Professor Helen Roche

Research

Professor Helen Roche PhD MSc BSc

Contact Details

Title	Associate Professor of Nutrigenomics
Address	Conway Institute of Biomolecular & Biomedical Research
Telephone:	+353-1-7166845
Fax:	+353-1-7166701
Email:	ei.dcu@ehcor.neleh

Title	Associate Professor
Address	School of Public Hlth, Physio & Pop Sc Conway Institute Belfield Dublin 4
Telephone:	Ext. 6845
Email:	ei.dcu@ehcor.neleh

Biography:

Helen Roche's academic background is in Human Nutriton & Molecular Meidcine, she was recently appointed Associate Professor of Nutrigenomics based at the Conway Institute, UCD, Ireland within the Food & Health Theme. She is also a SFI Principal Investigator. Prior to that as Wellcome Trust Fellow & Senior Lecturer in Molecular Nutrition at TCD, Dr Roche established the first Nutrigenomics research group in Ireland, at the Institute of Molecular Medicine at TCD.

Nutrigenomics uses state-of-the-art ‘omoics' technologies to investigate the interaction between Nutrition and the Human Genome and gain a greater understanding of the molecular effects of nutrition on health. Whilst it is known that nutrition plays an important role in health and disease, often the cellular and molecular effects of nutrients are not fully understood. In light of the Human Genome Project and the rapid advances in molecular biology, it is essential that these opportunities be applied to nutrition research to progress our understanding of the role of nutrition in health and disease. The potential scope of research within the context of Nutrigenomics is enormous and could include:

• Genetic determinants of nutrient status, metabolic response and predisposition to diet-related diseases (insulin resistance, type 2 disbetes mellitus (T2DM), cardiovascular diasese (CVD), some chronic pro-inflammatory conditions and cancers)

• Nutrient regulation of gene / protein expression, genetic determinant of responsiveness to nutritional therapy and/or diet-related disease progression, and the effects of dietary fatty acids on the expression of the genes involved in metabolic health (T2DM, CVD, inflammation and colon cancer).

Research Interests

The SFI Principal Investigator Programme entitled ‘The role of macrophage accumulation in adipose tissue in the development of obesity induced insulin resistance - insights into mechanisms and nutrient based therapies using a nutrigenomics approach' is determining the interaction between inflammatory and nutrient stressors within the context of obesity, insulin resistance and type 2 diabetes mellitus (T2DM). This project is in collaboration with Prof Kingston Mills, School of Biochemistry & Immunology, Trinity College Dublin, Ireland (http://www.tcd.ie/Biochemistry/research/k_mills.php). This programme compliments other projects including, LIPGENE an EU FP6 IP and NuGO an EU FP6 NoE which focus on the effect of genetic background and nutrient exposure, specifically the molecular effect of dietary fatty acids, on insulin sensitivity and inflammation, within the context of the metabolic syndrome.

LIPGENE: Diet, genomics and the metabolic syndrome: an integrated nutrition, agro-food, social and economic analysis. LIPGENE is an EU Framework 6 Integrated Project designed to determine the effects of dietary fatty acid composition and human genetic variation on the development and risk of the metabolic syndrome. Project involves a prospective genetic study and a human dietary intervention trial to test the interaction between dietary fat exposure and genetic risk of the metabolic syndrome. Prof Roche is PI for the Human Nutrition & Genomics Research Programme for UCD and the LIPGENE consortium. www.ucd.ie/lipgene

NuGO: NuGO is a European-funded Network of Excellence, the full title of which is 'The European Nutrigenomics Organisation: linking genomics, nutrition and health research' www.NuGo.org

NutSysBiol: Nutrigenomics & Functional Food Development: Towards a Nutritional Systems Biology Approach. This project will test the robustness of transcriptomic and proteomic approaches in determining the heath effects of fatty acid modified functional foods. A nutritional systems biology approach will be developed to understand the role of nutrients designed to prevent diabetes and atherosclerosis. This project is in collaboration with Dr Aidan Moloney, Teagasc Ashtown Food Research Centre, Ireland (http://www.teagasc.ie) and Dr Baukje De Roos, Rowett Research Institute, Aberdeen, Scotland (http://www.rowett.ac.uk/divisions/vhp/b_deroos.html). The Nutritional Systems Biology Programme is also being supported by IRSCET who are funding a PhD Programme in Nutritional Systems Biology within their EMBARK Postgraduate Research Scholarship Scheme (http://www.ircset.ie).

Functional Foods: Healthy fatty acid-enriched fresh beef: Implications for shelf-life, flavour and the health of the consumer. The project will determine if the health effects of CLA enriched beef are as potent as synthetic forms of the fatty acid on insulin sensitivity in male ob/ob mice, atherosclerosis in apo E knock out mice and chronic inflammation in a mouse model of IBD. This project is part of a larger FIRM programme being co-ordinated by Dr Aidan Moloney, Teagasc Ashtown Food Research Centre and is in collaboration with Dr Frank Monaghan, UCD School of Agriculture, Food Science & Veterinary Medicine (http://www.ucd.ie/agfoodvet/index.html).

