Research
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- Core Technologies
Professor Geraldine Butler BA PhD
Contact Details
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Biography:
| 1980-1984 BA (Mod) in Genetics, First class Honours, Trinity College Dublin 2011- Director, Wellcome Trust PhD Programme in Computational Infection Biology. July, 2011 : Elected Fellow of Society of Biology Geraldine Butler, UCD, Candida, genomics, evolution, transcriptomics, gene expression, biofilms, Conway, genetics
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Research Interests
| Virulence characteristics of pathogenic Candida species: my lab is interested in determining factors controlling virulence in pathogenic fungi, and in particular we are identifying the regulatory pathways controlling the growth of biofilms of Candida parapsilosis on medical devices; investigating the response of pathogenic yeast to hypoxia; and characterising the role of specific yeast transcription factors in virulence. We developed one of the first methods for generating gene knockouts in Candida parapsilosis, and are currently constructing a set of individual knockouts. We have also identified some regulators of biofilm development, including the Bcr1 transcription factor. Comparative genomics of pathogenic fungi: In 2009 we co-ordinated an international consortium analysing genomes of 8 Candida species, identifying virulence factors and species-specific pathways (in collaboration with the Broad Institute of Harvard and MIT, and the Wellcome Trust Sanger Institute). In particular, we investigated the evolution of mating and meiosis. We continue to study evolution of the Candida clade, and we have developed a genome browser (the Candida Gene Order Browser) to enable analysis of Candida genomes. Recently we have applied next generation sequencing methods (such as RNA-seq) to studying the transcriptome of C. parapsilosis, and to sequence the genome of a related species. Prof Butler is Director of the Wellcome Trust PhD Programme in Computational Infection Biology at UCD. |
Research Projects
| Sponsor : Science Foundation Ireland (SFI) Title : Comparative genome analysis of Candida species: Biofilm development and virulence Start Date / End Date : 01-JAN-09 / 31-DEC-12 |
| Sponsor : Health Research Board (HRB) Title : Regulation of the hypoxic response in pathogenic yeast Start Date / End Date : 01-OCT-08 / 01-JUN-12 |
Book Chapters
| Geraldine Butler, Michael Lorenz, Neil A.R. Gow (2012) 'Evolution and genomics of the pathogenic Candida species complex' In: L. David Sibley, Barbara J. Howlett, Joseph Heitman (eds). Evolution of Virulence in Eukaryotic Microbes. New Jersey: Wiley-Blackwell. [Details] |
| Butler, G; (2012) 'Comparative genomics of Candida species' In: Candida and Candidiasis, 2nd edition. Washington, DC: ASM Press. [Details] |
| David A. Fitzpatrick and Geraldine Butler; (2010) 'Comparative genomic analysis of pathogenic yeasts and the evolution of virulence' In: H. Ruth Asbee and Elanine M. Bignell (eds). The Yeast Handbook: Pathogenic Yeasts. Berlin: Springer. [Details] |
| Butler. G. ; (2007) 'The evolution of MAT - the ascomycetes' In: J. Heitman, J. Kronstad, J. Taylor, L. Casselton (eds). Sex in fungi: Molecular determination and evolutionary implications. Washington, DC: ASM Press. [Details] |
| Butler G. and Sullivan D.J. ; (2007) 'Comparative genomics of Candida species' In: B. Hube and C. d'Enfert (eds). Candida: comparative and functional genomics. Norfolk, U.K: Caister Academic Press. [Details] |
Peer Reviewed Journals
| Alessandro Riccombeni and Geraldine Butler (2012) 'Role of Genomics and RNA-seq in Studies of Fungal Virulence'. Current Fungal Infection Reports, . [Details] |
| (2012) 'Sequence and analysis of the genome of the pathogenic yeast Candida orthopsilosis'. PLoS ONE, 7 (:e35750). [Details] |
