Professor Stephen Gordon

Research

Professor Stephen Gordon PhD

Contact Details

Title	Associate Professor
Address	School of Veterinary Medicine Veterinary Science Centre Belfield Dublin 4
Telephone:	Ext. 6181
Email:	ei.dcu@nodrog.nehpets

Title	Conway Fellow
Address	Conway Institute of Biomolecular & Biomedical Research

Biography:

I hold a joint appointment across the School of Veterinary Medicine, School of Biomolecular and Biomedical Science, and School of Medicine and Medical Science.

1999-2007: TB Research Group, VLA Weybridge, UK.
1995-1999: Wellcome Trust Travelling Fellow, Institute Pasteur, Paris.
1995: Wellcome Trust Junior Fellow University of Leicester, UK.
1991-1995: PhD, Wellcome Trust Prize Student, University of Leicester, UK.
1990-1991: Research Assistant, Natl. University of Ireland, Galway
1986-1990: BSc (Hons) Natl. University of Ireland, Galway.

Research Interests

The Mycobacterium tuberculosis complex encompasses the aetiological agents of tuberculosis in man and a range of domesticated and wild animals. My current focus is on the exploitation of the genome sequence of human pathogen, Mycobacterium tuberculosis, and the bovine pathogen, Mycobacterium bovis, to accelerate vaccine and diagnostic development.

Research Projects

Sponsor : Higher Education Authority (HEA)
Title : PRTLI 5: MolCellBiol - Split Accounts School of VM
Start Date / End Date : 01-MAR-11 / 29-FEB-16

Sponsor : Dept. of Agriculture, Fisheries & Food (DAFF)
Title : MYCOBACTDIAGNOSIS
Start Date / End Date : 01-JUN-12 / 01-JUN-15

Sponsor : Science Foundation Ireland (SFI)
Title : Functional genomics and proteomics studies of bovine tuberculosis
Start Date / End Date : 01-SEP-09 / 01-SEP-14

Sponsor : EC Framework
Title : Novel secretion systems of Myco bacterium tuberculosis and their role in host pathogen interaction (NOVSEC-TB)
Start Date / End Date : 01-JAN-08 / 30-JUN-11

Current Postgraduate Students

Jing Chen, Doctor of Philosophy (PhD) - Thesis Supervisor

Claire Healy, Doctor of Philosophy (PhD) - Thesis Supervisor

Kerri Malone, Doctor of Philosophy (PhD) - Thesis Supervisor

Kevin Rue, Doctor of Philosophy (PhD) - Thesis Supervisor

Lorraine Carr, Doctor of Philosophy (PhD) - Thesis Supervisor

Peer Reviewed Journals

Chen J, Uplekar S, Gordon SV, Cole ST. (2012) 'A point mutation in cycA partially contributes to the D-cycloserine resistance trait of Mycobacterium bovis BCG vaccine strains'. PLoS ONE, . [DOI] [Details]

Rodriguez-Campos S, SchÃ¼rch AC, Dale J, Lohan AJ, Cunha MV, Botelho A, De Cruz K, Boschiroli ML, Boniotti MB, Pacciarini M, Garcia-Pelayo MC, Romero B, de Juan L, DomÃnguez L, Gordon SV, van Soolingen D, Loftus B, Berg S, Hewinson RG, Aranaz A, Smith NH (2012) 'European 2--a clonal complex of Mycobacterium bovis dominant in the Iberian Peninsula'. Gene, 12 (4):866-872. [DOI] [Details]

Chen JM, Uplekar S, Gordon SV, Cole ST (2012) 'A Point Mutation in cycA Partially Contributes to the D-cycloserine Resistance Trait of Mycobacterium bovis BCG Vaccine Strains'. PLoS ONE, 7 (8). [DOI] [Details]

Ussery DW, Gordon SV (2012) 'Two novel methods for using genome sequences to infer taxonomy'. Microbiology (Reading, England), 158 (Pt 6). [DOI] [Details]

Killick KE, Browne JA, Park SD, Magee DA, Martin I, Meade KG, Gordon SV, Gormley E, O'Farrelly C, Hokamp K, MacHugh DE (2011) 'Genome-wide transcriptional profiling of peripheral blood leukocytes from cattle infected with Mycobacterium bovis reveals suppression of host immune genes'. BMC Genomics, 12 . [DOI] [Details]

