Professor Ronan O'Connell

Research

Professor Ronan O'Connell MB BCh BAO MD FRCSI FRCS

Contact Details

Title	Professor of Surgery
Address	School of Medicine & Medical Science St Vincent'S Hospital Elm Park Dublin 4
Email:	ei.dcu@llennoco.nanor

Biography:

P. Ronan O'Connell is Professor of Surgery and Consultant Surgeon at St Vincent's University Hospital since September 2007. He was previously Senior Lecturer in Surgery at the Royal London Hospital (1989-1990), consultant surgeon at the Mater Misericordiae University Hospital (1990-2007) and Newman Clinical Research Professor at UCD (2002- 2007). In 2009 he was appointed head of the Section of Surgery and Surgical Sciences at University College Dublin. In 2011 he was elected Chairman of the South East Dublin Department of Surgery.

Prof O'Connell graduated from Dublin University, trained in Dublin and Cork and completed specialist training in Colon and Rectal Surgery at the Mayo Clinic, Minnesota, USA. Prof O'Connell received the Dublin University Travelling Scholarship in Surgery (1983), a Fogarty Travelling Fellowship from NIH (1984) and a Council of Europe Travelling Scholarship (1989). He holds fellowships of the Royal College of Surgeons in Ireland (1983) and the Royal College of Physicians and Surgeons of Glasgow (Honorary) (2001). He was elected to the Council of the Royal College of Surgeons in Ireland in June 2008.

Prof O'Connell is a member of the Irish Society of Coloproctology, a fellow of both the Association of Coloproctology of Great Britain and Ireland and the American Society of Colon and Rectal Surgeons and secretary of the European Association of Coloproctology. He is a fellow of the Association of Surgeons of Great Britain and Ireland and a member of the Society of Pelvic Surgeons and the International Surgical Group. He is an elected member and Editor in Chief for the European Surgical Association. In 2010 he was elected to the James¿ IV Society of Surgeons.

Prof O'Connell has published widely in the areas of inflammatory bowel disease, pelvic floor physiology and continence. His research has been recognised by numerous awards including the Patey Prize of the Surgical Research Society (1985), the British Journal of Surgery Prize at the Association of Coloproctology Great Britain and Ireland (1995, 1997, 1999 and 2007), the American Society of Colon and Rectal Surgeons Research Prize (2007 and 2010) and the Physiological Society (2009). His research is currently funded by Science Foundation Ireland and the Bowel Disease Research Foundation of ACPGBI.

Prof O'Connell is an Editorial Board member and Secretary elect of the British Journal of Surgery Society having served as associate editor (1999-2002) and editor (2002-6) of the Journal. He currently is associate editor of Diseases of the Colon and Rectum (since 2001) and is on the editorial board of several journals including the Annals of Surgery. He is joint editor of Bailey and Love's Short Practice of Surgery (25^th and 26^th editions) and the European Manual in Coloproctology. Prof O'Connell has given numerous invited lectures including the Bacon Lecture to the American Society of Colon and Rectal Surgeons (2003), the Sir Peter Freyer Lecture (2007), the Sir Alan Parks' Lecture at St Mark's Hospital, London (2007), the Hughes Lecture to the Colorectal Surgical Society of Australia and New Zealand (2007) and the Robert Smith lecture to the Association of Surgeons of Great Britain and Ireland (2009). In 2010, Prof O'Connell was an invited speaker in UK, France, United States and Chile and in 2011 he is an invited speaker in UK, United States, Canada, Australia, Germany and Switzerland

Research Interests

FUNDING
Current Active Grants:

1) Science Foundation Ireland 2010-2016 - ¿647,750 (co-investigator Prof D Winter) (09/IN.I/B2606)Colonisation by sulphate reducing bacteria subspecies in normal and inflamed human colon

2) Bowel Disease Research Foundation 2009-2010, ¿35,000 Colonisation by sulphate reducing bacteria subspecies in normal and inflamed colon.

3) Science Foundation Ireland 2011 -2015 ¿156,000 (co-investigator, Dr James Jones) (11/RFP/3115)

The effect of sacral neuromodulation on inputs to the somatosensory cortex

4) Bowel Disease Research Foundation 2010-12 £42,800 (¿50,000) (co-investigators Dr James Jones and Dr Sean Connolly)

A pilot study on predicting outcomes of sacral nerve neuromodulation

3) Health Research Board HRB/2007/1152007 - 2010 ¿172,000 The mechanism of action of sacral root stimulation in an animal model of neuropathic faecal incontinence Co-investigators Prof Colm O'Herlihy, Dr James Jones)

Research Projects

Sponsor : Mater Misericordiae University Hospital
Title : The effect of pudendal nerve injury on sensory neurons in an animal model of neuropathic faecal incontinence
Start Date / End Date : 01-OCT-08 / 01-OCT-09

Sponsor : Science Foundation Ireland (SFI)
Title : Colonisation by sulphate reducing bacteria (SRB) subspecies in normal and inflamed colon and colonocyte responses to the SRB metabolite hydrogen sulphide
Start Date / End Date : 10-JUL-10 / 10-JUL-15

Sponsor : Health Research Board (HRB)
Title : The effect of CTGF polymorphisms on surgical recurrence following terminal ileal resection for Crohn¿s disease.
Start Date / End Date : 30-JUL-12 / 21-SEP-12

Recent Postgraduates

Current Postgraduate Students:
PhD year1 - 1
PhD year 3 - 1
MD year 1 - 2
MD year 3 + 1
MSc year 1 - 1
MCh year 1 - 1
MAO year 2 - 2

Current Postgraduate Students

Niamh Bambury, Graduate Diploma - Thesis Supervisor

Aonghus Lavelle, Doctor of Philosophy (PhD) - Thesis Supervisor

Aine Balfe, Doctor of Philosophy (PhD) - Thesis Supervisor

Book Chapters

Joyce M, O¿ Connell PR; (2010) 'ANO-RECTAL STENOSIS' In: Clavien JC, Mortensen NMcC, Roche B (eds). ANORECTAL AND COLONIC DISEASES: A PRACTICAL GUIDE TO THEIR MANAGEMENT. Heidleberg: Springer-Verlag. [Details]

O¿Connell PR, Sheehan G; (2010) 'INTRA-ABDOMINAL SEPSIS, PERITONITIS AND PANCREATITIS' In: Cohen J, Opal SM, Powderly WG (eds). INFECTIOUS DISEASES 3rd Edition. New York: Elsevier. [Details]

Docherty NG, O'Connell PR; (2009) 'TNF a neutralization in the medical management of Crohn's Disease' In: Columbus F (eds). Tumour Necrosis Factor Alpha. New York: Nova Science. [Details]

Madoff R, O¿Connell PR, Laurberg S, Matzel K, Mellgren A, Mimura T, Varma M; (2009) 'Surgery for Fecal Incontinence' In: Abrams P, Cardozo L, Khoury S, Wein A (eds). Incontinence. Paris: Health Publications. [Details]

O'Connell PR; (2008) 'ANAL CANCER' In: Herold A, Matzel K, Lehur PA, O'Connell PR (eds). EUROPEAN MANUAL OF COLOPROCTOLOGY. Frankfurt: Springer. [Details]

