Professor William Watson

Research

Professor Bill Watson BSc, PhD

Book Chapters:

Foley, R., DiFranco, M., Bryan, K., Rexhepaj, E., Mulrane, L., Watson R. W., Cunningham, P., Gallagher, W. M. (2008) 'Automated image analysis approaches in histopathology' In: Handbook of Research on Systems Biology Applications in Medicine. Berlin, Germany: Andriani Daskalaki, Max Planck Institute for Molecular Genetics. [Details]

Walsh, S.E., Fitzpatrick, J.M. Watson, R.W.G. (2006) 'Apoptosis and prostate cancer' In: Prostate Cancer Principles and Practice. London: Taylor & Francis. [Details]

Watson R.W.G., McLornan L., McEleny K., Fitzpatrick J.M. (2003) 'Update on the regulation of apoptosis in prostate Cancer' In: J. Mydlo (eds). Prostate Cancer. [Details]

Morrissey C., Watson R.W.G, Fitzpatrick J.M. (2003) 'Apoptosis in the Prostate' In: Kirby R. and OLeary M (eds). Hot Topics in Urology. [Details]

Watson R.W.G., Coffey R., Fitzpatrick J.M. (2000) 'Future Trends in Basic Research: Apoptosis as a target' In: A. Belldegrun, R. Kirby and D.W.W. Newling (eds). New Perspectives in Prostate Cancer. [Details]

Watson R.W.G. (1998) 'Apoptosis: Its role in the systemic inflammatory response syndrome and the involvement of cytokines' In: H. Redl and G. Schlaged (eds). Cytokines in severe sepsis and septic shock. [Details]

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Peer Reviewed Journals:

O'Neill A.J., Prencipe M., Dowling C., Fan Y., Mulrane L., Gallagher W.M., O'Connor D., O'Connor R., Devery A., Corcoran C., Rani S., O¿Driscoll L., Fitzpatrick J., R., Watson R.W.G. (2011) 'Characterisation and Manipulation of Docetaxel Resistant Prostate Cancer Cell Lines'. MOL CANCER, . [Details]

Cuffe, S,Dowling, CM,Claffey, J,Pampillon, C,Hogan, M,Fitzpatrick, JM,Carty, MP,Tacke, M,Watson, RWG (2011) 'Effects of Titanocene Dichloride Derivatives on Prostate Cancer Cells, Specifically DNA Damage-Induced Apoptosis'. Prostate, 71 :111-124. [DOI] [Details]

Saldova, R,Fan, Y,Fitzpatrick, JM,Watson, RWG,Rudd, PM (2011) 'Core fucosylation and alpha 2-3 sialylation in serum N-glycome is significantly increased in prostate cancer comparing to benign prostate hyperplasia'. Glycobiology, 21 :195-205. [DOI] [Details]

Fan, Y,Murphy, TB,Byrne, JC,Brennan, L,Fitzpatrick, JM,Watson, RWG (2011) 'Applying Random Forests To Identify Biomarker Panels in Serum 2D-DIGE Data for the Detection and Staging of Prostate Cancer'. Journal of Proteome Research, 10 :1361-1373. [DOI] [Details]

Oon SF, Pennington SR, Fitzpatrick JM, Watson RW (2011) 'Biomarker research in prostate cancer-towards utility, not futility'. Nature reviews. Cancer, 8 (3):131-138. [Details]

DiFranco, M.D., O'Hurley, G., Kay, E.W., Watson, R.W.G., Cunningham, P., (2011) 'Ensemble based methodology for whole-slide prostate cancer probability mapping'. Computerized Medical Imaging and Graphics, .

[DOI] [Details]