Magee DA, Taraktsoglou M, Killick KE, Nalpas NC, Browne JA, Park SD, Conlon KM, Lynn DJ, Hokamp K, Gordon SV, Gormley E, MacHugh DE (2012) 'Global gene expression and systems biology analysis of bovine monocyte-derived macrophages in response to in vitro challenge with Mycobacterium bovis'. PLoS ONE, 7 (2). [DOI] [Details]
Smith, N.H., Berg, S., Dale, J., Allen, A., Rodriguez, S., Romero, B., Matos, F., Ghebremichael, S., Karoui, C., Donati, C., Machado, Ada. C., Mucavele, C., Kazwala, R.R., Hilty, M., Cadmus, S., Ngandolo, B.N., Habtamu, M., Oloya, J., Muller, A., Milian-Suazo, F., Andrievskaia, O., Projahn, M., Barandiarán, S., Macías, A., Müller, B., Zanini, M.S,. Ikuta, C.Y., Rodriguez, C.A., Pinheiro, S.R., Figueroa, A., Cho, S.N., Mosavari, N., Chuang, P.C., Jou, R., Zinsstag, J., van Soolingen, D., Costello, E., Aseffa, A., Proaño-Perez, F., Portaels, F., Rigouts, L., Cataldi, A.A, Collins, D.M., Boschiroli, M.L., Hewinson, R.G., Ferreira Neto, J.S., Surujballi, O., Tadyon, K., Botelho, A., Zárraga, A.M., Buller, N., Skuce, R., Michel, A., Aranaz, A., Gordon, S.V., Jeon, B.Y., Källenius, G., Niemann, S., Boniotti, M.B., van Helden, P.D., Harris, B., Zumárraga, M.J., Kremer, K.; (2011) 'European 1: a globally important clonal complex of Mycobacterium bovis'. Infection, Genetics and Evolution, 11 (6):1340-1351. [Details]
Cadmus, S.I., Gordon, S.V., Hewinson, R.G., Smith, N.H.; (2011) 'Exploring the use of molecular epidemiology to track bovine tuberculosis in Nigeria: An overview from 2002 to 2004'. Veterinary Microbiology, 151 (1 - 2):133-138. [DOI] [Details]
Vordermeier, M., Gordon, S.V., Hewinson, R.G.; (2011) 'Mycobacterium bovis antigens for the differential diagnosis of vaccinated and infected cattle'. Veterinary Microbiology, 151 (1-2):8-13. [DOI] [Details]
Ameni G, Vordermeier M, Firdessa R, Aseffa A, Hewinson G, Gordon SV, Berg S; (2010) 'Mycobacterium tuberculosis infection in grazing cattle in central Ethiopia'. Veterinary Journal, . [DOI] [Details]
Schiller I, Vordermeier HM, Waters WR, Kyburz A, Cagiola M, Whelan A, Palmer MV, Thacker TC, Meijlis J, Carter C, Gordon S, Egnuni T, Hardegger R, Marg-Haufe B, Raeber A, Oesch B; (2010) 'Comparison of tuberculin activity using the interferon-gamma assay for the diagnosis of bovine tuberculosis'. Veterinary Record, 167 (9):322-326. [DOI] [Details]
Muller, B,Hilty, M,Berg, S,Garcia-Pelayo, MC,Dale, J,Boschiroli, ML,Cadmus, S,Ngandolo, BNR,Godreuil, S,Diguimbaye-Djaibe, C,Kazwala, R,Bonfoh, B,Njanpop-Lafourcade, BM,Sahraoui, N,Guetarni, D,Aseffa, A,Mekonnen, MH,Razanamparany, VR,Ramarokoto, H,Djonne, B,Oloya, J,Machado, A,Mucavele, C,Skjerve, E,Portaels, F,Rigouts, L,Michel, A,Muller, A,Kallenius, G,van Helden, PD,Hewinson, RG,Zinsstag, J,Gordon, SV,Smith, NH; (2009) 'African 1, an Epidemiologically Important Clonal Complex of Mycobacterium bovis Dominant in Mali, Nigeria, Cameroon, and Chad'. Journal of Bacteriology, 191 :1951-1960. [DOI] [Details]
Ojo OO, Sheehan S, Corcoran DG, Nikolayevsky V, Brown T, O'Sullivan M, O'Sullivan K, Gordon SV, Drobniewski F, Prentice MB; (2010) 'Molecular epidemiology of Mycobacterium tuberculosis clinical isolates in Southwest Ireland'. Infection, Genetics and Evolution, . [DOI] [Details]
Mendoza Lopez P, Golby P, Wooff E, Garcia JN, Garcia Pelayo MC, Conlon K, Gema Camacho A, Hewinson RG, Polaina J, SuÃ¡rez GarcÃa A, Gordon SV; (2010) 'Characterisation of the transcriptional regulator Rv3124 of Mycobacterium tuberculosis identifies it as a positive regulator of molybdopterin biosynthesis and defines the functional consequences of a nonsynonymous SNP in the Mycobacterium bovis BCG orthologue'. Microbiology (Reading, England), . [DOI] [Details]
