :211-218. [DOI] [Details]
Eivers SS, McGivney BA, Fonseca RG, MacHugh DE, Menson K, Park SD, Rivero JLL, Taylor CT, Katz LM, Hill EW; (2010) 'Alterations in oxidative gene expression in equine skeletal muscle following exercise and training'. Physiological Genomics, 40 (2):83-93. [DOI] [Details]
Ryan, S.,Taylor, C. T.,McNicholas, W. T.; (2009) 'Systemic inflammation: a key factor in the pathogenesis of cardiovascular complications in obstructive sleep apnoea syndrome?'. Thorax, 64 (7):631-6. [Details]
Victor, VM,Nunez, C,D'Ocon, P,Taylor, CT,Esplugues, JV,Moncada, S; (2009) 'Regulation of Oxygen Distribution in Tissues by Endothelial Nitric Oxide'. Circulation, 104 :1178-121. [DOI] [Details]
O'Hagan, KA,Cocchiglia, S,Zhdanov, AV,Tambawala, MM,Cummins, EP,Monfared, M,Agbor, TA,Garvey, JF,Papkovsky, DB,Taylor, CT,Allan, BB; (2009) 'PGC-1 alpha is coupled to HIF-1 alpha-dependent gene expression by increasing mitochondrial oxygen consumption in skeletal muscle cells'. Proceedings of the National Academy of Sciences of the United States of America, 106 :2188-2193. [DOI] [Details]
Sebastia, J,Kieran, D,Breen, B,King, MA,Netteland, DF,Joyce, D,Fitzpatrick, SF,Taylor, CT,Prehn, JHM; (2009) 'Angiogenin protects motoneurons against hypoxic injury'. Cell, 16 :1238-1247. [DOI] [Details]
Garvey, J. F.,Taylor, C. T.,McNicholas, W. T.; (2009) 'Cardiovascular disease in obstructive sleep apnoea syndrome: the role of intermittent hypoxia and inflammation'. Eur Respir J, 33 (5):1195-205. [Details]
Leonard, MO,Howell, K,Madden, SF,Costello, CM,Higgins, DG,Taylor, CT,McLoughlin, P; (2008) 'Hypoxia Selectively Activates the CREB Family of Transcription Factors in the In Vivo Lung'. American Journal of Respiratory and Critical Care Medicine, 178 (NA):977-983. [DOI] [Details]
Daly P, Docherty N.G, Healy D.A, Taylor C.T, Fitzpatrick J.M and Watson R.W.G. ; (2008) 'The Single Insult of Hypoxic Preconditioning induces an Anti-apoptotic Response in Human Proximal Tubular Cells, in vitro, Across Cold Storage'. BJU International, . [Details]
Taylor CT, Cummins EP, Seeballuck F, Keely SJ, Mangan NE, Callanan JJ, Fallon PG, ; (2008) 'The hydroxylase inhibitor dimethyloxalylglycine is protective in a murine model of colitis'. Gastroenterology, 134 (1):156-165. [DOI] [Details]
Barry RE, Allan BB, Cummins EP, Kattla JJ, Giblin A, Scally N, Taylor CT, Brazil DP. ; (2007) 'Enhanced sensitivity of protein kinase B/Akt to insulin in hypoxia is independent of HIF1alpha and promotes cell viability'. European Journal of Cell Biology, 86 (7):393-403. [Details]
Barry, RE,Allan, BB,Cummins, EP,Kattla, JJ,Giblin, A,Scally, N,Taylor, CT,Brazil, DP; (2007) 'Enhanced sensitivity of protein kinase B/Akt to insulin in hypoxia is independent of HIF1 alpha and promotes cell viability'. European Journal of Cell Biology, 86 (NA):393-403. [DOI] [Details]
Comerford, KM; Leonard, MO; Cummins, EP; Fitzgerald, KT; Beullens, M; Bollen, M; Taylor, CT; ; (2006) 'Regulation of protein phosphatase 1 gamma activity in hypoxia through increased interaction with NIPP1: Implications for cellular metabolism'. Journal of Cellular Physiology, 209 (1):211-218. [Details]
Ryan, S,Taylor, CT,McNicholas, WT; (2006) 'Predictors of elevated nuclear factor-kappa B-dependent genes in obstructive sleep apnea syndrome'. American Journal of Respiratory and Critical Care Medicine, 174 :824-830. [DOI] [Details]
Molloy, EJ,O'Neill, AJ,Doyle, BT,Grantham, JJ,Taylor, CT,Sheridan-Pereira, M,Fitzpatrick, JM,Webb, DW,Watson, RWG; (2006) 'Effects of heat shock and hypoxia on neonatal neutrophil lipopolysaccharide responses: Altered apoptosis, Toll-like receptor-4 and CD11b expression compared with adults'. Biology of the Neonate, 90 :34-39. [DOI] [Details]
O'Reilly, SM,Leonard, MO,Kieran, N,Comerford, KM,Cummins, E,Pouliot, M,Lee, SB,Taylor, CT; (2006) 'Hypoxia induces epithelial amphiregulin gene expression in a CREB-dependent manner'. Cell, 290 :592-600. [DOI] [Details]
O'Neill, A; Morrissey, C; Cunningham, K; Taylor, C; Fitzpatrick, JM; Watson, RWG; ; (2006) 'Effects of hypoxia on MnSOD expression and subsequent epigallocatechin gallate induced prostate cancer cell apoptosis'. European Urology Supplements, 5 (14):797-797. [Details]
Molloy, EJ; O'Neill, AJ; Doyle, BT; Grantham, JJ; Taylor, CT; Sheridan-Pereira, M; Fitzpatrick, JM; Webb, DW; Watson, RWG; ; (2006) 'Effects of heat shock and hypoxia on neonatal neutrophil lipopolysaccharide responses: Altered apoptosis, Toll-like receptor-4 and CD11b expression compared with adults'. Biology of the Neonate, 90 (1):34-39. [Details]
Leonard MO, Kieran NE, Howell K, Burne MJ, Varadarajan R, Dhakshinamoorthy S, Porter AG, O'Farrelly C, Rabb H, Taylor CT.; (2006) 'Reoxygenation-specific activation of the antioxidant transcription factor Nrf2 mediates cytoprotective gene expression in ischemia-reperfusion injury'. Faseb Journal, 20 (14):2624-2626. [Details]
