Professor David Brayden

Research

Professor David Brayden BSc, MSC, PhD

Books:

Brayden, D. J. & Baird, A. W. (2004). Adv. Drug Del. Rev. (2004) Commentary: apical membrane receptors on intestinal M cells: potential targets for vaccine delivery. [Details]

Brayden, D.J. and Martinez, M.N. (2007) Advanced Drug delivery Reviews Theme Issue (Prediction of therapeutic and drug delivery outcomes using animal models). New York: Elsevier.

[Details]

Brayden, DJ & Baird, A.W. (2006) Current Opinion in Pharmacology: New Technologies. New York: Elsevier.

[Details]

Brayden, D. J. & Baird, A. W. (2004) Advanced Drug Delivery Reviews. Theme Issue. Pathogens and the intestine: mechanisms and exploitation. London: Elsevier. [Details]

Brayden, D.J. (1997) Special Issue: Proceedings of the the CRS Ireland Special Symposium on Current Topics in Peptide Delivery. : Elsevier. [Details]

Book Chapters:

Brayden, D.J., Oudot, E. & Baird, A.W. (2010) 'Drug delivery systems in domestic animal species' In: Lees, P., Cunningham, F., Elliot, J (eds). Handbook in Experimental Pharmacology. New York: Springer.

[Details]

Brayden, D.J. and Cuthbert, A.W. (1988) 'Electrogenic sodium absorption in cultured human sweat gland epithelial sheets' In: Wong, P.D.Y. and Young, J.M (eds). Exocrine Secretion. [Details]

Cutbert, A.W. and Brayden, D.J. (1988) 'Kinins can stimulate chloride secretion or sodium absorption in different human epithelia' In: Alan Liss Inc (eds). Kinins V. [Details]

Peer Reviewed Journals:

Maher, S.,Devocelle, M.,Ryan, S.,McClean, S.,Brayden, D. J. 'Impact of amino acid replacements on in vitro permeation enhancement and cytotoxicity of the intestinal absorption promoter, melittin'. Int J Pharm, 387 (1-21-2):154-60154.

[Details]

Walsh, E.G., Maher, S., Devocelle, M., O'Brien, P.J., Baird, A.W., Brayden, DJ. (2011) 'High content analysis to determine cytotoxicity of the antimicrobial peptide, melittin and selected structural analogs'. Peptides, 32 (8):1764-1773.

[DOI] [Details]

Ryan SM, Frías JM, Wang X, Sayers CT, Haddleton DM, Brayden DJ (2011) 'PK/PD modelling of comb-shaped PEGylated salmon calcitonin conjugates of differing molecular weights'. Journal of Controlled Release, 149 (2):126-132.

[Details]

Rawlinson LA, O'Gara JP, Jones DS, Brayden DJ (2011) 'Resistance of Staphylococcus aureus to the cationic antimicrobial agent poly(2-(dimethylamino ethyl)methacrylate) (pDMAEMA) is influenced by cell-surface charge and hydrophobicity'. Journal of Medical Microbiology, 60 (Pt 7):968-976.

[DOI] [Details]

Rawlinson, LAB,Ryan, SM,Mantovani, G,Syrett, JA,Haddleton, DM,Brayden, DJ (2010) 'Antibacterial Effects of Poly(2-(dimethylamino ethyl)methacrylate) against Selected Gram-Positive and Gram-Negative Bacteria'. Biomacromolecules, 11 (2):443-453.

[DOI] [Details]

Maher, S,Devocelle, M,Ryan, S,McClean, S,Brayden, DJ (2010) 'Impact of amino acid replacements on in vitro permeation enhancement and cytotoxicity of the intestinal absorption promoter, melittin'. International Journal of Pharmaceutics, 387 ((1-2)):154-160.

[DOI] [Details]