Jones GJ, Gordon SV, Hewinson RG, Vordermeier HM; (2010) 'Screening of Predicted Secreted Antigens from Mycobacterium bovis Reveals the Immunodominance of the ESAT-6 Protein Family'. Infection and Immunity, . [DOI] [Details]
Whelan AO, Coad M, Cockle PJ, Hewinson G, Vordermeier M, Gordon SV; (2010) 'Revisiting host preference in the Mycobacterium tuberculosis complex: experimental infection shows M. tuberculosis H37Rv to be avirulent in cattle'. PLoS ONE, 5 (1). [DOI] [Details]
Chavadi S, Wooff E, Coldham NG, Sritharan M, Hewinson RG, Gordon SV, Wheeler PR; (2009) 'Global effects of inactivation of the pyruvate kinase gene in the Mycobacterium tuberculosis complex'. Journal of Bacteriology, 191 (24):7545-7553. [DOI] [Details]
Blanco FC, Nunez-GarcÃa J, GarcÃa-Pelayo C, Soria M, Bianco MV, ZumÃ¡rraga M, Golby P, Cataldi AA, Gordon SV, Bigi F; (2009) 'Differential transcriptome profiles of attenuated and hypervirulent strains of Mycobacterium bovis'. Microbes and Infection, 11 (12):956-963. [DOI] [Details]
Smith NH, Hewinson RG, Kremer K, Brosch R, Gordon SV.; (2009) 'Myths and misconceptions: the origin and evolution of Mycobacterium tuberculosis'. Nature reviews. Microbiology, 7 (7):537-544. [DOI] [Details]
Santangelo Mde L, Klepp L, Nunez-GarcÃia J, Blanco FC, Soria M, Garcia-Pelayo Mdel C, Bianco MV, Cataldi AA, Golby P, Jackson M, Gordon SV, Bigi F.; (2009) 'Mce3R, a TetR-type transcriptional repressor, controls the expression of a regulon involved in lipid metabolism in Mycobacterium tuberculosis'. Microbiology (Reading, England), 155 (Pt 7):2245-2255. [DOI] [Details]
Berg S, Firdessa R, Habtamu M, Gadisa E, Mengistu A, Yamuah L, Ameni G, Vordermeier M, Robertson BD, Smith NH, Engers H, Young D, Hewinson RG, Aseffa A, Gordon SV.; (2009) 'The burden of mycobacterial disease in ethiopian cattle: implications for public health'. PLoS ONE, 4 (4). [DOI] [Details]
Vordermeier M, Gordon SV, Hewinson AR.; (2009) 'Antigen Mining to Define Mycobacterium bovis Antigens for the Differential Diagnosis of Vaccinated and Infected Animals: A VLA Perspective'. Transboundary and emerging diseases, 56 (6-7):240-247. [DOI] [Details]
Garcia Pelayo MC, Uplekar S, Keniry A, Mendoza Lopez P, Garnier T, Nunez Garcia J, Boschiroli L, Zhou X, Parkhill J, Smith N, Hewinson RG, Cole ST, Gordon SV; (2009) 'A comprehensive survey of single nucleotide polymorphisms (SNPs) across Mycobacterium bovis strains and M. bovis BCG vaccine strains refines the genealogy and defines a minimal set of SNPs that separate virulent M. bovis strains and M. bovis BCG strains'. Infection and Immunity, 77 (5):2230-2238. [DOI] [Details]
Gordon SV, Bottai D, Simeone R, Stinear TP, Brosch R.; (2009) 'Pathogenicity in the tubercle bacillus: molecular and evolutionary determinants'. BioEssays : news and reviews in molecular, cellular and developmental biology, . [DOI] [Details]
Gordon SV; (2008) 'Bovine TB: stopping disease control would block all live exports'. Nature, 456 (7223). [DOI] [Details]
Wheeler PR, Brosch R, Coldham NG, Inwald JK, Hewinson RG, Gordon SV; (2008) 'Functional analysis of a clonal deletion in an epidemic strain of Mycobacterium bovis reveals a role in lipid metabolism'. Microbiology (Reading, England), 154 (Pt 12):3731-3742. [DOI] [Details]