Oon SF, Watson RW, O'Leary JJ, Fitzpatrick JM. (2011) 'Epstein criteria for insignificant prostate cancer'. BJU international, 108 (4):518-525. [Details]
Fan, Y., Murphy, T.B., Byrne, J., Brennan, L., Fitzpatrick, J. and Watson, R.W.G. (2011) 'Applying Random Forests to identify biomarker panels in serum 2D-DIGE data for the detection and staging of prostate cancer'. Journal of Proteome Research, 10 (3):1361-1373. [DOI] [Details]
Kennedy SA, Scaife C, Dunn MJ, Wood AE, Watson RW. (2011) 'Benefits of heat treatment to the protease packed neutrophil for proteome analysis: halting protein degradation'. Proteomics, 11 (12):2560-2564. [Details]
Kinsella A, Raza A, Kennedy S, Fan Y, Wood AE, Watson RW (2011) 'The impact of high-dose statin therapy on transendothelial neutrophil migration and serum cholesterol levels in healthy male volunteers'. . [Details]
Oʼhurley G, Oʼgrady A, Smyth P, Byrne J, Oʼleary JJ, Sheils O, Watson RW, Kay EW. (2010) 'Evaluation of Zinc-alpha-2-Glycoprotein and Proteasome Subunit beta-Type 6 Expression in Prostate Cancer Using Tissue Microarray Technology'. Applied Immunohistochemistry, . [Details]
Burke JP, Cunningham MF, Watson RW, Docherty NG, Coffey JC, O'Connell PR (2010) 'Bacterial lipopolysaccharide promotes profibrotic activation of intestinal fibroblasts'. The British journal of surgery, 97 (7):1126-1134. [DOI] [Details]
Burke JP, Watson RW, Mulsow JJ, Docherty NG, Coffey JC, O'Connell PR (2010) 'Endoglin negatively regulates transforming growth factor beta1-induced profibrotic responses in intestinal fibroblasts'. The British journal of surgery, 97 (6):892-901. [DOI] [Details]
Watson RW, Downes MR, Byrne JC, Pennington SR, Dunn MJ, Fitzpatrick JM, (2007) 'Urinary markers for prostate cancer'. Bju International, 2 (NA):263-268. [DOI] [Details]
Watson RW, Downes MR, Byrne JC, Pennington SR, Dunn MJ, Fitzpatrick JM, (2007) 'Urinary markers for prostate cancer'. Bju International, 2 (NA):263-268. [DOI] [Details]
Watson RW, Downes MR, Byrne JC, Pennington SR, Dunn MJ, Fitzpatrick JM, (2007) 'Urinary markers for prostate cancer'. Bju International, 2 (NA):263-268. [DOI] [Details]
Fizazi K, Sternberg CN, Fitzpatrick JM, Watson RW, Tabesh M (2010) 'Role of targeted therapy in the treatment of advanced prostate cancer'. BJU international, 105 (6):748-767. [DOI] [Details]
Fanning, D. M.,Yue, F.,Fitzpatrick, J. M.,Watson, R. W. 'Novel predictive tools for Irish radical prostatectomy pathological outcomes: development and validation'. Ir J Med Sci, 179 (22):187-95187. [Details]
Smyth, L. G.,O'Hurley, G.,O'Grady, A.,Fitzpatrick, J. M.,Kay, E.,Watson, R. W. 'Carbonic anhydrase IX expression in prostate cancer'. Prostate Cancer Prostatic Dis, 13 (22):178-81178. [Details]
St John Floyd, M., Jr.,Teahan, S. J.,Fitzpatrick, J. M.,Watson, R. W. (2009) 'Differential mechanisms of bicalutamide-induced apoptosis in prostate cell lines'. Prostate Cancer Prostatic Dis, 12 (11):25-3325. [Details]
Fan, Y.,Murphy, T. B.,Watson, R. W. (2009) 'digeR: a graphical user interface R package for analyzing 2D-DIGE data'. Bioinformatics, 25 (2222):3033-43033. [Details]
Watson, J. A.,Watson, C. J.,McCrohan, A. M.,Woodfine, K.,Tosetto, M.,McDaid, J.,Gallagher, E.,Betts, D.,Baugh, J.,O'Sullivan, J.,Murrell, A.,Watson, R. W.,McCann, A. (2009) 'Generation of an epigenetic signature by chronic hypoxia in prostate cells'. Hum Mol Genet, 18 (1919):3594-6043594. [Details]
Saldova, R.,Fan, Y.,Fitzpatrick, J. M.,Watson, R. W.,Rudd, P. M. 'Core fucosylation and {alpha}2-3 sialylation in serum N-glycome is significantly increased in prostate cancer comparing to benign prostate hyperplasia'. Glycobiology, . [Details]
Fanning, DM,Kay, E,Fan, Y,Fitzpatrick, JM,Watson, RWG (2010) 'Prostate cancer grading: the effect of stratification of needle biopsy Gleason Score 4+3 as high or intermediate grade'. Bju International, 105 :631-635. [DOI] [Details]
Fanning, DM,Fan, Y,Fitzpatrick, JM,Watson, RWG (2010) 'External Validation of the 2007 and 2001 Partin Tables in Irish Prostate Cancer Patients'. Urologia Internationalis, 84 :174-179. [DOI] [Details]
Fanning, DM,Yue, F,Fitzpatrick, JM,Watson, RWG (2010) 'Novel predictive tools for Irish radical prostatectomy pathological outcomes: development and validation'. IRISH J MED SCI, 179 :187-195. [DOI] [Details]
Cuffe S, Dowling CM, Claffey J, Pampillón C, Hogan M, Fitzpatrick JM, Carty MP, Tacke M, Watson RW (2010) 'Effects of titanocene dichloride derivatives on prostate cancer cells, specifically DNA damage-induced apoptosis'. Prostate, . [Details]
Watson RW, Kay EW, Smith D (2010) 'Integrating biobanks: addressing the practical and ethical issues to deliver a valuable tool for cancer research'. nature review cancer, 10 (9):646-651. [Details]
Smyth, LG,O'Hurley, G,O'Grady, A,Fitzpatrick, JM,Kay, E,Watson, RWG (2010) 'Carbonic anhydrase IX expression in prostate cancer'. Prostate, 13 :178-181. [DOI] [Details]
Watson RW, Maher BM, Dhonnchu TN, Burke JP, Soo A, Wood AE, (2009) 'Statins alter neutrophil migration by modulating cellular Rho activity--a potential mechanism for statins-mediated pleotropic effects?'. Journal of Leukocyte Biology, 85 (1):186-193. [DOI] [Details]
Watson RW, Gill C, Dowling C, O'Neill AJ, (2009) 'Effects of cIAP-1, cIAP-2 and XIAP triple knockdown on prostate cancer cell susceptibility to apoptosis, cell survival and proliferation'. Cancer, 8 . [DOI] [Details]
Watson RW, Walsh S, Gill C, O'Neill A, Fitzpatrick JM, (2009) 'Hypoxia increases normal prostate epithelial cell resistance to receptor-mediated apoptosis via AKT activation'. International Journal of Cancer, 124 (8):1871-1878. [DOI] [Details]
McCann A, Watson JA, Watson CJ, McCrohan AM, Woodfine K, Tosetto M, McDaid J, Gallagher E, Betts D, Baugh J, O'Sullivan J, Murrell A, Watson RW, (2009) 'Generation of an epigenetic signature by chronic hypoxia in prostate cells'. Human Molecular Genetics, 18 (19):3594-3604. [DOI] [Details]
O'Connell PR, Burke JP, Watson RW, Murphy M, Docherty NG, Coffey JC, (2009) 'Simvastatin impairs smad-3 phosphorylation and modulates transforming growth factor beta1-mediated activation of intestinal fibroblasts'. British Journal of Surgery, 5 (NA):541-551. [DOI] [Details]
Daly, PJ,Docherty, NG,Healy, DA,McGuire, BB,Fitzpatrick, JM,Watson, RWG (2009) 'The single insult of hypoxic preconditioning induces an antiapoptotic response in human proximal tubular cells, in vitro, across cold storage'. Bju International, 103 (NA):254-259. [DOI] [Details]
Walsh, S,Gill, C,O'Neill, A,Fitzpatrick, JM,Watson, RWG (2009) 'Hypoxia increases normal prostate epithelial cell resistance to receptor-mediated apoptosis via AKT activation'. Cancer, 124 :1871-1878. [DOI] [Details]
Soo, A,Maher, B,McCarthy, J,Nolke, L,Wood, A,Watson, RWG (2009) 'Pre-operative Determination of an Individual's Neutrophil Response: A Potential Predictor of Early Cardiac Transplant Cellular Rejection'. Heart, 28 :1198-1205. [DOI] [Details]
Floyd, MSJ,Teahan, SJ,Fitzpatrick, JM,Watson, RWG (2009) 'Differential mechanisms of bicalutamide-induced apoptosis in prostate cell lines'. Prostate, 12 :25-33. [DOI] [Details]
Byrne, JC,Downes, MR,O'Donoghue, N,O'Keane, C,O'Neill, A,Fan, Y,Fitzpatrick, JM,Dunn, MJ,Watson, RWG (2009) '2D-DIGE as a Strategy To Identify Serum Markers for the Progression of Prostate Cancer'. Journal of Proteome Research, 8 :942-957. [DOI] [Details]
Foley, R,Marignol, L,Thomas, AZ,Cullen, IM,Perry, AS,Tewari, P,O'Grady, A,Kay, E,Dunne, B,Loftus, B,Watson, RW,Fitzpatrick, JM,Woodson, K,Lehman, T,Hollywood, D,Lynch, TH,Lawler, M (2009) 'The HIF-1 alpha C1772T polymorphism may be associated with susceptibility to clinically localised prostate cancer but not with elevated expression of hypoxic biomarkers'. Cancer, 8 :118-124. [Details]
Watson RW, Fanning DM, Yue F, Fitzpatrick JM, (2009) 'Novel predictive tools for Irish radical prostatectomy pathological outcomes: development and validation'. Irish Journal of Medical Science, (NA). [DOI] [Details]