Brayden DJ, Oudot EJ, Baird AW (2010) 'Drug delivery systems in domestic animal species'. Handbook of experimental pharmacology, (199):79-112. [DOI] [Details]
Cheng, W.P, Thompson, C. P. Ryan, S. M., Aguirre, T., Tetley, L. & Brayden, D.J. (2010) 'In vitro and in vivo characterisation of a novel peptide delivery system: amphiphilic polyelectrolyte-salmon calcitonin nanocomplexes'. Journal of controlled release : official journal of the Controlled Release Society, 147 (2):289-297. [DOI] [Details]
Rawlinson, L. B., O'Brien. P.J. & Brayden, D. J. (2010) 'High content analysis of cytotoxic effects of pDMAEMA on human intestinal epithelial and monocyte cultures'. Journal of controlled release : official journal of the Controlled Release Society, 146 (6):82-94. [DOI] [Details]
Brayden, D. J. & Maher, S (2010) 'Oral absorption enhancement: taking the next steps in therapeutic delivery'. Therapeutic Delivery, 1 (1):5-10. [Details]
Wang, X., Maher, S., & Brayden D. J. (2010) 'Restoration of rat colonic epithelium after in situ intestinal instillation of the absorption promoter, sodium caprate'. Therapeutic Delivery, 1 (1):75-82. [Details]
Maher S, Kennelly R, Bzik VA, Baird AW, Wang X, Winter D, Brayden, DJ (2009) 'Evaluation of intestinal absorption enhancement and local mucosal toxicity of two promoters. I. Studies in isolated rat and human colonic mucosae'. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 38 (4):291-300. [DOI] [Details]
Maher, S., Wang, X., Bzik, V, McClean, S. & Brayden, D. J. (2009) 'Evaluation of intestinal absorption and mucosal toxicity using two promoters. II. Rat instillation and perfusion studies'. European Journal of Pharmaceutical Sciences, 38 (4):301-311. [Details]
Maher, S., Leonard, T.W., Jacobsen, J., Brayden D. J. (2009) 'Safety and efficacy of sodium caprate in promoting oral drug absorption: from in vitro to the clinic'. ADVANCED DRUG DELIVERY REVIEWS, 61 (15):1427-1429. [Details]
Sayers, C.T., Mantovani, G., Ryan, S. M., Randev, R.K., Keiper, O., Leszczyszyn, O. I., Blindauer, C., Brayden, D. J., & Haddleton, D. M. (2009) 'Site-specific N-terminus conjugation of poly(mPEG1100) methacrylates to salmon calcitonin: synthesis and preliminary biological evaluation. Site-specific N-terminus conjugation of poly(mPEG1100) methacrylates to salmon calcitonin: synthesis and preliminary biological evaluation'. Soft Matter, 5 :3038-3046. [DOI] [Details]
Callanan JJ, Fletcher NF, Bexiga MG, Brayden DJ, Brankin B, Willett BJ, Hosie MJ, Jacque JM, (2009) 'Lymphocyte migration through the blood brain barrier (BBB) in feline immunodeficiency virus infection is significantly influenced by the pre-existence of virus and TNF-alpha within the CNS: studies using an in vitro feline BBB model'. Neuropathology and Applied Neurobiology, . [DOI] [Details]
Brayden DJ, Keely S, Ryan SM, Haddleton DM, Limer A, Mantovani G, Murphy EP, Colgan SP, (2009) 'Dexamethasone-pDMAEMA polymeric conjugates reduce inflammatory biomarkers in human intestinal epithelial monolayers'. Journal of controlled release : official journal of the Controlled Release Society, 135 (1):35-43. [DOI] [Details]
Brayden DJ, Ryan SM, Wang X, Mantovani G, Sayers CT, Haddleton DM, (2009) 'Conjugation of salmon calcitonin to a combed-shaped end functionalized poly(poly(ethylene glycol) methyl ether methacrylate) yields a bioactive stable conjugate'. Journal of controlled release : official journal of the Controlled Release Society, 135 (1):51-59. [DOI] [Details]
Jones, M., Mantovani, G., Ryan, S. M., Wang, X., Brayden, D. J., & Haddleton, D. M. (2009) 'Phosphine-mediated one-pot thiol-ene ¿click¿ approach to polymer¿protein conjugates'. Chemical Communications, 35 :5272-5274. [DOI] [Details]
Rathbone, MR & Brayden D (2009) 'Controlled release drug delivery in farmed animals: commercial challenges and academic opportunities'. Current Drug Delivery, 6 (4):383-390. [DOI] [Details]
Brayden DJ, Feighery LM, Cochrane SW, Quinn T, Baird AW, O'Toole D, Owens SE, O'Donoghue D, Mrsny RJ, (2008) 'Myosin light chain kinase inhibition: correction of increased intestinal epithelial permeability in vitro'. Pharmaceutical Research, 25 (6):1377-1386. [DOI] [Details]