Ojo O, Sheehan S, Corcoran GD, Okker M, Gover K, Nikolayevsky V, Brown T, Dale J, Gordon SV, Drobniewski F, Prentice MB; (2008) 'Mycobacterium bovis Strains Causing Smear-Positive Human Tuberculosis, Southwest Ireland'. Emerging infectious diseases, 14 (12):1931-1934. [Details]
Garcia Pelayo MC, Garcia JN, Golby P, Pirson C, Ewer K, Vordermeier M, Hewinson RG, Gordon SV; (2008) 'Gene expression profiling and antigen mining of the tuberculin production strain Mycobacterium bovis AN5'. Veterinary microbiology, (NA). [DOI] [Details]
Golby P, Nunez J, Cockle PJ, Ewer K, Logan K, Hogarth P, Vordermeier HM, Hinds J, Hewinson RG, Gordon SV ; (2008) 'Characterization of two in vivo-expressed methyltransferases of the Mycobacterium tuberculosis complex: antigenicity and genetic regulation'. Microbiology (Reading, England), 154 (Pt 4):1059-1067. [DOI] [Details]
Ameni G, Aseffa A, Sirak A, Engers H, Young DB, Hewinson RG, Vordermeier MH, Gordon SV ; (2007) 'Effect of skin testing and segregation on the prevalence of bovine tuberculosis, and molecular typing of Mycobacterium bovis, in Ethiopia'. Veterinary Record, 161 (23):782-786. [Details]
Golby P, Hatch KA, Bacon J, Cooney R, Riley P, Allnutt J, Hinds J, Nunez J, Marsh PD, Hewinson RG, Gordon SV ; (2007) 'Comparative transcriptomics reveals key gene expression differences between the human and bovine pathogens of the Mycobacterium tuberculosis complex'. Microbiology (Reading, England), 153 (Pt 10):3323-3336. [DOI] [Details]
Brosch R, Gordon SV, Garnier T, Eiglmeier K, Frigui W, Valenti P, Dos Santos S, Duthoy S, Lacroix C, Garcia-Pelayo C, Inwald JK, Golby P, Garcia JN, Hewinson RG, Behr MA, Quail MA, Churcher C, Barrell BG, Parkhill J, Cole ST ; (2007) 'Genome plasticity of BCG and impact on vaccine efficacy'. Proceedings of the National Academy of Sciences of the United States of America, 104 (13):5596-5601. [DOI] [Details]
Ameni G, Aseffa A, Engers H, Young D, Gordon S, Hewinson G, Vordermeier M; (2007) 'High prevalence and increased severity of pathology of bovine tuberculosis in Holsteins compared to zebu breeds under field cattle husbandry in central Ethiopia'. Vaccine, 14 (10):1356-1361. [DOI] [Details]
Winder CL, Gordon SV, Dale J, Hewinson RG, Goodacre R; (2006) 'Metabolic fingerprints of Mycobacterium bovis cluster with molecular type: implications for genotype-phenotype links'. Microbiology (Reading, England), 152 (Pt 9):2757-2765. [DOI] [Details]
Cockle PJ, Gordon SV, Hewinson RG, Vordermeier HM; (2006) 'Field evaluation of a novel differential diagnostic reagent for detection of Mycobacterium bovis in cattle'. Vaccine, 13 (10):1119-1124. [DOI] [Details]
Smith NH, Gordon SV, de la Rua-Domenech R, Clifton-Hadley RS, Hewinson RG; (2006) 'Bottlenecks and broomsticks: the molecular evolution of Mycobacterium bovis'. Nature reviews. Microbiology, 4 (9):670-681. [DOI] [Details]
Cadmus S, Palmer S, Okker M, Dale J, Gover K, Smith N, Jahans K, Hewinson RG, Gordon SV; (2006) 'Molecular analysis of human and bovine tubercle bacilli from a local setting in Nigeria'. Journal of Clinical Microbiology, 44 (1):29-34. [DOI] [Details]
Hewinson RG, Vordermeier HM, Smith NH, Gordon SV; (2006) 'Recent advances in our knowledge of Mycobacterium bovis: a feeling for the organism'. Veterinary Microbiology, 112 (2-4):127-139. [DOI] [Details]
Ewer K, Cockle P, Gordon S, Mansoor H, Govaerts M, Walravens K, MarchÃ© S, Hewinson G, Vordermeier M ; (2006) 'Antigen mining with iterative genome screens identifies novel diagnostics for the Mycobacterium tuberculosis complex'. Vaccine, 13 (1):90-97. [DOI] [Details]