HRB PhD Mol Med: The Nutrigenomics Research Group are part of the HRB funded PhD Trining Programme in Molecular Medicine based at Trinity College Dublin. This programme is supporting two PhD Research Programmes entitled ‘The role of the adipocyte in insulin resistance' and ‘The molecular interactions between obesity and cancer' (http://www.medicine.tcd.ie/clinical_medicine/courses/phd_molecular_medicine)

Books

SA Lanham-New, I Macdonald & HM Roche; (2010) Nutrition and Metabolism (The Nutrition Society Textbook). United Kingdom: Blackwell Publishing. [Details]

Book Chapters

Roche HM, HE Popeijus, & Mensink RJ; (2010) 'Molecular Nutrition' In: SA Lanham-New, I Macdonald & HM Roche (eds). Nutrition and Metabolism (The Nutrition Society Textbook Series). United Kingdom: Blackwell Publishing. [Details]

Roche HM & Mensink RJ. ; (2003) 'Molecular Nutrition' In: MJ Gibney, I Macdonald & HM Roche (eds). Nutrition and Metabolism, The Nutrition Society Text Book Series. *: Blackwell Publishing. [Details]

Gibney MJ & Roche HM ; (2001) 'Nutrition Policy Issues and Further Research On the Mediterranean Diet: The Importance of Monounsaturated Fatty Acids' In: Matalas A-L, Zampelas A, Stavrinos V & Wolinsky I (eds). The Mediterranean Diet: Constituents and Health Promotion. *: CRC Press. [Details]

Edited Books

Micheal J Gibney, Ian McDonald, Helen M Roche (Ed.). (2003) Nutrition & Metaboolism. Oxford, UK: Blackwell. [Details]

Peer Reviewed Journals

Gulseth, HL,Gjelstad, IMF,Tierney, AC,Lovegrove, JA,Defoort, C,Blaak, EE,Lopez-Miranda, J,Kiec-Wilk, B,Riserus, U,Roche, HM,Drevon, CA,Birkeland, KI; (2010) 'Serum Vitamin D Concentration Does Not Predict Insulin Action or Secretion in European Subjects With the Metabolic Syndrome'. Diabetes Care, 33 :923-925. [DOI] [Details]

Hartwich, J,Leszczynska-Golabek, I,Kiec-Wilk, B,Siedlecka, D,Perez-Martinez, P,Marin, C,Lopez-Miranda, J,Tierney, A,Mc Monagle, J,Roche, HM,Defoort, C,Wolkow, P,Dembinska-Kiec, A; (2010) 'Lipoprotein profile, plasma Ischemia Modified Albumin and LDL density change in the course of postprandial lipemia. Insights from the LIPGENE study'. Scand J Clin Lab Invest, 70 :201-208. [DOI] [Details]

van Hees, AMJ,Saris, WHM,Hul, GB,Schaper, NC,Timmerman, BE,Lovegrove, JA,Roche, HM,Blaak, EE,LIPGENE Consortium; (2010) 'Effects of dietary fat modification on skeletal muscle fatty acid handling in the metabolic syndrome'. Int J Obesity, 34 :859-870. [DOI] [Details]

Perez-Martinez, P,Moreno-Conde, M,Cruz-Teno, C,Ruano, J,Fuentes, F,Delgado-Lista, J,Garcia-Rios, A,Marin, C,Gomez-Luna, MJ,Perez-Jimenez, F,Roche, HM,Lopez-Miranda, J; (2010) 'Dietary fat differentially influences regulatory endothelial function during the postprandial state in patients with metabolic syndrome: From the LIPGENE study'. Atherosclerosis, 209 :533-538. [DOI] [Details]

O'Connor, A,Phelan, N,Tun, TK,Boran, G,Gibney, J,Roche, HM; (2010) 'High-Molecular-Weight Adiponectin Is Selectively Reduced in Women with Polycystic Ovary Syndrome Independent of Body Mass Index and Severity of Insulin Resistance'. J Clin Endocrinol Metab, 95 :1378-1385. [DOI] [Details]