Shields C, O'Connell PR; (2007) 'ELECTROCAUTERY' In: Trimbos JB, Trimbos-Kemper TC (eds). BASICS OF SURGERY:tools, techniques, attitude and expertise. Maarseen: Elsevier. [Details]
O'Connell PR; (2004) 'THE VERMIFORM APPENDIX' In: Russell RCG, Bulstrode C, Williams NS (eds). BAILEY and LOVE, SHORT PRACTICE OF SURGERY. London: Arnold. [Details]
Fynes M, O¿Herlihy C, O¿Connell PR; (2002) 'CHILDBIRTH AND PELVIC FLOOR INJURY' In: Pemberton J, Swash M, Henry MM (eds). PELVIC FLOOR: ITS FUNCTION AND DISORDERS. London: Saunders. [Details]
O'Connell PR; (2000) 'THE VERIMFORM APPENDIX' In: Russell RCG, Williams NS (eds). BAILEY and LOVE'S SHORT PRACTICE OF SURGERY. London: Arnold. [Details]
O'Connell PR; (1999) 'A BETTER VIEW IN ANORECTAL SURGERY' In: Walsh C, Jamieson N, Fazio V (eds). TOP TIPS IN GASTROINTESTINAL SURGERY. London: Blackwell. [Details]
O'Connell PR, Gorey TF; (1999) 'World Wide Views in Laparoscopic Colorectal Surgery' In: Wexner SD (eds). PROTOCOLS IN GENERAL SURGERY. New York: Wiley. [Details]
O'Connell PR; (1995) 'Hidradenitis Suppurativa' In: Wexner SD, Varnava AM (eds). Clinical Decision Making in Colorectal Surgery. New York: Igaku-Shoin. [Details]
O'Connell PR; (1991) 'Pseudo-obstruction' In: Kumar D, Waldron D, Williams NS (eds). Clinical Measurements in Coloproctology. London: Springer. [Details]
Womack NR, O'Connell PR; (1991) 'Dynamic Assessment of anorectal function' In: Kumar D, Waldron D, Williams NS (eds). Clinical Measurements in Coloproctology. London: Springer. [Details]
O'Connell PR, Keane FB; (1990) 'Surgery for Ulcerative colitis' In: Ulcerative Colitis. Florida: CRC press. [Details]
O'Connell PR, Kelly KA; (1987) 'The J Pouch' In: Lee E, Nolan DJ (eds). Inflammatory Bowel Disorders. London: Churchill Livingstone. [Details]
Joyce M, O'Connell PR; (2008) 'ANO-RECTAL STENOSIS' In: Clavien JC, Mortensen NMcC (eds). ANORECTAL SURGERY, A PRACTICAL GUIDE TO MANAGEMENT. Frankfurt: Springer. [Details]
O'Connell PR; (2008) 'THE VERMIFORM APPENDIX' In: Williams NS, Bulstrode CJK, O'Connell PR (eds). BAILEY and LOVE, SHORT PRACTICE OF SURGERY, 25th Edition. London: Arnold. [Details]
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Edited Books

Williams NS, Bulstrode CJK, O'Connell PR (Ed.). (2008) Bailey and Love's Short Practice of Surgery. London: Hodder Arnold. [Details]

Herold A, Lehur PA, Matzel KE, O'Connell PR (Ed.). (2008) Coloproctology. Frankfurt: Sphinger. [Details]

Peer Reviewed Journals

Buffini, M., O¿Halloran K.D., O¿Herlihy, C., O¿Connell, P.R., Jones, J.F.X (2012) 'COMPARISON OF THE MOTOR DISCHARGE TO THE VOLUNTARY SPHINCTERS OF CONTINENCE IN THE RAT'. Neurogastroenterology and Motility, 24 :e175-e184. [Details]

Kavanagh DO, Quinlan DM, Armstrong JG, Hyland JM, O'Connell PR, Winter DC (2012) 'MANAGEMENT OF SYNCHRONOUS RECTAL AND PROSTATE CANCER'. International Journal of Colorectal Disease, . [Details]

Buffini M, O'Halloran KD, O'Herlihy C, O'Connell PR, Jones JF (2012) 'Comparison of the motor discharge to the voluntary sphincters of continence in the rat'. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 24 (4):1-84. [DOI] [Details]

Griffin KM, O'Herlihy C, O'Connell PR, Jones JF (2012) 'Combined ischemic and neuropathic insult to the anal canal in an animal model of obstetric-related trauma'. Diseases of the Colon &Amp; Rectum, 55 (1):32-41. [DOI] [Details]

O¿Reilly E, Burke JP, O¿Connell PR (2012) 'LAPAROSCOPIC VERSUS OPEN APPROACH FOR PRIMARY, UNILATERAL, INGUINAL HERNIA: A META-ANALYSIS OF OUTCOMES'. Annals of Surgery, 255 :846-853. [Details]