Smith NH, Kremer K, Inwald J, Dale J, Driscoll JR, Gordon SV, van Soolingen D, Hewinson RG, Smith JM ; (2006) 'Ecotypes of the Mycobacterium tuberculosis complex'. Journal of theoretical biology, 239 (2):220-225. [DOI] [Details]
Bigi F, Garcia-Pelayo MC, NuÃ±ez-GarcÃa J, Peralta A, Caimi KC, Golby P, Hinds J, Cataldi A, Gordon SV, Romano MI ; (2005) 'Identification of genetic markers for Mycobacterium pinnipedii through genome analysis'. Fems Microbiology Letters, 248 (2):147-152. [DOI] [Details]
Renshaw PS, Lightbody KL, Veverka V, Muskett FW, Kelly G, Frenkiel TA, Gordon SV, Hewinson RG, Burke B, Norman J, Williamson RA, Carr MD ; (2005) 'Structure and function of the complex formed by the tuberculosis virulence factors CFP-10 and ESAT-6'. Embo Journal, 24 (14):2491-2498. [DOI] [Details]
Mostowy S, Inwald J, Gordon S, Martin C, Warren R, Kremer K, Cousins D, Behr MA; (2005) 'Revisiting the evolution of Mycobacterium bovis'. Journal of Bacteriology, 187 (18):6386-6395. [DOI] [Details]
Cadmus S, Oluwasola A, Gordon SV; (2005) 'Molecular methods needed for the accurate assessment of Mycobacterium bovis infection'. The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 9 (6). [Details]
Keating LA, Wheeler PR, Mansoor H, Inwald JK, Dale J, Hewinson RG, Gordon SV; (2005) 'The pyruvate requirement of some members of the Mycobacterium tuberculosis complex is due to an inactive pyruvate kinase: implications for in vivo growth'. Molecular Microbiology, 56 (1):163-174. [DOI] [Details]
Wheeler PR, Coldham NG, Keating L, Gordon SV, Wooff EE, Parish T, Hewinson RG; (2005) 'Functional demonstration of reverse transsulfuration in the Mycobacterium tuberculosis complex reveals that methionine is the preferred sulfur source for pathogenic Mycobacteria'. Journal of Biological Chemistry, 280 (9):8069-8078. [DOI] [Details]
Renshaw PS, Veverka V, Kelly G, Frenkiel TA, Williamson RA, Gordon SV, Hewinson RG, Carr MD; (2004) 'Sequence-specific assignment and secondary structure determination of the 195-residue complex formed by the Mycobacterium tuberculosis proteins CFP-10 and ESAT-6'. Journal of biomolecular NMR, 30 (2):225-226. [DOI] [Details]
Lightbody KL, Renshaw PS, Collins ML, Wright RL, Hunt DM, Gordon SV, Hewinson RG, Buxton RS, Williamson RA, Carr MD; (2004) 'Characterisation of complex formation between members of the Mycobacterium tuberculosis complex CFP-10/ESAT-6 protein family: towards an understanding of the rules governing complex formation and thereby functional flexibility'. Fems Microbiology Letters, 238 (1):255-262. [DOI] [Details]
Garcia-Pelayo MC, Caimi KC, Inwald JK, Hinds J, Bigi F, Romano MI, van Soolingen D, Hewinson RG, Cataldi A, Gordon SV; (2004) 'Microarray analysis of Mycobacterium microti reveals deletion of genes encoding PE-PPE proteins and ESAT-6 family antigens'. Tuberculosis (Edinburgh, Scotland), 84 (3-4):159-166. [DOI] [Details]
Kutalik Z, Inwald J, Gordon SV, Hewinson RG, Butcher P, Hinds J, Cho KH, Wolkenhauer O ; (2004) 'Advanced significance analysis of microarray data based on weighted resampling: a comparative study and application to gene deletions in Mycobacterium bovis'. Bioinformatics, 20 (3):357-363. [DOI] [Details]
Banu S, Gordon SV, Palmer S, Islam MR, Ahmed S, Alam KM, Cole ST, Brosch R; (2004) 'Genotypic analysis of Mycobacterium tuberculosis in Bangladesh and prevalence of the Beijing strain'. Journal of Clinical Microbiology, 42 (2):674-682. [Details]