Reynolds CM, Roche HM; (2010) 'Conjugated linoleic acid and inflammatory cell signalling'. Prostaglandins Leukotrienes and Essential Fatty Acids, 82 :199-204. [Details]
Morine MJ, McMonagle J, Toomey S, Reynolds CM, Moloney AP, Gormley IC, O Gaora P, Roche HM; (2010) 'Bi-directional gene set enrichment and canonical correlation analysis identify key diet-sensitive pathways and biomarkers of metabolic syndrome'. BMC Bioinformatics, 11 (1). [DOI] [Details]
Helal O, Defoort C, Robert S. Marin C, Lesavre N, Lopez-Miranda J, Risérus U, Basu S, Lovegrove J, McMonagle J, Roche HM, Dignat-George F, Lairon D. ; (2010) 'Increased levels of microparticles originating from endothelium, platelet and erythrocyte in subjects with metabolic syndrome: relationship with oxidative stress'. Nutrition Metabolism and Cardiovascular Diseases, 21 (9):665-671. [Details]
Gulseth HL, Gjelstad IMF, Tierney AC, Shaw DI, Helal O, Hees AM, Delgado-Lista J, Leszczynska-Golabek I, Karlström B, Lovegrove J, Defoort C, Blaak EE, Lopez-Miranda J, Dembinska-Kiec A, Risérus U, Roche HM, Birkeland KI, Drevon CA; (2010) 'Effects of dietary fat modifications on blood pressure in subjects with the metabolic syndrome in the Lipgene dietary intervention study'. British Journal of Nutrition, 5 :1-4. [Details]
Ferguson, JF,Phillips, CM,Tierney, AC,Perez-Martinez, P,Defoort, C,Helal, O,Lairon, D,Planells, R,Shaw, DI,Lovegrove, JA,Gjelstad, IMF,Drevon, CA,Blaak, EE,Saris, WHM,Leszczynska-Golabek, I,Kiec-Wilk, B,Riserus, U,Karlstrom, B,Lopez-Miranda, J,Roche, HM; (2010) 'Gene-nutrient interactions in the metabolic syndrome: single nucleotide polymorphisms in ADIPOQ and ADIPOR1 interact with plasma saturated fatty acids to modulate insulin resistance'. American Journal of Clinical Nutrition, 91 :794-801. [DOI] [Details]
Roche HM, Reynolds CM, Draper E, Keogh B, Rahman A, Moloney AP, Mills KH, Loscher CE, ; (2009) 'A Conjugated Linoleic Acid-Enriched Beef Diet Attenuates Lipopolysaccharide-Induced Inflammation in Mice in Part through PPAR{gamma}-Mediated Suppression of Toll-Like Receptor 4'. Journal of Nutrition, . [DOI] [Details]
Roche HM, Phillips CM, Goumidi L, Bertrais S, Field MR, Peloso GM, Shen J, McManus R, Hercberg S, Lairon D, Planells R, ; (2009) 'Dietary saturated fat modulates the association between STAT3 polymorphisms and abdominal obesity in adults'. Journal of Nutrition, 139 (11):2011-2017. [DOI] [Details]
Mullen A, Loscher CE, Roche HM, ; (2009) 'Anti-inflammatory effects of EPA and DHA are dependent upon time and dose-response elements associated with LPS stimulation in THP-1-derived macrophages'. Journal of Nutritional Biochemistry, 8 :658-666. [DOI] [Details]
Osada J, GuillÃ©n N, Navarro MA, Arnal C, Noone E, ArbonÃ©s-Mainar JM, AcÃn S, Surra JC, Muniesa P, Roche HM, ; (2009) 'Microarray analysis of hepatic gene expression identifies new genes involved in steatotic liver'. Physiological Genomics, 37 (3):187-198. [DOI] [Details]
Dembinska-KieÄ¿ A, Hartwich J, Malec MM, Partyka L, PÃ©rez-Martinez P, Marin C, LÃ³pez-Miranda J, Tierney AC, Mc Monagle J, Roche HM, Defoort C, Wolkow P, ; (2009) 'The effect of the plasma n-3/n-6 polyunsaturated fatty acid ratio on the dietary LDL phenotype transformation - insights from the LIPGENE study'. Clinical Nutrition, 28 (5):510-515. [DOI] [Details]
Roche HM, Phillips CM, Goumidi L, Bertrais S, Ferguson JF, Field MR, Kelly ED, Peloso GM, Cupples LA, Shen J, Ordovas JM, McManus R, Hercberg S, Portugal H, Lairon D, Planells R, ; (2009) 'Complement component 3 polymorphisms interact with polyunsaturated fatty acids to modulate risk of metabolic syndrome'. American Journal of Clinical Nutrition, . [DOI] [Details]
Phillips, CM,Goumidi, L,Bertrais, S,Ferguson, JF,Field, MR,Kelly, ED,Peloso, GM,Cupples, LA,Shen, J,Ordovas, JM,McManus, R,Hercberg, S,Portugal, H,Lairon, D,Planells, R,Roche, HM; (2009) 'Complement component 3 polymorphisms interact with polyunsaturated fatty acids to modulate risk of metabolic syndrome'. American Journal of Clinical Nutrition, 90 :1665-1673. [DOI] [Details]
Hartwich, J,Malec, MM,Partyka, L,Perez-Martinez, P,Marin, C,Lopez-Miranda, J,Tierney, AC,Mc Monagle, J,Roche, HM,Defoort, C,Wolkowe, P,Dembinska-Kiec, A; (2009) 'The effect of the plasma n-3/n-6 polyunsaturated fatty acid ratio on the dietary LDL phenotype transformation - Insights from the LIPGENE study'. Nutrition, 28 :510-515. [DOI] [Details]
McGillicuddy, FC,Chiquoine, EH,Hinkle, CC,Kim, RJ,Shah, R,Roche, HM,Smyth, EM,Reilly, MP; (2009) 'Interferon gamma Attenuates Insulin Signaling, Lipid Storage, and Differentiation in Human Adipocytes via Activation of the JAK/STAT Pathway'. J BIOL CHEM, 284 :31936-31944. [DOI] [Details]
de Ross, B,Rungapamestry, V,Ross, K,Rucklidge, G,Reid, M,Duncan, G,Horgan, G,Toomey, S,Browne, J,Loscher, CE,Mills, KHG,Roche, HM; (2009) 'Attenuation of inflammation and cellular stress-related pathways maintains insulin sensitivity in obese type I interleukin-1 receptor knockout mice on a high-fat diet'. Proteomics, 9 :3244-3256. [DOI] [Details]
Guillen, N,Navarro, MA,Arnal, C,Noone, E,Arbones-Mainar, JM,Acin, S,Surra, JC,Muniesa, P,Roche, HM,Osada, J; (2009) 'Microarray analysis of hepatic gene expression identifies new genes involved in steatotic liver'. Genomics, 37 :187-198. [DOI] [Details]
Lovegrove JA, Shaw DI, Tierney AC, McCarthy S, Upritchard J, Vermunt S, Gulseth HL, Drevon CA, Blaak EE, Saris WH, KarlstrÃ¶m B, Helal O, Defoort C, Gallego R, LÃ³pez-Miranda J, Siedlecka D, Malczewska-Malec M, Roche HM, ; (2009) 'LIPGENE food-exchange model for alteration of dietary fat quantity and quality in free-living participants from eight European countries'. British Journal of Nutrition, 101 (5):750-759. [DOI] [Details]