Watson RW, Docherty NG, Calvo IF, Quinlan MR, PÃ©rez-Barriocanal F, McGuire BB, Fitzpatrick JM, (2009) 'Increased E-cadherin expression in the ligated kidney following unilateral ureteric obstruction'. Kidney International, 2 (NA):205-213. [DOI] [Details]
Watson RW, Docherty NG, Calvo IF, Quinlan MR, PÃ©rez-Barriocanal F, McGuire BB, Fitzpatrick JM, (2009) 'Increased E-cadherin expression in the ligated kidney following unilateral ureteric obstruction'. Kidney International, 2 (NA):205-213. [DOI] [Details]
Watson RW, Fanning DM, Kay E, Fan Y, Fitzpatrick JM, (2009) 'Prostate cancer grading: the effect of stratification of needle biopsy Gleason Score 4 + 3 as high or intermediate grade'. Bju International, . [DOI] [Details]
Watson RW, Soo A, Maher B, McCarthy J, NÃ¶lke L, Wood A, (2009) 'Pre-operative Determination of an Individual's Neutrophil Response: A Potential Predictor of Early Cardiac Transplant Cellular Rejection'. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, . [DOI] [Details]
Quinlan, M. R., Watson, R. W. G., Docherty, N. G., Fitzpatrick, J. M., (2008) 'Establishment of an in vitro model of mechanical stretch-induced renal tubular cell apoptosis'. Bju International, 101 :41-41. [Details]
Molloy, EJ,O'Neill, AJ,Grantham-Sloan, JJ,Webb, DW,Watson, RWG (2008) 'Maternal and neonatal lipopolysaccharide and Fas responses are altered by antenatal risk factors for sepsis'. Immunology, 151 :244-250. [DOI] [Details]
O'Connell PR, Burke JP, Ferrante M, Dejaegher K, Watson RW, Docherty NG, De Hertogh G, Vermeire S, Rutgeerts P, D'Hoore A, Penninckx F, Geboes K, Van Assche G, (2008) 'Transcriptomic analysis of intestinal fibrosis-associated gene expression in response to medical therapy in Crohn's disease'. Inflammatory bowel diseases, 14 (9):1197-1204. [DOI] [Details]
Docherty N.G , Fuentes Calvo I, Quinlan M.R, Perez-Barriocanal F, McGuire B.B, Fitzpatrick J.M and Watson R.W.G (2008) 'Relative Increases in E-cadherin Expression in Ligated Versus Non-Ligated Kidneys Following Unilateral Ureteric Obstruction'. Kidney International, . [Details]
Burke, JP,Ferrante, M,Dejaegher, K,Watson, RWG,Docherty, NG,De Hertogh, G,Vermeire, S,Rutgeerts, P,D'Hoore, A,Penninckx, F,Geboes, K,Van Assche, G,O'Connell, PR (2008) 'Transcriptomic analysis of intestinal fibrosis-associated gene expression in response to medical therapy in Crohn's disease'. Inflammatory bowel diseases, 14 (NA):1197-1204. [DOI] [Details]
Quinlan M.R, Perez-Barriocanal F, Wright E, Dillon-Murphy R, Watson RWG, Fitzpatrick JM and Docherty NG. (2008) 'Analysis of Urinary and Plasma Electrolytes in a Rat Model of Unilateral Ureteric Obstruction (UUO)'. Open Journal of Urology and Neprology, . [Details]
Docherty N.G , Fuentes Calvo I, Quinlan M.R, Perez-Barriocanal F, McGuire B.B, Fitzpatrick J.M and Watson R.W.G (2008) 'Increased E-cadherin Expression in the Ligated Kidney Following Unilateral Ureteric Obstruction'. Kidney International, . [Details]
Daly P, Docherty N.G, Healy D.A, Taylor C.T, Fitzpatrick J.M and Watson R.W.G. (2008) 'The Single Insult of Hypoxic Preconditioning induces an Anti-apoptotic Response in Human Proximal Tubular Cells, in vitro, Across Cold Storage'. BJU International, . [Details]
Byrne, J. C., Downes, M. R., O'Donoghue, N., Fitzpatrick, J. M., Dunn, M. J., Watson, R. W. G., (2008) 'Fasting status as a consideration for human serum collection and preparation prior to depletion and analysis'. Electrophoresis, 29 (14):3055-3059. [DOI] [Details]
Burke, JP, Mulsow, JJ, O'Keane, C, Docherty, NG, Watson, RWG, O'Connell, PR, (2007) 'Fibrogenesis in Crohn's disease'. The American journal of gastroenterology, 102 (2):439-448. [DOI] [Details]
Bannon, JH,Fichtner, I,O'Neill, A,Pampillon, C,Sweeney, NJ,Strohfeldt, K,Watson, RW,Tacke, M,Mc Gee, MM (2007) 'Substituted titanocenes induce caspase-dependent apoptosis in human epidermoid carcinoma cells in vitro and exhibit antitumour activity in vivo'. British Journal of Cancer, 97 :1234-1241. [DOI] [Details]
Perry, AS,Loftus, B,Moroose, R,Lynch, TH,Hollywood, D,Watson, RWG,Woodson, K,Lawler, M (2007) 'In silico mining identifies IGFBP3 as a novel target of methylation in prostate cancer'. Cancer, 96 :1587-1594. [DOI] [Details]
Hogan, M,Claffey, J,Pampillon, C,Watson, RWG,Tacke, M (2007) 'Synthesis and cytotoxicity studies of new dimethylamino-functionalized and azole-substituted titanocene anticancer drugs'. Meta, 26 :2501-2506. [DOI] [Details]
Lebret, T,Watson, RWG,Molinie, V,Poulain, JE,O'Neill, A,Fitzpatrick, JM,Botto, H (2007) 'HSP90 expression: A new predictive factor for BCG response in stage Ta-T1 grade 3 bladder tumours'. EUR UROL, 51 :161-167. [DOI] [Details]
Lebret, T; Watson, RWG; Molinie, V; Poulain, JE; O'Neill, A; Fitzpatrick, JM; Botto, H; (2007) 'HSP90 expression: A new predictive factor for BCG response in stage Ta-T1 grade 3 bladder tumours'. European Urology, 51 (1):161-167. [Details]
Lebret, T; Watson, RWG; Molinie, V; Poulain, JE; O'Neill, A; Fitzpatrick, JM; Botto, H; (2007) 'HSP90 expression: A new predictive factor for BCG response in stage Ta-T1 grade 3 bladder tumours'. European Urology, 51 (1):161-167. [Details]
Mc Guire, B, Docherty, NG, Fitzpatrick, JM, Watson, RWG, (2007) 'Acute ureteric obstruction leads to increased expression of collagen XVIII and endostatin spanning fragment neostatin'. EUR UROL SUPPL, 6 :114-114. [Details]
McGuire, BB, Watson, RWG, Perez-Barriocanal, F, Fitzpatrick, JM, Docherty, NG, (2007) 'Gender differences in the renin-angiotensin and nitric oxide systems: Relevance in the normal and diseased kidney'. KIDNEY BLOOD PRESS R, 30 :67-80. [Details]
Molloy EJ, O'Neill AJ, Grantham J, Sheridan-Pereira M, Fitzpatrick JM, Webb DW, Watson RWG. (2007) 'Maternal and neonatal lipopolysaccharide responses are altered in encephalopathy'. American Journal of Perinatology, . [Details]
Molloy EJ, O'Neill AJ, Grantham J, Sheridan-Pereira M, Fitzpatrick JM, Webb DW, Watson RWG. (2007) 'Maternal and Neonatal Lipopolysaccharide and Fas responses are altered by sepsis'. Clinical & Experimental Immunology, . [Details]
Healy DG, Wood AE, O Neill A, McCarthy JF, Fitzpatrick JM, Watson RW. (2007) 'Can preoperative modelling of individual neutrophil adhesion responses predict renal morbidity'. European Journal of Cardio-Thoracic Surgery, 31 :1088-1093. [Details]
Healy DG, Watson RW, Fitzpatrick JM, Wood AE. (2007) 'Differential white cell count relationships with human cardiac allograft rejection'. Transplantation Proceedings, 39 (1):218-222. [Details]
Morrissey C, Brown M, O'sullivan J, Weathered N, Watson RW, Tenniswood M. (2007) 'Epigallocatechin-3-gallate and bicalutamide cause growth arrest and apoptosis in NRP-152 and NRP-154 prostate epithelial cells'. Journal of Urology, 14 (6):545-551. [Details]
Hogan, M., Claffey, J. Pampillón, C., Watson, R. W. G., Tacke, M. (2007) 'Synthesis and Cytotoxicity Studies of New Dimethylamino-Functionalised and Azole-Substituted Titanocene Anti-Cancer Drugs'. Organometallics, 26 (10):2501-2506. [Details]
Perrv, A, Loftus, B, Moroose, R, Lynch, T, Hollywood, D, Watson, RWG, Woodson, K, Lawler, M, (2007) 'Promoter hypermethylation of IGFBP3 is an early event in prostate carcinogenesis'. EUR UROL SUPPL, 6 :191-191. [Details]
Beddy, D; Mulsow, J; Watson, RWG; Fitzpatrick, JM; O'Connell, PR; (2006) 'Expression and regulation of connective tissue growth factor by transforming growth factor beta and tumour necrosis factor alpha in fibroblasts isolated from strictures in patients with Crohn's disease'. British Journal of Surgery, 93 (10):1290-1296. [Details]
Healy, DA; Daly, PJ; Docherty, NG; Murphy, M; Fitzpatrick, JM; Watson, RWG; (2006) 'Heat shock-induced protection of renal proximal tubular epithelial cells from cold storage and rewarming injury'. Journal of the American Society of Nephrology, 17 (3):805-812. [Details]
Docherty, NG; McGuire, B; O'Sullivan, OE; Watson, RWG; Fitzpatrick, JM; (2006) 'N-cadherin is upregulated in the obstructed rat kidney and during mechanical stretch and TGF-beta 1 induced emt of tubular cell cultures'. Nephrology Dialysis Transplantation, 21 (NA):37-37. [Details]