Molloy EJ, O'Neill AJ, Doyle BT, Grantham J, Taylor Ct, Sheridan-Pereira M, Fitzpatrick JM, Webb DW, Watson RWG. ; (2006) 'Altered lipopolysaccharide-induced neutrophil responses following hypoxia and heatshock in both adults and neonates in vitro'. Biology of the Neonate, 90 (1):34-39. [Details]
Taylor CT, Leonard MO, Kieran NE, Howell K, Burne MJ, Varadarajan R, Dhakshinamoorthy S, Porter AG, O'farrelly C, Rabb H, ; (2006) 'Reoxygenation-specific activation of the antioxidant transcription factor Nrf2 mediates cytoprotective gene expression in ischemia-reperfusion injury'. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 20 (NA):2624-2626. [DOI] [Details]
Cummins, EP; Berra, E; Comerford, KM; Ginouves, A; Fitzgerald, KT; Seeballuck, F; Godson, C; Nielsen, JE; Moynagh, P; Pouyssegur, J; Taylor, CT; ; (2006) 'Prolyl hydroxylase-1 negatively regulates I kappa B kinase-beta, giving insight into hypoxia-induced NF kappa B activity'. Proceedings of the National Academy of Sciences of the United States of America, 103 (48):18154-18159. [Details]
Molloy, EJ; O'Neill, AJ; Doyle, BT; Grantham, JJ; Taylor, CT; Sheridan-Pereira, M; Fitzpatrick, JM; Webb, DW; Watson, RWG; ; (2006) 'Effects of heat shock and hypoxia on neonatal neutrophil lipopolysaccharide responses: Altered apoptosis, Toll-like receptor-4 and CD11b expression compared with adults'. Biology of the Neonate, 90 (1):34-39. [Details]
Molloy, EJ; O'Neill, AJ; Doyle, BT; Grantham, JJ; Taylor, CT; Sheridan-Pereira, M; Fitzpatrick, JM; Webb, DW; Watson, RWG; ; (2006) 'Effects of heat shock and hypoxia on neonatal neutrophil lipopolysaccharide responses: Altered apoptosis, Toll-like receptor-4 and CD11b expression compared with adults'. Biology of the Neonate, 90 (1):34-39. [Details]
O'Neill, A; Morrissey, C; Cunningham, K; Taylor, C; Fitzpatrick, JM; Watson, RWG; ; (2006) 'Effects of hypoxia on MnSOD expression and subsequent epigallocatechin gallate induced prostate cancer cell apoptosis'. European Urology Supplements, 5 (14):797-797. [Details]
O'Neill, A; Morrissey, C; Cunningham, K; Taylor, C; Fitzpatrick, JM; Watson, RWG; ; (2006) 'Effects of hypoxia on MnSOD expression and subsequent epigallocatechin gallate induced prostate cancer cell apoptosis'. European Urology Supplements, 5 (14):797-797. [Details]
O'Reilly, SM; Leonard, MO; Kieran, N; Comerford, KM; Cummins, E; Pouliot, M; Lee, SB; Taylor, CT; ; (2006) 'Hypoxia induces epithelial amphiregulin gene expression in a CREB-dependent manner'. American Journal of Physiology-Cell Physiology, 290 (2):592-600. [Details]
Cummins, EP; Berra, E; Comerford, KM; Ginouves, A; Fitzgerald, KT; Seeballuck, F; Godson, C; Nielsen, JE; Moynagh, P; Pouyssegur, J; Taylor, CT; ; (2006) 'Prolyl hydroxylase-1 negatively regulates I kappa B kinase-beta, giving insight into hypoxia-induced NF kappa B activity'. Proceedings of the National Academy of Sciences of the United States of America, 103 (48):18154-18159. [Details]
Cummins, EP; Berra, E; Comerford, KM; Ginouves, A; Fitzgerald, KT; Seeballuck, F; Godson, C; Nielsen, JE; Moynagh, P; Pouyssegur, J; Taylor, CT; ; (2006) 'Prolyl hydroxylase-1 negatively regulates I kappa B kinase-beta, giving insight into hypoxia-induced NF kappa B activity'. Proceedings of the National Academy of Sciences of the United States of America, 103 (48):18154-18159. [Details]
O'Reilly, SM; Leonard, MO; Kieran, N; Comerford, KM; Cummins, E; Pouliot, M; Lee, SB; Taylor, CT; ; (2006) 'Hypoxia induces epithelial amphiregulin gene expression in a CREB-dependent manner'. American Journal of Physiology-Cell Physiology, 290 (2):592-600. [Details]
Zaman, MB; Leonard, MO; Ryan, EJ; Nolan, NP; Maguire, D; Traynor, O; Taylor, CT; Hegarty, JE; Geoghegan, JG; O'Farrelly, C; ; (2006) 'Activation of hepatic Nrf-2 following ischemia-reperfusion of donor organ during orthotopic liver transplantation'. Hepatology, 44 (4):472-473. [Details]
Ryan, S; Taylor, CT; McNicholas, WT; ; (2006) 'Predictors of elevated nuclear factor-kappa B-dependent genes in obstructive sleep apnea syndrome'. American Journal of Respiratory and Critical Care Medicine, 174 (7):824-830. [Details]
Ryan, S, Taylor, CT, McNicholas, WT, ; (2006) 'Predictors of elevated nuclear factor-kappa B-dependent genes in obstructive sleep apnea syndrome'. American Journal of Respiratory and Critical Care Medicine, 174 (7):824-830. [DOI] [Details]
Cummins, EP,Berra, E,Comerford, KM,Ginouves, A,Fitzgerald, KT,Seeballuck, F,Godson, C,Nielsen, JE,Moynagh, P,Pouyssegur, J,Taylor, CT; (2006) 'Prolyl hydroxylase-1 negatively regulates I kappa B kinase-beta, giving insight into hypoxia-induced NF kappa B activity'. Proceedings of the National Academy of Sciences of the United States of America, 103 :18154-18159. [DOI] [Details]
Leonard, MO,Kieran, NE,Howell, K,Burne, MJ,Varadarajan, R,Dhakshinamoorthy, S,Porter, AG,O'Farrelly, C,Rabb, H,Taylor, CT; (2006) 'Reoxygenation-specific activation of the antioxidant transcription factor Nrf2 mediates cytoprotective gene expression in ischemia-reperfusion injury'. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 20 . [DOI] [Details]