Phillips CP, Tierney AC & Roche HM.; (2008) 'Gene-Nutrient Interactions in the Metabolic Syndrome'. Journal of Nutrigenetics & Nutrigenomics, 1 :136-151. [Details]
Van, H. A. M. J., Lovegrove, J., Devron, C. A., Lairon, D., Lopez-Miranda, J., Dembi, S. K. A., Vessby, B., Williams, C. M., Roche, H. M., Gibney, M. J., Saris, W. H. M., Blaak, E. E., Lipenge Consortium, ; (2008) 'Determinants of diet induced changes in insulin sensitivity in subjects with the metabolic syndrome: The Lipgene study'. International Journal of Obesity, 32 :27-27. [Details]
Lairon D, Szabo de Edelenyi F, Goumidi L, Bertrais S, Phillips C, Macmanus R, Roche H, Planells R, ; (2008) 'Prediction of the metabolic syndrome status based on dietary and genetic parameters, using Random Forest'. Genes & Nutrition, 3 (3-4):173-176. [DOI] [Details]
Roche HM, Morine MJ, O'Brien C, ; (2008) 'Session 2: Personalised nutrition. Transcriptomic signatures that have identified key features of metabolic syndrome'. The Proceedings of the Nutrition Society, 67 (4):395-403. [DOI] [Details]
de Wit N, Baccini M, Bachmaier EM, Biggeri A, Boekschoten MV, Bouwman FG, Brennan L, Caesar R, Cinti S, Coort SL, Crosley K, Daniel H, Drevon CA, Duthie S, Eijssen L, Elliott RM, van Erk M, Evelo C, Gibney M, Heim C, Horgan GW, Johnson IT, Kelder T, Kleemann R, Kooistra T, van Iersel MP, Mariman EC, Mayer C, McLoughlin G, MÃ¼ller M, Mulholland F, van Ommen B, Polley AC, Pujos-Guillot E, Rubio-Aliaga I, Roche HM, de Roos B, Sailer M, Tonini G, Williams LM, ; (2008) 'The NuGO proof of principle study package: a collaborative research effort of the European Nutrigenomics Organisation'. Genes & Nutrition, 3 (3-4):147-151. [DOI] [Details]
Reynolds, CM,Loscher, CE,Moloney, AP,Roche, HM; (2008) 'Cis-9, trans-11-conjugated linoleic acid but not its precursor trans-vaccenic acid attenuate inflammatory markers in the human colonic epithelial cell line Caco-2'. British Journal of Nutrition, 100 :13-17. [DOI] [Details]
Daniel H, van Ommen B, Cavallieri D, Roche HM, Klein UI, ; (2008) 'The challenges for molecular nutrition research 4: the nutritional systems biology level'. Genes & Nutrition, 3 (3-4):107-113. [DOI] [Details]
Phillips, CM; Goumidi, L; Bertrais, S; Ferguson, J; McManus, R; Hercberg, S; Lairon, D; Roche, HM; Planells, R; ; (2007) 'Interaction between dietary fatty acids and genetic variation in the metabolic syndrome'. Atherosclerosis Supp, 8 :45-45. [Details]
Tierney, A. C., Lovegrove, J. A., Gulseth, H. L., Defoort, C., Blaak, E., Marin, C., Partyka, L., Karlstrom, B., Vessby, B., Dembinska-Kiec, A., Miranda, J. L., Saris, W., Lairon, D., Drevon, C. A., Williams, C. M., Gibney, M. J., Roche, H. M., ; (2007) 'LIPGENE Dietary Intervention: cohort details and study design'. Proceedings of the Nutrition Society, 66 :33-33. [Details]
Roche HM, Mullen A, Moloney F, Nugent AP, Doyle L, Cashman KD, ; (2007) 'Conjugated linoleic acid supplementation reduces peripheral blood mononuclear cell interleukin-2 production in healthy middle-aged males'. J Nutr Biochem, 10 (NA):658-666. [DOI] [Details]
Walsh, MC,Brennan, L,Malthouse, JPG,Roche, HM,Gibney, MJ; (2006) 'Effect of acute dietary standardization on the urinary, plasma, and salivary metabolomic profiles of healthy humans'. American Journal of Clinical Nutrition, 84 :531-539. [Details]
Roche HM, Norris LA, Weldon S, Nugent A, ; (2006) 'LPS induced tissue factor expression in the THP-1 monocyte cell line is attenuated by conjugated linoleic acid'. Thrombosis Research, 117 (4):475-480. [DOI] [Details]
Toomey S, McMonagle J, Roche HM; (2006) 'Conjugated linoleic acid: a functional nutrient in the different pathophysiological components of the metabolic syndrome?'. Current Opinion in Clinical Nutrition and Metabolic Care, 6 :740-747. [Details]
Duffy, P. E., Quinn, S. M., Roche, H. M. Evans, P; (2006) 'Synthesis of trans-Vaccenic Acid and cis-9-trans-11-Conjugated Linoleic Acid'. TETRAHEDRON, . [Details]
Roche HM, de Roos B, Rucklidge G, Reid M, Ross K, Duncan G, Navarro MA, Arbones-Mainar JM, Guzman-Garcia MA, Osada J, Browne J, Loscher CE, ; (2005) 'Divergent mechanisms of cis9, trans11-and trans10, cis12-conjugated linoleic acid affecting insulin resistance and inflammation in apolipoprotein E knockout mice: a proteomics approach'. FASEB Journal, 19 (12):1746-1748. [DOI] [Details]
Gibney, MJ; Walsh, M; Brennan, L; Roche, HM; German, B; van Ommen, B; ; (2005) 'Metabolomics in human nutrition: opportunities and challenges'. American Journal of Clinical Nutrition, 82 (3):497-503. [Details]
Colgan HA, Floyd S, Noone EJ, Gibney MJ, Roche HM; (2004) 'Increased intake of fruit and vegetables and a low fat diet with and without low-fat sterol-enriched spread consumption: effects on plasma lipoprotein and carotenoid metabolism'. Journal of Human Nutrition and Dietetics, :571-574. [Details]
Black IL, Roche HM, Tully AM, Gibney MJ; (2003) 'Acute-on-chronic effects of fatty acids on intestinal triacylglycerol-rich lipoprotein metabolism'. Br J Nutr, :661-669. [Details]
MYNETT-JOHNSON, LA, KEENAN, C, BLACK, IL, LIVINGSTONE, WJ, LAWLER, M, ROCHE, HM, WHITE, B, GIBNEY, MJ, MCKEON, P, SMITH, OP; (2002) 'THERMOLABILE METHYLENETETRAHYDROFOLATE REDUCTASE (C677T): FREQUENCY IN THE IRISH POPULATION'. IRISH JOURNAL OF MEDICAL SCIENCE, 171 :37-39. [Details]
Gibney MJ, Noone EJ, Roche HM, Nugent AP, ; (2002) 'The effect of dietary supplementation using isomeric blends of conjugated linoleic acid on lipid metabolism in healthy human subjects'. British Journal of Nutrition, 88 (3):243-251. [DOI] [Details]