Byrne, J; Downes, M; O'Donoghue, N; Dunn, MJ; Fitzpatrick, JM; Watson, RWG; Pennington, SR; (2006) 'Utilising proteomic platforms for the identification of novel serum markers of prostate cancer'. European Urology Supplements, 5 (14):789-789. [Details]
Gill, C; Walsh, S; Morrissey, C; Fitzpatrick, JM; Watson, RWG; (2006) 'Sensitisation of prostate cancer cells to apoptosis involves altered expression of IAPs and increased caspase activation'. European Urology Supplements, 5 (14):796-796. [Details]
Quinlan, JF; Watson, RWG; Kelly, G; Kelly, PM; O'Byrne, JM; Fitzpatrick, JM; (2006) 'Transforming growth factor-beta (TGF-beta) in acute injuries of the spinal cord'. Journal of Bone and Joint Surgery-British Volume, 88B (3):406-410. [Details]
Byrne, J; Downes, M; O'Donoghue, N; Dunn, MJ; Fitzpatrick, JM; Watson, RWG; Pennington, SR; (2006) 'Utilising proteomic platforms for the identification of novel serum markers of prostate cancer'. European Urology Supplements, 5 (14):789-789. [Details]
Byrne, JC; Brennan, L; Downes, MR; O'Donoghue, N; Fitzpatrick, JM; Dunn, MJ; Watson, RWG; Pennington, SR; (2006) 'A combined proteomic and metabolomic analysis of prostate cancer serum samples'. Molecular & Cellular Proteomics, 5 (10):71-71. [Details]
Healy, DG; Watson, RWG; O'Keane, C; Egan, JJ; McCarthy, JF; Hurley, J; Fitzpatrick, J; Wood, AE; (2006) 'Neutrophil transendothelial migration potential predicts rejection severity in human cardiac transplantation'. European Journal of Cardio-Thoracic Surgery, 29 (5):760-766. [Details]
Docherty, NG, McGuire, B, O'Sullivan, OE, Watson, RWG, Fitzpatrick, JM, (2006) 'N-cadherin is upregulated in the obstructed rat kidney and during mechanical stretch and TGF-beta 1 induced emt of tubular cell cultures'. Nephrology Dialysis Transplantation, 21 (NA):37-37. [DOI] [Details]
Molloy, EJ,O'Neill, AJ,Doyle, BT,Grantham, JJ,Taylor, CT,Sheridan-Pereira, M,Fitzpatrick, JM,Webb, DW,Watson, RWG (2006) 'Effects of heat shock and hypoxia on neonatal neutrophil lipopolysaccharide responses: Altered apoptosis, Toll-like receptor-4 and CD11b expression compared with adults'. Biology of the Neonate, 90 :34-39. [DOI] [Details]
O'Kane, HF,Watson, CJ,Johnston, SR,Petak, I,Watson, RWG,Williamson, KE (2006) 'Targeting death receptors in bladder, prostate and renal cancer'. Journal of Urology, 175 :432-438. [DOI] [Details]
Watson RW, O'Connor K, Gill C, Tacke M, Rehmann FJ, Strohfeldt K, Sweeney N, Fitzpatrick JM, (2006) 'Novel titanocene anti-cancer drugs and their effect on apoptosis and the apoptotic pathway in prostate cancer cells'. Apoptosis, 7 (NA):1205-1214. [DOI] [Details]
Healy, D. A.,Daly, P. J.,Docherty, N. G.,Murphy, M.,Fitzpatrick, J. M.,Watson, R. W. (2006) 'Heat shock-induced protection of renal proximal tubular epithelial cells from cold storage and rewarming injury'. J Am Soc Nephrol, 17 (3):805-12. [Details]
Healy D, Watson RWG, O Keane C, O Neill AL, Egan JJ, McCarthy JF, Hurley J, Fitzpatrick JM, Wood AE (2006) 'Individual variation in early neutrophil infiltration of the allograft influences rejection in human cardiac transplantation'. European Journal of Cardio-Thoracic Surgery, 29 (5):760-766. [Details]
Healy DG, Watson RW, O Keane C, Egan JJ, McCarthy JF, Hurley J, Fitzpatrick J, Wood AE. (2006) 'Neutrophil transendothelial migration potential predicts rejection severity in human cardiac transplantation'. European Journal of Cardio-Thoracic Surgery, 29 :760-766. [Details]
Molloy EJ, O'Neill AJ, Doyle BT, Grantham J, Taylor Ct, Sheridan-Pereira M, Fitzpatrick JM, Webb DW, Watson RWG. (2006) 'Altered lipopolysaccharide-induced neutrophil responses following hypoxia and heatshock in both adults and neonates in vitro'. Biology of the Neonate, 90 (1):34-39. [Details]
Pennington SR, Downes MR, Byrne JC, Dunn MJ, Fitzpatrick JM, Watson RW, (2006) 'Application of proteomic strategies to the identification of urinary biomarkers for prostate cancer: a review'. Biomarkers, 5 (NA):406-416. [DOI] [Details]
O'Connell PR, Beddy D, Mulsow J, Watson RW, Fitzpatrick JM, (2006) 'Expression and regulation of connective tissue growth factor by transforming growth factor beta and tumour necrosis factor alpha in fibroblasts isolated from strictures in patients with Crohn's disease'. British Journal of Surgery, 10 (NA):1290-1296. [DOI] [Details]
Watson, RWG, O'Neill, A, Brannigan, AE, Coffey, R, Marshall, JC, Brady, HR, Fitzpatrick, JM, (2006) 'Regulation of Fas antibody induced neutrophil apoptosis is both caspase and mitochondrial dependent (vol 453, pg 67, 1999)'. FEBS Letters, 580 (3):996-996. [Details]
Docherty, N. G.,O'Sullivan, O. E.,Healy, D. A.,Murphy, M.,O'Neill A, J.,Fitzpatrick, J. M.,Watson, R. W. (2006) 'TGF-beta1-induced EMT can occur independently of its proapoptotic effects and is aided by EGF receptor activation'. Am J Physiol Renal Physiol, 290 (5):F1202-12. [Details]
Healy, DG; Watson, RW; O'Neill, AJ; Egan, JJ; McCarthy, JF; Hurley, JP; Fitzpatrick, JM; Wood, AE; (2005) 'Cytoimmunological surveillance in human cardiac transplantation with the neutrophil'. British Journal of Surgery, 92 (10):1322-1322. [Details]
Docherty, NG; Healy, DA; O'Sullivan, OE; Fitzpatrick, JM; Watson, RWG; (2005) 'The presence of EGF increases proliferation and reduces apoptosis without exerting an anti-fibrotic action during TGF-beta 1 induced EMT of tubular epithelial cells'. Nephrology Dialysis Transplantation, 20 (NA):205-205. [Details]
Docherty, NG, Healy, DA, O'Sullivan, OE, Fitzpatrick, JM, Watson, RWG, (2005) 'The presence of EGF increases proliferation and reduces apoptosis without exerting an anti-fibrotic action during TGF-beta 1 induced EMT of tubular epithelial cells'. Nephrology Dialysis Transplantation, 20 (NA):205-205. [Details]
Molloy, EJ; O'Neill, AJ; Grantham, JJ; Sheridan-Pereira, M; Fitzpatrick, JM; Webb, DW; Watson, RWG; (2005) 'Granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor have differential effects on neonatal and adult neutrophil survival and function'. Pediatric Research, 57 (6):806-812. [Details]
Daly, PJA; Power, RE; Healy, DA; Hickey, DP; Fitzpatrick, JM; Watson, RWG; (2005) 'Delayed graft function: a dilemma in renal transplantation'. Bju International, 96 (4):498-501. [Details]
Watson, RWG; Fitzpatrick, JM; (2005) 'Targeting apoptosis in prostate cancer: focus on caspases and inhibitors of apoptosis proteins'. Bju International, 96 (NA):30-34. [Details]
Coffey, RNT,Morrissey, C,Taylor, CT,Fitzpatrick, JM,Watson, RWG (2005) 'Resistance to caspase-dependent, hypoxia-induced apoptosis is not hypoxia-inducible factor-1 alpha mediated in prostate carcinoma cells'. Cancer, 103 :1363-1374. [DOI] [Details]
Beddy, D.,Watson, R. W.,Fitzpatrick, J. M.,O'Connell, P. R. (2004) 'Increased vascular endothelial growth factor production in fibroblasts isolated from strictures in patients with Crohn's disease'. Br J Surg, 91 (1):72-7. [Details]
Power, RE; Doyle, BT; Higgins, D; Brady, HR; Fitzpatrick, JM; Watson, RWG; (2004) 'Mechanical deformation induced apoptosis in human proximal renal tubular epithelial cells is caspase dependent'. Journal of Urology, 171 (1):457-461. [Details]
Molloy, EJ; O'Neill, A; Grantham, JJ; Sheridan-Pereira, M; Fitzpatrick, JM; Webb, DW; Watson, RW; (2004) 'Gender alters neonatal neutrophil survival and lipopolysaccharlde (LPS) responsiveness'. Pediatric Research, 55 (4):398-399. [Details]
Galvin, DJ; Watson, RWG; O'Neill, A; Coffey, RNT; Taylor, C; Gillespie, JI; Fitzpatrick, JM; (2004) 'Hypoxia inhibits human bladder smooth muscle cell proliferation: A potential mechanism of bladder dysfunction'. Neurourology and Urodynamics, 23 (4):342-348. [Details]
Molloy, EJ; O'Neill, AJ; Grantham, JJ; Sheridan-Pereira, M; Fitzpatrick, JM; Webb, DW; Watson, RWG; (2004) 'Labour promotes neonatal neutrophil survival and lipopolysaccharide responsiveness'. PEDIATRIC RESEARCH, 56 (1):99-103. [Details]
Beddy, D, Watson, RWG, Fitzpatrick, JM, O'Connell, PR, (2004) 'Increased vascular endothelial growth factor production in fibroblasts isolated from strictures in patients with Crohn's disease - Author's reply'. British Journal of Surgery, 91 (5):646-646. [Details]