Brayden DJ, Feighery LM, Smith P, O'Mahony L, Fallon PG, (2008) 'Effects of Lactobacillus salivarius 433118 on intestinal inflammation, immunity status and in vitro colon function in two mouse models of inflammatory bowel disease'. Digestive Diseases and Sciences, 53 (9):2495-2506. [DOI] [Details]
Brayden DJ, Cox AB, Rawlinson LA, Baird AW, Bzik V, (2008) 'In vitro interactions between the oral absorption promoter, sodium caprate (C(10)) and S. typhimurium in rat intestinal ileal mucosae'. Pharmaceutical Research, 25 (1):114-122. [DOI] [Details]
Brayden DJ, Feighery L, Smyth A, Keely S, Baird AW, O'Connor WT, Callanan JJ, (2008) 'Increased intestinal permeability in rats subjected to traumatic frontal lobe percussion brain injury'. The Journal of trauma, 64 (1):131-11. [DOI] [Details]
Brayden DJ, Keely S, Rawlinson LA, Haddleton DM, (2008) 'A tertiary amino-containing polymethacrylate polymer protects mucus-covered intestinal epithelial monolayers against pathogenic challenge'. Pharmaceutical Research, 25 (5):1193-1201. [DOI] [Details]
Callanan JJ, Fletcher NF, Brayden DJ, Brankin B, (2008) 'Feline immunodeficiency virus infection: a valuable model to study HIV-1 associated encephalitis'. Veterinary Immunology and Immunopathology, 123 (1-2):134-137. [DOI] [Details]
Maher S, Brayden DJ, Feighery L, McClean S (2008) 'Cracking the junction: update on the progress of gastrointestinal absorption enhancement in the delivery of poorly absorbed drugs'. Critical Reviews in Therapeutic Drug Carrier Systems, 25 (2):117-168. [Details]
Griffin J, Brayden DJ, (2008) 'Avermectin transepithelial transport in MDR1- and MRP-transfected canine kidney monolayers'. Veterinary Research, 32 (1):93-106. [DOI] [Details]
Ryan SM, Mantovani G, Wang X, Haddleton DM, Brayden DJ. (2008) 'Advances in PEGylation of important biotech molecules: delivery aspects'. Expert Opinion in Drug Delivery, 5 (4):371-383. [Details]
Fletcher, N. F., Bexiga, M., Brayden, D. J., Brankin, B., Willett, B. J., Hosie, M. J., Jacque, J. M., Callanan, J. J., (2008) 'Cell migration through the blood brain barrier (BBB) in feline immunodeficiency virus infection is significantly influenced by the pre-existence of virus and tnf-alpha within the CNS: studies using an in vitro feline BBB model'. Journal of Neuroimmunology, 197 (2):161-161. [Details]
Brayden, D. J., Martinez, M. N., (2007) 'Prediction of therapeutic and drug delivery outcomes using animal models - Preface'. ADVANCED DRUG DELIVERY REVIEWS, 59 (11):1071-1072. [Details]
Maher, S; Feighery, L; Brayden, DJ; McClean, S; (2007) 'Melittin as an epithelial permeability enhancer I: Investigation of its mechanism of action in Caco-2 monolayers'. PHARMACEUTICAL RESEARCH, 24 (7):1336-1345. [Details]
Maher, S, Feighery, L, Brayden, DJ, McClean, S, (2007) 'Melittin as a permeability enhancer II: In vitro investigations in human mucus secreting intestinal monolayers and rat colonic mucosae'. Pharmaceutical Research, 24 :1346-1356. [Details]
Leonard, T. W., O'Toole, E., Brennan, F., Brayden, D.J. (2006) 'Absorption enhancement: promoting the oral absorption of drugs in humans using Gastro-Intestinal Permeation Enhancement Technology (GIPET)'. Drug Delivery Technology, :2-8. [Details]
Brayden DJ, Soni J, Baird AW, O'Brien LM, McElroy M, Callanan JJ, Bassett HF, Campion D, (2006) 'Rat, ovine and bovine Peyer's patches mounted in horizontal diffusion chambers display sampling function'. Journal of controlled release : official journal of the Controlled Release Society, 115 (1):68-77. [DOI] [Details]
Fletcher, NF; Brayden, DJ; Brankin, B; Worrall, S; Callanan, JJ; (2006) 'Growth and characterisation of a cell culture model of the feline blood-brain barrier'. Veterinary Immunology and Immunopathology, 109 (3-4):233-244. [Details]
Limer, AJ; Rullay, AK; San Miguel, V; Peinado, C; Keely, S; Fitzpatrick, E; Carrington, SD; Brayden, D; Haddleton, DM; (2006) 'Fluorescently tagged star polymers by living radical polymerisation for mucoadhesion and bioadhesion'. Reactive and Functional Polymers, 66 (1):51-64. [Details]