| Guida A, Lindstaedt C, Maguire SL, Ding C, Higgins DG, Corton NJ, Berriman M, Butler G; (2011) 'Using RNA-seq to determine the transcriptional landscape and the hypoxic response of the pathogenic yeast Candida parapsilosis'. BMC Genomics, 12 . [Details] |
| Ding C, Vidanes GM, Maguire SL, Guida A, Synnott JM, Andes DR, Butler G.; (2011) 'Conserved and Divergent Roles of Bcr1 and CFEM Proteins in Candida parapsilosis and Candida albicans'. PLoS ONE, 6 . [Details] |
| Silva AP, Miranda IM, Guida A, Synnott J, Rocha R, Silva R, Amorim A, Pina-Vaz C, Butler G, Rodrigues AG.; (2011) 'Transcriptional Profiling of Azole-Resistant Candida parapsilosis Strains'. Antimicrobial Agents and Chemotherapy, 55 :3546-3556. [Details] |
| Sai S, Holland LM, McGee CF, Lynch DB, Butler G; (2011) 'Evolution of Mating within the Candida parapsilosis Species Group'. Eukaryotic Cell, 10 (4):578-587. [DOI] [Details] | |||||||||
| Synnott JM, Guida A, Mulhern-Haughey S, Higgins DG, Butler G.; (2010) 'Regulation of the hypoxic response in Candida albicans'. Eukaryotic Cell, . [Details] | |||||||||
| Lynch DB, Logue ME, Butler G, Wolfe KH.; (2010) 'Chromosomal G + C Content Evolution in Yeasts: Systematic Interspecies Differences, and GC-Poor Troughs at Centromeres'. Genome Biology and Evolution, 2 :572-583. [Details] | |||||||||
| Fitzpatrick DA, O'Gaora P, Byrne KP, Butler G; (2010) 'Analysis of gene evolution and metabolic pathways using the Candida Gene Order Browser'. BMC Genomics, 11 . [DOI] [Details] | |||||||||
| Morrissey JP, Holcombe LJ, McAlester G, Munro CA, Enjalbert B, Brown AJ, Gow NA, Ding C, Butler G, O'Gara F, ; (2010) 'Pseudomonas aeruginosa secreted factors impair biofilm development in Candida albicans'. Microbiology (Reading, England), 156 :1476-1486. [DOI] [Details] | |||||||||
| Butler G, ; (2010) 'Fungal sex and pathogenesis'. Clinical Microbiology Reviews, 23 (1):140-159. [DOI] [Details] | |||||||||
| Haynes K, Stead DA, Walker J, Holcombe L, Gibbs SR, Yin Z, Selway L, Butler G, Brown AJ, ; (2010) 'Impact of the transcriptional regulator, Ace2, on the Candida glabrata secretome'. Proteomics, 10 :212-223. [DOI] [Details] | |||||||||
| Rossignol, T,Ding, C,Guida, A,d'Enfert, C,Higgins, DG,Butler, G; (2009) 'Correlation between Biofilm Formation and the Hypoxic Response in Candida parapsilosis'. Eukaryotic Cell, 8 :550-559. [DOI] [Details] | |||||||||
| Berriman M, Jackson AP, Gamble JA, Yeomans T, Moran GP, Saunders D, Harris D, Aslett M, Barrell JF, Butler G, Citiulo F, Coleman DC, de Groot PW, Goodwin TJ, Barrell B, Quail MA, McQuillan J, Munro CA, Pain A, Poulter RT, Rajandream MA, Renauld H, Spiering MJ, Tivey A, Gow NA, Sullivan DJ, ; (2009) 'Comparative genomics of the fungal pathogens Candida dubliniensis and Candida albicans'. Genome Research, 19 (12):2231-2244. [DOI] [Details] | |||||||||
| Butler G, Rasmussen MD, Lin MF, Santos MA, Sakthikumar S, Munro CA, Rheinbay E, Grabherr M, Forche A, Reedy JL, Agrafioti I, Arnaud MB, Bates S, Brown AJ, Brunke S, Costanzo MC, Fitzpatrick DA, de Groot PW, Harris D, Hoyer LL, Hube B, Klis FM, Kodira C, Lennard N, Logue ME, Martin R, Neiman AM, Nikolaou E, Quail MA, Quinn J, Santos MC, Schmitzberger FF, Sherlock G, Shah P, Silverstein KA, Skrzypek MS, Soll D, Staggs R, Stansfield I, Stumpf MP, Sudbery PE, Srikantha T, Zeng Q, Berman J, Berriman M, Heitman J, Gow NA, Lorenz MC, Birren BW, Kellis M,Cuomo CA. ; (2009) 'Evolution of pathogenicity and sexual reproduction in eight Candida genomes'. Nature, 459 :657-662. [DOI] [Details] | |||||||||
| Roetzer A, Gregori C, Jennings AM, Quintin J, Ferrandon D, Butler G, Kuchler K, Ammerer G, Schüller C.; (2008) 'Candida glabrata environmental stress response involves Saccharomyces cerevisiae Msn2/4 orthologous transcription factors'. Molecular Microbiology, 69 :603-620. [Details] | |||||||||
| Butler G, Fitzpatrick DA, Logue ME, ; (2008) 'Evidence of recent interkingdom horizontal gene transfer between bacteria and Candida parapsilosis'. BMC Evolutionary Biology, 8 (1). [DOI] [Details] | |||||||||