Smith NH, Dale J, Inwald J, Palmer S, Gordon SV, Hewinson RG, Smith JM; (2003) 'The population structure of Mycobacterium bovis in Great Britain: clonal expansion'. Proceedings of the National Academy of Sciences of the United States of America, 100 (25):15271-15275. [DOI] [Details]
Inwald J, Jahans K, Hewinson RG, Gordon SV; (2003) 'Inactivation of the Mycobacterium bovis homologue of the polymorphic RD1 gene Rv3879c (Mb3909c) does not affect virulence'. Tuberculosis (Edinburgh, Scotland), 83 (6):387-393. [Details]
Stefanova T, Chouchkova M, Hinds J, Butcher PD, Inwald J, Dale J, Palmer S, Hewinson RG, Gordon SV; (2003) 'Genetic composition of Mycobacterium bovis BCG substrain Sofia'. Journal of Clinical Microbiology, 41 (11). [Details]
Carr MD, Bloemink MJ, Dentten E, Whelan AO, Gordon SV, Kelly G, Frenkiel TA, Hewinson RG, Williamson RA; (2003) 'Solution structure of the Mycobacterium tuberculosis complex protein MPB70: from tuberculosis pathogenesis to inherited human corneal desease'. Journal of Biological Chemistry, 278 (44):43736-43743. [DOI] [Details]
Inwald J, Hinds J, Palmer S, Dale J, Butcher PD, Hewinson RG, Gordon SV; (2003) 'Genomic analysis of Mycobacterium tuberculosis complex strains used for production of purified protein derivative'. Journal of Clinical Microbiology, 41 (8):3929-3932. [Details]
Garnier T, Eiglmeier K, Camus JC, Medina N, Mansoor H, Pryor M, Duthoy S, Grondin S, Lacroix C, Monsempe C, Simon S, Harris B, Atkin R, Doggett J, Mayes R, Keating L, Wheeler PR, Parkhill J, Barrell BG, Cole ST, Gordon SV, Hewinson RG; (2003) 'The complete genome sequence of Mycobacterium bovis'. Proceedings of the National Academy of Sciences of the United States of America, 100 (13):7877-7882. [DOI] [Details]
Cockle PJ, Gordon SV, Lalvani A, Buddle BM, Hewinson RG, Vordermeier HM; (2002) 'Identification of novel Mycobacterium tuberculosis antigens with potential as diagnostic reagents or subunit vaccine candidates by comparative genomics'. Infection and Immunity, 70 (12):6996-7003. [Details]
Inwald J, Hinds J, Dale J, Palmer S, Butcher P, Hewinson RG, Gordon SV; (2002) 'Microarray-Based Comparative Genomics: Genome Plasticity in Mycobacterium bovis'. Genomics, 3 (4):342-344. [DOI] [Details]
Renshaw PS, Panagiotidou P, Whelan A, Gordon SV, Hewinson RG, Williamson RA, Carr MD; (2002) 'Conclusive evidence that the major T-cell antigens of the Mycobacterium tuberculosis complex ESAT-6 and CFP-10 form a tight, 1:1 complex and characterization of the structural properties of ESAT-6, CFP-10, and the ESAT-6CFP-10 complex. Implications for pathogenesis and virulence'. Journal of Biological Chemistry*, 277 (24):21598-21603. [DOI] [Details]
Wooff E, Michell SL, Gordon SV, Chambers MA, Bardarov S, Jacobs WR Jr, Hewinson RG, Wheeler PR; (2002) 'Functional genomics reveals the sole sulphate transporter of the Mycobacterium tuberculosis complex and its relevance to the acquisition of sulphur in vivo'. Molecular Microbiology, 43 (3):653-663. [Details]
Gordon SV, Brosch R, Eiglmeier K, Garnier T, Hewinson RG, Cole ST; (2002) 'Royal Society of Tropical Medicine and Hygiene Meeting at Manson House, London, 18th January 2001. Pathogen genomes and human health. Mycobacterial genomics'. Transactions of the Royal Society of Tropical Medicine and Hygiene, 96 (1):1-6. [Details]
Brosch R, Gordon SV, Marmiesse M, Brodin P, Buchrieser C, Eiglmeier K, Garnier T, Gutierrez C, Hewinson G, Kremer K, Parsons LM, Pym AS, Samper S, van Soolingen D, Cole ST; (2002) 'A new evolutionary scenario for the Mycobacterium tuberculosis complex'. Proceedings of the National Academy of Sciences of the United States of America, 99 (6):3684-3689. [DOI] [Details]