BLACK, IL, ROCHE, HM, GIBNEY, MJ; (2002) 'CHRONIC BUT NOT ACUTE TREATMENT WITH CONJUGATED LINOLEIC ACID (CLA) ISOMERS (TRANS-10, CIS-12 CLA AND CIS-9, TRANS-11 CLA) AFFECTS LIPID METABOLISM IN CACO-2 CELLS'. JOURNAL OF NUTRITION, 132 :2167-2173. [Details]
Roche HM, Terres AM, Black IB, Gibney MJ, Kelleher D.; (2001) 'Fatty acids and epithelial permeability: effect of conjugated linoleic acid in Caco-2 cells'. GUT, 48 (6):797-802. [Details]
ROCHE, HM, GIBNEY, MJ; (2000) 'EFFECT OF LONG-CHAIN N-3 POLYUNSATURATED FATTY ACIDS ON FASTING AND POSTPRANDIAL TRIACYLGLYCEROL METABOLISM'. AMERICAN JOURNAL OF CLINICAL NUTRITION, :232S-237S. [Details]
ROCHE, HM, BLACK, IL, NOONE, E, TULLY, AM, WHITEHEAD, AS, GIBNEY, MJ; (2000) 'POSTPRANDIAL FACTOR VII METABOLISM: THE EFFECT OF THE R353Q AND 10 BP POLYMORPHISMS'. BRITISH JOURNAL OF NUTRITION, :467-472. [Details]
JACKSON, KG, ZAMPELAS, A, KNAPPER, JME, ROCHE, HM, GIBNEY, MJ, KAFATOS, A, GOULD, BJ, WRIGHT, JW, WILLIAMS, CM; (2000) 'DIFFERENCES IN GLUCOSE-DEPENDENT INSULINOTROPHIC POLYPEPTIDE HORMONE AND HEPATIC LIPASE IN SUBJECTS OF SOUTHERN AND NORTHERN EUROPE: IMPLICATIONS FOR POSTPRANDIAL LIPEMIA'. AMERICAN JOURNAL OF CLINICAL NUTRITION, :13-20. [Details]
Roche HM, Gibney MJ.; (2000) 'The impact of postprandial lipemia in accelerating atherothrombosis'. J Cardiovasc Risk, :317-324. [Details]
ROCHE, HM, GIBNEY, MJ; (1999) 'LONG-CHAIN N-3 POLYUNSATURATED FATTY ACIDS AND TRIACYLGLYCEROL METABOLISM IN THE POSTPRANDIAL STATE'. LIPIDS, 34 :S259-S265. [Details]
WILLIAMS, CM, FRANCIS-KNAPPER, JA, WEBB, D, BROOKES, CA, ZAMPELAS, A, TREDGER, JA, WRIGHT, J, MEIJER, G, CALDER, PC, YAQOOB, P, ROCHE, H, GIBNEY, MJ; (1999) 'CHOLESTEROL REDUCTION USING MANUFACTURED FOODS HIGH IN MONOUNSATURATED FATTY ACIDS: A RANDOMIZED CROSSOVER STUDY'. BRITISH JOURNAL OF NUTRITION, :439-446. [Details]
SHISHEHBOR, F, ROCHE, HM, GIBNEY, MJ; (1999) 'THE EFFECT OF LOW AND MODERATE FAT INTAKES ON THE POSTPRANDIAL LIPAEMIC AND HORMONAL RESPONSES IN HEALTHY VOLUNTEERS'. BRITISH JOURNAL OF NUTRITION, :25-30. [Details]
NOONE, E, ROCHE, HM, BLACK, I, TULLY, AM, GIBNEY, MJ; (1999) 'EFFECT OF POSTPRANDIAL LIPAEMIA AND TAQ 1B POLYMORPHISM OF THE CHOLESTERYL ESTER TRANSFER PROTEIN (CETP) GENE ON CETP MASS, ACTIVITY, ASSOCIATED LIPOPROTEINS AND PLASMA LIPIDS'. BRITISH JOURNAL OF NUTRITION, :203-209. [Details]
ROCHE, HM, ZAMPELAS, A, KNAPPER, JME, WEBB, D, BROOKS, C, JACKSON, KG, WRIGHT, JW, GOULD, BJ, KAFATOS, A, GIBNEY, MJ, WILLIAMS, CM; (1998) 'EFFECT OF LONG-TERM OLIVE OIL DIETARY INTERVENTION ON POSTPRANDIAL TRIACYLGLYCEROL AND FACTOR VII METABOLISM'. AMERICAN JOURNAL OF CLINICAL NUTRITION, :552-560. [Details]
SHISHEHBOR, F, ROCHE, HM, GIBNEY, MJ; (1998) 'THE EFFECT OF ACUTE CARBOHYDRATE LOAD ON THE MONOPHASIC OR BIPHASIC NATURE OF THE POSTPRANDIAL LIPAEMIC RESPONSE TO ACUTE FAT INGESTION IN HUMAN SUBJECTS'. BRITISH JOURNAL OF NUTRITION, :411-418. [Details]
SHISHEHBOR, F, ROCHE, HM, GIBNEY, MJ; (1998) 'THE EFFECT OF ACUTE CARBOHYDRATE LOAD ON THE MONOPHASIC OR BIPHASIC NATURE OF THE POSTPRANDIAL LIPAEMIC RESPONSE TO ACUTE FAT INGESTION IN HUMAN SUBJECTS'. BRITISH JOURNAL OF NUTRITION, :411-418. [Details]
ZAMPELAS, A, ROCHE, H, KNAPPER, JME, JACKSON, KG, TORNARITIS, M, HATZIS, C, GIBNEY, MJ, KAFATOS, A, GOULD, BJ, WRIGHT, J, WILLIAMS, CM; (1997) 'DIFFERENCES IN POSTPRANDIAL LIPAEMIC RESPONSE BETWEEN NORTHERN AND SOUTHERN EUROPEANS'. ATHEROSCLEROSIS, :83-93. [Details]
ROCHE, HM, GIBNEY, MJ; (1997) 'POSTPRANDIAL COAGULATION FACTOR VII ACTIVITY: THE EFFECT OF MONOUNSATURATED FATTY ACIDS'. BRITISH JOURNAL OF NUTRITION, :537-549. [Details]
ROCHE, HM, GIBNEY, MJ; (1996) 'POSTPRANDIAL TRIACYLGLYCEROLAEMIA: THE EFFECT OF LOW-FAT DIETARY TREATMENT WITH AND WITHOUT FISH OIL SUPPLEMENTATION'. EUROPEAN JOURNAL OF CLINICAL NUTRITION, :617-624. [Details]
Roche HM, Gibney MJ.; (1995) 'Postprandial triacylglycerolaemia--nutritional implications'. Prog Lipid Res, :249-266. [Details]
ROCHE, H, GIBNEY, MJ; (1994) 'THE EFFECT OF CONSUMPTION OF FISH OIL-ENRICHED SPREADABLE FATS ON PLATELET PHOSPHOLIPID FATTY-ACID COMPOSITION IN HUMAN VOLUNTEERS'. INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH, :237-242. [Details]
Moloney, F; Toomey, S; Noone, E; Nugent, A; Allan, B; Loscher, CE; Roche, HM; ; (2007) 'Antidiabetic effects of cis-9, trans-11-conjugated linoleic acid may be mediated via anti-inflammatory effects in white adipose tissue'. DIABETES, 56 :574-582. [Details]
Weldon, SM; Mullen, AC; Loscher, CE; Hurley, LA; Roche, HM; ; (2007) 'Docosahexaenoic acid induces an anti-inflammatory profile in lipopolysaccharide-stimulated human THP-1 macrophages more effectively than eicosapentaenoic acid'. J NUTR BIOCHEM, 18 :250-258. [Details]
Tierney AC Tierney & Roche HM; (2007) 'The potential role of olive oil-derived MUFA in insulin sensitivity'. Mol Nutr Food Res 2, 51 (10):1235-1248. [Details]
Shah SA, Mahmud N, Mftah M, Roche HM, Kelleher D. ; (2006) 'Chronic but not acute conjugated linoleic acid treatment inhibits deoxycholic acid-induced protein kinase C and nuclear factor-kappaB activation in human colorectal cancer cells'. European Journal of Cancer Prevention, 15 (2):125-133. [Details]
Arbonés-Mainar JM, Navarro MA, Acín S, Guzmán MA, Arnal C, Surra JC, Carnicer R, Roche HM & Osada J; (2006) 'Trans-10, cis-12 and cis-9, trans-11- Conjugated Linoleic Acid Isomers Selectively Modify HDL Apolipoprotein Composition in Apolipoprotein E Knockout Mice'. Journal of Nutrition, 136 (2):353-359. [Details]