| Ding, C, Butler, G, ; (2007) 'Development of a gene knockout system in Candida parapsilosis reveals a conserved role for BCR1 in biofilm formation'. Eukaryotic Cell, 6 :1310-1319. [Details] | |||||||||
| Dignard, D, El-Naggar, AL, Logue, ME, Butler, G, Whiteway, M, ; (2007) 'Identification and characterization of MFA1, the gene encoding Candida albicans a-factor pheromone'. Eukaryotic Cell, 6 :487-494. [Details] | |||||||||
| Scannell D.R, Butler G. and Wolfe K.H.; (2007) 'Yeast genome evolution - the origin of the species'. Yeast, 24 :929-942. [Details] | |||||||||
| Rossignol T, Logue ME, Reynolds K, Grenon M, Lowndes NF, Butler G.; (2007) 'Analysis of the transcriptional response of Candida parapsilosis following exposure to farnesol'. Antimicrob Agents Chemother, 51 (2304). [Details] | |||||||||
| Mulhern, SM; Logue, ME; Butler, G; ; (2006) 'Candida albicans transcription factor Ace2 regulates metabolism and is required for filamentation in hypoxic conditions'. EUKARYOTIC CELL, 5 (12):2001-2013. [Details] | |||||||||
| Fitzpatrick, DA; Logue, ME; Stajich, JE; Butler, G; ; (2006) 'A fungal phylogeny based on 42 complete genomes derived from supertree and combined gene analysis'. BMC EVOLUTIONARY BIOLOGY, 6 (NA). [Details] | |||||||||
| MacCallum, DM; Findon, H; Kenny, CC; Butler, G; Haynes, K; Odds, FC; ; (2006) 'Different consequences of ACE2 and SW15 gene disruptions for virulence of pathogenic and nonpathogenic yeasts'. Infection and Immunity, 74 (9):5244-5248. [Details] | |||||||||
| Lasker, BA; Butler, G; Lott, TJ; ; (2006) 'Molecular genotyping of Candida parapsilosis group I clinical isolates by analysis of polymorphic microsatellite markers'. Journal of Clinical Microbiology, 44 (3):750-759. [Details] | |||||||||
| Logue, ME; Wong, S; Wolfe, KH; Butler, G; ; (2005) 'A genome sequence survey shows that the pathogenic yeast Candida parapsilosis has a defective MTLa1 allele at its mating type locus'. Eukaryotic Cell, 4 (6):1009-1017. [Details] | |||||||||
| Laffey, SF; Butler, G; ; (2005) 'Phenotype switching affects biofilm formation by Candida parapsilosis'. Microbiology-Sgm, 151 (NA):1073-1081. [Details] | |||||||||
| Butler G, Kenny C, Fagan A, Kurischko C, Gaillardin C, Wolfe KH. ; (2004) 'Evolution of the MAT locus and its Ho endonuclease in yeast species'. Proceedings of the National Academy of Sciences, 101 :1632-1637. [Details] | |||||||||
| Kelly, MT; MacCallum, DM; Clancy, SD; Odds, FC; Brown, AJP; Butler, G; ; (2004) 'The Candida albicans CaACE2 gene affects morphogenesis, adherence and virulence'. Molecular Microbiology, 53 (3):969-983. [Details] | |||||||||
| Kamran, M; Calcagno, AM; Findon, H; Bignell, E; Jones, MD; Warn, P; Hopkins, P; Denning, DW; Butler, G; Rogers, T; Muhlschlegel, FA; Haynes, K; ; (2004) 'Inactivation of transcription factor gene ACE2 in the fungal pathogen Candida glabrata results in hypervirulence'. Eukaryotic Cell, 3 (2):546-552. [Details] | |||||||||
| Kelly, MT; Odds, F; Butler, G; ; (2003) 'Investigation of the potential role of Ace2p as a virulence factor in Candida albicans'. Yeast, 20 (NA):72-72. [Details] | |||||||||
| Wong, S; Fares, MA; Zimmermann, W; Butler, G; Wolfe, KH; ; (2003) 'Evidence from comparative genomics for a complete sexual cycle in the 'asexual' pathogenic yeast Candida glabrata'. Genome Biology, 4 (2). [Details] | |||||||||
| Walsh, DW; Wolfe, KH; Butler, G; ; (2002) 'Genomic differences between Candida glabrata and Saccharomyces cerevisiae around the MRPL28 and GCN3 loci'. Yeast, 19 (11):991-994. [Details] | |||||||||
| Wong, S; Butler, G; Wolfe, KH; ; (2002) 'Gene order evolution and paleopolyploidy in hemiascomycete yeasts'. Proceedings of the National Academy of Sciences of the United States of America, 99 (14):9272-9277. [Details] | |||||||||