Coffey, RNT; Morrissey, C; Taylor, CT; Fitzpatrick, JM; Watson, RWG; ; (2005) 'Resistance to caspase-dependent, hypoxia-induced apoptosis is not hypoxia-inducible factor-1 alpha mediated in prostate carcinoma cells'. Cancer, 103 (7):1363-1374. [Details]
Leonard, MO,Godson, C,Brady, HR,Taylor, CT; (2005) 'Potentiation of glucocorticoid activity in hypoxia through induction of the glucocorticoid receptor'. J IMMUNOL, 174 :2250-2257. [Details]
Coffey, RNT,Morrissey, C,Taylor, CT,Fitzpatrick, JM,Watson, RWG; (2005) 'Resistance to caspase-dependent, hypoxia-induced apoptosis is not hypoxia-inducible factor-1 alpha mediated in prostate carcinoma cells'. Cancer, 103 :1363-1374. [DOI] [Details]
Leonard, M. O.,Godson, C.,Brady, H. R.,Taylor, C. T.; (2005) 'Potentiation of glucocorticoid activity in hypoxia through induction of the glucocorticoid receptor'. J Immunol, 174 (4):2250-7. [Details]
Coffey, RNT; Morrissey, C; Taylor, CT; Fitzpatrick, JM; Watson, RWG; ; (2005) 'Resistance to caspase-dependent, hypoxia-induced apoptosis is not hypoxia-inducible factor-1 alpha mediated in prostate carcinoma cells'. Cancer, 103 (7):1363-1374. [Details]
Ryan, S,Taylor, CT,McNicholas, WT; (2005) 'Selective activation of inflammatory pathways by intermittent hypoxia in obstructive sleep apnea syndrome'. Circulation, 112 :2660-2667. [DOI] [Details]
Leonard, MO; Godson, C; Brady, HR; Taylor, CT; ; (2005) 'Potentiation of glucocorticoid activity in hypoxia through induction of the glucocorticoid receptor'. Immunology, 174 (4):2250-2257. [Details]
Ryan, S; Taylor, CT; McNicholas, WT; ; (2005) 'Selective activation of inflammatory pathways by intermittent hypoxia in obstructive sleep apnea syndrome'. Circulation, 112 (17):2660-2667. [Details]
Ryan, S, Taylor, CT, McNicholas, WT, ; (2005) 'Selective activation of inflammatory pathways by intermittent hypoxia in obstructive sleep apnea syndrome'. Circulation, 112 (17):2660-2667. [Details]
Galvin, DJ; Watson, RWG; O'Neill, A; Coffey, RNT; Taylor, C; Gillespie, JI; Fitzpatrick, JM; ; (2004) 'Hypoxia inhibits human bladder smooth muscle cell proliferation: A potential mechanism of bladder dysfunction'. Neurourology and Urodynamics, 23 (4):342-348. [Details]
Galvin, DJ; Watson, RWG; O'Neill, A; Coffey, RNT; Taylor, C; Gillespie, JI; Fitzpatrick, JM; ; (2004) 'Hypoxia inhibits human bladder smooth muscle cell proliferation: A potential mechanism of bladder dysfunction'. Neurourology and Urodynamics, 23 (4):342-348. [Details]
Leonard, MO; O'Reilly, S; Comerford, KM; Taylor, CT; ; (2004) 'Identification of cyclic AMP response element-binding protein-dependent transcriptional responses in hypoxia by microarray analysis'. Methods in Enzymology, 381 (NA):511-524. [Details]
Galvin, DJ; Watson, RWG; O'Neill, A; Coffey, RNT; Taylor, C; Gillespie, JI; Fitzpatrick, JM; ; (2004) 'Hypoxia inhibits human bladder smooth muscle cell proliferation: A potential mechanism of bladder dysfunction'. Neurourology and Urodynamics, 23 (4):342-348. [Details]
Galvin, DJ,Watson, RWG,O'Neill, A,Coffey, RNT,Taylor, C,Gillespie, JI,Fitzpatrick, JM; (2004) 'Hypoxia inhibits human bladder smooth muscle cell proliferation: A potential mechanism of bladder dysfunction'. Journal of Urology, 23 :342-348. [DOI] [Details]
Comerford, K.M., Cummins, E.P., and Taylor, C.T. ; (2004) 'c-Jun HH2-terminal kinase activation contributes to hypoxia-inducible factor-1 alpha- dependent P-glycoprotein expression in hypoxia'. Cancer Research, 64 :9057-9061. [Details]
Leonard MO, O'Reilly S, Comerford KM, Taylor CT. ; (2004) 'Identification of cyclic AMP response element-binding protein-dependent transcriptional responses in hypoxia by microarray analysis'. Methods in Enzymology, 381 :511-524. [Details]
Comerford, KM,Cummins, EP,Taylor, CT; (2004) 'c-Jun NH2-terminal kinase activation contributes to hypoxia-inducible factor 1 alpha-dependent P-glycoprotein expression in hypoxia'. Cancer, 64 :9057-9061. [Details]
Kieran, NE; Doran, PP; Connolly, SB; Greenan, MC; Higgins, DF; Leonard, M; Godson, C; Taylor, CT; Henger, A; Kretzler, M; Burne, MJ; Rabb, H; Brady, HR; ; (2003) 'Modification of the transcriptomic response to renal ischemia/reperfusion injury by lipoxin analog'. Kidney International, 64 (2):480-492. [Details]
Leonard, MO; Cottell, DC; Godson, C; Brady, HR; Taylor, CT; ; (2003) 'The role of HIF-1 alpha in transcriptional regulation of the proximal tubular epithelial cell response to hypoxia'. Journal of Biological Chemistry, 278 (41):40296-40304. [Details]
Leonard, MO; Godson, C; Brady, HR; Taylor, CT; ; (2003) 'Involvement of HIF-1 alpha in hypoxia mediated alterations in human proximal tubular epithelial cell transcription'. Journal of the American Society of Nephrology, 14 (NA):24-24. [Details]