Brosch R, Pym AS, Gordon SV, Cole ST; (2001) 'The evolution of mycobacterial pathogenicity: clues from comparative genomics'. Trends in microbiology, 9 (9):452-458. [Details]
Gordon SV, Eiglmeier K, Garnier T, Brosch R, Parkhill J, Barrell B, Cole ST, Hewinson RG; (2001) 'Genomics of Mycobacterium bovis'. Tuberculosis (Edinburgh, Scotland), 81 (1-2):157-163. [DOI] [Details]
Brosch R, Gordon SV, Pym A, Eiglmeier K, Garnier T, Cole ST; (2000) 'Comparative genomics of the mycobacteria'. International Journal of Medical Microbiology, 290 (2):143-152. [Details]
Brosch R, Gordon SV, Buchrieser C, Pym AS, Garnier T, Cole ST; (2000) 'Comparative genomics uncovers large tandem chromosomal duplications in Mycobacterium bovis BCG Pasteur'. Yeast, 17 (2):111-123. [DOI] [Details]
Brosch R, Gordon SV, Eiglmeier K, Garnier T, Cole ST; (2000) 'Comparative genomics of the leprosy and tubercle bacilli'. Research in Microbiology, 151 (2):135-142. [Details]
Tekaia F, Gordon SV, Garnier T, Brosch R, Barrell BG, Cole ST; (1999) 'Analysis of the proteome of Mycobacterium tuberculosis in silico'. Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 79 (6):329-342. [Details]
Brosch R, Philipp WJ, Stavropoulos E, Colston MJ, Cole ST, Gordon SV; (1999) 'Genomic analysis reveals variation between Mycobacterium tuberculosis H37Rv and the attenuated M. tuberculosis H37Ra strain'. Infection and Immunity, 67 (11):5768-5774. [Details]
Gordon SV, Brosch R, Billault A, Garnier T, Eiglmeier K, Cole ST; (1999) 'Identification of variable regions in the genomes of tubercle bacilli using bacterial artificial chromosome arrays'. Molecular Microbiology, 32 (3):643-655. [Details]
Gordon SV, Heym B, Parkhill J, Barrell B, Cole ST; (1999) 'New insertion sequences and a novel repeated sequence in the genome of Mycobacterium tuberculosis H37Rv'. Microbiology (Reading, England), 145 ( Pt 4) :881-892. [Details]
Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE 3rd, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jagels K, Krogh A, McLean J, Moule S, Murphy L, Oliver K, Osborne J, Quail MA, Rajandream MA, Rogers J, Rutter S, Seeger K, Skelton J, Squares R, Squares S, Sulston JE, Taylor K, Whitehead S, Barrell BG; (1998) 'Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence'. Nature, 393 (6685):537-544. [DOI] [Details]
Brosch R, Gordon SV, Billault A, Garnier T, Eiglmeier K, Soravito C, Barrell BG, Cole ST; (1998) 'Use of a Mycobacterium tuberculosis H37Rv bacterial artificial chromosome library for genome mapping, sequencing, and comparative genomics'. Infection and Immunity, 66 (5):2221-2229. [Details]
O'Brien LM, Gordon SV, Roberts IS, Andrew PW; (1996) 'Response of Mycobacterium smegmatis to acid stress'. Fems Microbiology Letters, 139 (1):11-17. [Details]
Gordon S, Andrew PW; (1996) 'Mycobacterial virulence factors'. Society for Applied Bacteriology symposium series, 25 :1-1. [Details]
Gordon S, Houldsworth S, Duncan K, Roberts IS, Andrew PW; (1996) 'Rapid measurement of antimycobacterial drug activity'. Research in Microbiology, 147 (1-2):79-86. [Details]
Gordon S, Parish T, Roberts IS, Andrew PW; (1994) 'The application of luciferase as a reporter of environmental regulation of gene expression in mycobacteria'. Letters in applied microbiology, 19 (5):336-340. [Details]
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Book Chapters