| Doolin, MT; Johnson, AL; Johnston, LH; Butler, G; ; (2001) 'Overlapping and distinct roles of the duplicated yeast transcription factors Ace2p and Swi5p'. Molecular Microbiology, 40 (2):422-432. [Details] | |||||||||
| Geoghegan, SM; Mayhew, SG; Yalloway, GN; Butler, G; ; (2000) 'Cloning, sequencing and expression of the gene for flavodoxin from Megasphaera elsdenii and the effects of removing the protein negative charge that is closest to N(1) of the bound FMN'. European Journal of Biochemistry, 267 (14):4434-4444. [Details] | |||||||||
| O'Conallain, C; Doolin, MT; Taggart, C; Thornton, F; Butler, G; ; (1999) 'Regulated nuclear localisation of the yeast transcription factor Ace2p controls expression of chitinase (CTS1) in Saccharomyces cerevisiae'. Molecular & General Genetics, 262 (2):275-282. [Details] | |||||||||
| King, L; Butler, G; ; (1998) 'Ace2p, a regulator of CTS1 (chitinase) expression, affects pseudohyphal production in Saccharomyces cerevisiae'. Current Genetics, 34 (3):183-191. [Details] | |||||||||
| O'Conallain, C; Doolin, T; Butler, G; ; (1998) 'Inappropriate expression of the yeast transcription factor Ace2p affects cell growth'. Biochemical Society Transactions, 26 (1):78-78. [Details] | |||||||||
| Wolfe, K; Butler, G; ; (1997) 'Yeast's clickable chromosomes and other genome browsers'. Trends in Genetics, 13 (6):246-247. [Details] | |||||||||
| McDonnell, R; Butler, G; ; (1997) 'Identification of proteins which interact with YRB1'. European Journal of Cell Biology, 72 (NA):52-52. [Details] | |||||||||
| O'Neill, H, Mayhew, SG, Butler, G, ; (1998) 'Cloning and analysis of the genes for a novel electron-transferring flavoprotein from Megasphaera elsdenii - Expression and characterization of the recombinant protein'. Journal of Biological Chemistry, 273 (33):21015-21024. [Details] | |||||||||
| NEILL, D; MCNAMARA, M; BUTLER, G; ; (1995) 'REGULATED NUCLEAR ENTRY OF A YEAST TRANSCRIPTION FACTOR'. Biochemical Society Transactions, 23 (2):346-346. [Details] | |||||||||
| Butler G, Dawes IW, McConnell DJ.; (1990) 'Butler G, Dawes IW, McConnell DJ'. Molecular and General Genetics, 223 :449-456. [Details] | |||||||||
| ONEILL, HM; BUTLER, G; MAYHEW, SG; ; (1995) 'CLONING OF ELECTRON-TRANSFERRING FLAVOPROTEIN FROM MEGASPHAERA-ELSDENII'. Biochemical Society Transactions, 23 (2):379-379. [Details] | |||||||||
| Butler G, McConnell DJ.; (1988) 'Identification of an upstream activation site in the pyruvate decarboxylase structural gene (PDC1) of Saccharomyces cerevisiae'. Current Genetics, 14 :405-412. [Details] | |||||||||
| GEOGHEGAN, SM; BUTLER, G; MAYHEW, SG; ; (1995) 'CLONING OF THE GENE FOR FLAVODOXIN FROM THE ANAEROBIC BACTERIUM MEGASPHAERA-ELSDENII'. Biochemical Society Transactions, 23 (2):384-384. [Details] | |||||||||
| Banerjee M, West RW Jr, Chen SM, Putz H, Butler G, ; (1987) 'GAL1-GAL10 divergent promoter region of Saccharomyces cerevisiae contains negative control elements in addition to functionally separate and possibly overlapping upstream activating sequences'. Genes & Development, 1 (10):1118-1131. [Details] | |||||||||
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Other Journals
| Geoghegan, S.M., Butler, G. and Mayhew, S.G; (1995) 'Cloning of the gene for flavodoxin from the anaerobic bacterium Megasphaera elsdenii' Biochemical Society Transactions 23 . [Details] |
| O'Neill, H.M., Butler, G. and Mayhew, S.G.; (1995) 'Cloning of electron-transferring flavoprotein from Megasphaera elsdenii' Biochemical Society Transactions 23 . [Details] |
Conference Publications
| Rossignol, T., Logue, M.E. and Butler, G.; (2005) Genome sequence survey and design of microarrays for Candida parapsilosis 22nd International Conference on Yeast Genetics and Molecular Biology Bratislava, Slovakia, , 26-AUG-05 - 31-AUG-05 [Details] |
| Butler, G.; (2005) Candida parapsilosis: genomic analysis and biofilm development 22nd International Conference on Yeast Genetics and Molecular Biology Bratislava, Slovakia, , 26-AUG-05 - 31-AUG-05 [Details] |