Kieran, NE; Doran, PP; Connolly, SB; Greenan, MC; Higgins, DF; Leonard, M; Godson, C; Taylor, CT; Henger, A; Kretzler, M; Burne, MJ; Rabb, H; Brady, HR; ; (2003) 'Modification of the transcriptomic response to renal ischemia/reperfusion injury by lipoxin analog'. Kidney International, 64 (2):480-492. [Details]
Kieran, NE; Doran, PP; Connolly, SB; Greenan, MC; Higgins, DF; Leonard, M; Godson, C; Taylor, CT; Henger, A; Kretzler, M; Burne, MJ; Rabb, H; Brady, HR; ; (2003) 'Modification of the transcriptomic response to renal ischemia/reperfusion injury by lipoxin analog'. Kidney International, 64 (2):480-492. [Details]
Comerford, KM,Leonard, MO,Karhausen, J,Carey, R,Colgan, SP,Taylor, CT; (2003) 'Small ubiquitin-related modifier-1 modification mediates resolution of CREB-dependent responses to hypoxia'. Proceedings of the National Academy of Sciences of the United States of America, 100 :986-991. [DOI] [Details]
Kieran, NE,Doran, PP,Connolly, SB,Greenan, MC,Higgins, DF,Leonard, M,Godson, C,Taylor, CT,Henger, A,Kretzler, M,Burne, MJ,Rabb, H,Brady, HR; (2003) 'Modification of the transcriptomic response to renal ischemia/reperfusion injury by lipoxin analog'. Kidney International, 64 :480-492. [Details]
Leonard, MO,Cottell, DC,Godson, C,Brady, HR,Taylor, CT; (2003) 'The role of HIF-1 alpha in transcriptional regulation of the proximal tubular epithelial cell response to hypoxia'. J BIOL CHEM, 278 :40296-40304. [DOI] [Details]
Hagen, T,Taylor, CT,Lam, F,Moncada, S; (2003) 'Redistribution of intracellular oxygen in hypoxia by nitric oxide: Effect on HIF1 alpha'. Science, 302 :1975-1978. [Details]
Comerford, KM; Leonard, MO; Karhausen, J; Carey, R; Colgan, SP; Taylor, CT; ; (2003) 'Small ubiquitin-related modifier-1 modification mediates resolution of CREB-dependent responses to hypoxia'. Proceedings of the National Academy of Sciences of the United States of America, 100 (3):986-991. [Details]
Leonard MO, Cottell DC, Godson C, Brady HR, Taylor CT. ; (2003) 'The role of HIF-1 alpha in transcriptional regulation of the proximal tubular epithelial cell response to hypoxia'. Journal of Biological Chemistry, 278 (41):40298-40304. [Details]
Comerford, K.M., Leonard, M.L., Karhausen, J., Carey, R., Colgan, S.P., and Taylor, C.T.; (2003) 'Small ubiquitin-related modifier-1 modification mediates resolution of CREB-dependent responses to hypoxia'. Proceedings of the National Academy of Sciences of the, 100 :986-991. [Details]
Kieran, N. E.,Doran, P. P.,Connolly, S. B.,Greenan, M. C.,Higgins, D. F.,Leonard, M.,Godson, C.,Taylor, C. T.,Henger, A.,Kretzler, M.,Burne, M. J.,Rabb, H.,Brady, H. R.; (2003) 'Modification of the transcriptomic response to renal ischemia/reperfusion injury by lipoxin analog'. Kidney Int, 64 (2):480-92. [Details]
Leonard, M. O.,Cottell, D. C.,Godson, C.,Brady, H. R.,Taylor, C. T.; (2003) 'The role of HIF-1 alpha in transcriptional regulation of the proximal tubular epithelial cell response to hypoxia'. J Biol Chem, 278 (41):40296-304. [Details]
Brady HR, Kieran NE, Doran PP, Connolly SB, Greenan MC, Higgins DF, Leonard M, Godson C, Taylor CT, Henger A, Kretzler M, Burne MJ, Rabb H, ; (2003) 'Modification of the transcriptomic response to renal ischemia/reperfusion injury by lipoxin analog'. Kidney International, 64 (2):480-492. [DOI] [Details]
Leonard, M. O.,Hannan, K.,Burne, M. J.,Lappin, D. W.,Doran, P.,Coleman, P.,Stenson, C.,Taylor, C. T.,Daniels, F.,Godson, C.,Petasis, N. A.,Rabb, H.,Brady, H. R.; (2002) '15-Epi-16-(para-fluorophenoxy)-lipoxin A(4)-methyl ester, a synthetic analogue of 15-epi-lipoxin A(4), is protective in experimental ischemic acute renal failure'. J Am Soc Nephrol, 13 (6):1657-62. [Details]
Leonard MO, Hannan K, Burne MJ, Lappin DW, Doran P, Coleman P, Stenson C, Taylor CT, Daniels F, Godson C, Petasis NA, Rabb H, Brady HR.; (2002) '15-Epi-16-(para-fluorophenoxy)-lipoxin A(4)-methyl ester, a synthetic analogue of 15-epi-lipoxin A(4), is protective in experimental ischemic acute renal failure'. Journal of the American Society of Nephrology, 13 (6):1657-1662. [Details]
Leonard, MO,Hannan, K,Burne, MJ,Lappin, DWP,Doran, P,Coleman, P,Stenson, C,Taylor, CT,Daniels, F,Godson, C,Petasis, NA,Rabb, H,Brady, HR; (2002) '15-Epi-16-(para-fluorophenoxy)-lipoxin A(4)-methyl ester, a synthetic analogue of 15-epi-lipoxin A(4), is protective in experimental ischemic acute renal failure'. J AM SOC NEPHROL, 13 . [DOI] [Details]
Leonard, MO; Hannan, K; Burne, MJ; Lappin, DWP; Doran, P; Coleman, P; Stenson, C; Taylor, CT; Daniels, F; Godson, C; Petasis, NA; Rabb, H; Brady, HR; ; (2002) '15-Epi-16-(para-fluorophenoxy)-lipoxin A(4)-methyl ester, a synthetic analogue of 15-epi-lipoxin A(4), is protective in experimental ischemic acute renal failure'. Journal of the American Society of Nephrology, 13 (6). [Details]
Coffey, RNT; Watson, RWG; Taylor, CT; Fitzpatrick, JM; ; (2002) 'Altered sensitivity to hypoxia in prostate cancer cell lines; Hypoxia-induced apoptosis a mitochondrial independent event'. British Journal of Cancer, 86 (NA):101-101. [Details]
