| Pacquelet S, Lehmann M, Luxen S, Regazzoni K, Frausto M, Noack D, Knaus UG (2008) 'Inhibitory action of NoxA1 on dual oxidase activity in airway cells'. J BIOL CHEM, 283 (36):24649-24658. [Details] |
| Luxen S, Belinsky SA, Knaus UG (2008) 'Silencing of DUOX NADPH oxidases by promoter hypermethylation in lung cancer'. Cancer Research, 68 (4):1037-1045. [Details] |
| Lozano E, Frasa MA, Smolarczyk K, Knaus UG, Braga VM (2008) 'PAK is required for the disruption of E-cadherin adhesion by the small GTPase Rac'. J Cell Sci, 121 (Pt7):933-938. [Details] |
| Maroto B, Ye MB, von Lohneysen K, Schnelzer A, Knaus UG (2008) 'p21-activated kinase is required for mitotic progression and regulates Plk1'. Oncogene, 27 (36):4900-4908. [Details] |
| Kim JS, Diebold BA, Babior BM, Knaus UG, Bokoch GM (2007) 'Regulation of Nox1 activity via protein kinase A-mediated phosphorylation of NoxA1 and 14-3-3 binding'. J BIOL CHEM, 282 (48):34787-34800. [Details] |
| Lombardo E, Alvarez-Barrientos A, Maroto B, Bosca L, Knaus UG (2007) 'TLR4-mediated survival of macrophages is MyD88-dependent and requires TNF-alpha autocrine signaling'. J IMMUNOL, 178 (6):3731-3739. [Details] |
| Zhu Y, Marchal CC, Casbon AJ, Stull N, von Lohneysen K, Knaus UG, Jesaitis AJ, McCormick S, Nauseef WM, Dinauer MC (2006) 'Deletion mutagenesis of p22phox subunit of flavocytochrome b558: identification of regions critical for gp91phox maturation and NADPH oxidase activity'. J BIOL CHEM, 281 (41):30336-30346. [Details] |
| Kravchenko VV, Kaufmann GF, Mathison JC, Scott DA, Katz AZ, Wood MR, Brogan AP, Lehmann M, Mee JM, Iwata K, Pan Q, Fearns C, Knaus UG, Meijler MM, Janda KD, Ulevitch RJ (2006) 'N-(3-oxo-acyl) homoserine lactones signal cell activation through a mechanisms distinct from the canonical pathogen-associated molecular pattern recognition receptor pathways'. J BIOL CHEM, 281 (39):28822-28830. [Details] |
| Perry BN, Govindarajan B, Bhandarkar SS, Knaus UG, Valo M, Sturk C, Carillo CO, Sohn A, Cerimele F, Dumont D, Losken A, Willimas J, Brown LF, Tan X, Ioffe E, Yancopoulos GD, Arbiser JL (2006) 'Pharmacologic blockade of angiopoietin-2 is efficacious against model hemangiomas in mice'. J Invest Dermatol, 126 (10):2316-2322. [Details] |
| Ruse M, Knaus, UG (2006) 'New players in TLR-mediated innate immunity: PI3K and small Rho GTPases'. Immunol Res, 34 (1):33-48. [Details] |
| Martyn KD, Frederick LM, von Lohneysen K, Dinauer MC, Knaus UG (2006) 'Functional analysis of Nox4 reveals unique characteristics compared to other NADPH oxidases'. Cell Signal, 18 (1):69-82. [Details] |
| Martyn KD, Kim MJ, Quinn MT, Dinauer MC, Knaus UG (2005) 'p21-activated kinase (Pak) regulates NADPH oxidase activation in human neutrophils'. Blood, 106 (12):3962-3969. [Details] |
| Yamauchi A, Marchal CC, Molitoris J, Pech N, Knaus U, Towe J, Atkinson SJ, Dinauer MC (2005) 'Rac GTPase isoform-specific regulation of NADPH oxidase and chemotaxis in murine neutrophils in vivo'. J BIOL CHEM, 280 (2):953-964. [Details] |
| Chan AY, Coniglio SJ, Chuang YY, Michaelson D, Knaus UG, Philips MR, Symons M (2005) 'Roles of the Rac1 and Rac3 GTPases in human tumor cell invasion'. Oncogene, 24 (53):7821-7829. [Details] |