Kennelly RP, Heeney A, White A, Fennelly D, Sheahan K, Hyland JM, O'Connell PR, Winter DC. (2012) 'A PROSPECTIVE ANALYSIS OF PATIENT OUTCOME FOLLOWING'. International Journal of Colorectal Disease, 27 :759-764. [Details]
Maeda Y, O'Connell PR, Matzel KE, Laurberg S. (2012) 'SACRAL NERVE STIMULATION FOR FECAL INCONTINENCE: AT A CROSSROAD AND FUTURE CHALLENGES'. Diseases of the colon and rectum, 55 :621-624. [Details]
Smith F, Chang KH, Sheahan K, Hyland JH, O¿Connell PR, Winter DC (2012) 'THE SURGICAL SIGNIFICANCE OF RESIDUAL MUCOSAL ABNORMALITIES IN RECTAL CANCER FOLLOWING NEOADJUVANT CHEMORADIOTHERAPY'. British Journal of Surgery, 99 :993-1001. [Details]
Mohan HM, McDermott S, Fenelon L, Fearon NM, O'Connell PR, Oon SF, Burke J, Keane E, Shields C, Winter DC (2012) 'PLASTIC WOUND RETRACTORS AS BACTERIOLOGICAL BARRIERS IN GASTROINTESTINAL SURGERY: A PROSPECTIVE MULTI-INSTITUTIONAL TRIAL'. Journal of Hospital Infection, . [Details]
Peirce, C,O'Herlihy, C,O'Connell, PR,Jones, JFX; (2011) 'Effect of injury on S1 dorsal root ganglia in an experimental model of neuropathic faecal incontinence'. British Journal of Surgery, 98 :1155-1159. [DOI] [Details]
Rowan, F,Docherty, NG,Murphy, M,Murphy, TB,Coffey, JC,O'Connell, PR; (2010) 'Bacterial Colonization of Colonic Crypt Mucous Gel and Disease Activity in Ulcerative Colitis'. Annals of Surgery, 252 :869-874. [DOI] [Details]
Cunningham, MF,Docherty, NG,Burke, JP,O'Connell, PR; (2010) 'S100A4 expression is increased in stricture fibroblasts from patients with fibrostenosing Crohn's disease and promotes intestinal fibroblast migration'. American Journal of Physics, 299 :457-466. [DOI] [Details]
Cunningham, MF,Docherty, NG,Coffey, JC,Burke, JP,O'Connell, PR; (2010) 'Postsurgical Recurrence of Ileal Crohn's Disease: An Update on Risk Factors and Intervention Points to a Central Role for Impaired Host-Microflora Homeostasis'. World journal of surgery, 34 :1615-1628. [DOI] [Details]
Burke, JP,Cunningham, MF,Watson, RWG,Docherty, NG,Coffey, JC,O'Connell, PR; (2010) 'Bacterial lipopolysaccharide promotes profibrotic activation of intestinal fibroblasts'. British Journal of Surgery, 97 :1126-1134. [DOI] [Details]
Medani M, Collins D, Docherty NG, Baird AW, O'Connell PR, Winter DC; (2010) 'Emerging role of hydrogen sulfide in colonic physiology and pathophysiology'. Inflammatory bowel diseases, . [DOI] [Details]
Joyce EA, Kavanagh DO, O'Connell PR, Hyland JM; (2011) 'Massive intra-abdominal haemorrhage following stapled haemorrhoidopexy'. Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland, . [DOI] [Details]
Burke JP, Cunningham MF, Sweeney C, Docherty NG, O'Connell PR; (2011) 'N-cadherin is overexpressed in Crohn's stricture fibroblasts and promotes intestinal fibroblast migration'. Inflammatory bowel diseases, 17 (8):1665-1673. [DOI] [Details]
Eogan M, O'Brien C, Daly L, Behan M, O'Connell PR, O'Herlihy C; (2011) 'The dual influences of age and obstetric history on fecal continence in parous women'. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 112 (2):93-97. [DOI] [Details]
O'Connell PR; (2011) 'Suboptimal outcome following sacral nerve stimulation for faecal incontinence (Br J Surg 2011; 98: 140-147)'. The British journal of surgery, 98 (1). [DOI] [Details]
Griffin KM, Pickering M, O'Herlihy C, O'Connell PR, Jones JF; (2011) 'Sacral nerve stimulation increases activation of the primary somatosensory cortex by anal canal stimulation in an experimental model'. The British journal of surgery, 98 (8):1160-1169. [DOI] [Details]
Kell MR, O'Connell PR; (2000) 'Femoral nerve neuropraxia after abdominoperineal resection'. Diseases of the Colon &Amp; Rectum, 43 (5). [Details]
Griffin, KM,Blau, CW,Kelly, ME,O'Herlihy, C,O'Connell, PR,Jones, JFX,Kerskens, CM; (2010) 'Propofol allows precise quantitative arterial spin labelling functional magnetic resonance imaging in the rat'. Neuroimage, 51 (4):1395-1404. [DOI] [Details]
O'Connell PR, Heeney A, Mulsow J, ; (2010) 'Vacuum-assisted closure of chronic anorectal fistula'. Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland, . [DOI] [Details]
Peirce, C,Alexander, LE,O'Herlihy, C,O'Connell, PR,Jones, JFX; (2010) 'Central Representation of the Inferior Rectal Nerve of the Rat'. Diseases of the Colon &Amp; Rectum, 53 :315-320. [DOI] [Details]
O'Connell PR, Cunningham MF, Docherty NG, Coffey JC, Burke JP, ; (2010) 'Postsurgical Recurrence of Ileal Crohn's Disease: An Update on Risk Factors and Intervention Points to a Central Role for Impaired Host-Microflora Homeostasis'. World journal of surgery, . [DOI] [Details]
Burke, JP,Watson, RWG,Mulsow, JJ,Docherty, NG,Coffey, JC,O'Connell, PR; (2010) 'Endoglin negatively regulates transforming growth factor beta 1-induced profibrotic responses in intestinal fibroblasts'. British Journal of Surgery, 97 :892-901. [DOI] [Details]
O'Connell PR, Ryan JD, Joyce MR, Pierce C, Brannigan A, ; (2009) 'Haematoma in a hydrocele of the canal of Nuck mimicking a Richter's hernia'. Hernia : the journal of hernias and abdominal wall surgery, (NA). [DOI] [Details]
O'Connell PR, Burke JP, Watson RW, Murphy M, Docherty NG, Coffey JC, ; (2009) 'Simvastatin impairs smad-3 phosphorylation and modulates transforming growth factor beta1-mediated activation of intestinal fibroblasts'. British Journal of Surgery, 5 (NA):541-551. [DOI] [Details]
O'Connell PR, Coffey JC, Rowan F, Burke J, Dochery NG, Kirwan WO, ; (2009) 'Pathogenesis of and unifying hypothesis for idiopathic pouchitis'. American Journal of Gastroenterology, 4 (NA):1013-1023. [DOI] [Details]
Jones JF, Banahan M, Peirce C, Buffini M, O'Herlihy C, O'Connell PR, ; (2010) 'Atrophy of the sphincters of continence in an experimental model'. Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland, . [DOI] [Details]
O'Connell PR, Coffey JC, Docherty NG, ; (2009) 'Hydrogen sulphide: an increasing need for scientific equipoise'. Gastroenterology, 137 (6):2181-211. [DOI] [Details]
Jones JF, Peirce C, Healy CF, O'Herlihy C, O'Connell PR, ; (2009) 'Reduced somatosensory cortical activation in experimental models of neuropathic fecal incontinence'. Diseases of the Colon &Amp; Rectum, 8 (NA):1417-1422. [DOI] [Details]
Peirce C, Buffini M, O'Herlihy C, O'Connell PR, Jones JF.; (2009) 'Central representation of the inferior rectal nerve in the rat'. Diseases of the Colon and Rectum, . [Details]
O'Riordan JM, Healy CF, McLoughlin D, Cassidy M, Brannigan AE, O'Connell PR.; (2009) 'ANTIPLATELET AGENTS IN THE PERIOPERATIVE PERIOD'. Archives of Surgery, 144 (1):69-76. [Details]
O'Connell PR, Rowan FE, Docherty NG, Coffey JC, ; (2009) 'Sulphate-reducing bacteria and hydrogen sulphide in the aetiology of ulcerative colitis'. British Journal of Surgery, 2 (NA):151-158. [DOI] [Details]
Healy, CF,McMorrow, C,O'Herlihy, C,O'Connell, PR,Jones, JFX; (2008) 'External anal sphincter fatigue is not improved by N-acetylcysteine in an animal model'. Gastroenterology, 20 :719-724. [DOI] [Details]
Peirce C, Healy CF, O'Herlihy C, O'Connell, PR & Jones JFX; (2008) 'Effect of prolonged vaginal distention and sphincter transection on physiologic function of the external anal sphincter in an animal model'. Obstetrics and Gynecology, 112 (4):943-944. [Details]
Mahony, R,Behan, M,O'Connell, PR,O'Herlihy, C; (2008) 'Effect of second vaginal delivery on anal function in patients at risk of occult anal sphincter injury after first forceps delivery'. Diseases of the Colon &Amp; Rectum, 51 (NA):1361-1366. [DOI] [Details]
Fakhro A, O¿Riordan JM, Lawler LP, O¿Connell PR; (2008) 'CECAL VULVULUS AS A COMPLICATION OF GASTRIC BANDING'. Obesity Surgery, . [DOI] [Details]
Jones JF, Healy CF, McMorrow C, O'Herlihy C, O'Connell PR, ; (2008) 'External anal sphincter fatigue is not improved by N-acetylcysteine in an animal model'. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 6 (NA):719-724. [DOI] [Details]
Jones JF, Healy CF, O'Herlihy C, O'Brien C, O'Connell PR, ; (2008) 'Experimental models of neuropathic fecal incontinence: an animal model of childbirth injury to the pudendal nerve and external anal sphincter'. Diseases of the Colon &Amp; Rectum, 11 (NA):1619-161. [DOI] [Details]
Jones JF, Peirce C, Healy CF, O'Herlihy C, O'Connell PR, ; (2008) 'Effect of prolonged vaginal distention and sphincter transection on physiologic function of the external anal sphincter in an animal model'. Obstetrics & Gynecology, 4 (NA):943-91. [DOI] [Details]
O'Connell PR, ; (2008) 'Stapled haemorrhoidopexy for the treatment of haemorrhoids: a systematic review Burch J, Epstein D, Baba-Akbari Sari A et al, Colorectal Disease doi: 10.1111/j.1463-1318.2008.01638.x'. Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland, (NA). [DOI] [Details]