Coffey, RNT; Watson, RWG; Taylor, CT; Fitzpatrick, JM; ; (2002) 'Altered sensitivity to hypoxia in prostate cancer cell lines; Hypoxia-induced apoptosis a mitochondrial independent event'. British Journal of Cancer, 86 (NA):101-101. [Details]
Leonard, MO; Hannan, K; Burne, MJ; Lappin, DWP; Doran, P; Coleman, P; Stenson, C; Taylor, CT; Daniels, F; Godson, C; Petasis, NA; Rabb, H; Brady, HR; ; (2002) '15-Epi-16-(para-fluorophenoxy)-lipoxin A(4)-methyl ester, a synthetic analogue of 15-epi-lipoxin A(4), is protective in experimental ischemic acute renal failure'. Journal of the American Society of Nephrology, 13 (6). [Details]
Leonard, MO; Cottell, D; Godson, C; Brady, HR; Taylor, CT; ; (2002) 'Gene expression profile clustering of proximal tubule epithelial cells in hypoxia and reoxygenation'. Journal of the American Society of Nephrology, 13 (NA):118-118. [Details]
Furuta, G.T., Turner, J.R., Taylor, C.T., Hershberg, R.M., Comerford, K.M., Narravula, S., Podolsky, D.K., and Colgan, S.P. ; (2001) 'Hypoxia-inducible factor-1-dependent induction of intestinal trefoil factor protects barrier function during hypoxia'. Journal of Experimental Medicine, (193):1027-1034. [Details]
Taylor, CT; Winter, DC; Skelly, MM; O'Donoghue, DP; O'Sullivan, GC; Harvey, BJ; Baird, AW; ; (1999) 'Berberine inhibits ion transport in human colonic epithelia'. European Journal of Pharmacology, 368 (1):111-118. [Details]
Winter, DC; Taylor, C; O'Sullivan, GC; Baird, AW; Harvey, BJ; ; (1999) 'Regulation of prostaglandin F2-alpha-induced secretion in human colon'. Gastroenterology, 116 (4):946-946. [Details]
Winter, DC; Taylor, CT; Skelly, MM; O'Donoghue, DP; O'Sullivan, GC; Baird, AW; Harvey, BJ; ; (1998) 'Berberine modulates human colonic secretion by blocking serosal membrane potassium channels'. Gastroenterology, 114 (4):433-433. [Details]
Baird. A.W., Taylor, C.T. and Brayden, D.J.; (1997) 'A review of the pharmacology and in vitro drug delivery of the anti-diarrhoeal agents: berberine and loperamide'. Advanced Drugs Delivery Review, 23 :111-120. [Details]
Taylor, CT; Murphy, A; Kelleher, D; Baird, AW; ; (1997) 'Changes in barrier function of a model intestinal epithelium by intraepithelial lymphocytes require new protein synthesis by epithelial cells'. Gut, 40 (5):634-640. [Details]
Taylor, CT; Murphy, A; Kelleher, D; Baird, AW; ; (1996) 'Regulation of intestinal epithelial barrier function by intraepithelial lymphocytes'. Gastroenterology, 110 (4):1027-1027. [Details]
Taylor, CT; Baird, AW; ; (1996) 'Berberine inhibition of epithelial ion transport in human tissue'. Gastroenterology, 110 (4):1027-1027. [Details]
TAYLOR, CT; MORIARTY, DV; SKELLY, MM; ODONOGHUE, DP; BAIRD, AW; ; (1995) 'ANTI-SECRETORY EFFECTS OF BERBERINE IN HUMAN COLONIC EPITHELIUM'. Gastroenterology, 108 (4):331-331. [Details]
TAYLOR, CT; BAIRD, AW; ; (1995) 'BERBERINE INHIBITION OF ELECTROGENIC ION-TRANSPORT IN RAT COLON'. British Journal of Pharmacology, 116 (6):2667-2672. [Details]
TAYLOR, CT; MURPHY, A; KELLEHER, D; BAIRD, AW; ; (1995) 'REGULATION OF EPITHELIAL PERMEABILITY BY INTRAEPITHELIAL LYMPHOCYTES INVOLVES NOVEL PROTEIN-SYNTHESIS'. Gastroenterology, 108 (4):331-331. [Details]
TAYLOR, CT; SKELLY, M; ODONOGHUE, DP; BAIRD, AW; ; (1994) 'BERBERINE INHIBITION OF EPITHELIAL ION-TRANSPORT'. Gastroenterology, 106 (4):275-275. [Details]
Victor, VM, Nunez, C, D'Ocon, P, Taylor, CT, Esplugues, JV and Moncada, S. ; (2009) 'Regulation of oxygen distribution in tissues by nitric oxide'. Circulation Research, 104 :1178-1183. [Details]
O¿Hagan, KA, Cochiglia, S, Zhdanov, AV, Tambawala, MM, Cummins, EP, Monafared, M, Agbor, TA, Garvey, JF, Papkovsky, D, Taylor, CT* & Allan, BB* ; (2009) 'PGC-1? is coupled to HIF-1?-dependent gene expression by increasing mitochondrial oxygen consumption in skeletal muscle cells'. PNAS, 106 :2188-2193. [Details]
Sebastia, J, Kieran, D, Breen, B, King, MA, Netteland, DF, Joyce, D, Fitzpatrick, SF, Dyer, KD, Taylor, CT and Prehn, JHM. ; (2009) 'Angiogenin protects motorneurons against hypoxic injury. Cell Death and Differentiation'. Cell Death and Differentiation, 16 :1237-1247. [Details]
Prime, TA, Blaikie, FH, Evans, C, Nodtochiy, SM, James, AM, Dahm, CC, Vitturi, DA, Patel, RP, Hiley, CR, Abakumova, I, Requejo, R, Chouchani, ET, Hurd, TR, Garvey, JF, Taylor, CT, Brookes, PS, Smith, RAJ & Murphy, MP. ; (2009) 'A mitochondria-targeted S-nitrosothiol modulates respiration, nitrosates thiols, and protects against ischemia-reperfusion injury'. PNAS, 106 :10764-10769. [Details]
Taylor, C. T., , ; (2008) 'Mitochondria and cellular oxygen sensing in the HIF pathway'. Biochemical Journal, 409 :19-26. [Details]
Taylor, C. T., , ; (2008) 'Mitochondria, oxygen sensing, and the regulation of HIF-2 alpha. Focus on "Induction of HIF-2 alpha is dependent on mitochondrial O-2 consumption in an O-2-sensitive adrenomedullary chromaffin cell line"'. American Journal of Physiology-Cell Physiology, 294 (6):1300-1302. [Details]