Molloy, EJ,O'Neill, AJ,Grantham, JJ,Sheridan-Pereira, M,Fitzpatrick, JM,Webb, DW,Watson, RW (2004) 'Labor induces a maternal inflammatory response syndrome'. Stet, 190 :448-455. [DOI] [Details]
Beddy, D; Watson, RWG; Fitzpatrick, JM; O'Connell, PR; (2004) 'Increased vascular endothelial growth factor production in fibroblasts isolated from strictures in patients with Crohn's disease - Author's reply'. British Journal of Surgery, 91 (5):646-646. [Details]
O'Neill, AJ; Doyle, BT; Molloy, E; Watson, C; Phelan, D; Greenan, MC; Fitzpatrick, JM; Watson, RWG; (2004) 'Gene expression profile of inflammatory neutrophils: Alterations in the inhibitors of apoptosis proteins during spontaneous and delayed apoptosis'. Shock, 21 (6):512-518. [Details]
Molloy, EJ; O'Neill, A; Grantham, JJ; Sheridan-Pereira, M; Fitzpatrick, JM; Webb, DW; Watson, RW; (2004) 'Gender alters neonatal neutrophil survival and lipopolysaccharlde (LPS) responsiveness'. Pediatric Research, 55 (4):398-399. [Details]
Hegarty, P; Watson, RWG; Hegarty, NJ; Coffey, RNT; Fitzpatrick, JM; (2004) 'Pressure effects on cellular systems: Is there a link with benign prostatic hyperplasia?'. Journal of Urology, 64 (2):195-200. [Details]
Mulsow, J; Watson, RW; Fitzpatrick, JM; O'Connell, R; (2004) 'Transforming growth factor-beta mediates increased production of extracellular matrix by intestinal fibroblasts'. British Journal of Surgery, 91 (NA):64-65. [Details]
Morrissey, C; Bektic, J; Spengler, B; Galvin, D; Christoffel, V; Klocker, H; Fitzpatrick, JM; Watson, RWG; (2004) 'Phytoestrogens derived from Belamcanda chinensis have an antiproliferative effect on prostate cancer cells in vitro'. Journal of Urology, 172 (6):2426-2433. [Details]
Molloy, EJ; O'Neill, AJ; Grantham, JJ; Sheridan-Pereira, M; Fitzpatrick, JM; Webb, DW; Watson, RWG; (2004) 'Labor promotes neonatal neutrophil survival and lipopolysaccharide responsiveness'. Pediatric Research, 56 (1):99-103. [Details]
Galvin, DJ; Watson, RWG; O'Neill, A; Coffey, RNT; Taylor, C; Gillespie, JI; Fitzpatrick, JM; (2004) 'Hypoxia inhibits human bladder smooth muscle cell proliferation: A potential mechanism of bladder dysfunction'. Neurourology and Urodynamics, 23 (4):342-348. [Details]
O'Neill, A; Greenan, MC; Doyle, B; Fitzpatrick, JM; Watson, RWG; (2004) 'Gene profiling of in vitro and in vivo models of delayed neutrophil apoptosis: a common pathway?'. Biochemical Society Transactions, 32 (NA):470-473. [Details]
Bates, JJ; Watson, RWG; Glynn, CM; O'Neill, AJ; Fitzpatrick, JM; Buggy, DJ; (2004) 'Aspirin preserves neutrophil apoptosis after cardiopulmonary bypass'. Shock, 21 (6):495-499. [Details]
McEleny, K; Coffey, R; Morrissey, C; Williamson, K; Zangemeister-Wittke, U; Fitzpatrick, JM; Watson, RWG; (2004) 'An antisense oligonucleotide to cIAP-1 sensitizes prostate cancer cells to Fas and TNF alpha mediated apoptosis'. Prostate, 59 (4):419-425. [Details]
Doyle, BT; O'Neill, AJ; Fitzpatrick, JM; Watson, RWG; (2004) 'Differentiation-induced HL-60 cell apoptosis: A mechanism independent of mitochondrial disruption?'. Apoptosis, 9 (3):345-352. [Details]
Galvin, DJ,Watson, RWG,O'Neill, A,Coffey, RNT,Taylor, C,Gillespie, JI,Fitzpatrick, JM (2004) 'Hypoxia inhibits human bladder smooth muscle cell proliferation: A potential mechanism of bladder dysfunction'. Journal of Urology, 23 :342-348. [DOI] [Details]
Molloy, EJ,O'Neill, AJ,Grantham, JJ,Sheridan-Pereira, M,Fitzpatrick, JM,Webb, DW,Watson, RWG (2004) 'Labor promotes neonatal neutrophil survival and lipopolysaccharide responsiveness'. Pediatric Research, 56 :99-103. [DOI] [Details]
O'Neill, AJ,Doyle, BT,Molloy, E,Watson, C,Phelan, D,Greenan, MC,Fitzpatrick, JM,Watson, RWG (2004) 'Gene expression profile of inflammatory neutrophils: Alterations in the inhibitors of apoptosis proteins during spontaneous and delayed apoptosis'. Shock, 21 :512-518. [DOI] [Details]
McEleny, K,Coffey, R,Morrissey, C,Williamson, K,Zangemeister-Wittke, U,Fitzpatrick, JM,Watson, RWG (2004) 'An antisense oligonucleotide to cIAP-1 sensitizes prostate cancer cells to Fas and TNF alpha mediated apoptosis'. Prostate, 59 :419-425. [DOI] [Details]
Doyle, BT,O'Neill, AJ,Fitzpatrick, JM,Watson, RWG (2004) 'Differentiation-induced HL-60 cell apoptosis: A mechanism independent of mitochondrial disruption?'. Apoptosis, 9 :345-352. [Details]
Power, RE; Doyle, BT; Higgins, D; Brady, HR; Fitzpatrick, JM; Watson, RWG; (2004) 'Mechanical deformation induced apoptosis in human proximal renal tubular epithelial cells is caspase dependent'. Journal of Urology, 171 (1):457-461. [Details]
Doyle, BT; O'Neill, AJ; Fitzpatrick, JM; Watson, RWG; (2004) 'Differentiation-induced HL-60 cell apoptosis: A mechanism independent of mitochondrial disruption?'. Apoptosis, 9 (3):345-352. [Details]
Galvin, DJ; Watson, RWG; O'Neill, A; Coffey, RNT; Taylor, C; Gillespie, JI; Fitzpatrick, JM; (2004) 'Hypoxia inhibits human bladder smooth muscle cell proliferation: A potential mechanism of bladder dysfunction'. Neurourology and Urodynamics, 23 (4):342-348. [Details]
Beddy, D, Watson, RWG, Fitzpatrick, JM, O'Connell, PR, (2004) 'Increased vascular endothelial growth factor production in fibroblasts isolated from strictures in patients with Crohn's disease'. British Journal of Surgery, 91 (1):72-77. [DOI] [Details]
Morrissey, C,Bektic, J,Spengler, B,Galvin, D,Christoffel, V,Klocker, H,Fitzpatrick, JM,Watson, RWG (2004) 'Phytoestrogens derived from Belamcanda chinensis have an antiproliferative effect on prostate cancer cells in vitro'. Journal of Urology, 172 :2426-2433. [DOI] [Details]
A.J. O'Neill, M.C. Greenan, B. Doyle, J.M. Fitzpatrick, R.W.G. Watson (2004) 'Gene profiling of in vitro and in vivo models of delayed neutrophil apoptosis: a common pathway?'. Biochemical Society Transactions, 32 (Pt3) (NA):470-473. [Details]
Lebret, T; Watson, RWG; Molinie, V; O'Neill, A; Gabriel, C; Fitzpatrick, JM; Botto, H; (2003) 'Heat shock proteins HSP27, HSP60, HSP70, and HSP90'. Cancer, 98 (5):970-977. [Details]
Shaw, CM; Watson, RWG; Fitzpatrick, JM; Kerin, MJ; (2003) 'The impact of extracellular matrix proteins on drug resistance in breast cancer cells'. Breast Cancer Research and Treatment, 82 (NA):88-89. [Details]
Beddy, D; Watson, RWG; Fitzpatrick, JM; O'Connell, PR; (2003) 'Increased VEGF production in fibroblasts isolated from patients with Crohn's disease'. British Journal of Surgery, 90 (NA):6-6. [Details]
Beddy, D, Watson, RWG, Fitzpatrick, JM, O'Connell, PR, (2003) 'TNF-alpha regulates expression of cyclooxygenase-2 by fibroblasts in Crohn's disease'. British Journal of Surgery, 90 (5):629-629. [Details]
Beddy, D, Watson, RWG, Fitzpatrick, JM, O'Connell, PR, (2003) 'Increased VEGF production in fibroblasts isolated from patients with Crohn's disease'. British Journal of Surgery, 90 (NA):6-6. [Details]
Hegarty NJ, Young LS, O'Neill AJ, Watson RW, Fitzpatrick JM (2003) 'Endothelin in unilateral uretheral obstruction: vascular and cellular effects'. Journal of Urology, 169 (2):740-744. [Details]
Kell, MR; Sweeney, K; Beddy, D; Connelly, J; Winter, DC; Watson, RGW; Fitzpatrick, JM; Kerin, M; (2003) 'Systemic T-cells are primed for a tumour permissive phenotype in breast cancer patients'. British Journal of Surgery, 90 (5):602-603. [Details]
Beddy, D; Watson, RWG; Fitzpatrick, JM; O'Connell, PR; (2003) 'TNF-alpha regulates expression of cyclooxygenase-2 by fibroblasts in Crohn's disease'. British Journal of Surgery, 90 (5):629-629. [Details]
Healy, DA,Watson, RWG,Newsholme, P (2003) 'Polyunsaturated and monounsaturated fatty acids increase neutral lipid accumulation, caspase activation and apoptosis in a neutrophil-like, differentiated HL-60 cell line'. Clinical Science, 104 :171-179. [Details]
Murphy, BM,O'Neill, AJ,Adrain, C,Watson, RWG,Martin, SJ (2003) 'The apoptosome pathway to caspase activation in primary human Neutrophils exhibits dramatically reduced requirements for cytochrome c'. Experimental Medicine, 197 :625-632. [DOI] [Details]