Mahony R, Behan M, Daly L, Kirwan C, O'Herlihy C, O'Connell PR.; (2007) 'Internal anal sphincter defect influences continence outcome following obstetric anal sphincter injury'. American Journal of Obstetrics and Gynecology, 196 (3). [Details]
O'Connell PR, Burke JP, Mulsow JJ, O'Keane C, Docherty NG, Watson RW, ; (2007) 'Fibrogenesis in Crohn's disease'. American Journal of Gastroenterology, 2 (NA):439-448. [DOI] [Details]
Eogan M, Daly L, Behan M, O'Connell PR, O'Herlihy C.; (2007) 'Randomised clinical trial of a laxative alone versus a laxative and a bulking agent after primary repair of obstetric anal sphincter injury'. British Journal of Obstetrics and Gynaecology, 114 (6):736-740. [Details]
McGuire, B. B.,Brannigan, A. E.,O'Connell, P. R.; (2007) 'Ileal pouch-anal anastomosis'. Br J Surg, 94 (7):812-23. [Details]
Beddy, D.,Mulsow, J.,Watson, R. W.,Fitzpatrick, J. M.,O'Connell, P. R.; (2006) 'Expression and regulation of connective tissue growth factor by transforming growth factor beta and tumour necrosis factor alpha in fibroblasts isolated from strictures in patients with Crohn's disease'. Br J Surg, 93 (10):1290-6. [Details]
Eogan, M., Daly, O'Connell, PR L., O'Herlihy, C.; (2006) 'Does the angle of episiotomy affect the incidence of anal sphincter injury?'. BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 113 (2):190-194. [Details]
Burke JP, Cunningham MF, Watson RWG, , Docherty NG, Coffey JC, O¿Connell PR ; (2010) 'Bacterial lipopolysaccharide promotes profibrotic activation of intestinal fibroblasts'. British Journal of Surgery, 97 (7):1126-1134. [Details]
Mulsow, J. J.,Watson, R. W.,Fitzpatrick, J. M.,O'Connell, P. R.; (2005) 'Transforming growth factor-beta promotes pro-fibrotic behavior by serosal fibroblasts via PKC and ERK1/2 mitogen activated protein kinase cell signaling'. Ann Surg, 242 (6):880-7, discus. [Details]
Cunningham MF, Docherty NG, Burke JP, O'Connell PR; (2010) 'S100A4 expression is increased in stricture fibroblasts from patients with fibrostenosing Crohn's disease and promotes intestinal fibroblast migration'. American Journal of Physiology Gastrointestinal Physiology, 299 (2):457-466. [Details]
McGuire, B.,Brannigan, A. E.,O'Connell, P. R.; (2005) 'Hyaluronidase assisted reduction of intestinal intussusception; a novel application'. Ir Med J, 98 (5):146-7. [Details]
Rowan F, Docherty NG, Murphy M, Murphy B, Calvin Coffey J, O'Connell PR.; (2010) 'Desulfovibrio bacterial species are increased in ulcerative colitis'. Diseases of the Colon &Amp; Rectum, 53 (11):1530-1536. [Details]
Healy, D. G.,Veerasingam, D.,O'Connell, P. R.,Hurley, J.; (2004) 'Acute acalculous cholecystitis following coronary artery bypass surgery'. Ir J Med Sci, 173 (3):160-1. [Details]
Buffini M, O'Halloran KD, O'Herlihy C, O'Connell R, Jones JF; (2010) 'Comparison of the contractile properties, oxidative capacities and fibre type profiles of the voluntary sphincters of continence in the rat'. Journal of Anatomy, 217 (3):187-195. [Details]
Mahony, RT; Malone, PA; Nalty, J; Behan, M; O'Connell, PR; O'Herlihy, C; ; (2004) 'Randomized clinical trial of intra-anal electromyographic biofeedback physiotherapy with intra-anal electromyographic biofeedback augmented with electrical stimulation of the anal sphincter in the early treatment of postpartum fecal incontinence'. American Journal of Obstetrics and Gynecology, 191 (3):885-890. [Details]
Rowan FE, Docherty NG, Coffey JC, Murphy M, Murphy B, O¿Connell PR; (2010) 'CULTURE INDEPENDENT QUANTIFICATION OF TOTAL BACTERIAL COLONIZATION OF COLONIC CRYPTS IN PATIENTS WITH ULCERATIVE COLITIS AND CONTROLS'. Annals of Surgery, . [Details]
Beddy, D; Watson, RWG; Fitzpatrick, JM; O'Connell, PR; ; (2004) 'Increased vascular endothelial growth factor production in fibroblasts isolated from strictures in patients with Crohn's disease'. British Journal of Surgery, 91 (1):72-77. [Details]
O'Brien, C; O'Herlihy, C; O'Connell, PR; ; (2004) 'Pudendal neuropathy is best determined by full neurophysiologic assessment'. American Journal of Obstetrics and Gynecology, 191 (5):1836-1836. [Details]
Beddy, DJ; Watson, WR; Fitzpatrick, JM; O'Connell, PR; ; (2004) 'Critical involvement of stress-activated mitogen-activated protein kinases in the regulation of intracellular adhesion molecule-1 in serosal fibroblasts isolated from patients with Crohn's disease'. Journal of the American College of Surgeons, 199 (2):234-242. [Details]
McGuinness, J.,Winter, D. C.,O'Connell, P. R.; (2004) 'Balloon tamponade to control haemorrhage following transanal rectal surgery'. Int J Colorectal Dis, 19 (4):395-6. [Details]
Mahony, R.,Behan, M.,O'Herlihy, C.,O'Connell, P. R.; (2004) 'Randomized, clinical trial of bowel confinement vs. laxative use after primary repair of a third-degree obstetric anal sphincter tear'. Dis Colon Rectum, 47 (1):12-7. [Details]
Beddy, D, Watson, RWG, Fitzpatrick, JM, O'Connell, PR, ; (2004) 'Increased vascular endothelial growth factor production in fibroblasts isolated from strictures in patients with Crohn's disease - Author's reply'. British Journal of Surgery, 91 (5):646-646. [Details]
Beddy, D. J.,Watson, W. R.,Fitzpatrick, J. M.,O'Connell, P. R.; (2004) 'Critical involvement of stress-activated mitogen-activated protein kinases in the regulation of intracellular adhesion molecule-1 in serosal fibroblasts isolated from patients with Crohn's disease'. J Am Coll Surg, 199 (2):234-42. [Details]
Beddy, DJ, Watson, WR, Fitzpatrick, JM, O'Connell, PR, ; (2004) 'Critical involvement of stress-activated mitogen-activated protein kinases in the regulation of intracellular adhesion molecule-1 in serosal fibroblasts isolated from patients with Crohn's disease'. Journal of the American College of Surgeons, 199 (2):234-242. [Details]
Mahony, R, Malone, P, Nalty, J, Cassidy, M, O'Connell, PR, O'Herlihy, C, ; (2003) 'Prospective randomized comparison of intra-anal electromyographic biofeedback and intra-anal electromyographic biofeedback augmented with electrical stimulation of the anal sphincter'. American Journal of Obstetrics and Gynecology, 189 (6):71-71. [Details]
Beddy, D, Watson, RWG, Fitzpatrick, JM, O'Connell, PR, ; (2003) 'Increased VEGF production in fibroblasts isolated from patients with Crohn's disease'. British Journal of Surgery, 90 (NA):6-6. [Details]
Beddy, D, Watson, RWG, Fitzpatrick, JM, O'Connell, PR, ; (2003) 'TNF-alpha regulates expression of cyclooxygenase-2 by fibroblasts in Crohn's disease'. British Journal of Surgery, 90 (5):629-629. [Details]
Beddy, D; Watson, RWG; Fitzpatrick, JM; O'Connell, PR; ; (2003) 'TNF-alpha regulates expression of cyclooxygenase-2 by fibroblasts in Crohn's disease'. British Journal of Surgery, 90 (5):629-629. [Details]
Beddy, D; Watson, RWG; Fitzpatrick, JM; O'Connell, PR; ; (2003) 'Increased VEGF production in fibroblasts isolated from patients with Crohn's disease'. British Journal of Surgery, 90 (NA):6-6. [Details]
Fitzpatrick, M,Behan, M,O'Connell, PR,O'Herlihy, C; (2003) 'Randomised clinical trial to assess anal sphincter function following forceps or vacuum assisted vaginal delivery'. Stet, 110 :424-429. [DOI] [Details]
Harkin, R,Fitzpatrick, M,O'Connell, PR,O'Herlihy, C; (2003) 'Anal sphincter disruption at vaginal delivery: is recurrence predictable?'. Stet, 109 :149-152. [DOI] [Details]
Mulsow, J.,Winter, D. C.,O'Keane, J. C.,O'Connell, P. R.; (2003) 'Sentinel lymph node mapping in colorectal cancer'. Br J Surg, 90 (6):659-67. [Details]
McNamara, D. A.,Fitzpatrick, J. M.,O'Connell, P. R.; (2003) 'Urinary tract involvement by colorectal cancer'. Dis Colon Rectum, 46 (9):1266-76. [Details]
McGuinness, J. G.,Winter, D. C.,O'Connell, P. R.; (2003) 'Vacuum-assisted closure of a complex pilonidal sinus'. Dis Colon Rectum, 46 (2):274-6. [Details]
Beddy, D; Watson, RWG; Fitzpatrick, JM; O'Connell, PR; ; (2003) 'TNF-alpha regulates expression of cyclooxygenase-2 by fibroblasts in Crohn's disease'. British Journal of Surgery, 90 (5):629-629. [Details]
Eogan, M; O'Brien, C; Behan, M; O'Connell, PR; O'Herlihy, C; ; (2003) 'Long-term effects of childbirth on fecal continence and pudendal nerve function'. American Journal of Obstetrics and Gynecology, 189 (6):72-72. [Details]
Mahony, R; Malone, P; Nalty, J; Cassidy, M; O'Connell, PR; O'Herlihy, C; ; (2003) 'Prospective randomized comparison of intra-anal electromyographic biofeedback and intra-anal electromyographic biofeedback augmented with electrical stimulation of the anal sphincter'. American Journal of Obstetrics and Gynecology, 189 (6):71-71. [Details]
Mahony, R; Fitzpatrick, N; Kirwan, C; O'Connell, PR; O'Herlihy, C; ; (2003) 'Review of four hundred women presenting after a third-degree tear'. American Journal of Obstetrics and Gynecology, 189 (6):201-201. [Details]