Honours and Awards
| Year: 2011. Title: Fellow of Society of Biology |
Other Activities
| Editor, Eukaryotic Cell, 2012- |
| Editorial Advisory Board, FEMS Yeast Research, 2010-2011 |
| Editorial Advisory Board, Eukaryotic Cell, Jan 2010 - |
| Editorial Advisory Board, PLoS One, 2007-2010 |
Committees
| Committee : Eukaryotic cell group, Society for Microbiology |
| Committee : Steering committee, Genomics, genetics and molecular biology, International Mycology Congress 9. |
| Committee : Finance and Policy Committee, International Conference on Yeast Genetics and Moleculer Biology |
| Committee : Scientific Advisory Board, FEBS Advanced Lecture Course on Human Fungal Pathogens |
Associations
| Association: Society General Microbiology, Function/Role: Committee Member, Eukaryotic cell group |
Conference Contributions
| Geraldine Butler (2012) Evolution of the hypoxic response in fungal species. [Invited Oral Presentation], Keystone conference on Fungal Pathogens: from basic biology to drug discovery, Santa Fe, New Mexico , 15-JAN-12 - 20-JAN-12. |
| Geraldine Butler (2012) Evolution of the hypoxic response in fungi. [Invited Oral Presentation], 18th Congress of ISHAM, Berlin, Germany , 11-JUN-12 - 15-JUN-12. |
| Geraldine Butler; (2011) Evolution of hypoxic regulation in Candida species. [Invited Lecture], 26th Fungal Genetics Conference, Asilomar, California, USA , 15-MAR-11 - 20-MAR-11. |
| Vidanes GM, Ding C., Guida A, Synnott, JM, Maguire S, Butler G. ; (2011) Iron acquisition regulated by CFEM genes in C. parapsilosis. [Poster Presentation], FEBS Advanced Course on Human Fungal Pathogens, La Colle sur Loup, France , 07-MAY-11 - 13-MAY-11. |
| Holland L, Butler G.; (2011) Construction of a gene knock-out collection in Candida parapsilosis. [Poster Presentation], FEBS Advanced Course on Human Fungal Pathogens, La Colle sur Loup, France , 07-MAY-11 - 13-MAY-11. |
| Geraldine Butler; (2011) Genomics and virulence and in pathogenic fungi. [Invited Lecture], Trends in Medical Mycology (TIMMS), Valencia, Spain , 02-OCT-11 - 04-OCT-11. | |||||||||
| Sai S, Maguire S, Butler G.; (2011) Analysis of the hypoxic response in Candida glabrata. [Poster Presentation], FEBS Advanced Course on Human Fungal Pathogens, La Colle sur Loup, France , 07-MAY-11 - 13-MAY-11. | |||||||||
| Maguire SL, Fitzpatrick DA, O¿Gaora P, Byrne KP, Butler G; (2011) CGOB: the Candida gene order browser. [Poster Presentation], FEBS Advanced Course on Human Fungal Pathogens, La Colle sur Loup, France , 08-MAY-11 - 13-MAY-11. | |||||||||
| Lynch DB, Wolfe KH, Butler G; (2011) Comparative analysis of non-coding RNAs and novel transcripts in Candida albicans. [Poster Presentation], FEBS Advanced Course on Human Fungal Pathogens, La Colle sur Loup, Frnace , 08-MAY-11 - 13-MAY-11. | |||||||||
| Connolly L, Butler G.; (2011) Identification of regulators of biofilm development in Candida parapsilosis. [Poster Presentation], FEBS Advanced Course on Human Fungal Pathogens, La Colle sur Loup, France , 07-MAY-11 - 13-MAY-11. | |||||||||
| Geraldine Butler; (2011) Horizontal Gene Transfer. [Chaired Session], Society General Microbiology, York, UK , 05-SEP-11 - 08-SEP-11. | |||||||||
| Geraldine Butler; (2010) Evolution of mating in the Candida parapsilosis species group. [Invited Oral Presentation], International Mycology Congress 9, Edinburgh , 01-AUG-10 - 06-AUG-10. | |||||||||
| Geraldine Butler; (2010) Evolution of mating and virulence in Candida species. [Invited Oral Presentation], American Society of Microbiology General Meeting, San Diego, California , 23-MAY-10 - 28-APR-10. | |||||||||
| Geraldine Butler; (2010) Evolution of virulence in eukaryotic pathogens. [Chaired Session], American Society of Microbiology General Meeting, San Diego, California , 23-MAY-10 - 28-MAY-10. | |||||||||
| Geraldine Butler; (2010) Genomic analysis of the Candida parapsilosis species group. [Invited Oral Presentation], 10th ASM Conference on Candida and Candidiasis, Miami, Florida , 22-MAR-10 - 26-JUL-10. | |||||||||