Norris LA, Weldon S, Nugent A & Roche HM; (2006) 'LPS induced tissue factor expression in the THP-1 monocyte cell line is attenuated by conjugated linoleic acid'. Thrombosis Research, 117 :475-480. [Details]
Renaville B, Mullen A, Moloney F, Larondelle Y, Schneider Y-J & Roche HM ; (2006) 'EPA and 3,10 dithia stearic acid inhibit the desaturation of trans-vaccenic acid into c9, t11-CLA through different pathways in Caco-2 and T84 cells'. British Journal of Nutrition, 95 :688-695. [Details]
Toomey, S; Harhen, B; Roche, HM; Fitzgerald, D; Belton, O; ; (2006) 'Profound resolution of early atherosclerosis with conjugated linoleic acid'. Atherosclerosis, 187 (1):40-49. [Details]
Arbonés-Mainar JM., Navarro MA, Guzmán MA, Arnal C, Surra JC, Acín S, Carnicer R, Osada J & Roche HM; (2006) 'Selective Effect of Conjugated Linoleic Acid Isomers on Atherosclerotic Lesion Development in Apolipoprotein E Knockout Mice'. Atherosclerosis, 189 (2):318-327. [Details]
Toomey S, McMonagle J & Roche HM; (2006) 'Conjugated linoleic acid: a functional nutrient in the different pathophysiological components of the metabolic syndrome?'. Curr Opin Clin Nutr Metab Care, 9 (6):740-747. [Details]
Roche HM; (2006) 'Nutrigenomics - new approaches for human nutrition research'. Journal of the Science of Food and Agriculture, 86 :1156-1163. [Details]
Loscher CE, Draper E, Leavy O, Kelleher D, Mills KHG & Roche HM; (2005) 'Conjugated linoleic acid suppresses NF-B activation and IL-12 production in dendritic cells through ERK-mediated IL-10 induction'. Journal of Immunology, 175 (8):4990-4998. [Details]
Roche HM, Phillips C, Gibney MJ; (2005) 'The Metabolic Syndrome: the cross roads of diet and genetics'. Proceedings of the Nutrition Society, 64 (3):371-377. [Details]
Nugent AP, Roche HM, Noone EJ, Long A, Kelleher DK & Gibney MJ; (2005) 'The effects of conjugated linoleic acid supplementation on immune function in healthy volunteers'. European Journal of Clinical Nutrition, 59 :742-750. [Details]
Roche HM; (2005) 'Fatty acids and the metabolic syndrome'. Proceedings of the Nutrition Society, 64 (1):23-29. [Details]
Doyle L, Mullen A, Roche HM & Cashman K; (2005) 'The effect of dietary supplementation with conjugated linoleic acid on markers of calcium and bone metabolism in healthy adult men'. European Journal of Clinical Nutrition, 59 (3):432-440. [Details]
Roche HM; (2004) 'Dietary lipids and gene expression'. Biochemical Society Transactions, 32 (6):999-1002. [Details]
Moloney F, Yeow T-P, Mullen A, Nolan JJ & Roche HM ; (2004) 'Conjugated linoleic acid supplementation, insulin sensitivity and lipoprotein metabolism in patients with type 2 diabetes mellitus'. American Journal of Clinical Nutrition, 80 :887-895. [Details]
Tully AM, Roche HM, Doyle R, Fallon C, Bruce I, Lawlor B, Coakley D, Gibney MJ. ; (2003) 'Low serum cholesteryl ester-docosahexaenoic acid levels in Alzheimer's disease: a case-control study'. British Journal of Nutrition, 89 :483-490. [Details]
Roche HM, Noone E, Sewter C, Mc Bennett S, Savage D, Gibney MJ, O'Rahilly S & Vidal-Puig AJ.; (2002) 'Isomer dependent metabolic effects of Conjugated Linoleic Acid (CLA), insights from molecular markers: SREBP-1c and LXR'. Diabetes, 51 (7):2037-2044. [Details]
Black IL, Roche HM & Gibney MJ.; (2002) 'Acute and chronic effects of conjugated linoleic acid (CLA) isomers (trans-10, cis-12 CLA and cis-9, trans-11 CLA) on human colon carcinoma (Caco-2) cell line lipid metabolism'. Journal of Nutrition, 132 (8):2167-2173. [Details]
Mynett-Johnson LA, Keenan C, Black IL, Livingstone WJ, Lawler M, Roche HM, White B, Gibney MJ, McKeon P, Smith OP.; (2002) 'Thermolabile methylenetetrahydrofolate reductase (C677T): frequency in the Irish population'. Irish Journal of Medical Science, 171 (1):37-39. [Details]
Roche HM, Noone E, Nugent A & Gibney MJ. ; (2001) 'Conjugated linoleic acid: A novel therapeutic nutrient?'. Nutrition Research Reviews, 14 :173-187. [Details]
Higgins S, Carroll YL, McCarthy SN, Corridan BM, Roche HM, Wallace JMW, O'Brien NM & Morrissey PA. ; (2001) 'Susceptibility of LDL to oxidative modifications in healthy volunteers supplemented with low doses of polyunsaturated fatty acids'. British Journal of Nutrition, 85 :23-31. [Details]
Roche HM. ; (2001) 'Olive oil, high-oleic acid sunflower oil and CHD. Invited commentary'. British Journal of Nutrition, 85 :3-4. [Details]
Roche HM & Gibney MJ. ; (2000) 'The Impact of postprandial lipaemia in accelerating atherothrombosis'. J Cardiovascular Risk, 7 :317-324. [Details]
Noone E, Roche HM, Black IL, Tully A-M & Gibney MJ ; (2000) 'Effect of postprandial lipaemia and Taq 1B polymorphism of the cholesteryl ester transfer protein (CETP) gene on CETP mass, activity, associated lipoproteins and plasma lipids'. British Journal of Nutrition, 84 :203-209. [Details]
Wallace JM, McCabe AJ, Roche HM, Higgins S, Robson PJ, Gilmore WS, McGlynn H & Strain JJ; (2000) 'The effect of low-dose fish oil supplementation on serum growth factors in healthy humans'. European Journal of Clinical Nutrition, 54 (9):690-694. [Details]
Roche HM, Gibney MJ, Kafatos A, Zampelas A & Williams CM. ; (2000) 'Beneficial properties of olive oil'. Food Research International, 33 :227-231. [Details]
Higgins S, Carroll YL, McCarthy SN, Corridan BM, Roche HM, Wallace JMW, O'Brien NM & Morrissey PA. ; (2000) 'Measurement of free cholesterol, cholesteryl esters and cholesteryl linoleate hydroperoxide in copper-oxidised low density lipoprotein in healthy volunteers supplemented with a low dose of n-3 polyunsaturated fatty acids'. NutrRes, 20 (8):1091-1102. [Details]
Hide