Agbor, T. A., Taylor, C. T., ; (2008) 'SUMO, hypoxia and the regulation of metabolism'. Biochemical Society Transactions, 36 :445-448. [Details]
Taylor, CT, Keely, SJ, ; (2007) 'The autonomic nervous system and inflammatory bowel disease'. AUTON NEUROSCI-BASIC, 133 :104-114. [Details]
Taylor, C. T.,Keely, S. J.; (2007) 'The autonomic nervous system and inflammatory bowel disease'. Auton Neurosci, 133 (1):104-14. [Details]
Zaman, M. B., Nolan, N. P., Hoti, E., Maguire, D., Mulcahy, H., Traynor, O., Taylor, C. T., Hegarty, J. E., Geoghegan, J. G., O'Farrelly, C., Leonard, M. O., Ryan, E. J., ; (2007) 'Lower expression of Nrf2 mRNA in older donor livers: A possible contributor to increased ischemia-reperfusion injury?'. Transplantation, 84 (10):1272-1278. [Details]
Ryan, S, Nolan, GM, Hannigan, E, Cunningham, S, Taylor, C, McNicholas, WT, ; (2007) 'Cardiovascular risk markers in obstructive sleep apnoea syndrome and correlation with obesity'. Thorax, 62 :509-514. [Details]
Taylor, C. T., Colgan, S. P., ; (2007) 'Hypoxia and gastrointestinal disease'. Journal of Molecular Medicine-Jmm, 85 (12):1295-1300. [Details]
ORiordan, TC, Fitzgerald, K, Ponomarev, GV, Mackrill, J, Hynes, J, Taylor, C, Papkovsky, DB, ; (2007) 'Sensing intracellular oxygen using near-infrared phosphorescent probes and live-cell fluorescence imaging'. American Journal of Physiology-Renal Physiology, 292 :1613-162. [Details]
Ryan, S, McNicholas, WT, Taylor, CT, ; (2007) 'A critical role for p38 map kinase in NF-kappa B signaling during intermittent hypoxia/reoxygenation'. Biochemical and Biophysical Research Communications, 355 :728-733. [Details]
Zaman, MB, Ryan, EJ, Leonard, MO, Nolan, NP, Maguire, D, Mulcahy, H, Traynor, O, Taylor, CT, Hegarty, J, Geoghegan, JG, OFarrelly, C, ; (2007) 'Activation of the transcription factor Nrf-2 in donor liver during ischemia reperfusion is associated with less inflammatory damage and lower trasaminase levels posttransplant'. Liver Transplant, 13 :101-101. [Details]
Leonard, M. O.,Kieran, N. E.,Howell, K.,Burne, M. J.,Varadarajan, R.,Dhakshinamoorthy, S.,Porter, A. G.,O'Farrelly, C.,Rabb, H.,Taylor, C. T.; (2006) 'Reoxygenation-specific activation of the antioxidant transcription factor Nrf2 mediates cytoprotective gene expression in ischemia-reperfusion injury'. Faseb J, 20 (14):2624-6. [Details]
Taylor, C, Jobin, C, ; (2005) 'Ubiquitin protein modification and signal transduction: Implications for inflammatory bowel diseases'. Inflammatory bowel diseases, 11 (12):1097-1107. [Details]
Blumberg, R. S.,Pitman, R. S.,Taylor, C. T.,Colgan, S. P.; (2005) 'Cholera toxin potentiates influences of IFN-gamma through activation of NF-kappaB and release of tumor necrosis factor-alpha'. J Interferon Cytokine Res, 25 (4):209-19. [Details]
Taylor CT, Furuta GT, Synnestvedt K, Colgan SP; (2000) 'Phosphorylation-dependent targeting of cAMP response element binding protein to the ubiquitin/proteasome pathway in hypoxia'. Proceedings of the National Academy of Sciences, 97 (22):12091-12096. [Details]
Taylor CT, Fueki N, Agah A, Hershberg RM, Colgan SP. ; (1999) 'Critical role of cAMP response element binding protein expression in hypoxia-elicited induction of epithelial tumor necrosis factor-alpha'. Journal of Biological Chemistry, 274 (27):19447-19454. [Details]
Taylor CT, Dzus AL & Colgan SP. ; (1998) 'Autocrine regulation of epithelial permeability by hypoxia: role for polarized release of tumor necrosis factor '. Gastroenterology, 114 (4):657-668. [Details]
Eoin P. Cummins2, Fergal Seeballuck2,3, Stephen J. Keely4, Niamh E. Mangan1, John J. Callanan2, Padraic G. Fallon1, & Cormac T. Taylor2.; (2008) 'The hydroxylase inhibitor Dimethyloxalylglycine is protective in a murine model of colitis'. Gastroenterology*, . [Details]
Taylor CT, Pouyssegur J.; (2007) 'Oxygen, hypoxia, and stress'. Annals of the New York Academy of Science, 1113 :87-94. [Details]
Ryan, S, McNicholas, WT & Taylor, CT.; (2007) 'A critical role for p38 MAP kinase in NF-kB signaling during intermittent hypoxia / reoxygenation'. Biochemical and Biophysical Research Communications, 355 (3):728-733. [Details]
O'Reilly, SM; Leonard, MO; Kieran, N; Comerford, KM; Cummins, E; Pouliot, M; Lee, SB; Taylor, CT; ; (2006) 'Hypoxia induces epithelial amphiregulin gene expression in a CREB-dependent manner'. American Journal of Physiology-Cell Physiology, 290 (2):592-600. [Details]
Ryan, S., Taylor, C.T., McNicholas, W.T.; (2006) 'Predictors of elevated nuclear factor-kappaB-dependent genes in obstructive sleep apnea syndrome'. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDIC, 174 :824-830. [Details]