| Geraldine Butler; (2009) Comparative genomic analysis of mating and virulence in Candida species. [Chaired Session], 17th Congress of the International Society for Human and Animal Mycology, Tokyo, Japan , 25-MAY-09 - 29-MAY-09. | |||||||||
| Geraldine Butler; (2010) Candida Genome Structure and Evolution. [Chaired Session], 10th ASM Meeting on Candida and Candidiasis, Miami, Florida , 22-MAR-10 - 26-MAR-10. | |||||||||
| Geraldine Butler; (2009) Comparative genomic analysis of virulence in Candida species. [Invited Lecture], UK Society for General Microbiology, Cork, Ireland , 22-APR-09 - 22-APR-09. | |||||||||
| Geraldine Butler; (2009) GC variation in Candida species. [Invited Lecture], EMBO Conference: Comparative genomics of eukaryotic microorganisms, San Feliu de Guixols, Spain , 17-OCT-09 - 22-OCT-09. | |||||||||
| G. Vidanes, C. Ding, A. Guida, J.M. synnott, G. Butler; (2010) Functional comparison of the biofilm transcription factor Bcr1. [Poster Presentation], 10th ASM Conference on Candida and Candidiasis, Miami, Florida , 22-MAR-10 - 26-MAR-10. | |||||||||
| A.P. Silva, M. Miranda, A. Guida, J. Synnott, A.G. rodrigues, C. Pina-Vaz, G. Butler; (2010) Transcriptional profiling of azole resistant Candida parapsilosis strains. [Poster Presentation], 10th ASM Conference on Candida and Candidiasis, Miami, Florida , 22-MAR-10 - 26-MAR-10. | |||||||||
| S. Sai, J. Synnott, C. Linstaedt, C. Ding, G. Butler; (2010) Analysis of the hypoxic response in Candida species. [Poster Presentation], 10th ASM Conference on Candida and Candidiasis, Miami, Florida , 22-MAR-10 - 26-MAR-10. | |||||||||
| L. M. Holland, S. Sai, C. Magee, G. Butler; (2010) Analysis of mating in the Candida parapsilosis species group. [Poster Presentation], 10th ASM Conference on Candida and Candidiasis, Miami, Florida , 22-MAR-10 - 26-MAR-10. | |||||||||
| Sai S., McGee C and Butler G; (2009) The mating-type locus in the Candida parapsilosis species group. [Poster Presentation], 3rd FEBS Advanced Lecture Course on Human Fungal Pathogens, La Colle sur Loup, France , 02-MAY-09 - 08-MAY-09. | |||||||||
| Ding C., Guida A., Synnott J., Connolly C. and Butler G; (2009) Re-wiring of the Bcr1 transcription factor in C. albicans and c. parapsilosis. [Poster Presentation], 3rd FEBS Advanced Lecture Course on Human Fungal Pathogens, La Colle sur Loup, France , 02-MAY-09 - 08-MAY-09. | |||||||||
| Jurgensen C., Guida A and Butler G; (2009) Transcriptional profiling in C. parapsilosis. [Poster Presentation], 3rd FEBS Advanced Lecture Course on Human Fungal Pathogens, La Colle sur Loup, France , 02-MAY-09 - 08-MAY-09. | |||||||||
| Synnott J., Guida A., Mulhern-Haughey S. and Butler G; (2009) Analysis of the role of Upc2 in the hypoxic response in Candida albicans. [Poster Presentation], 3rd FEBS Advanced Lecture Course on Human Fungal Pathogens, La Colle sur Loup, France , 02-MAY-09 - 08-MAY-09. | |||||||||
| Lynch D., Logue M.E., Butler G. and Wolfe K.H. ; (2009) G+C variation in the Saccharomycotina. [Poster Presentation], 3rd FEBS Advanced Lecture Course on Human Fungal Pathogens, La Colle sur Loup, France , 02-MAY-09 - 08-MAY-09. | |||||||||
| Rossignol T., Din C., d¿Enfert C. and Butler G; (2008) Biofilm formation and hypoxia in Candida parapsilosis. [Poster Presentation], 9th Candida and Candidiasis ASM Conference, Jersey City, USA , 24-MAR-08 - 28-MAR-08. | |||||||||
| Geraldine Butler; (2008) Candida evolution and epidemiology. [Chaired Session], 9th Candida and Candidiasis ASM Conference, Jersey City, USA , 24-MAR-08 - 28-MAR-08. | |||||||||
| Geraldine Butler; (2008) CGOB: a synteny browser for Candida genomes. [Oral Presentation], 9th Candida and Candidiasis ASM Conference, Jersey City, USA , 24-MAR-08 - 28-MAR-08. | |||||||||