Brayden, D.J. and Baird, A.W. (2006) 'Pharmacology applied: delivering the goods'. Current Opinion in Pharmacology, 6 (5):491-493. [Details]
Brayden, D.J. (2006) 'Promoting absorption of drugs in humans using medium-chain fatty acid-based solid dosage forms: GIPET'. Expert Opinion in Drug Delivery, 3 (5):685-692. [Details]
Griffin, J; Fletcher, N; Clemence, R; Blanchflower, S; Brayden, DJ; (2005) 'Selamectin is a potent substrate and inhibitor of human and canine P-glycoprotein'. Journal of Veterinary Pharmacology and Therapeutics, 28 (3):257-265. [Details]
Roth-Walter, F; Bohle, B; Scholl, I; Untersmayr, E; Scheiner, O; Boltz-Nitulescu, G; Gabor, F; Brayden, DJ; Jensen-Jarolim, E; (2005) 'Targeting antigens to murine and human M-cells with Aleuria aurantia lectin-functionalized microparticles'. IMMUNOLOGY LETTERS, 100 (2):182-188. [Details]
Brayden, D. J., Jepson, MA. R. & Baird, A. W. (2005) 'Intestinal Peyer's patches and oral vaccine targeting. Invited Keynote Review'. DRUG DISCOVERY TODAY, 10 (17):1145-1157. [Details]
Brayden DJ, Baird AW, Campion DP, O'Brien L, (2004) 'Oral delivery of pathogens from the intestine to the nervous system'. Journal of Drug Targeting, 12 (2):71-78. [DOI] [Details]
Lo, D; Tynan, W; Dickerson, J; Scharf, M; Cooper, J; Byrne, D; Brayden, D; Higgins, L; Evans, C; O'Mahony, DJ; (2004) 'Cell culture modeling of specialized tissue: identification of genes expressed specifically by follicle-associated epithelium of Peyer's patch by expression profiling of Caco-2/Raji co-cultures'. International Immunology, 16 (1):91-99. [Details]
Brayden, D. J. & Baird, A. W. (2004) 'Preface. Pathogen invasion across the intestine: mechanisms and potential exploitation'. Advanced Drugs Delivery Review, 56 (6):717-719. [Details]
Baird AW, Brayden DJ, (2004) 'Apical membrane receptors on intestinal M cells: potential targets for vaccine delivery'. ADVANCED DRUG DELIVERY REVIEWS, 56 (6):721-726. [DOI] [Details]
Brayden DJ, (2003) 'Controlled release technologies for drug delivery'. Drug Discovery Today, 8 (21):976-978. [Details]
Brayden, D. J. (2003) 'Novel drug delivery systems in veterinary medicine'. IRISH VETERINARY JOURNAL, 56 (6):310-316. [Details]
Lo, D., Tynan, W., Dickerson, J., Mendy, J. Chang, H-W., Scharf, Byrne, D., Brayden, D.J., Higgins, L., Evans, C., O,Mahoby, D. (2003) 'Peptidoglycan recognition protein expression in mouse Peyer's patch follicle-associated epithelium suggests functional specialization'. Cellular Immunology, Cellular Immunology (In Press) (224 (1)):8-16. [Details]
Lo, D., Hilbush, B., Mah, S., Brayden, D., Byrne, D., Higgins, L., O'Mahony, D (2002) 'Catching target receptors for drug and vaccine delivery using TOGA expression profiling'. Advanced Drugs Delivery Review, 54 :1213-1223. [Details]
Baird AW, Brayden DJ, (2001) 'Microparticle vaccine approaches to stimulate mucosal immunisation'. Microbes and Infection, 3 (10):867-876. [Details]
Brayden DJ, (2001) 'Oral vaccination in man using antigens in particles: current status'. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 14 (3):183-189. [Details]
Conway, M., Madrigal-Estebas, L., McClean, S., Brayden, D.J. and Mills, K.H.G. (2001) 'Protection against B. pertussis infection following parenteral or oral immunisationwith antigens entrapped in biodegradable particles: effect of formulation and route of administration on Th1 and Th2 cells'. Vaccine, (19):1940-1950. [Details]
Brayden, D. and Baird, A.W. (2001) 'Microparticle vaccine approachesto stimulate mucosal immunisation'. Microbes and Infection, 3 :867-876. [Details]
Brayden, D.J., Templeton, L., McClean, S. et al (2001) 'Encapsulation in biodegradable microparticles enhances serum antibody response to parenterally-delivered beta amyloid in mice'. Vaccine, 19 :4185-4193. [Details]
Brayden, D. (2001) 'Oral vaccination in man using microparticles: current status'. European Journal of Pharmacology, 14 :183-189. [Details]
Clark, A., Blair, H., Liang, L., Brey, R., Brayden, D. and Hirst, B. H. (2001) 'Targeting polymerised liposome vaccine carriers to intestinal M cells'. Vaccine, 20 (1-2):208-217. [Details]