Lebret, T,Watson, RWG,Molinie, V,O'Neill, A,Gabriel, C,Fitzpatrick, JM,Botto, H (2003) 'Heat shock proteins HSP27, HSP60, HSP70, and HSP90'. Cancer, 98 :970-977. [DOI] [Details]
Molloy, EJ,O'Neill, AJ,Grantham, JJ,Sheridan-Pereira, M,Fitzpatrick, JM,Webb, DW,Watson, RWG (2003) 'Sex-specific alterations in neutrophil apoptosis: the role of estradiol and progesterone'. Blood, 102 :2653-2659. [Details]
Higgins, DF,Lappin, DWP,Kieran, NE,Anders, HJ,Watson, RWG,Strutz, F,Schlondorff, D,Haase, VH,Fitzpatrick, JM,Godson, C,Brady, HR (2003) 'DNA oligonucleotide microarray technology identifies fisp-12 among other potential fibrogenic genes following murine unilateral ureteral obstruction (UUO): Modulation during epithelial-mesenchymal transition'. Kidney International, 64 :2079-2091. [Details]
Burke, JG,Watson, RWG,Conhyea, D,McCormack, D,Dowling, FE,Walsh, MG,Fitzpatrick, JM (2003) 'Human nucleus pulposis can respond to a pro-inflammatory stimulus'. Spine, 28 :2685-2693. [Details]
Kell, MR, Sweeney, K, Beddy, D, Connelly, J, Winter, DC, Watson, RGW, Fitzpatrick, JM, Kerin, M, (2003) 'Systemic T-cells are primed for a tumour permissive phenotype in breast cancer patients'. British Journal of Surgery, 90 (5):602-603. [Details]
Hegarty, NJ,Young, LS,O'Neill, AJ,Watson, RWG,Fitzpatrick, JM (2003) 'Endothelin in unilateral ureteral obstruction: Vascular and cellular effects'. Journal of Urology, 169 :740-744. [DOI] [Details]
Kell, MR, Sweeney, K, Beddy, D, Connelly, J, Winter, DC, Watson, RGW, Fitzpatrick, JM, Kerin, M, (2003) 'Systemic T-cells are primed for a tumour permissive phenotype in breast cancer patients'. British Journal of Surgery, 90 (5):602-603. [Details]
Hegarty, NJ; Young, LS; O'Neill, AJ; Watson, RWG; Fitzpatrick, JM; (2003) 'Endothelin in unilateral ureteral obstruction: Vascular and cellular effects'. Journal of Urology, 169 (2):740-744. [Details]
Burke, JG; Watson, RWG; Conhyea, D; McCormack, D; Dowling, FE; Walsh, MG; Fitzpatrick, JM; (2003) 'Human nucleus pulposis can respond to a pro-inflammatory stimulus'. Spine, 28 (24):2685-2693. [Details]
Murphy, BM; O'Neill, AJ; Adrain, C; Watson, RWG; Martin, SJ; (2003) 'The apoptosome pathway to caspase activation in primary human Neutrophils exhibits dramatically reduced requirements for cytochrome c'. Experimental Medicine, 197 (5):625-632. [Details]
Lebret, T; Watson, RWG; Molinie, V; O'Neill, A; Gabriel, C; Fitzpatrick, JM; Botto, H; (2003) 'Heat shock proteins HSP27, HSP60, HSP70, and HSP90'. Cancer, 98 (5):970-977. [Details]
Molloy, EJ; O'Neill, AJ; Grantham, JJ; Sheridan-Pereira, M; Fitzpatrick, JM; Webb, DW; Watson, RWG; (2003) 'Sex-specific alterations in neutrophil apoptosis: the role of estradiol and progesterone'. BLOOD, 120 (7):2653-2659. [Details]
Healy, DA; Watson, RWG; Newsholme, P; (2003) 'Polyunsaturated and monounsaturated fatty acids increase neutral lipid accumulation, caspase activation and apoptosis in a neutrophil-like, differentiated HL-60 cell line'. Clinical Science, 104 (2):171-179. [Details]
Hegarty, NJ; Young, LS; O'Neill, AJ; Watson, RWG; Fitzpatrick, JM; (2003) 'Endothelin in unilateral ureteral obstruction: Vascular and cellular effects'. Journal of Urology, 169 (2):740-744. [Details]
Brady HR, Higgins DF, Lappin DW, Kieran NE, Anders HJ, Watson RW, Strutz F, Schlondorff D, Haase VH, Fitzpatrick JM, Godson C, (2003) 'DNA oligonucleotide microarray technology identifies fisp-12 among other potential fibrogenic genes following murine unilateral ureteral obstruction (UUO): modulation during epithelial-mesenchymal transition'. Kidney International, 64 (6):2079-2091. [DOI] [Details]
Brady HR, Higgins DF, Lappin DW, Kieran NE, Anders HJ, Watson RW, Strutz F, Schlondorff D, Haase VH, Fitzpatrick JM, Godson C, (2003) 'DNA oligonucleotide microarray technology identifies fisp-12 among other potential fibrogenic genes following murine unilateral ureteral obstruction (UUO): modulation during epithelial-mesenchymal transition'. Kidney International, 64 (6):2079-2091. [DOI] [Details]
Brady HR, Higgins DF, Lappin DW, Kieran NE, Anders HJ, Watson RW, Strutz F, Schlondorff D, Haase VH, Fitzpatrick JM, Godson C, (2003) 'DNA oligonucleotide microarray technology identifies fisp-12 among other potential fibrogenic genes following murine unilateral ureteral obstruction (UUO): modulation during epithelial-mesenchymal transition'. Kidney International, 64 (6):2079-2091. [DOI] [Details]
Coffey, RNT; Watson, RWG; O'Neill, AJ; Mc Eleny, K; Fitzpatrick, JM; (2002) 'Androgen-mediated resistance to apoptosis'. Prostate, 53 (4):300-309. [Details]
Barry, TL; Watson, RWG; Kennedy, M; Fitzpatrick, JM; Kerin, MJ; (2002) 'Expression versus-activity. A mechanism implicating cyclooxygenase-2 in breast cancer drug resistance'. Journal of Pathology, 198 (NA):28-28. [Details]
McEleny, KR; Watson, RWG; Coffey, RNT; O'Neill, AJ; Fitzpatrick, JM; (2002) 'Inhibitors of apoptosis proteins in prostate cancer cell lines'. Prostate, 51 (2):133-140. [Details]
Hegarty, PK; Watson, RWG; Coffey, RNT; Webber, MM; Fitzpatrick, JM; (2002) 'Effects of cyclic stretch on prostatic cells in culture'. Journal of Urology, 168 (5):2291-2295. [Details]
Higgins, DF; Lappin, DWP; Isaka, Y; Watson, RW; Godson, C; Imai, E; Fitzpatrick, JM; Brady, HR; (2002) 'Transcriptomic responses underpinning renal tubulointerstitial fibrosis as identified by DNA oligonucleotide microarray technology'. Journal of the American Society of Nephrology, 13 (NA):560-560. [Details]
Burke, JG,Watson, RWG,McCormack, D,Dowling, FE,Walsh, MG,Fitzpatrick, JM (2002) 'Intervertebral discs which cause low back pain secrete high levels of proinflammatory mediators'. Bone, 84B :196-201. [Details]
McEleny, KR,Watson, RWG,Coffey, RNT,O'Neill, AJ,Fitzpatrick, JM (2002) 'Inhibitors of apoptosis proteins in prostate cancer cell lines'. Prostate, 51 :133-140. [DOI] [Details]
Hegarty, NJ,Watson, RWG,Young, LS,O'Neill, AJ,Brady, HR,Fitzpatrick, JM (2002) 'Cytoprotective effects of nitrates in a cellular model of hydronephrosis'. Kidney International, 62 :70-77. [Details]
Burke, JG,Watson, RWG,McCormack, D,Dowling, FE,Walsh, MG,Fitzpatrick, JM (2002) 'Spontaneous production of monocyte chemoattractant protein-1 and interleukin-8 by the human lumbar intervertebral disc'. Spine, 27 :1402-1407. [Details]
Healy, DA,Watson, RWG,Newsholme, P (2002) 'Glucose, but not glutamine, protects against spontaneous and anti-Fas antibody-induced apoptosis in human neutrophils'. Clinical Science, 103 :179-189. [Details]
Hegarty, PK,Watson, RWG,Coffey, RNT,Webber, MM,Fitzpatrick, JM (2002) 'Effects of cyclic stretch on prostatic cells in culture'. Journal of Urology, 168 :2291-2295. [DOI] [Details]
Galvin, DJ,Watson, RWG,Gillespie, JI,Brady, H,Fitzpatrick, JM (2002) 'Mechanical stretch regulates cell survival in human bladder smooth muscle cells in vitro'. American Journal of Physiology-Renal Physiology, 283 :1192-1199. [DOI] [Details]
Coffey, RNT,Watson, RWG,O'Neill, AJ,Mc Eleny, K,Fitzpatrick, JM (2002) 'Androgen-mediated resistance to apoptosis'. Prostate, 53 :300-309. [DOI] [Details]
Burke, JG; Watson, RWG; McCormack, D; Dowling, FE; Walsh, MG; Fitzpatrick, JM; (2002) 'Intervertebral discs which cause low back pain secrete high levels of proinflammatory mediators'. Journal of Bone and Joint Surgery-British Volume, 84B (2):196-201. [Details]
Healy, DA; Watson, RWG; Newsholme, P; (2002) 'Glucose, but not glutamine, protects against spontaneous and anti-Fas antibody-induced apoptosis in human neutrophils'. Clinical Science, 103 (2):179-189. [Details]
Higgins, DF; Lappin, DWP; Isaka, Y; Watson, RW; Godson, C; Imai, E; Fitzpatrick, JM; Brady, HR; (2002) 'Transcriptomic responses underpinning renal tubulointerstitial fibrosis as identified by DNA oligonucleotide microarray technology'. Journal of the American Society of Nephrology, 13 (NA):560-560. [Details]
McEleny, KR; Watson, RWG; Coffey, RNT; O'Neill, AJ; Fitzpatrick, JM; (2002) 'Inhibitors of apoptosis proteins in prostate cancer cell lines'. Prostate, 51 (2):133-140. [Details]