Fitzpatrick, M.,O'Brien, C.,O'Connell P, R.,O'Herlihy, C.; (2003) 'Patterns of abnormal pudendal nerve function that are associated with postpartum fecal incontinence'. Am J Obstet Gynecol, 189 (3):730-5. [Details]
Fitzpatrick, M, Cassidy, M, O'Connell, PR, O'Herlihy, C, ; (2002) 'Experience with an obstetric perineal clinic'. European Journal of Obstetrics Gynecology and Reproductive Biology, 100 (2):199-203. [Details]
Fitzpatrick, M,Cassidy, M,O'Connell, PR,O'Herlihy, C; (2002) 'Experience with an obstetric perineal clinic'. Stet, 100 :199-203. [Details]
Brannigan, AE, Watson, WG, Beddy, D, Hurley, H, Fitzpatrick, JM, O'Connell, PR, ; (2002) 'Increased adhesion molecule expression in serosal fibroblasts isolated from patients with inflammatory bowel disease is secondary to inflammation'. Annals of Surgery, 235 (4):507-511. [Details]
Fitzpatrick, M.,Cassidy, M.,O'Connell, P. R.,O'Herlihy, C.; (2002) 'Experience with an obstetric perineal clinic'. Eur J Obstet Gynecol Reprod Biol, 100 (2):199-203. [Details]
Fitzpatrick, M; Harkin, R; McQuillan, K; O'Brien, C; O'Connell, PR; O'Herlihy, C; ; (2002) 'A randomised clinical trial comparing the effects of delayed versus immediate pushing with epidural analgesia on mode of delivery and faecal continence'. Bjog-An International Journal of Obstetrics and Gynaecology, 109 (12):1359-1365. [Details]
Fitzpatrick, M; Cassidy, M; O'Connell, PR; O'Herlihy, C; ; (2002) 'Experience with an obstetric perineal clinic'. European Journal of Obstetrics Gynecology and Reproductive Biology, 100 (2):199-203. [Details]
Tan, M.,O'Hanlon, D. M.,Cassidy, M.,O'Connell, P. R.; (2001) 'Advantages of a posterior fourchette incision in anal sphincter repair'. Dis Colon Rectum, 44 (11):1624-9. [Details]
Fitzpatrick, M, Fynes, M, Cassidy, M, Behan, M, O'Connell, PR, O'Herlihy, C, ; (2000) 'Prospective study of the influence of parity and operative technique on the outcome of primary anal sphincter repair following obstetrical injury'. European Journal of Obstetrics Gynecology and Reproductive Biology, 89 (2):159-163. [Details]
Fitzpatrick, M, Behan, M, O'Connell, PR, O'Herlihy, C, ; (2000) 'A randomized clinical trial comparing primary overlap with approximation repair of third-degree obstetric tears'. American Journal of Obstetrics and Gynecology, 183 (5):1220-1224. [Details]
Brannigan, AE; O'Connell, PR; Hurley, H; O'Neill, A; Brady, HR; Fitzpatrick, JM; Watson, RWG; ; (2000) 'Neutrophil apoptosis is delayed in patients with inflammatory bowel disease'. Shock, 13 (5):361-366. [Details]
Fitzpatrick, M; Fynes, M; Cassidy, M; Behan, M; O'Connell, PR; O'Herlihy, C; ; (2000) 'Prospective study of the influence of parity and operative technique on the outcome of primary anal sphincter repair following obstetrical injury'. European Journal of Obstetrics Gynecology and Reproductive Biology, 89 (2):159-163. [Details]
Fynes, MM; Behan, M; O'Herlihy, C; O'Connell, PR; ; (2000) 'Anal vector volume analysis complements endoanal ultrasonographic assessment of postpartum anal sphincter injury'. British Journal of Surgery, 87 (9):1209-1214. [Details]
Regan, M. C.,Flavin, B. M.,Fitzpatrick, J. M.,O'Connell, P. R.; (2000) 'Stricture formation in Crohn's disease: the role of intestinal fibroblasts'. Ann Surg, 231 (1):46-50. [Details]
O'Connell, P. R.; (2000) 'What should surgeons write?'. Br J Surg, 87 (2):132-4. [Details]
Fitzpatrick, M.,Fynes, M.,Cassidy, M.,Behan, M.,O'Connell, P. R.,O'Herlihy, C.; (2000) 'Prospective study of the influence of parity and operative technique on the outcome of primary anal sphincter repair following obstetrical injury'. Eur J Obstet Gynecol Reprod Biol, 89 (2):159-63. [Details]
Fynes, MM, Marshall, K, Cassidy, M, Behan, M, Walsh, D, O'Connell, PR, O'Herlihy, C, ; (1999) 'A prospective, randomized study comparing the effect of augmented biofeedback with sensory biofeedback alone on fecal incontinence after obstetric trauma'. Diseases of the Colon &Amp; Rectum, 42 (6):753-758. [Details]
Prendergast, P. J.,Beverland, D. E.,Blayney, A. W.,Dunne, N. J.,Gorey, T. F.,Grace, P. A.,McCormack, B. A.,McGloughlin, T.,O'Connell, P. R.,Orr, J. F.; (1999) 'Modelling medical devices: the application of bioengineering in surgery'. Ir J Med Sci, 168 (1):3-7. [Details]
Delaney, C. P.,O'Connell, P. R.; (1999) 'Towards consensus on the fate of the normal appendix at laparoscopy for suspected appendicitis'. Ir J Med Sci, 168 (2):109-10. [Details]
Fynes, M.,Donnelly, V.,Behan, M.,O'Connell, P. R.,O'Herlihy, C.; (1999) 'Effect of second vaginal delivery on anorectal physiology and faecal continence: a prospective study'. Lancet, 354 (9183):983-6. [Details]
Duffy, MM, Regan, MC, Harrington, MG, Fitzpatrick, JM, O'Connell, PR, ; (1998) 'Metabolic substrate utilization differs in ileal faecal and urinary reservoirs'. British Journal of Surgery, 85 (6):804-808. [Details]
Donnelly, V, Fynes, M, Campbell, D, Johnson, H, O'Connell, PR, O'Herlihy, C, ; (1998) 'Obstetric events leading to anal sphincter damage'. Obstetrics & Gynecology, 92 (6):955-961. [Details]
Duffy, MM, Regan, MC, Ravichandran, P, O'Keane, C, Harrington, MG, Fitzpatrick, JM, O'Connell, PR, ; (1998) 'Mucosal metabolism in ulcerative colitis and Crohn's disease'. Diseases of the Colon &Amp; Rectum, 41 (11):1399-1405. [Details]
Donnelly, VS; O'Herlihy, C; Campbell, DM; O'Connell, PR; ; (1998) 'Postpartum fecal incontinence is more common in women with irritable bowel syndrome'. Diseases of the Colon &Amp; Rectum, 41 (5):586-589. [Details]
Teh, S. H.,O'Riordain, D. S.,O'Connell, P. R.; (1998) 'Colonic pseudo-obstruction following acute pancreatitis'. Ir J Med Sci, 167 (1):41-2. [Details]
Fynes, M.,Donnelly, V. S.,O'Connell, P. R.,O'Herlihy, C.; (1998) 'Cesarean delivery and anal sphincter injury'. Obstet Gynecol, 92 (4 Pt 1):496-500. [Details]
Duncan, C. O.,Earley, M. J.,O'Connell, P. R.; (1998) 'Enterocutaneous fistula: a reconstructive dilemma'. Ir J Med Sci, 167 (1):9-10. [Details]
Duffy, M. M.,Regan, M. C.,Ravichandran, P.,O'Keane, C.,Harrington, M. G.,Fitzpatrick, J. M.,O'Connell, P. R.; (1998) 'Mucosal metabolism in ulcerative colitis and Crohn's disease'. Dis Colon Rectum, 41 (11):1399-405. [Details]
Duffy, M. M.,Regan, M. C.,Harrington, M. G.,Fitzpatrick, J. M.,O'Connell, P. R.; (1998) 'Metabolic substrate utilization differs in ileal faecal and urinary reservoirs'. Br J Surg, 85 (6):804-8. [Details]
Donnelly, V. S.,O'Herlihy, C.,Campbell, D. M.,O'Connell, P. R.; (1998) 'Postpartum fecal incontinence is more common in women with irritable bowel syndrome'. Dis Colon Rectum, 41 (5):586-9. [Details]
Corby, H.,Donnelly, V. S.,O'Herlihy, C.,O'Connell, P. R.; (1997) 'Anal canal pressures are low in women with postpartum anal fissure'. Br J Surg, 84 (1):86-8. [Details]
Donnelly, V.,O'Connell, P. R.,O'Herlihy, C.; (1997) 'The influence of oestrogen replacement on faecal incontinence in postmenopausal women'. Br J Obstet Gynaecol, 104 (3):311-5. [Details]
Gul, Y. A.,Waldron, D. J.,O'Connell, P. R.; (1997) 'Stercoral perforation associated with parathyroid adenoma'. Ir Med J, 90 (1). [Details]
O'Riordain, D. S.,O'Connell, P. R.; (1997) 'Completion proctectomy in ulcerative colitis'. Br J Surg, 84 (4):436-7. [Details]
Campbell, D. M.,Behan, M.,Donnelly, V. S.,O'Herlihy, C.,O'Connell, P. R.; (1996) 'Endosonographic assessment of postpartum anal sphincter injury using a 120 degree sector scanner'. Clin Radiol, 51 (8):559-61. [Details]
O'Byrne, J. M.,O'Connell, P. R.,Nolan, N.,Keane, F. B.,Tanner, W. A.; (1996) 'Morphology, mucin histochemistry and crypt cell kinetics of ileal mucosa in an experimental model'. Int J Colorectal Dis, 11 (1):52-5. [Details]
Durkan, G. C.,Cross, K. S.,O'Connell, P. R.; (1996) 'Case report: vitello-intestinal remnant complicating laparoscopic cholecystectomy'. Ir J Med Sci, 165 (3). [Details]
Kent, P.,Bannon, C. A.,Beausang, O.,O'Connell, P. R.,Corrigan, T. P.,Gorey, T. F.; (1995) 'The introduction of laparoscopic cholecystectomy--audit of transition period with late follow-up'. Ir J Med Sci, 164 (1):1-3. [Details]
Attwood, S. E.,Kelly, I.,O'Connell, P. R.,Corrigan, T.; (1993) 'Laparoscopic mobilization and exteriorization for minimally invasive small bowel resection'. Br J Surg, 80 (2). [Details]
Hickey, K.,McKenna, P.,O'Connell, P. R.,Gillan, J. E.; (1993) 'Actinomycosis presenting as appendicitis in pregnancy'. Br J Obstet Gynaecol, 100 (6):595-6. [Details]
Horgan, P. G.,O'Connell, P. R.; (1993) 'Subumbilical hernia following laparoscopic cholecystectomy'. Br J Surg, 80 (12). [Details]