CUTHBERT, AW; BRAYDEN, DJ; DUNNE, A; SMYTH, RL; WALLWORK, J; (1990) 'ALTERED SENSITIVITY TO AMILORIDE IN CYSTIC-FIBROSIS - OBSERVATIONS USING CULTURED SWEAT GLANDS'. British Journal of Clinical Pharmacology, 29 (2):227-234. [Details]
Leonard, M, Creed, E, Brayden, D, Baird, AW, (2000) 'Evaluation of the Caco-2 monolayer as a model epithelium for iontophoretic transport'. Pharmaceutical Research, 17 (10):1181-1188. [Details]
Leonard, M., Creed, E., Brayden, D. and Baird, A.W. (2000) 'Iontophoresis-enhanced absorptive flux of polar molecules across intestinal tissue in vitro'. Pharmaceutical Research, 17 (4):476-478. [Details]
Brayden, D.J. and O'Mahony, D. (1998) 'Novel drug delivery gateways for biotechnology products: polypeptides and vaccines'. Pharmaceutical Science & Technology Today, 1 (7):289-297. [Details]
McClean, S., Prosser, E., Meehan, E., O'Malley, D., Blark, N., Ramtoola, Z. and Brayden, D.J. (1998) 'Binding and uptake of biodegradable poly-DL-lactide micro- and nanoparticles in intestinal epithelia'. European Journal of Pharmaceutical Science, 6 :153-163. [Details]
Brayden, D.J., Moriarty, D. and Baird, A.W. (1998) 'A novel in vitro electrophysiological bioassay for transport of loperamide across intestinal epithelia'. Pharmaceutical Research, 14 (7):942-945. [Details]
Brayden, D.J. (1997) 'Human intestinal epithelial monolayers as pre-screens for oral drug delivery'. Pharmaceutical News, 4 :111-115. [Details]
Raoof, A., Moriarty, D., Brayden, D.J. et al (1997) 'Comparison of methodologies for evaluating regional inestinal permeability'. Advances in Experimental Medical Biology, 423 :181-189. [Details]
Baird. A.W., Taylor, C.T. and Brayden, D.J. (1997) 'A review of the pharmacology and in vitro drug delivery of the anti-diarrhoeal agents: berberine and loperamide'. Advanced Drugs Delivery Review, 23 :111-120. [Details]
Brayden, D.J., Creed, E., Meehan, E. and O'Malley, K (1995) 'Passive transepithelial diltiazem absorption across intestinal tissue leading to tight junction openings'. Journal of Controlled Release, 38 :193-203. [Details]
Brayden, D.J. and Fitzpatrick, J.M. (1995) 'Cutured human sweat gland epithelia: isolation of glands using neutral red. '. Pharmaceutical Research, 12 :171-175. [Details]
Brayden, D.J. and Baird, A.W. (1994) 'A distinctive eletrophysiological signature from the Peyer's patch of the rabbit'. British Journal of Clinical Pharmacology, 113 :593-599. [Details]
Brayden, D.J., Krouse, M.E., Law, T. and Wine, J.J. (1993) 'Stilbenes stimulate T84 chloride secretion by elevating calcium'. American Journal of Physiology, 264 :G325-G333. [Details]
Brayden, D.J., Pickles, R. J.and Cuthbert, A.W. (1991) 'Ion transport in cultured epithelia from human sweat glands: comparison of normal and CF tissues'. British Journal of Clinical Pharmacology, 102 :57-65. [Details]
Wine, J.J., Brayden, D.J., Hagiwara, G. et al. (1991) 'Cystic fibrosis, CFTR, and the rectifying chloride channel'. Advances in Experimental Medical Biology, 290 :253-273. [Details]
Brayden, D.J. and Cuthbert, A.W. (1990) 'A novel method for culturing sweat gland epithelia;comparison of normal and cystic fibrosis tissues. '. British Journal of Clinical Pharmacology, 29 :235-238. [Details]
Keely, S; Rullay, A; Wilson, C; Carmichael, A; Carrington, S; Corfield, A; Haddleton, DM; Brayden, DJ; (2005) 'In vitro and ex vivo intestinal tissue models to measure mucoadhesion of poly (methacrylate) and N-trimethylated chitosan polymers'. PHARMACEUTICAL RESEARCH, 22 (1):38-49. [Details]
Gullberg, E; Leonard, M; Karlsson, J; Hopkins, AM; Brayden, D; Baird, AW; Artursson, P; (2000) 'Expression of specific markers and particle transport in a new human intestinal M-cell model'. Biochemical and Biophysical Research Communications, 279 (3):808-813. [Details]
Brayden, D.J., Hanley, M.R., Thastrup, O., and Cuthbert, A.W. (1989) 'Thapsigargin, a new calcium-dependent epithelial anion secretagogue'. British Journal of Clinical Pharmacology, 98 :809-816. [Details]
Brayden, A.W., Cuthbert, A.W., and Lee, C.M. (1988) 'Human eccrine sweat gland epithelial cultures express ductal characteristics'. Journal of Physiology, 405 :657-676. [Details]
Hide