Show All

Other Journals

Toomey, S., Harhen,B., Roche, H.M., Fitzgerald, D., Belton, O.; (2006) 'Profound resolution of early atherosclerosis with conjugated linoleic acid' Atherosclerosis . [Details]

Conference Publications

Oliver E, McGillicuddy F, Philips C, Toomey S, Roche HM (2010) ; (2010) The role of inflammation and macrophage accumulation in the development of obesity induced type 2 diabetes mellitus and the possible therapeutic effects of LC n-3 PUFA Nutrition Society Conference [Details]

Phillips, CM; Goumidi, L; Bertrais, S; Ferguson, J; McManus, R; Hercberg, S; Lairon, D; Roche, HM; Planells, R; ; (2007) Interaction between dietary fatty acids and genetic variation in the metabolic syndrome European Atherosclerosis Meeting , pp.45-45 [Details]

Draper, EL; Roche, HM; Mills, KHG; Loscher, CE; ; (2007) Polyunsaturated fatty acids modulate dendritic cell activation and their induction of inflammatory and pathogenic T cells International Immunology Conference , pp.18-18 [Details]

Tierney, A. C., Lovegrove, J. A., Gulseth, H. L., Defoort, C., Blaak, E., Marin, C., Partyka, L., Karlstrom, B., Vessby, B., Dembinska-Kiec, A., Miranda, J. L., Saris, W., Lairon, D., Drevon, C. A., Williams, C. M., Gibney, M. J., Roche, H. M., ; (2007) LIPGENE Dietary Intervention: cohort details and study design The Nutrition Society , pp.33-33 [Details]

Phillips, CM, Goumidi, L, Bertrais, S, Ferguson, J, McManus, R, Hercberg, S, Lairon, D, Roche, HM, Planells, R, ; (2007) ATHEROSCLEROSIS SUPP Interaction between dietary fatty acids and genetic variation in the metabolic syndrome , pp.45-45 [Details]