Chapman, M. A.,Grahn, M. F.,Giamundo, P.,O'Connell, P. R.,Onwu, D.,Hutton, M.,Maudsley, J.,Norton, B.,Rogers, J.,Williams, N. S.; (1993) 'New technique to measure mucosal metabolism and its use to map substrate utilization in the healthy human large bowel'. Br J Surg, 80 (4):445-9. [Details]
GOREY, TF,OCONNELL, PR,WALDRON, D,CRONIN, K,KERIN, M,FITZPATRICK, JM; (1993) 'LAPAROSCOPICALLY ASSISTED REVERSAL OF HARTMANNS PROCEDURE'. British Journal of Surgery, 80 :109-109. [Details]
McAnena, O. J.,Austin, O.,O'Connell, P. R.,Hederman, W. P.,Gorey, T. F.,Fitzpatrick, J.; (1992) 'Laparoscopic versus open appendicectomy: a prospective evaluation'. Br J Surg, 79 (8):818-20. [Details]
Giamundo, P.,Grahn, M. F.,O'Connell, P. R.,Williams, N. S.; (1991) 'Mucosal metabolic activity in endoscopic intestinal biopsy specimens'. Dig Dis Sci, 36 (4). [Details]
O'Connell, P. R.,Williams, N. S.; (1991) 'Mucosectomy in restorative proctocolectomy'. Br J Surg, 78 (2):129-30. [Details]
O'Donnell, A. F.,O'Connell, P. R.,Royston, D.,Johnston, D. H.,Barnard, R.,Bouchier-Hayes, D.; (1991) 'Suture technique affects perianastomotic colonic crypt cell production and tumour formation'. Br J Surg, 78 (6):671-4. [Details]
O'Riordain, D. S.,O'Connell, P. R.,Kirwan, W. O.; (1991) 'Hereditary sacral agenesis with presacral mass and anorectal stenosis: the Currarino triad'. Br J Surg, 78 (5):536-8. [Details]
O'Connell, P. R.,Lynch, G.; (1990) 'Reversed intestinal rotation associated with anomalous mesenteric venous drainage. Report of a case'. Dis Colon Rectum, 33 (10):883-5. [Details]
Young, V.,O'Connell, P. R.,Keane, F. B.; (1990) 'The role of adjuvant therapy in the management of node negative breast cancer'. Ir Med J, 83 (1):34-5. [Details]
Horgan, P. G.,O'Connell, P. R.,Shinkwin, C. A.,Kirwan, W. O.; (1989) 'Effect of anterior resection on anal sphincter function'. Br J Surg, 76 (8):783-6. [Details]
Crowley, K. J.,Cunningham, A. J.,Conroy, B.,O'Connell, P. R.,Collins, P. G.; (1988) 'Phaeochromocytoma--a presentation mimicking malignant hyperthermia'. Anaesthesia, 43 (12):1031-2. [Details]
O'Connell, P. R.,Kirwan, W. O.,Brady, M. P.,O'Donnell, J. A.; (1988) 'Surgical audit: the value of a morbidity and mortality conference'. Ir J Med Sci, 157 (4):100-3. [Details]
O'Connell, P. R.,Stryker, S. J.,Metcalf, A. M.,Pemberton, J. H.,Kelly, K. A.; (1988) 'Anal canal pressure and motility after ileoanal anastomosis'. Surg Gynecol Obstet, 166 (1):47-54. [Details]
O'Connell, P. R.,Kelly, K. A.; (1987) 'Enteric transit and absorption after canine ileostomy. Effect of pacing'. Arch Surg, 122 (9):1011-7. [Details]
O'Connell, P. R.,Pemberton, J. H.,Brown, M. L.,Kelly, K. A.; (1987) 'Determinants of stool frequency after ileal pouch-anal anastomosis'. Am J Surg, 153 (2):157-64. [Details]
O'Connell, P. R.,Pemberton, J. H.,Kelly, K. A.; (1987) 'Motor function of the ileal J pouch and its relation to clinical outcome after ileal pouch-anal anastomosis'. World J Surg, 11 (6):735-41. [Details]
O'Connell, P. R.,Kelly, K. A.,Brown, M. L.; (1986) 'Scintigraphic assessment of neorectal motor function'. J Nucl Med, 27 (4):460-4. [Details]
O'Connell, P. R.,Rankin, D. R.,Weiland, L. H.,Kelly, K. A.; (1986) 'Enteric bacteriology, absorption, morphology and emptying after ileal pouch-anal anastomosis'. Br J Surg, 73 (11):909-14. [Details]
Healy, C. F.,McMorrow, C.,O'Herlihy, C.,O'Connell, P. R.,Jones, J. F.; (2008) 'External anal sphincter fatigue is not improved by N-acetylcysteine in an animal model'. Neurogastroenterol Motil, 20 (6):719-24. [Details]
O'Riordan, J. M.,Healy, C. F.,McLoughlin, D.,Cassidy, M.,Brannigan, A. E.,O'Connell, P. R.; (2008) 'Sacral nerve stimulation for faecal incontinence'. Ir J Med Sci, 177 (2):117-9. [Details]
Brennan DJ , Moynagh M , Brannigan AE , Gleeson F , Rowland M , O'Connell PR; (2007) 'Routine mobilization of the splenic flexure is not necessary during anterior resection for rectal cancer'. Diseases of the Colon and Rectum, 50 :302-307. [Details]
Mahony R, O'Brien C, Kinsley B, Firth R, Coffey M, O'Connell R, O'Herlihy C; (2007) 'Antepartum pudendal neuropathy and the effect of vaginal delivery in women with type 1 diabetes mellitus'. International Journal of Diabetes and Metabolism, . [Details]
Eogan, M; O'Brien, C; Daly, L; Byrne, P; O'Connell, PR; O'Herlihy, C; ; (2005) 'Monitoring pudendal nerve conduction during labor and early puerperium'. American Journal of Obstetrics and Gynecology, 193 (6):41-41. [Details]
O'Brien, C; O'Herlihy, C; O'Connell, PR; ; (2004) 'Pudendal neuropathy is best determined by full neurophysiologic assessment'. American Journal of Obstetrics and Gynecology, 191 (5):1836-1836. [Details]
Mahony, R; Behan, M; O'Herlihy, C; O'Connell, PR; ; (2004) 'Randomized, clinical trial of bowel confinement vs. laxative use after primary repair of a third-degree obstetric anal sphincter tear'. Diseases of the Colon &Amp; Rectum, 47 (1):12-17. [Details]
Harkin, R; Fitzpatrick, M; O'Connell, PR; O'Herlihy, C; ; (2003) 'Anal sphincter disruption at vaginal delivery: is recurrence predictable?'. European Journal of Obstetrics Gynecology and Reproductive Biology, 109 (2):149-152. [Details]
McNamara, DA; Fitzpatrick, JM; O'Connell, PR; ; (2003) 'Urinary tract involvement by colorectal cancer'. Diseases of the Colon &Amp; Rectum, 46 (9):1266-1276. [Details]
Mulsow, J; Winter, DC; O'Keane, JC; O'Connell, PR; ; (2003) 'Sentinel lymph node mapping in colorectal cancer'. British Journal of Surgery, 90 (6):659-667. [Details]
Fitzpatrick, M; Behan, M; O'Connell, PR; O'Herlihy, C; ; (2003) 'Randomised clinical trial to assess anal sphincter function following forceps or vacuum assisted vaginal delivery'. Bjog-An International Journal of Obstetrics and Gynaecology, 110 (4):424-429. [Details]
Fitzpatrick, M; O'Brien, C; O'Connell, PR; O'Herlihy, C; ; (2003) 'Patterns of abnormal pudendal nerve function that are associated with postpartum fecal incontinence'. American Journal of Obstetrics and Gynecology, 189 (3):730-735. [Details]
Mahony, R; Fitzpatrick, N; Kirwan, C; O'Connell, PR; O'Herlihy, C; ; (2003) 'Review of four hundred women presenting after a third-degree tear'. American Journal of Obstetrics and Gynecology, 189 (6):201-201. [Details]
McGuinness, JG; Winter, DC; O'Connell, PR; ; (2003) 'Vacuum-assisted closure of a complex pilonidal sinus'. Diseases of the Colon &Amp; Rectum, 46 (2):274-276. [Details]
Medani M, Docherty NG, O¿Connell PR, Winter DC ; (2010) 'THE EMERGING ROLE OF HYDROGEN SULPHIDE IN COLONIC PHYSIOLOGY'. Inflammatory bowel diseases, . [Details]
Burke JP, Cunningham MF, Docherty NG, O¿Connell PR ; (2010) 'N-CADHERIN IS OVER-EXPRESSED IN CROHN'S STRICTURE FIBROBLASTS AND PROMOTES INTESTINAL FIBROBLAST MIGRATION'. Inflammatory bowel diseases, . [Details]
Donohoe CL, Brannigan AE, O'Connell PR.; (2010) 'PALLIATIVE ENDOSCOPIC TRANS-ANAL RESECTION OF ADVANCED RECTOSIGMOID CARCINOMA'. Irish Journal of Medical Science, . [Details]
Shields CJ, Tiret E, Winter DC, Baum RP, Mortensen N, Fazio VW, Stocchi L, Sheahan K, O¿Keane C, Brannigan A, O¿Connell PR, Parc Y, Mourra N,Garcia-Olmo D, Soreide K, Prasad V, Kaemmerer D, Flemming M, Sagar P.; (2010) 'CARCINOID TUMOURS OF THE RECTUM ¿ A MULTI-INSTITUTIONAL INTERANTIONAL COLLABORATION'. Annals of Surgery, 252 :750-755. [Details]
O'Connell R, Skrabanek P, Cannon D, Powell D; (1976) 'High-sensitivity radioimmunoassay for substance P'. IRISH J MED SCI, 145 :392-398. [Details]
Kanazawa I, Bird E, O'Connell R, Powell D.; (1977) 'Evidence for a decrease in substance P content of substantia nigra in Huntington's chorea'. Brain Research, 120 :387-392. [Details]
Rowan F, Coffey JC, Oʼconnell PR, Docherty NG, Murphy M, Murphy TB.; (2011) 'Ileal Pouch Microbial Diversity'. Annals of Surgery, . [Details]
O'Connor MK, O'Connell R, Keane FB, Byrne PJ, Hennessy TP; (1983) 'The relationship between technetium 99m pertechnetate gastric scanning and gastric contents'. British Journal of Radiology, 56 :817-822. [Details]
Hennessy TP, O'Connell R; (1984) 'Surgical treatment of squamous cell carcinoma of the oesophagus'. British Journal of Surgery, 71 :750-751. [Details]
Hennessy TP, O'Connell R; (1986) 'Carcinoma of the hypopharynx, esophagus and cardia'. Journal of the American College of Surgeons, 162 :243-247. [Details]
Martin ST, Heeney A, Pierce C, O'Connell PR, Hyland JM, Winter DC.; (2011) 'Use of an electrothermal bipolar sealing device in ligation of major mesenteric vessels during laparoscopic colorectal resection'. Techniques in coloproctology, 15 (3):285-289. [Details]
Donohoe CL, Brannigan AE, O'Connell PR; (2011) 'PALLIATIVE ENDOSCOPIC TRANS-ANAL RESECTION OF ADVANCED RECTOSIGMOID CARCINOMA'. The Irish Journal of Medical Science, 180 :541-544. [DOI] [Details]
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Other Journals