Show All

Conference Publications:

Walsh, E. G., Leonard, T. W. & Brayden, D. J. (2011) High-content analysis (HCA) for determination of potential cytotoxicity effects of sodium caprate (C10) on Caco-2 cells Transactions of the 38th Int. Soc. Controlled Release Society, Maryland, Abstract 821 [Details]

Ahmad, T., Simpson, J. C. & Brayden, D.J. (2011) Uptake of glucan particles via dectin-1 receptor mediated endocytosis in Peyer¿s patches? Transactions of the 38th Int. Soc. Controlled Release Society, Maryland, Abstract 524 [Details]

Petersen, S. B, Nolan, G., Maher, S., Rahbek, U. L., Guldbrandt, M., & Brayden, D. J. (2011) Tetradecylmaltoside is a permeability enhancer: isolated rat colonic mucosae in Ussing chambers Transactions of the 38th Int. Soc. Controlled Release Society, Maryland, Abstract 759 [Details]

Ryan, S.M, Patel, H.B., Kornerup, K. N., Tajber, L., Umerska, A., Perretti, M., & Brayden, D. J. (2011) Intra-articular delivery of salmon calcitonin nanocomplexes to the K/BxN murine model of osteoarthritis 24th conference of the European Society of Biomaterials [Details]

Maher, S., Walsh, E. G., Bahar, B, Baird, A. W. & Brayden, D. J. (2011) Investigations of intestinal epithelial compensatory responses to permeation enhancement caused by sodium caprate (C10) . In: Selected Podium Session, Abstract 179 eds. Transactions of the 38th Int. Soc. Controlled Release Society, Maryland [Details]

Aguirre, T., Rosa, M. Coulter, I., & Brayden, D. J. (2011) Enhancement of Intestinal Absorption of Salmon Calcitonin Using a Novel Liquid Emulsion Drug Delivery System LEDDS® Transactions of the 38th Int. Soc. Controlled Release Society, Maryland, Abstract 687 [Details]