| Teusch N, Lombardo E, Eddleston J, Knaus UG (2004) 'The low molecular weight GTPase RhoA and atypical protein kinase Czeta are required for TLR2-mediated gene transcription'. J IMMUNOL, 173 (1):507-514. [Details] |
| Shalom-Barak T, Knaus UG (2002) 'A p21-activated kinase-controlled metabolic switch up-regulates phagocytic NADPH oxidase'. J BIOL CHEM, 277 (43):40659-40665. [Details] |
| Price MO, McPhail LC, Lambeth JD, Han CH, Knaus UG, Dinauer MC (2002) 'Creation of a genetic system for analysis of the phagocyte respiratory burst: high-level reconstitution of the NADPH oxidase in a nonhematopoietic system'. Blood, 99 (8):2653-2661. [Details] |
| Price MO, Atkinson SJ, Knaus UG, Dinauer MC (2002) 'Rac activation induces NADPH oxidase activity in transgenic COSphox cells, and the level of superoxide production is exchange factor-dependent'. J BIOL CHEM, 277 (21):19220-19228. [Details] |
| Arbibe L, Mira JP, Teusch N, Kline L, Guha M, Mackman N, Godowski PJ, Ulevitch RJ, Knaus UG (2000) 'Toll-like receptor2-mediated NF-kappaB activation requires a Rac1-dependent pathway'. Nat Immunol, 1 (6):533-540. [Details] |
| Schnelzer A, Prechtel D, Knaus U, Dehne K, Gerhard M, Graeff H, Harbeck N, Schmitt M, Lengyel E (2000) 'Rac1 in human breast cancer: overexpression, mutation analysis, and characterization of a new isoform, Rac1b'. Oncogene, 19 (26):3013-3020. [Details] |
| Knaus UG (2000) 'Rho GTPase signaling in inflammation and transformation'. Immunol Res, 21 (2-3):103-109. [Details] |
| Mira JP, Benard V, Groffen J, Sanders LC, Knaus UG (2000) 'Endogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21-activated kinase-dependent pathway'. PNAS, 97 (1):185-189. [Details] |
| Wen Y, Gu J, Knaus UG, Thomas L, Gonzales N, Nadler JL (2000) 'Evidence that 12-lipoxygenase product 12-hydroxyeicosatetranoic acid activates p21-activated kinase'. Biochem J, 349 (Pt2):481-487. [Details] |
| Fazal N, Knaus UG, Sabeh F, Gamelli RL, McNulty JA, Sayeed MM (1999) 'Enhanced expression of neutrophil NADPH oxidase components in intestine of rats after burn injury'. Shock, 12 (6):438-442. [Details] |
| Lopes LR, Hoyal CR, Knaus UG, Babior BM (1999) 'Activation of the leukocyte NADPH oxidase by protein kinase C in a partially recombinant cell-free system'. J BIOL CHEM, 274 (22):15533-15537. [Details] |
| Brzeska H, Young R, Knaus UG, Korn ED (1999) 'Myosin I heavy chain kinase: cloning of the full-length gene and acidic lipid-dependent activation by Rac and Cdc42'. PNAS, 96 (2):394-399. [Details] |
| Knaus Ug, Wang Y, Reilly AM, Warnock D, Jackson JH (1998) 'Structural requirements for PAK activation by Rac GTPases'. J BIOL CHEM, 273 (34):21512-21518. [Details] |
| Jones SL, Knaus UG, Bokoch GM, Brown EJ (1998) 'Two signaling mechanisms for activation of alphaM beta2 avidity in polymorphonuclear neutrophils'. J BIOL CHEM, 273 (17):10556-10566. [Details] |
| Bokoch GM, Reilly AM, Daniels RH, King CC, Olivera A, Spiegel S, Knaus UG (1998) 'A GTPase-independent mechanism of p21-activated kinase activation. Regulation by sphingosine and other biologically active lipids'. J BIOL CHEM, 273 (14):8137-8144. [Details] |
| Sells MA, Knaus UG, Bagrodia S, Ambrose DM, Bokoch GM, Chernoff J (1997) 'Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells'. Current Biology, 7 (3):202-210. [Details] |
