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Research

Professor Paul McLoughlin MB, BCh, BAO, BSc, PhD, MRCPI

Research Interests:

Our research group is focused on the exploration and understanding of key mechanisms in the development and progression of lung diseases. These diseases including chronic obstructive pulmonary disease (COPD), emphysema, cystic fibrosis, adult respiratory distress syndrome and occupational lung diseases and are amongst the most common (and increasing) causes of death and disability worldwide. No major therapeutic advances targeting novel molecular pathways have been made for many years due to our extremely limited knowledge of the underlying mechanisms. 

Lung diseases all cause reduced oxygen in the lung which then activates mechanisms that are pro-inflammatory, pro-thrombotic and promote maladaptive vascular remodelling.  Our current research is focused on understanding the specific mechanisms in the lung through which hypoxia promotes these disease responses.  An understanding of these mechanisms allows us to identify potential therapeutic strategies that can be used to target the disease process within the lung without causing unwanted adverse effects in other organs.   

Research Projects:

Sponsor : University College Dublin Foundation Ltd.
Title : Gremlin in Acute Lung Injury SVAF
Start Date / End Date : 01-DEC-11 / 01-DEC-14
Sponsor : University College Dublin Foundation Ltd.
Title : Gremlin in ALI (ICSI)
Start Date / End Date : 01-OCT-11 / 30-SEP-13
Sponsor : Higher Education Authority (HEA)
Title : PRTLI 5: MolCellBiol - Split Accounts School of MMS
Start Date / End Date : 01-MAR-11 / 29-FEB-16
Sponsor : University College Dublin Foundation Ltd.
Title : Basic mechanisms in human lung disease
Start Date / End Date : 01-AUG-11 / 31-JUL-13
Sponsor : University College Dublin Foundation Ltd.
Title : PVRF: ALI and CREB
Start Date / End Date : 01-NOV-10 / 31-OCT-12
Sponsor : University College Dublin Foundation Ltd.
Title : Intensive-care Medicine
Start Date / End Date : 31-DEC-10 / 30-DEC-13