Show All

Editorial

Baccini, M,Bachmaier, EM,Biggeri, A,Boekschoten, MV,Bouwman, FG,Brennan, L,Caesar, R,Cinti, S,Coort, SL,Crosley, K,Daniel, H,Drevon, CA,Duthie, S,Eijssen, L,Elliott, RM,van Erk, M,Evelo, C,Gibney, M,Heim, C,Horgan, GW,Johnson, IT,Kelder, T,Kleemann, R,Kooistra, T,van Iersel, MP,Mariman, EC,Mayer, C,McLoughlin, G,Muller, M,Mulholland, F,van Ommen, B,Polley, AC,Pujos-Guillot, E,Rubio-Aliaga, I,Roche, HM,de Roos, B,Sailer, M,Tonini, G,Williams, LM,de Wit, N,NuGO PPS Team; (2008) The NuGO proof of principle study package: a collaborative research effort of the European Nutrigenomics Organisation. Editorial [DOI] [Details]

Abstract

Phillips C, Goumidi L, Bertrais S, Ferguson J, McManus R, Hercberg S, Lairon D, Roche HM, Planells R; (2007) Interaction between dietary fatty acids and genetic variation in the metabolic syndrome. Abstract [Details]

Toomey SM, Dooley CM, Sharkey CT, Roche HM, Fitzgerald DJ, and Belton OA.; (2003) Profound resolution of atherosclerotic lesions by the 9-cis, 11-trans isomer of Conjugated Linoleic Acid. Abstract [Details]

Reviews

Gibney, M.J., Walsh, M., Brennan, L., Roche, H.M., German, B., van Ommen, B. ; (2005) Metabolomics in human nutrition: opportunities and challenges. Reviews [Details]

Honours and Awards

Year: 2002.
Title: Royal Irish Academy Nutrition Sciences Award

Year: 2000.
Title: By-Fellow Churchill College, The University of Cambridge, UK

Year: 1999.
Title: The Wellcome Trust New Blood Lectureship

Associations

Association: The Nutrition Society, Function/Role: Nutritional Genomics Theme Leader (UK)

Association: International Life Sciences Institute, Function/Role: Scientific Advisory Committee

Association: Irish Nutrition & Dietetic Institute, Function/Role: Member

Committees

Committee : The Nutrition Society (UK)

Committee : Food Safety Authority of Ireland, Nutrition Sub-Committee

Internal Collaborators

Dr Lorraine Brennan
Dr Orina Belton
Prof Mike Gibney

Prof Catherine Godson

Prof Philip Newsholme

Dr Paul Crossey

External Collaborators

Prof Muredach P Reilly, School of Medicine, University of Pennsylvania, USA

Prof Kingston Mills, School of Biochemistry & Immunology, Trinity College Dublin, Ireland
Prof John Reynolds, School of Medicine, Trinity College Dublin, Ireland
Dr Christine Loscher, School of Biotechnology, Dublin City University, Ireland
Dr Aidan Moloney, Teagasc, Astown Food Research Centre, Co Meath, Ireland

Dr Baukje De Roos, Rowett Research Institute, Aberdeen, Scotland
Dr Julie Lovegrove & Prof Christine WIlliams, University of Reading, UK
Prof Christian Drevon, University of Oslo, Norway
Prof Rolf Berge, University of Bergen, OSlo, Norway
Prof Denis Larion & Dr Catherine Defort, INSERM, Marseille, France
Prof Ellen Blaak & Prof Wim Saris, University of Maastricht, The Netherlands
Prof Jose Lopez Miranda, University of Cordoba, Spain
Prof Aldona Dembinska-Kiek, Jagiellonian University Medical College, krakow, Poland
Prof Bengt Vessby, University of Uppsala, Sweeden

Teaching Interests

Nutrition & Genomics / Molecular Nutrition within the BSc (Human Nutrition) at UCD.
Nutrigenomics within the PhD Molecular Medicine at TCD.

Recent Postgraduates

At anyone time there are 5-7 PhD students working within the Nutrigenomics Research group, each of whom are spread accoss the current research projects. Currently PhD programmes are linked to on going research programmes as follows:

Karen Hartford: SFI PI Principal Investigator Programme entitled ‘The role of macrophage accumulation in adipose tissue in the development of obesity induced insulin resistance - insights into mechanisms and nutrient based therapies using a nutrigenomics approach'.

Audrey Tierney, Jolene Mc Monagle, Jane Ferguson & Annalouise O'Connor: LIPGENE ‘Diet, genomics and the metabolic syndrome: an integrated nutrition, agro-food, social and economic analysis'. LIPGENE is an EU Framework 6 Integrated Project designed to determine the effects of dietary fatty acid composition and human genetic variation on the development and risk of the metabolic syndrome. Project involves a prospective genetic study and a human dietary intervention trial to test the interaction between dietary fat exposure and genetic risk of the metabolic syndrome.

Melissa Morine: NutSysBiol 'Nutrigenomics & Functional Food Development: Towards a Nutritional Systems Biology Approach'. This project will test the robustness of transcriptomic and proteomic approaches in determining the heath effects of fatty acid modified functional foods. The Nutritional Systems Biology Programme is also being supported by IRSCET who are funding a PhD Programme in Nutritional Systems Biology within their EMBARK Postgraduate Research Scholarship Scheme.

Clare Reynolds & Jolene Mc Monagle: Functional Foods 'Healthy fatty acid-enriched fresh beef: Implications for shelf-life, flavour and the health of the consumer'. The project will determine if the health effects of CLA enriched beef are as potent as synthetic forms of the fatty acid on insulin sensitivity in male ob/ob mice, atherosclerosis in apo E knock out mice and chronic inflammation in a mouse model of IBD.

Elizabeth Oliver & Emma Allot: HRB PhD Mol Med The Nutrigenomics Research Group are part of the HRB funded PhD Trining Programme in Molecular Medicine based at Trinity College Dublin. This programme is supporting two PhD Research Programmes entitled ‘The role of the adipocyte in insulin resistance' and ‘The molecular interactions between Obesity in Cancer'.

Current Postgraduate Students

Annalouise O Connor, - Thesis Supervisor

Melissa Morine, - Thesis Supervisor

Jane Ferguson, - Thesis Supervisor

Karen Harford, - Thesis Supervisor

Clare Reynolds, - Thesis Supervisor