Coffey, RNT; Watson, RWG; Taylor, CT; Fitzpatrick, JM; (2002) 'Altered sensitivity to hypoxia in prostate cancer cell lines; Hypoxia-induced apoptosis a mitochondrial independent event'. British Journal of Cancer, 86 (NA):101-101. [Details]
Murphy, DG; Fitzpatrick, JM; Watson, RWG; (2002) 'Changes in the apoptotic phenotype of prostatic epithelial cells during their differentiation from basal to luminal secretory'. British Journal of Cancer, 86 (NA):81-81. [Details]
Barry, T; Watson, RWG; Hanlon, DO; Kennedy, M; Gorey, TF; Fitzpatrick, JM; Kerin, MJ; (2002) 'A mechanism of drug resistance in breast cancer implicating Cox-2. Will NSAIDs be the answer?'. British Journal of Cancer, 86 (NA):22-22. [Details]
Hegarty, N. J.,Watson, R. W.,Young, L. S.,O'Neill, A. J.,Brady, H. R.,Fitzpatrick, J. M. (2002) 'Cytoprotective effects of nitrates in a cellular model of hydronephrosis'. Kidney Int, 62 (1):70-7. [Details]
Hegarty, N.J., Watson, R.W.G., Young, L.S., ONeill, A.J., Brady, H.R., and Fitzpatrick, J.M. (2002) 'Cytoprotective effects of nitrates in a cellular model of hydronephrosis'. 62 (1):70-77. [Details]
Brannigan, A. E.,Watson, R. W.,Beddy, D.,Hurley, H.,Fitzpatrick, J. M.,O'Connell, P. R. (2002) 'Increased adhesion molecule expression in serosal fibroblasts isolated from patients with inflammatory bowel disease is secondary to inflammation'. Ann Surg, 235 (4):507-11. [Details]
Doyle, BT,O'Neill, AJ,Newsholme, P,Fitzpatrick, JM,Watson, RWG (2002) 'The loss of IAP expression during HL-60 cell differentiation is caspase-independent'. Journal of Leukocyte Biology, 71 (NA):247-254. [Details]
Doyle, BT,O'Neill, AJ,Newsholme, P,Fitzpatrick, JM,Watson, RWG (2002) 'The loss of IAP expression during HL-60 cell differentiation is caspase-independent'. Journal of Leukocyte Biology, 71 (NA):247-254. [Details]
Coffey, RNT; Watson, RWG; Hegarty, PK; Watson, CL; Wolohan, L; Brady, HR; O'Keane, C; Fitzpatrick, JM; (2001) 'Priming prostate carcinoma cells for increased apoptosis is associated with up-regulation of the caspases'. Cancer, 92 (9):2297-2308. [Details]
Kavanagh, EG; Watson, RW; Lederer, JA; Fitzpatrick, JM; O'Connell, PR; (2001) 'Activated neutrophils upregulate T-cell responses in patients with acute pancreatitis'. British Journal of Surgery, 88 (5):745-746. [Details]
O'Brien, MF; Watson, RWG; Fitzpatrick, JM; (2001) 'Insulin-like growth factor I and prostate cancer'. Journal of Urology, 58 (1):1-7. [Details]
Coffey, RNT; Watson, RWG; Fitzpatrick, JM; (2001) 'Signaling for the caspases: Their role in prostate cell apoptosis'. Journal of Urology, 165 (1):5-14. [Details]
Goh, J; Baird, AW; O'Keane, C; Watson, RWG; Cottell, D; Bernasconi, G; Petasis, NA; Godson, C; Brady, HR; MacMathuna, P; (2001) 'Lipoxin A(4) and aspirin-triggered 15-epi-lipoxin A(4) antagonize TNF-alpha-stimulated neutrophil-enterocyte interactions in vitro and attenuate TNF-alpha-induced chemokine release and colonocyte apoptosis in human intestinal mucosa ex vivo'. Immunology, 167 (5):2772-2780. [Details]
O'Neill, AJ,Boran, SA,O'Keane, C,Coffey, RNT,Hegarty, NJ,Hegarty, P,Gaffney, EF,Fitzpatrick, JM,Watson, RWG (2001) 'Caspase 3 expression in benign prostatic hyperplasia and prostate carcinoma'. Prostate, 47 :183-188. [Details]
Goh, J,Baird, AW,O'Keane, C,Watson, RWG,Cottell, D,Bernasconi, G,Petasis, NA,Godson, C,Brady, HR,MacMathuna, P (2001) 'Lipoxin A(4) and aspirin-triggered 15-epi-lipoxin A(4) antagonize TNF-alpha-stimulated neutrophil-enterocyte interactions in vitro and attenuate TNF-alpha-induced chemokine release and colonocyte apoptosis in human intestinal mucosa ex vivo'. J IMMUNOL, 167 :2772-2780. [Details]
Kavanagh, EG, Watson, RW, Lederer, JA, Fitzpatrick, JM, O'Connell, PR, (2001) 'Activated neutrophils upregulate T-cell responses in patients with acute pancreatitis'. British Journal of Surgery, 88 (5):745-746. [Details]
Goh, J; Baird, AW; O'Keane, C; Watson, RWG; Cottell, D; Bernasconi, G; Petasis, NA; Godson, C; Brady, HR; MacMathuna, P; (2001) 'Lipoxin A(4) and aspirin-triggered 15-epi-lipoxin A(4) antagonize TNF-alpha-stimulated neutrophil-enterocyte interactions in vitro and attenuate TNF-alpha-induced chemokine release and colonocyte apoptosis in human intestinal mucosa ex vivo'. Immunology, 167 (5):2772-2780. [Details]
Goh, J., Baird, A.W., O'Keane, C., Watson, R.W., Cottell, D., Bernasconi, G., Petasis, N.A., Godson, C., Brady H.R., and MacMathuna (2001) 'Lipoxin A(4) and aspirin-triggered 15-epi-lipoxin A(4) antagonize TNF-alpha-stimulated neutrophil-enterocyte interactions in vitro and attenuate TNF-alpha-induced chemokine release and colonocyte apoptosis in human intestinal mucosa ex vivo'. Immunology, 167 :2772-2780. [Details]
Hegarty, N.J., Young, L.S., Bouchier-Hayes, D.M., Sweeney, P., Watson, R.G.W., and Fitzpatrick, J.M. (2001) 'Regional renal blood flow changes following ureteric obstruction'. 59 :1059-1065. [Details]
Coffey, R. N.,Watson, R. W.,Hegarty, P. K.,Watson, C. L.,Wolohan, L.,Brady, H. R.,O'Keane, C.,Fitzpatrick, J. M. (2001) 'Priming prostate carcinoma cells for increased apoptosis is associated with up-regulation of the caspases'. Cancer, 92 (9):2297-308. [Details]
Goh, J.,Baird, A. W.,O'Keane, C.,Watson, R. W.,Cottell, D.,Bernasconi, G.,Petasis, N. A.,Godson, C.,Brady, H. R.,MacMathuna, P. (2001) 'Lipoxin A(4) and aspirin-triggered 15-epi-lipoxin A(4) antagonize TNF-alpha-stimulated neutrophil-enterocyte interactions in vitro and attenuate TNF-alpha-induced chemokine release and colonocyte apoptosis in human intestinal mucosa ex vivo'. J Immunol, 167 (5):2772-80. [Details]
O'Neill, AJ; Doyle, BT; Fitzpatrick, JM; Watson, RWG; (2001) 'Inhiitors of apoptosis proteins expressed at a basal level in normal or inflammatory neutrophils'. FASEB Journal, 15 (4):335-335. [Details]
Molloy, EJ; O'Neill, AJ; Sheridan-Pereira, M; Fitzpatrick, JM; Webb, DW; Watson, RWG; (2001) 'Maternal and neonatal apoptosis at delivery: A mechanism for bacterial susceptibility?'. FASEB Journal, 15 (4):369-369. [Details]
Doyle, BT; O'Neill, AJ; Newsholme, P; Fitzpatrick, JM; Watson, RWG; (2001) 'HL-60 cell differentiation and resulting apoptosis is associated with decreased expression of the inhibitors of apoptosis protein'. FASEB Journal, 15 (4):313-313. [Details]
Hurley, H; Doyle, BT; O'Neill, AJ; Fitzpatrick, JM; Watson, RWG; (2001) 'Heat shock protein expression inhibits etoposide induced apoptosis in HL60 cells'. FASEB Journal, 15 (4):315-315. [Details]
Molloy, EJ; O'Neill, AJ; Sheridan-Pereira, M; Fitzpatrick, JM; Webb, DW; Watson, RWG; (2001) 'Maternal and neonatal apoptosis at delivery: A mechanism for bacterial susceptibility?'. FASEB Journal, 15 (4):369-369. [Details]
Doyle, BT; O'Neill, AJ; Newsholme, P; Fitzpatrick, JM; Watson, RWG; (2001) 'HL-60 cell differentiation and resulting apoptosis is associated with decreased expression of the inhibitors of apoptosis protein'. FASEB Journal, 15 (4):313-313. [Details]
Hurley, H; Doyle, BT; O'Neill, AJ; Fitzpatrick, JM; Watson, RWG; (2001) 'Heat shock protein expression inhibits etoposide induced apoptosis in HL60 cells'. FASEB Journal, 15 (4):315-315. [Details]
Doyle, BT; O'Neill, AJ; Newsholme, P; Fitzpatrick, JM; Watson, RWG; (2001) 'HL-60 cell differentiation and resulting apoptosis is associated with decreased expression of the inhibitors of apoptosis protein'. FASEB Journal, 15 (4):313-313. [Details]
Brannigan, AE; O'Connell, PR; Hurley, H; O'Neill, A; Brady, HR; Fitzpatrick, JM; Watson, RWG; (2000) 'Neutrophil apoptosis is delayed in patients with inflammatory bowel disease'. Shock, 13 (5):361-366. [Details]
O'Neill, AJ,O'Neill, S,Hegarty, NJ,Coffey, RNT,Gibbons, N,Brady, H,Fitzpatrick, JM,Watson, RWG (2000) 'Glutathione depletion-induced neutrophil apoptosis is caspase 3 dependent'. Shock, 14 :605-609. [Details]
Gibbons, NB,Watson, RWG,Coffey, RNT,Brady, HP,Fitzpatrick, JM (2000) 'Heat-shock proteins inhibit induction of prostate cancer cell apoptosis'. Prostate, 45 :58-65. [Details]