| Brzeska H, Knaus UG, Wang ZY, Bokoch GM, Korn ED (1997) 'p21-activated kinase has substrate specificity similar to Acanthamoeba myosin I heavy chain kinase and activates Acanthamoeba myosin I'. PNAS, 94 (4):1092-1095. [Details] |
| Ding J, Knaus UG, Lian JP, Bokoch GM, Badwey JA (1996) 'The renaturable 69 and 63-kDa protein kinases that undergo rapid activation in chemoattractant-stimulated guinea pig neutrophils are p21-activated kinases'. J BIOL CHEM, 271 (40):24869-24873. [Details] |
| Bokoch GM, Vlahos CJ, Wang Y, Knaus UG, Traynor-Kaplan AE (1996) 'Rac GTPase interacts specifically with phosphatidylinositol 3-kinase'. Biochem J, 315 (Pt3):775-779. [Details] |
| Knaus UG, Wagner H (1996) 'Effects of boswellic acid of Boswellia serrata and other triterpenic acids on the complement system'. Phytomedicine, 3 :77-81. [Details] |
| Bokoch GM, Wang Y, Bohl BP, Sells MA, Quilliam LA, Knaus UG (1996) 'Interaction of the Nck adapter protein with p21-activated kinase (PAK1)'. J BIOL CHEM, 271 (42):25746-25749. [Details] |
| Zhang S, Han J, Sells MA, Chernoff J, Knaus UG, Ulevitch RJ, Bokoch GM (1995) 'Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pak1'. J BIOL CHEM, 270 (41):23934-23936. [Details] |
| Knaus UG, Morris S, Dong HJ, Chernoff J, Bokoch GM (1995) 'Regulation of human leukocyte p21-activated kinases through G protein-coupled receptors'. Science, 269 (5221):221-223. [Details] |
| Heyworth PG, Knaus UG, Settleman J, Curnutte JT, Bokoch GM (1993) 'Regulation of NADPH oxidase activity by Rac GTPase activating protein(s)'. Mol Biol Cell, 4 (11):1217-1223. [Details] |
| Heyworth PG, Knaus UG, Xu X, Uhlinger DJ, Conroy L, Bokoch GM, Curnutte JT (1993) 'Requirement for posttranslational processing of Rac GTP-binding proteins for activation of human neutrophil NADPH oxidase'. Mol Biol Cell, 4 (3):261-269. [Details] |
| Chuang TH, Xu X, Knaus UG, Hart MJ, Bokoch GM (1993) 'GDP dissociation inhibitor prevents intrinsic and GTPase activating protein-stimulated GTP hydrolysis by the Rac GTP-binding protein'. J BIOL CHEM, 268 (2):775-778. [Details] |
| Puhlmann J, Knaus U, Tubaro A, Schaefer W, Wagner H (1992) 'Immunologically active metallic ion-containing polysaccharides of Achyrocline Satureioides'. Phytochemistry, 31 :2617-2621. [Details] |
| Knaus, UG, Heyworth, PG, Kinsella, BT, Curnutte, JT, Bokoch, GM, (1992) 'Purification and characterization of Rac2 - a cytosolic GTP-binding protein that regulates human neutrophil NADPH oxidase'. J BIOL CHEM, 267 (33):23575-23582. [Details] |
| Knaus UG, Heyworth PG, Kinsella BT, Curnutte JT, Bokoch GM (1992) 'Purification and characterization of Rac2. A cytosolic GTP-binding protein that regulates the human neutrophil NADPH oxidase'. J BIOL CHEM, 267 (33):23575-23582. [Details] |
| Knaus UG, Heyworth PG, Evans T, Curnutte JT, Bokoch GM (1991) 'Regulation of phagocyte oxygen radical production by the GTP-binding protein Rac2'. Science, 254 (5037):1512-1515. [Details] |
| Knaus UG, Wagner H (1988) 'Effects of various polysaccharides on the complement system'. Planta Medica, 54 :565-566. [Details] |
| Wagner H, Fessler B, Knaus UG, Wierer N (1987) 'Zum Wirknachweis antiphlogistischer wirksamer Arzneidrogen'. Zeitschrift fuer Phytotherapie, 8 :135-140. [Details] |
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