Gordon, SV and Pym, AS; (2008) 'Genomics of the Mycobacterium tuberculosis complex' In: Kaufmann, SHE and Rubin, E (eds). Hanbook of Tuberculosis. Weinheim: Wiley-VCH. [Details]

Gordon, SV and Brosch, R; (2005) 'Genomics of the Mycobacterium tuberculosis complex and Mycobacterium leprae' In: Encyclopaedia of Genetics, Genomics, Proteomics and Bioinformatics. -: Wiley Interscience. [Details]

Gordon SV and Supply P; (2004) 'Repetitive DNA in the M. tuberculosis complex' In: Tuberculosis and the tubercle bacillus. Washington, DC: ASM Press. [Details]

Cole ST, Bentley SD, Brosch R, Gordon SV, and Hopwood DA ; (2004) 'Genomics of Actinobacteria, the High G+C of Gram-Postive Bacteria' In: Microbial Genomes. -: Humana Press. [DOI] [Details]

Behr, Ma and Gordon, SV; (2002) 'Genomics of the Mycobacterium tuberculosis Complex and BCG Vaccines' In: Pathogen Genomics: Impact on Drug Discovery. USA: Blackwell. [Details]

Conference Contributions

Stephen Gordon (2012) Session Chair: Closing keynote lectures. [Chaired Session], Tuberculosis 2012: Biology, Pathogenesis, Intervention Strategies, Institut Pasteur, Paris, France , 11-SEP-12 - 15-SEP-12.

Stephen Gordon (2012) Next Generation analysis of Mycobacterium bovis. [Plenary Lecture], 1st Mycobacterium bovis American Regional Conference, Merida, Mexico , 19-AUG-12 - 22-AUG-12.

Stephen Gordon (2011) Application of pathogen genomics to TB disease control. [Invited Lecture], Roslin Institute Dept. Seminars, Roslin Institute, Edinburgh, Scotland , 15-JUN-11 - 15-JUN-11.

Stephen Gordon; (2010) Application of genomics to TB disease control. [Invited Lecture], Dept. Genomes and Genetics, Institute Pasteur. Paris , 30-SEP-10 - 30-SEP-10.

Gordon SV; (2010) The molecular evolution of the BCG Vaccine strain. [Plenary Lecture], Latin American Society of Tuberculosis, Zacatecas, Mexico , 23-AUG-10 - 25-AUG-10.

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Reviews

Tuberculosis: Editorial Board member.

Plos One: Editorial Board member.

Microbiology-Sgm: Editorial Board member.

External Collaborators

Prof Glyn Hewinson, Dr Martin Vordermeier, Dr Noel Smith, AHVLA Weybridge, Surrey, UK.

Dr Roland Brosch, Institute Pasteur, Paris, France.

Dr Ed Lavelle, Trinity College, Dublin.

Prof. Stewart T. Cole, EPFL, Lausanne, Switzerland.

Dr Graham Stewart, Univ. Surrey, UK.

Dr Kristine Arnvig, National Institute for Medical Research, UK.

Dr Jean Louis Herrmann, Hopital Raymond Poincaré, and Université de Versailles St Quentin, France.

Teaching Philosophy

Director of Thematic Doctoral Programme in Infection Biology.

Systems Microbiology (INDM40090)

Genomics and Proteomics (BMOL30050)

Intro Veterinary Microbiology (VET30030)

Advances in Infection Biology (VET40080)

Current Concepts in Infection Biology A (VET40090)

Current Concepts in Infection Biology B (VET40100)

Modules Coordinated

201200 VET40250 Veterinary Medicine: MolCellBiol Current Concepts

201200 VET40080 Veterinary Medicine: Advances in Infection Biology

201200 VET40350 Veterinary Medicine: MolCellBiol Current Concepts B

Gordon SV; (2010) Tuberculosis in humans and cattle in Ethiopia:Implications for public health. [Invited Lecture], Trinity International Development Initiative, Trinity College Dublin , 26-FEB-10 - 26-FEB-10.
Gordon SV; (2010) The application of genomics to TB Disease control. [Invited Oral Presentation], Society for General Micorbiology Annual Meeting, Edinburgh, Scotland , 29-MAR-10 - 01-APR-10.
Gordon SV; (2009) Mycobacterial Molecular Genetics. [Invited Oral Presentation], Many Hosts of Mycobacteria, Louisianna , 16-NOV-09 - 17-NOV-09.
Gordon, SV; (2008) Functional Genomics of the Mycobacterium tuberculosis complex:BCG. [Invited Oral Presentation], International Congress of Bacteriology and Applied Microbiology, Istanbul, Turkey , 05-AUG-08 - 09-AUG-08.
Gordon SV; (2008) Genomic Analyses of BCG vaccine strains. [Plenary Lecture], 29th Annual Congress European Society of Mycobacteriology, Plovdic, Bulgaria , 06-JUL-08 - 09-JUL-08.
Gordon SV; (2008) Exploring the genetic basis for host preference between Mycobacteirum tuberculosis and Mycobacterium bovis. [Invited Lecture], Global Health Institute, EPFL, Lausanne, Switzerland , 26-MAY-08 - 26-MAY-08.
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