| Ding C., Guida A. and Butler G. ; (2008) Analysis of the transcriptional profile of a Candida parapsilosis BCR1 knockout. [Poster Presentation], 9th Candida and Candidiasis ASM Conference, Jersey City, USA , 24-MAR-08 - 28-MAR-08. | |||||||||
| Synnott J.M. Mulhern-Haughey S.M., Logue M.E. and Butler G. ; (2008) Analysis of the hypoxic response in Candida albicans. [Poster Presentation], 9th Candida and Candidiasis ASM Conference, Jersey City, USA , 24-MAR-08 - 28-MAR-08. | |||||||||
| Logue M.E., McGee C, Butler G; (2008) Genomic analysis of mating and meiosis in Candida species. [Poster Presentation], 9th Candida and Candidiasis ASM Conference, Jersey City, USA , 24-MAR-08 - 28-MAR-08. | |||||||||
| McAlester G., Munro C.A., Ding C., Enjalbert B., Gow N.A., O¿Gara F., Butler G, Morrissey J. P. ; (2008) Pseudomonas aeruginosa secreted factors dramatically reduce adherence and biofilm formation in Candida albicans. [Poster Presentation], 9th Candida and Candidiasis ASM Conference, Jersey City, USA , 24-MAR-08 - 28-MAR-08. | |||||||||
| Geraldine Butler; (2007) Evolution of mating and meiosis in Candida species. [Invited Lecture], 2nd FEBS Advanced Lecture Course: Human Fungal Pathogens, La Colle sur Loup, France , 11-MAY-07 - 17-MAY-07. | |||||||||
| Geraldine Butler; (2007) Evolution of mating and meiosis in Candida species. [Invited Oral Presentation], 24th Fungal Genetics Conference, Asilomar, California , 20-MAR-07 - 27-MAR-07. | |||||||||
| Warwick B. Dunn, Siobhan Mulhern, Marie Brown, Stephen Oliver, Geraldine Butler and Douglas B. Kell; (2007) A metabolic footprinting investigation of Candida albicans transcription factor ace2, different carbon sources and their influence on metabolism. [Poster Presentation], Metabolomics Society Conference, Manchester, UK , 06-JUN-07 - 06-JUN-07. | |||||||||
| Fitzpatrick DA and Butler G; (2007) Using comparative genomics to identify virulence characteristics in pathogenic yeast. [Poster Presentation], 24th Fungal Genetics Conference, Asilomar, California , 20-MAR-07 - 27-MAR-07. | |||||||||
| Christina Cuomo, Matthew Rasmussen, Manfred Grabherr, David DeCaprio, Lohith Kini, Chinnappa Kodira, Esther Rheinbay, Radek Szklarczyk, Geraldine Butler, Neil Gow, Joseph Heitman, Michael Lorenz, Andre Nantel, Manolis Kellis, and Bruce Birren; (2007) Sequencing and Comparative Analysis of Candida Genomes. [Poster Presentation], 24th Fungal Genetics Conference, Asilomar, California , 20-MAR-07 - 27-MAR-07. | |||||||||
| Ding C, and Butler G. ; (2007) Developing tools for generating gene disruptions in Candida parapsilosis. [Poster Presentation], 2nd FEBS Advanced Lecture Course on Human Fungal Pathogens, La Colle sur Loup, France , 11-MAY-07 - 17-MAY-07. | |||||||||
| Synnott J., Logue M.E., Kenny C. and Butler G. ; (2007) Analysis of the transcriptional response of mouse macrophages to infection with Candida glabrata. [Poster Presentation], 2nd FEBS Advanced Lecture Course on Human Fungal Pathogens, La Colle sur Loup, France , 11-MAY-07 - 17-MAY-07. | |||||||||
| Mulhern S. and Butler G; (2007) Analysis of the hypoxic response in Candida albicans. [Poster Presentation], 2nd FEBS Advanced Lecture Course on Human Fungal Pathogens, La Colle sur Loup, France , 11-MAY-07 - 17-MAY-07. | |||||||||
| Cuomo C., Grabherr M., Grochow J., Rasmussen M., Kodira C., Decaprio D., Butler G., Gow N., Lorenz M., Kellis M. and Birren B. ; (2006) Sequencing and comparative analysis of Candida genomes. [Poster Presentation], 8th ASM Candida and Candidiasis conference, Denver, Colorado , 13-MAR-06 - 17-MAR-06. | |||||||||
| Fitzpatrick D.A., Logue M.E. and Butler G. ; (2006) A phylogenetic supertree of completely sequenced fungal genomes. [Oral Presentation], 8th ASM Candida and Candidiasis conference, Denver, Coloraado , 13-MAR-06 - 17-MAR-06. | |||||||||
| Jennings A., Kenny C., Haynes K. and Butler G. ; (2006) Analysis of transcription factors ACE2 and SWI5 in the pathogenic yeast Candida glabrata. [Poster Presentation], 8th ASM Candida and Candidiasis conference, Denver, Colorado , 13-MAR-06 - 17-MAR-06. | |||||||||