Leonard, MO; Kieran, NE; Howell, K; Burne, MJ; Varadarajan, R; Dhakshinamoorthy, S; Porter, AG; O'Farrelly, C; Rabb, H; Taylor, CT; ; (2006) 'Reoxygenation-specific activation of the antioxidant transcription factor Nrf2 mediates cytoprotective gene expression in ischemia-reperfusion injury'. FASEB JOURNAL, 20 (14):2624-2626. [Details]
Cummins, EP; Berra, E; Comerford, KM; Ginouves, A; Fitzgerald, KT; Seeballuck, F; Godson, C; Nielsen, JE; Moynagh, P; Pouyssegur, J; Taylor, CT; ; (2006) 'Prolyl hydroxylase-1 negatively regulates I kappa B kinase-beta, giving insight into hypoxia-induced NF kappa B activity'. Proceedings of the National Academy of Sciences of the United States of America, 103 (48):18154-18159. [Details]
Ryan, S; Taylor, CT; McNicholas, WT; ; (2006) 'Predictors of elevated nuclear factor-kappa B-dependent genes in obstructive sleep apnea syndrome'. American Journal of Respiratory and Critical Care Medicine, 174 (7):824-830. [Details]
Comerford, KM; Leonard, MO; Cummins, EP; Fitzgerald, KT; Beullens, M; Bollen, M; Taylor, CT; ; (2006) 'Regulation of protein phosphatase 1 gamma activity in hypoxia through increased interaction with NIPP1: Implications for cellular metabolism'. Journal of Cellular Physiology, 209 (1):211-218. [Details]
Molloy, EJ; O'Neill, AJ; Doyle, BT; Grantham, JJ; Taylor, CT; Sheridan-Pereira, M; Fitzpatrick, JM; Webb, DW; Watson, RWG; ; (2006) 'Effects of heat shock and hypoxia on neonatal neutrophil lipopolysaccharide responses: Altered apoptosis, Toll-like receptor-4 and CD11b expression compared with adults'. Biology of the Neonate, 90 (1):34-39. [Details]
Cummins, EP; Taylor, CT; ; (2005) 'Hypoxia-responsive transcription factors'. Pflugers Archiv-European Journal of Physiology, 450 (6):363-371. [Details]
Ryan, S; Taylor, CT; McNicholas, WT; ; (2005) 'Selective activation of inflammatory pathways by intermittent hypoxia in obstructive sleep apnea syndrome'. Circulation, 112 (17):2660-2667. [Details]
Coffey, RNT; Morrissey, C; Taylor, CT; Fitzpatrick, JM; Watson, RWG; ; (2005) 'Resistance to caspase-dependent, hypoxia-induced apoptosis is not hypoxia-inducible factor-1 alpha mediated in prostate carcinoma cells'. Cancer, 103 (7):1363-1374. [Details]
Leonard, MO; Godson, C; Brady, HR; Taylor, CT; ; (2005) 'Potentiation of glucocorticoid activity in hypoxia through induction of the glucocorticoid receptor'. Immunology, 174 (4):2250-2257. [Details]
Leonard, MO; O'Reilly, S; Comerford, KM; Taylor, CT; ; (2004) 'Identification of cyclic AMP response element-binding protein-dependent transcriptional responses in hypoxia by microarray analysis'. Methods in Enzymology, 381 :511-524. [Details]
Comerford, KM; Cummins, EP; Taylor, CT; ; (2004) 'c-Jun NH2-terminal kinase activation contributes to hypoxia-inducible factor 1 alpha-dependent P-glycoprotein expression in hypoxia'. Cancer Research, 64 (24):9057-9061. [Details]
Comerford, KM, Cummins, EP & Taylor, CT; (2004) 'JNK activation contributes to HIF-1-dependent p-glycoprotein expression in hypoxia'. Cancer Research, 64 :9057-9061. [Details]
Galvin, DJ; Watson, RWG; O'Neill, A; Coffey, RNT; Taylor, C; Gillespie, JI; Fitzpatrick, JM; ; (2004) 'Hypoxia inhibits human bladder smooth muscle cell proliferation: A potential mechanism of bladder dysfunction'. Neurourology and Urodynamics, 23 (4):342-348. [Details]
Kieran, NE; Doran, PP; Connolly, SB; Greenan, MC; Higgins, DF; Leonard, M; Godson, C; Taylor, CT; Henger, A; Kretzler, M; Burne, MJ; Rabb, H; Brady, HR; ; (2003) 'Modification of the transcriptomic response to renal ischemia/reperfusion injury by lipoxin analog'. Kidney International, 64 (2):480-492. [Details]
Hagen, T; Taylor, CT; Lam, F; Moncada, S; ; (2003) 'Redistribution of intracellular oxygen in hypoxia by nitric oxide: Effect on HIF1 alpha'. Science, 302 (5652):1975-1978. [Details]
Leonard, MO; Godson, C; Brady, HR; Taylor, CT; ; (2003) 'Involvement of HIF-1 alpha in hypoxia mediated alterations in human proximal tubular epithelial cell transcription'. Journal of the American Society of Nephrology, 14 (NA):24-24. [Details]
Leonard, MO; Cottell, DC; Godson, C; Brady, HR; Taylor, CT; ; (2003) 'The role of HIF-1 alpha in transcriptional regulation of the proximal tubular epithelial cell response to hypoxia'. Journal of Biological Chemistry, 278 (41):40296-40304. [Details]
Comerford, KM; Leonard, MO; Karhausen, J; Carey, R; Colgan, SP; Taylor, CT; ; (2003) 'Small ubiquitin-related modifier-1 modification mediates resolution of CREB-dependent responses to hypoxia'. Proceedings of the National Academy of Sciences of the United States of America, 100 (3):986-991. [Details]
Leonard, MO; Hannan, K; Burne, MJ; Lappin, DWP; Doran, P; Coleman, P; Stenson, C; Taylor, CT; Daniels, F; Godson, C; Petasis, NA; Rabb, H; Brady, HR; ; (2002) '15-Epi-16-(para-fluorophenoxy)-lipoxin A(4)-methyl ester, a synthetic analogue of 15-epi-lipoxin A(4), is protective in experimental ischemic acute renal failure'. Journal of the American Society of Nephrology, 13 (6). [Details]
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Other Journals