Rowan F, Docherty NG, Murphy M, Murphy TB, Coffey JC, O'Connell PR; (2011) 'Ileal pouch microbial diversity' Annals of Surgery 254 (4) :669-670. [DOI] [Details]

Peirce C, Alexander LE, Buffini, M. O'Herlihy C, O'Connell PR, Jones JF.; (2009) 'Investigation of the nerve supply to the external anal sphincter (EAS) in the female rat' British Journal of Surgery 96(S5) :37 . [Details]

Conference Publications

Pierce C, Alexander LE, Buffini, M. O'Herlihy C, O'Connell PR, Jones JF.; (2009) Investigation of the nerve supply to the external anal sphincter (EAS) in the female rat.96(S5) :37 British Journal of Surgery [Details]

Peirce C, Alexander LE, O'Herlihy C, O'Connell PR, Jones JFX; (2009) Activating transcription factor 3 (ATF-3) as a marker of injury in experimental models of neuropathic faecal Irish Journal of Medical Science [Details]

O'Connell PR, Burke JP, Watson RW, Murphy M, Docherty NG, Coffey JC, ; (2009) The British journal of surgery Simvastatin impairs smad-3 phosphorylation and modulates transforming growth factor beta1-mediated activation of intestinal fibroblasts , pp.541-551 [DOI] [Details]

O'Connell PR, Beddy D, Mulsow J, Watson RW, Fitzpatrick JM, ; (2006) The British journal of surgery Expression and regulation of connective tissue growth factor by transforming growth factor beta and tumour necrosis factor alpha in fibroblasts isolated from strictures in patients with Crohn's disease , pp.1290-1296 [DOI] [Details]

Editorial

O'Connell, PR; (2011) Suboptimal outcome following sacral nerve stimulation for faecal incontinence (Br J Surg 2011; 98: 140-147). Editorial [DOI] [Details]

Invited papers

O¿Connell PR; (2009) STAPLED TRANSANAL RECTAL RESECTION FOR OBSTRUCTIVE DEFECATION SYNDROME: ONE YEAR RESULTS OF THE EUROPEAN STARR REGISTRY¿. Invited papers [Details]

Abstract

O¿Connell PR; (2009) STAPLED HAEMORRHOIDOPEXY FOR THE TREATMENT OF HAEMORRHOIDS: A SYSTEMATIC REVIEW¿. Abstract [Details]

Honours and Awards

Year: 2010.
Title: ASCRS research prize

Year: 2009.
Title: Best Oral Presentation

Year: 2007.
Title: SIR PETER FREYER RESEARCH PRIZE

Year: 2007.
Title: ASCRS RESEARCH PRIZE

Year: 2007.
Title: BRITISH JOURNAL OF SURGERY PRIZE

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Associations

Association: European Surgical Association, Function/Role: Editor in Chief

Association: American Society of Colon and Rectal Surgeonsl, Function/Role: elected Fellow

Association: James IV Surgical Society, Function/Role: Elected member

Association: Society of Pelvic Surgons, Function/Role: elected fellow

Association: International Surgical Group, Function/Role: elected fellow

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Conference Contributions

PR O'Connell; (2008) The role of Sentinel Node Biopsy. [Invited Lecture], St Gallen International Colorectal Cancer Meeting, St Galen, Switzerland , 10-DEC-08 - 12-DEC-08.

PR O'Connell; (2008) Colorectal Surgery - Quo vadis. [Invited Oral Presentation], Annual Meeting ACPGBI, Birmingham , 03-JUL-08 - 04-JUL-08.

O'Connell PR; (2008) Complex Diverticular Disease. [Invited Oral Presentation], Americian Socierty of Colon and Rectal Surgeons, Boston , 03-JUN-08 - 04-JUN-08.

PR O'Connell; (2009) An update on rectal Prolapse. [Invited Lecture], Annual Meeting Italian Society of Colon and Rectal Surgeons, Catania, Sicily , 05-OCT-09 - 07-OCT-09.