| Mulhern S.M. and Butler G; (2006) Knocking out CaACE2 affects metabolism and morphogenesis in hypoxic conditions. [Poster Presentation], 8th ASM Candida and Candidiasis conference, Denver, Colorado , 13-MAR-06 - 17-MAR-06. | |||||||||
| Logue M.E., Wong S., Wolfe K.H. and Butler G. ; (2005) Candida parapsilosis has a defective mating type locus. [Poster Presentation], FEBS Advanced Lecture Course on Human Fungal Pathogens, La Colle sur Loup, France , 21-MAY-05 - 28-MAY-05. | |||||||||
| Mulhern S. and Butler G. ; (2005) The Ace2 transcription factor from C. albicans regulates cell separation and metabolism. [Poster Presentation], FEBS Advanced Lecture Course on Human Fungal Pathogens, La Colle sur Loup, France , 21-MAY-05 - 28-MAY-05. | |||||||||
| Findon H., Holcombe L., Calcagno A-M., Bignell E., Butler G., Rogers T., Muhlschlegal F. and Haynes K; (2005) Functional analysis of Candida glabrata Ace2, a transcriptional regulator mediating avirulence. [Poster Presentation], FEBS Advanced Lecture Course on Human Fungal Pathogens, La Colle sur Loup, France , 21-MAY-05 - 28-MAY-05. | |||||||||
| Jennings A.M and Butler G; (2005) Identification of targets of the transcription factors Ace2p and Swi5p from the pathogenic yeast Candida glabrata. [Poster Presentation], British Yeast Group Meeting, Canterbury, UK , 05-APR-05 - 07-APR-05. | |||||||||
| Kenny C. and Butler G. ; (2005) Analysis of the Swi5p transcription factor in Candida glabrata. [Poster Presentation], British Yeast Group Meeting, Canterbury, UK , 05-APR-05 - 07-APR-05. | |||||||||
| Rossignol T., Logue M.E. and Butler G; (2005) Genome sequence survey and design of microarrays for Candida parapsilosis. [Poster Presentation], 22nd International Conference on Yeast Genetics and Molecular Biology, Bratislava, Slovakia , 07-AUG-05 - 12-AUG-05. | |||||||||
| Geraldine Butler; (2008) Comparative analysis of Candida genomes. [Invited Lecture], British Yeast Group Meeting, National University of Maynooth , 18-MAR-08 - 20-MAR-08. | |||||||||
| Geraldine Butler; (2008) EMBO workshop. [Invited Lecture], Evolutionary and environmental genomics of yeast, EMBL, Heidleberg, Germany , 01-OCT-08 - 05-OCT-08. | |||||||||
| Butler, G.; (2006) Evolution of mating in Candida parapsilosis and related species. [Invited Oral Presentation], Gordon Research Conference on Cellular and Fungal Biology, Holderness School, New Hampshire , 18-JUN-06 - 23-JUN-06. | |||||||||
| Butler, G.; (2005) Candida parapsilosis: genomic analysis and biofilm development. [Invited Oral Presentation], 22nd International Conference on Yeast Genetics and Molecular Biology, Bratislava, Slovakia , 01-AUG-05 - 05-AUG-05. | |||||||||
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Employment
| Employer: University College Dublin Position: Associate Professor of Genetics |
| Employer: University College Dublin Position: Senior Lecturer |
| Employer: University of New South Wales Position: Visiting Research Scientist |
| Employer: University College Dublin Position: College Lecturer |
| Employer: University of Michigan Position: Thurneau Research Fellow |
Education
| Year 1984 Institution: Trinity College Dublin Qualification: BA Subject: |
| Year 1991 Institution: Trinity College Dublin Qualification: PhD Subject: |
| Year 1984 Institution: Trinity College Dublin Qualification: BA (Mod) Subject: Genetics |
External Collaborators
| Prof Ken Wolfe, Trinity College Dublin Prof Ken Haynes, Imperial College London Prof Neil Gow, University of Aberdeen Dr Mike Lorenz, University of Texas Dr Christina Cuomo, Broad Institute |
Teaching Philosophy
| Above all, I believe that students should have the opportunity to excel. It is my job to introduce them to concepts, to teach them how to find and how to evaluate information, but they must have the space to progress to the limits of their ability. |