Comerford, K.M., Leonard, M.O., Cummins, E.P., Fitzgerald, K., Beullens, M., Bollen, M. Taylor C.T.; (2006) 'Regulation of progin phosphatase 1 activity in hypoxia through increased interaction with NIPP1: implications for cellular metaboliism' J.Cell Physiol . [Details]

Cummins, E.P. Taylor, C.T.; (2005) 'Hypoxia-responsive transcription factors' Eur. J. Physiol . [Details]

Molloy, E.J., O'Neill, A.J., Doyle, B.T., Grantham, J.J., Taylor, C.T., Sheridan-Pereira, M., Fitzpatrick, J.M. Watson, R.W.G.; (2006) 'Effects of heat shock and hypoxia on neonatal neutrophil lipopolysaccharide responses: altered apoptosis, toll-like receptor-4 and CD11b expression compared with adults' Biology of the Neonate . [Details]

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Conference Publications

Batti L., Taylor C.T. & O¿Connor J.J. ; (2009) Modulatory actions of TNF-α on synaptic transmission during hypoxia in the rat hippocampus British Neuroscience Association, Liverpool [Details]

Batti L., Taylor C.T. & O¿Connor J.J. ; (2009) Modulation of synaptic transmission by TNF-α after hypoxic exposure in rat hippocampal slices Procedings of the Physiological Society [Details]

Batti, L., Taylor, C., O¿Connor, J.J. ; (2009) A role for the prolyl hydroxylase inhibitor, DMOG, on synaptic transmission and neuroprotection in an ex vivo model of cerebral ischaemia Neuroscience Ireland 2009 [Details]

Batti L., Taylor C.T. & O¿Connor J.J. ; (2008) A role for adenosine receptors in hypoxia in rat hippocampal slices J. Neuroimmunology, Vol. 197, page 171 [Details]

Batti, L., Taylor, C., O¿Connor, J.J. ; (2008) Effects of mild hypoxic exposure in rat hippocamal slices: role for adenosine A1 receptors in the maintenance of LTP Biosymposia; Hypoxia, Ischemia, and inflammation, Boston, USA [Details]

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Editorial

Taylor, CT; (2008) Mitochondria, oxygen sensing, and the regulation of HIF-2 alpha. Focus on Induction of HIF-2 alpha is dependent on mitochondrial O-2 consumption in an O-2-sensitive adrenomedullary chromaffin cell line. Editorial [DOI] [Details]

Taylor, C,Jobin, C; (2005) Ubiquitin protein modification and signal transduction: Implications for inflammatory bowel diseases. Editorial [Details]

Internal Collaborators

Martin Leonard, Ph.D. (Postdoctoral Fellow)
Katrina Comerford, Ph.D. (Postdoctoral Fellow; HRB funded)
Kathleen Fitzgerald, Ph.D. (Postdoctoral Fellow)
Eoin Cummins, BSc. (Ph. D Student)
Silke Ryan, MD (Ph.D. Student; HRB funded)
Annemarie Griffin (Technician)

External Collaborators

Prof. Salvador Moncada
University College London.

Dr. Sean P. Colgan
Harvard Medical School

Teaching Interests

Recent Postgraduates

Current Postgraduate Students

Luca Felice, Doctor of Philosophy (PhD) - Thesis Supervisor

Murtaza Tambuwala, Doctor of Philosophy (PhD) - Thesis Supervisor

Bettina Schaible, Doctor of Philosophy (PhD) - Thesis Supervisor

Carsten Scholz, Doctor of Philosophy (PhD) - Thesis Supervisor

Susan Fitzpatrick, Doctor of Philosophy (PhD) - Thesis Supervisor

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Batti, L., Taylor, C., Sheridan, G., Herron, C.E., O¿Connor, J.J. ; (2008) Differential responses to hypoxia in the rat hippocampus CA1 and dentate gyrus regions in vitro American Society for Neuroscience [Details]
Batti, L., Taylor, C., O¿Connor, J.J. ; (2008) Differential responses to hypoxia in the rat hippocampus CA1 and dentate gyrus regions in vitro Biosymposia; Hypoxia, Ischemia, and inflammation, Boston, USA [Details]
Batti, L., Taylor, C., O¿Connor, J.J. ; (2008) Effects of mild hypoxic exposure in rat hippocamal slices: role for adenosine A1 receptors in the maintenance of LTP American Society for Neuroscience [Details]
Batti, L., Taylor, C., O¿Connor, J.J. ; (2008) An investigation into the role of adenosine A1 receptors in hippocampal LTP after exposure to mild hypoxia Irish Journal of Medical Science [Details]
Batti, L., Taylor, C., Sheridan, G., O¿Connor, J.J. ; (2008) Hippocampal CA1 and granule cells respond differentially to mild hypoxia: roles for HIF-1α and NF-κB Irish journal of Medical Science [Details]
TAYLOR, CT; MURPHY, A; FAN, XG; KELLEHER, D; BAIRD, AW; ; (1994) EFFECTS OF T-LYMPHOCYTES ON PERMEABILITY OF T84 MONOLAYERS American Gastroenterology Association , pp.782-782 [Details]
TAYLOR, C; BAIRD, AW; ; (1993) BERBERINE INHIBITS ELECTROGENIC CHLORIDE SECRETION IN RAT COLON IN-VITRO British Pharmacological Society , pp.129-129 [Details]
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