PR O'Connell; (2009) Changing paradigms in Pelvic Surgery. [Invited Lecture], German Society of Coloproctology, Munich, Germany , 12-MAR-09 - 13-MAR-09.

PR O'Connell; (2009) Tailoring the surgery to the patient. [Invited Lecture], Cancer Conference 2009, St James's Hospital and TCD , 13-MAY-09 - 14-MAY-09.
PR O'Connell; (2009) Robert Smith Lecture. [Invited Lecture], Annual Meeting Association of Surgeons of Great Britain and Ireland, Glasgow , 14-MAY-09 - 15-MAY-09.
PR O'Connell; (2009) Pelvic Floor Disorders ¿ changing paradigms. [Invited Lecture], 14th Conference on Colorectal and Anal Fuction, Tokyo Japan , 31-JUL-09 - 02-AUG-09.
PR O'Connell; (2010) Pelvic Floor Disorders ¿ changing paradigms. [Keynote Address], CHILEAN SCOIETY OF COLOPROCTOLOGY, Pucon, Chile , 22-NOV-10 - 23-NOV-10.
PR O'Connell; (2010) Sacral Nerve Stimulation for Fecal Incontinence. [Keynote Address], COLON AND RECTAL SURGERY: CURRENT PRINCIPLES AND PRACTICE, Minneapolis, Minnesota, USA , 21-OCT-10 - 22-OCT-10.
PR O'Connell; (2010) New paradigms in treatment of Diverticular Disease. [Keynote Address], MINNEAPOLIS SURGICAL SOCIETY, Minneaplois, Minnesota, USA , 20-OCT-10 - 20-JUL-11.
P R O'Connell; (2010) Sacral Nerve Neuromodulation. [Invited Lecture], HÔPITAL SAINTE ANTOINE ¿ DIGESTIVE SURGERY STUDY DAY, Paris , 25-JAN-10 - 25-JAN-10.
PR O'Connell; (2010) Ileoanal anastomosis: the state of play 30 years on. [Invited Lecture], HÔPITAL SAINTE ANTOINE ¿ DIGESTIVE SURGERY STUDY DAY, Paris France , 25-JAN-10 - 25-JAN-10.
PR O'Connell; (2010) Trials that have changed practice in Coloproctology. [Invited Lecture], ASSOCIATION of SURGEONS GREAT BRITAIN AND IRELAND, Liverpool, UK , 21-APR-10 - 22-APR-10.
PR O'Connell; (2010) SNS ¿ the new gold standard for treatment of fecal incontinence¿. [Invited Lecture], KRAKENHAUS WALDFRIEDE COLORECTAL COURSE, Berlin, Germany , 24-JUN-10 - 25-JUN-10.
PR O'Connell; (2010) Neuromodulation in the treatment of fecal incontinence. [Invited Oral Presentation], INTERNATIONAL SURGICAL GROUP, Louisville Kentucky, USA , 15-SEP-10 - 16-JUL-11.
PR O'Connell; (2011) Pathophysiology of ulcerative colitis & pouchitis. [Invited Lecture], ROYAL AUSTRALASIAN COLLEGE OF SURGEONS ANNUAL SCIENTIFIC CONGRESS, Adelaide, SA, Australia , 02-MAY-11 - 05-MAY-11.
PR O'Connell; (2011) Pelvic floor physiology, sacral nerve stimulation and neuromodulation. [Keynote Address], ROYAL AUSTRALASIAN COLLEGE OF SURGEONS ANNUAL SCIENTIFIC CONGRESS, Adelaide, Australia , 02-MAY-11 - 05-MAY-11.
O'Connell, PR.; (2006) Anal Sphincter Repair. [Invited Lecture], ALPINE COLORECTAL MEETING, Verbier, Switzerland , 01-JAN-06.
O'Connell, PR.; (2006) The Pathogenesis of Faecal Incontinence. [Keynote Address], INTERNATIONAL CONTINENCE MEETING, Bari, Italy , 01-SEP-06.
O'Connell, PR.; (2006) The Timing and Technique of Anal Sphincter Repair. [Invited Lecture], INTERNATIONAL CONTINENCE MEETING, Bari, Italy , 01-SEP-06.
O'Connell, PR.; (2006) Publication ' an essential component of surgical training. [Invited Lecture], WATERFORD SURGICAL OCTOBER MEETING, Waterford , 01-OCT-06.
O'Connell, PR.; (2006) The SECCA Procedure. [Invited Lecture], KOREAN SOCIETY OF COLOPROCTOLOGY, Seoul, South Korea , 01-NOV-06.
O'Connell, PR.; (2006) Anal Sphincter Repair. [Invited Lecture], KOREAN SOCIETY OF COLOPROCTOLOGY, Seoul, South Korea , 01-NOV-06.
O'Connell, PR.; (2007) Aetiology, Investigation and Management of Pelvic Floor Disorders. [Invited Lecture], 7TH INTERNATIONAL SYMPOSIUM IN COLORECTAL SURGERY, Lodz, Poland , 01-MAY-07.
O'Connell, PR.; (2007) Publication in an Electronic Era. [Invited Lecture], 7TH INTERNATIONAL SYMPOSIUM IN COLORECTAL SURGERY, Lodz, Poland , 01-MAY-07.
O'Connell, PR.; (2007) Developments in Management of Faecal Incontinence. [Invited Lecture], ANNUAL MEETING CHARTERED PHYSIOTHERAPISTS, Dublin , 01-MAY-07.
O'Connell, PR.; (2007) Fibrogenesis in Crohn's Disease. [Invited Lecture], INTERNATIONAL SURGICAL GROUP, London , 01-AUG-07.
O'Connell, PR.; (2007) Publication in an electronic era. [Invited Lecture], SIR PETER FREYER MEETING, Galway , 01-SEP-07.
O'Connell, PR.; (2007) Obstetric injury to faecal continence mechanisms. [Invited Lecture], COLORECTAL SURGICAL SOCIETY OF AUSTRALIA AND NEW ZEALAND and SECTION OF COLON AND RECTAL SURGERY, ROYAL AUSTRALASIAN COLLEGE OF SURGEONS, Adelaide, Australia , 01-OCT-07.
O'Connell, PR.; (2007) How to get published. [Invited Lecture], COLORECTAL SURGICAL SOCIETY OF AUSTRALIA AND NEW ZEALAND and SECTION OF COLON AND RECTAL SURGERY, ROYAL AUSTRALASIAN COLLEGE OF SURGEONS, Adelaide, Australia , 01-OCT-07.
O'Connell, PR.; (2007) Strictures in Crohn's Disease. [Invited Lecture], COLORECTAL SURGICAL SOCIETY OF AUSTRALIA AND NEW ZEALAND and SECTION OF COLON AND RECTAL SURGERY, ROYAL AUSTRALASIAN COLLEGE OF SURGEONS, Adelaide, Australia , 01-OCT-07.
O'Connell, PR.; (2007) Why are research and publication important to the modern surgeon. [Invited Lecture], FRONTIERS IN COLORECTAL SURGERY MEETING, St Mark¿s Hospital, London , 01-NOV-07.
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Committees

Committee : Natioanl Colon Cancer Screening Advisory Committee

Education

Year 1983 Institution: Royal Coll Surgeons in Ireland
Qualification: FRCSI Subject:

Year 1987 Institution: Trinity College Dublin
Qualification: MD Subject:

Year 1979 Institution: Trinity College Dublin
Qualification: BA Subject:

Year 1979 Institution: Trinity College Dublin
Qualification: BCh Subject:

Year 1979 Institution: Trinity College Dublin
Qualification: BAO Subject:

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Internal Collaborators

Prof Colm O'Herlihy, Professor of Obsteterics and Gynaecology

Dr James Jones, Senior Lecture in Physiology

Prof Desmond Winter, Dept of Surgery St Vincent's University Hopsital

Prof John Hyland, Dept of Surgery, St Vincent's University Hospital

External Collaborators

Prof Gert van Asche, University Leuven, Belgium

Prof Soren Laurberg, University Aarhus, Denmark

Prof Steve Collins, MacMaster University, Hamilton, Ontario, Canada

Mr Charles H Knowles, Barts and the London School of Medicine, London, UK

Prof Fergus Shanahan, University College Cork

Dr Paul Ross, APC Centre, Teagasc, Fermoy, Co Cork

Dr Neil Docherty, Dept of Physiology, Trinity College Dublin