Fletcher, N.F., Brayden, D.J., Brankin, B. Worrall S. & Callanan J.J. (2005) Growth and characterisation of a felin in-vitro blood-brain barrier 23rd metting of the European Society of Veterinary Pathology , 07-SEP-05 - 10-SEP-05 [Details]
Ahmad, T., Ostroff, G. R., Wang, M., Czech, M. P., & Brayden, D. J. (2010) Uptake and translocation of yeast-derived glucan microparticles across an vitro M-cell model Transactions of the 37th Int. Soc. Controlled Release Society, Portland, Oregon [Details]
D. J. Brayden (2010) Intestinal Permeation Enhancement for Poorly Absorbed Drugs: Matching Mechanism of Action with Biological Assessment Transactions of the 37th Int. Soc. Controlled Release Society, Portland [Details]
Ryan, S. M., McMorrow, J. P., Murphy, E. P. & Brayden, D. J. (2010) Salmon calcitonin reduces expression of a novel biomarker family in inflammatory arthritis:a new target for controlled release formulations? Transactions of the 37th Int. Soc. Controlled Release Society, Portland, Oregon [Details]
Bzik, V., Sheridan, C., & Brayden, D. J. (2010) Inhibition of electrogenic ion transport in rat colonic mucosae by zinc is enabled by the tight junction opener, cytochalasin D Transactions of the 37th Int. Soc. Controlled Release Society, Portland, Oregon [Details]
Rawlinson, L.B & Brayden, D. J. (2010) Use of cellular high content analysis (HCA) to screen cytotoxicity of antimicrobial polymers: A comparison with MTT and whole tissue assays 11th Annual Scientific Meeting of the Australian Society for Antimicrobials (Antimicrobials 2010) [Details]
Bzik, V & Brayden DJ (2009) Permeating-enhancing and cytotoxic effects of 1-phenyl piperazine in rat colonic mucosa 36th Int. Soc. Controlled Release Society [Details]
Wang, X & Brayden, D.J. (2009) Bone regeneration after acute injected bisphophonate and calcitonin repeated treatments in overiectomised rats Osteoporosis Conference 2009, Manchester [Details]
Ryan, SM, McMorrow, J., Murphy, E.P. & Brayden, D. J. (2009) Salmon calcitonin as a potential therapeutic for osteoarthritis and rheumatoid arthritis 36th Int. Soc. Controlled Release Society, Copenhagen [Details]
Ryan, S., Wang, X., Mantovani, G, Haddleton, D. M. & Brayden, D.J. (2008) Enhanced intestinal delivery and stability both in vivo and in vitro of site-specific PEGylation of salmon calcitonin to different molecular sizes of POLYPEG® Transactions of the 35th Int. Soc. Controlled Release Society, Abstract 918 [Details]
Fletcher, N.F., Bexiga, M., Brayden, D. J., Brankin, B., Willett, B. J., Hosie, M. J., Jacque, J. M. & Callanan, J. J. (2008) Cell migration through the blood-brain barrier in FIV virus infection is significantly influenced by the pre-existence of virus and TNF-a within the CNS: studies using an in vitro feline BBB model J. Immunology, 197: p. 161, Abstract 3 [Details]
Wang, X., Tambuwala, M., & Brayden, DJ (2008) Improved absorption of salmon calcitonin from rat intestine in vivo with sodium caprate and a mucolytic, n-acetyl cysteine Transactions of the 35th Int. Soc. Controlled Release Society [Details]
Wang, X, Tambuwala, M., & Brayden, D. J. (2008) Investigation of the absorption-enhancing effects of ethanol in rats Transactions of the 35th Int. Soc. Controlled Release Society [Details]
Rawlinson, LB & Brayden DJ (2008) A methacrylate polymer is bactericidal to Gram-positive and Gram-negative bacteria Society for General Microbiology [Details]
Fletcher, N.F., Brayden, D., Brankin, B., Willett, B., Hosie, M. and Callanan, J.J. (2007) Migration of feline immunodeficiency virus infected lymphocytes across an invitro feline blood brain barrier model is promoted by the basolateral presence of FIV and TNF 25th Annual metting of European Society of Veterinary Pathology [Details]
Fletcher, N., Brayden, D., Brankin, B. and Callanan, J.J. (2006) The interaction of feline immunodeficiency virus with a cell culture model of the felin blood brain barrier Neuroscience Ireland, Inagural Conference , 21-SEP-06 - 22-SEP-06 [Details]
Halligan, E, Reid, C, Keely, S, Brayden, DJ, Carrington, S, Lunec, J, (2005) FREE RADICAL RESEARCH The role of the mucus barrier and lipid peroxides in diet: An in vitro model of a dietary genotoxicity and colorectal cancer , pp.61-61 [Details]
Halligan, E, Reid, C, Keely, S, Brayden, DJ, Carrington, S, Lunec, J, (2005) FREE RADICAL RESEARCH The role of the mucus barrier and lipid peroxides in diet: An in vitro model of a dietary genotoxicity and colorectal cancer , pp.61-61 [Details]
Bzik, V & Brayden DJ (2008) Comparison of three in vitro intestinal diffusion systems Transactions of the 35th Int. Soc. Controlled Release Society, New York [Details]
Maher, S., Wang, X, Bzik, V, McClean, S. & Brayden, D. J. (2008) Increased intestinal permeability induced by the anti-microbial peptide, melittin: in vivo and ex vivo studies Transactions of the 35th Int. Soc. Controlled Release Society, Abstract 912 [Details]
Haddleton, D. M., Mantovani, G. & Brayden, D. J. (2007) Synthetic glycopolymers and protein bioconjugates from living radical polymerization 235th American Chemical Society meeting [Details]
Brayden, D.J., Bourke, E. and Baird, A.W. (1996) Berberine: enhancement of flux of a poorly absorbed anti-diarrhoeal agent as indicated by a parallel electrogenic ion transport in rat colon and T84 . In: Couvreur, P., Duchenne, D, and Kalles, I eds. Minutes of the European Symposium on Formulation of Poorly Soluble Drugs. In: Editions de Sante , pp.191-194 [Details]
Feighery, LM; Keely, S; Smyth, A; Gilchrist, M; Baird, AW; O'Connor, WT; Brayden, DJ; (2004) MOLECULAR BIOLOGY OF THE CELL Demonstration of compromised ileal structure and function following severe acute trauma to the left forebrain in the isoflourane anaesthetized rat , pp.67-67 [Details]
Le Ferrec, E., Chesne, C., Artursson, P., Brayden, D. et al. (2001) 29, 6 (2001) In vitro models of the intestinal barrier The report and recommendations of the ECVAM workshop *, , pp.649-668 [Details]
Brayden, D.J. and Kelly, J.G. (1994) A novel electrophysiological signature from the Peyer's patch of rabbit intestine. Editions de Sante. (1994) Minutes of the European Symposium in in vitro and ex vivo test systems to rationalize drug design and delivery *, , pp.217-221 [Details]
Keely, S., Limer, A., Wilson, C., Carrington, S., Haddleton, D.M., Brayden, D.J. (2006) In vitro mucus-secreting intestinal models for adhesion of conjugated and branched pDMAEMA polymers Proceedings of the International Symposium of Controlled Release of Bioactive Materials , 22-JUL-06 - 26-JUL-06 [Details]
Ryan, S.M., Tao, L., Haddleton, D.M. Brayden, D. J. (2006) Oral polymeric conjugate system for salmon calcitonin: cytotoxicity studies Proceedings of the International Symposium of Controlled Release of Bioactive Materials , 20-JUL-06 - 24-JUL-06 [Details]
Keely, S., Carrington, S., Haddleton, D.M. Brayden, D. J. (2006) An in vitro mucus-secreting intestinal cell model for screening antibiotic effects of polymers Proceedings of the International Symposium of Controlled Release of Bioactive Materials , 20-JUL-06 - 24-JUL-06 [Details]
Haddleton, D.M., Limer, A.J., Mantovani, G, Brayden, D. San Miguel, V. (2005) Amphiphilic polymers from living radical polymerization for personal care applications 230th American Chemical Society Meeting , 28-AUG-05 - 31-AUG-05 [Details]
Ulrich, C., Quinn, T., Baird, A.W., Jones, B, Brayden, D.J. (2002) Ion transport across isolated canine colonic mucosae: leaky tight junctions in inflammatory bowel disease Irish Association of Veterinary Teachers and Research Workers UCD, , 04-NOV-02 [Details]
Brayden, D.J. and Kelly, J.G. (21) (1994) Rabbit Peyer's patches: a novel electrophysiological signature in response to cholinomimetics Proceedings of the Interntional Symposium Control. Rel. Bioactive Mater *, , 01-JUL-94 , pp.276-277 [Details]
Haddleton, DM; Rullay, AK; Limer, AJ; Carrington, S; Keely, S; Brayden, D; (2004) ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Mucoadhesive polymers from living radical polymerisation , pp.358-358 [Details]
Forrest, AS; Quinn, T; Keenan, AK; Usher, C; Parsons, ME; Brayden, DJ; Baird, AW; (2002) BRITISH JOURNAL OF PHARMACOLOGY Megacolon in the streptozotocin-treated diabetic rat [Details]
Cochrane, S; Quinn, T; O'Donoghue, DP; Baird, AW; Brayden, DJ; (2002) BRITISH JOURNAL OF PHARMACOLOGY The effect of myosin light chain kinase inhibition on pharmalogically induced changes in paracellular intestinal epithelial permeability [Details]
Feighery, LM; Quinn, TM; Baird, AW; Brayden, DJ; (2004) MOLECULAR BIOLOGY OF THE CELL Pharmacological manipulation of tight junctions in rat colonic mucosa in vitro , pp.67-67 [Details]
Haddleton, DM; Limer, AJ; Mantovani, G; Brayden, D; Miguel, VS; (2005) ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Amphiphilic polymers from living radical polymerization for personal care applications , pp.4170-4171 [Details]
Leonard, M; Creed, E; Brayden, D; Baird, AW; (2000) PHARMACEUTICAL RESEARCH Iontophoresis-enhanced absorptive flux of polar molecules across intestinal tissue in vitro , pp.476-478 [Details]
Leonard, M; Brayden, DJ; Baird, AW; (2001) BRITISH JOURNAL OF PHARMACOLOGY An in vitro intestinal cell culture model of M-cells displays a Th1 type cytokine profile [Details]
Byrne, D; Leonard, M; Mah, S; Lo, D; Baird, A; O'Mahony, D; Brayden, D; (2001) BRITISH JOURNAL OF PHARMACOLOGY Differential expression of genes in a Peyer's Patch M cell co-culture model by TOGA (TM) [Details]
Hide

Show All

Published Reports:

Brayden, D. J., Armstrong, G., O¿Driscoll, C. M. (2010) The 2nd Annual Irish Drug Delivery Network Conference with UK and Ireland Controlled Release Society-Advancing Drug Delivery. Informa, London. [Details]

Research