O'Neill, S,O'Neill, AJ,Conroy, E,Brady, HR,Fitzpatrick, JM,Watson, RWG (2000) 'Altered caspase expression results in delayed neutrophil apoptosis in acute pancreatitis'. Journal of Leukocyte Biology, 68 :15-20. [Details]
Brannigan, AE,O'Connell, PR,Hurley, H,O'Neill, A,Brady, HR,Fitzpatrick, JM,Watson, RWG (2000) 'Neutrophil apoptosis is delayed in patients with inflammatory bowel disease'. Shock, 13 :361-366. [Details]
Brannigan, AE, O'Connell, PR, Hurley, H, O'Neill, A, Brady, HR, Fitzpatrick, JM, Watson, RWG, (2000) 'Neutrophil apoptosis is delayed in patients with inflammatory bowel disease'. Shock, 13 (5):361-366. [Details]
O'Neill, AJ; O'Neill, S; Hegarty, NJ; Coffey, RNT; Gibbons, N; Brady, H; Fitzpatrick, JM; Watson, RWG; (2000) 'Glutathione depletion-induced neutrophil apoptosis is caspase 3 dependent'. Shock, 14 (6):605-609. [Details]
O'Neill, S; O'Neill, AJ; Conroy, E; Brady, HR; Fitzpatrick, JM; Watson, RWG; (2000) 'Altered caspase expression results in delayed neutrophil apoptosis in acute pancreatitis'. Journal of Leukocyte Biology, 68 (1):15-20. [Details]
Watson, RWG; Fitzpatrick, JM; (2000) 'Target sites for manipulating apoptosis in prostate cancer'. Bju International, 85 (NA):38-44. [Details]
Gibbons, NB; Watson, RWG; Coffey, RNT; Brady, HP; Fitzpatrick, JM; (2000) 'Heat-shock proteins inhibit induction of prostate cancer cell apoptosis'. Prostate, 45 (1):58-65. [Details]
Brannigan, AE; O'Connell, PR; Hurley, H; O'Neill, A; Brady, HR; Fitzpatrick, JM; Watson, RWG; (2000) 'Neutrophil apoptosis is delayed in patients with inflammatory bowel disease'. Shock, 13 (5):361-366. [Details]
Smith, JD; O'Neill, A; Brady, HR; Fitzpatrick, JM; Watson, RWG; (2000) 'Cellular glutathione extrusion is an integral part of neutrophil apoptosis'. FASEB Journal, 14 (4):194-194. [Details]
O'Neill, AJ; Brady, HR; Fitzpatrick, JM; Watson, RWG; (2000) 'Neutrophil apoptosis is associated with altered caspase processing'. FASEB Journal, 14 (4):194-194. [Details]
Smith, JD; O'Neill, A; Brady, HR; Fitzpatrick, JM; Watson, RWG; (2000) 'Cellular glutathione extrusion is an integral part of neutrophil apoptosis'. FASEB Journal, 14 (4):194-194. [Details]
Coffey, R. N.,Watson, R. W.,Hegarty, N. J.,O'Neill, A.,Gibbons, N.,Brady, H. R.,Fitzpatrick, J. M. (2000) 'Thiol-mediated apoptosis in prostate carcinoma cells'. Cancer, 88 (9):2092-104. [Details]
O'Neill, S.,O'Neill, A. J.,Conroy, E.,Brady, H. R.,Fitzpatrick, J. M.,Watson, R. W. (2000) 'Altered caspase expression results in delayed neutrophil apoptosis in acute pancreatitis'. J Leukoc Biol, 68 (1):15-20. [Details]
O'Neill, S; O'Neill, AJ; Conroy, E; Brady, HR; Fitzpatrick, JM; Watson, RWG; (2000) 'Altered caspase expression results in delayed neutrophil apoptosis in acute pancreatitis'. Journal of Leukocyte Biology, 68 (1):15-20. [Details]
Brannigan, A. E.,O'Connell, P. R.,Hurley, H.,O'Neill, A.,Brady, H. R.,Fitzpatrick, J. M.,Watson, R. W. (2000) 'Neutrophil apoptosis is delayed in patients with inflammatory bowel disease'. Shock, 13 (5):361-6. [Details]
Brannigan, A. E.,O'Connell, P. R.,Hurley, H.,O'Neill, A.,Brady, H. R.,Fitzpatrick, J. M.,Watson, R. W. (2000) 'Neutrophil apoptosis is delayed in patients with inflammatory bowel disease'. Shock, 13 (5):361-6. [Details]
Watson, RWG; Coffey, R; O'Neill, A; Fitzpatrick, JM; (1999) 'Caspase protease manipulation: a novel approach to apoptotic induction in prostate cancer'. Prostate Cancer and Prostatic Diseases, 2 (NA):34-34. [Details]
Watson, RWG; Coffey, R; O'Neill, A; Fitzpatrick, JM; (1999) 'Caspase protease manipulation: a novel approach to apoptotic induction in prostate cancer'. Prostate Cancer and Prostatic Diseases, 2 (NA):34-34. [Details]
O'Neill, AJ; Brady, HR; Fitzpatrick, JM; Watson, RWG; (1999) 'Differential role of the mitochondria in neutrophil apoptosis'. FASEB Journal, 13 (5):661-661. [Details]
O'Neill, AJ; Murtagh, JC; Brady, HR; Fitzpatrick, JM; Watson, RWG; (1999) 'Delayed neutrophil apoptosis is associated with altered caspase 3 processing'. Journal of Leukocyte Biology, -1 (NA):25-25. [Details]
O'Neill, S; Conroy, E; O'Neill, A; Brady, HR; Fitzpatrick, JM; Watson, RWG; (1999) 'Altered caspase expression results in delayed neutrophil apoptosis in acute pancreatitis'. FASEB Journal, 13 (5):661-661. [Details]
O'Neill, S; Conroy, E; O'Neill, A; Brady, HR; Fitzpatrick, JM; Watson, RWG; (1999) 'Altered caspase expression results in delayed neutrophil apoptosis in acute pancreatitis'. FASEB Journal, 13 (5):661-661. [Details]
Watson, R. W.,O'Neill, A.,Brannigan, A. E.,Coffey, R.,Marshall, J. C.,Brady, H. R.,Fitzpatrick, J. M. (1999) 'Regulation of Fas antibody induced neutrophil apoptosis is both caspase and mitochondrial dependent'. FEBS Lett, 453 (1-2):67-71. [Details]
Watson, RWG; Rotstein, OD; Parodo, J; Bitar, R; Fitzpatrick, J; Marshall, JC; (1998) 'Fas induced neutrophil apoptosis is caspase dependent and regulated by thiols'. FASEB Journal, 12 (5):1045-1045. [Details]
Watson, RWG; Brannigen, AE; Fitzpatrick, JM; (1998) 'Fas-induced neutrophil apoptosis is mediated through mitochondrial permeability and caspases'. British Journal of Surgery, 85 (11):1563-1563. [Details]
O'Connell PR, Burke JP, Ferrante M, Dejaegher K, Watson RW, Docherty NG, De Hertogh G, Vermeire S, Rutgeerts P, D'Hoore A, Penninckx F, Geboes K, Van Assche G, (2008) 'Transcriptomic analysis of intestinal fibrosis-associated gene expression in response to medical therapy in Crohn's disease'. Inflammatory bowel diseases, (NA). [DOI] [Details]
Dowling, C. M., Claffey, J., Cuffe, S., Fichtner, I., Pampillon, C., Sweeney, N. J., Strohfeldt, K., Watson, R. W. G., Tacke, M., (2008) 'Antitumor activity of Titanocene Y in xenografted PC3 tumors in mice'. Letters in Drug Design & Discovery, 5 (2):141-144. [Details]
Molloy, E. J., O'Neill, A. J., Grantham-Sloan, J. J., Webb, D. W., Watson, R. W. G., (2008) 'Maternal and neonatal lipopolysaccharide and Fas responses are altered by antenatal risk factors for sepsis'. Clinical and Experimental Immunology, 151 (2):244-250. [Details]
Watson RW, Molloy EJ, O'Neill AJ, Grantham-Sloan JJ, Sheridan-Pereira M, Fitzpatrick JM, Webb DW, (2007) 'Neonatal encephalopathy is associated with altered perinatal systemic neutrophil apoptosis'. American journal of perinatology, 9 (NA):525-530. [DOI] [Details]
Hogan, M, Claffey, J, Pampillon, C, Watson, RWG, Tacke, M, (2007) 'Synthesis and cytotoxicity studies of new dimethylamino-functionalized and azole-substituted titanocene anticancer drugs'. Organometallics, 26 :2501-2506. [Details]
Watson RW, Gill C, Walsh SE, Morrissey C, Fitzpatrick JM, (2007) 'Resveratrol sensitizes androgen independent prostate cancer cells to death-receptor mediated apoptosis through multiple mechanisms'. Prostate, 15 (NA):1641-1653. [DOI] [Details]
Perry, AS, Loftus, B, Moroose, R, Lynch, TH, Hollywood, D, Watson, RWG, Woodson, K, Lawler, M, (2007) 'In silico mining identifies IGFBP3 as a novel target of methylation in prostate cancer'. British Journal of Cancer, 96 :1587-1594. [Details]
Mc Guire, B, Docherty, NG, Fitzpatrick, JM, Watson, RWG, (2007) 'Acute ureteric obstruction leads to increased expression of collagen XVIII and endostatin spanning fragment neostatin'. European Urology, 6 :114-114. [Details]
Healy, DG; Watson, RWG; Fitzpatrick, JM; Wood, AE; (2007) 'Differential white cell count relationships with human cardiac allograft rejection'. Transplantation Proceedings, 39 (1):218-222. [Details]
Burke, JP; Mulsow, JJ; O'Keane, C; Docherty, NG; Watson, RWG; O'Connell, PR; (2007) 'Fibrogenesis in Crohn's disease'. American Journal of Gastroenterology, 102 (2):439-448. [Details]
O'Neill, A; Morrissey, C; Cunningham, K; Taylor, C; Fitzpatrick, JM; Watson, RWG; (2006) 'Effects of hypoxia on MnSOD expression and subsequent epigallocatechin gallate induced prostate cancer cell apoptosis'. European Urology Supplements, 5 (14):797-797. [Details]
Docherty, NG; McGuire, B; O'Sullivan, OE; Watson, RWG; Fitzpatrick, JM; (2006) 'N-cadherin is upregulated in the obstructed rat kidney and during mechanical stretch and TGF-beta 1 induced emt of tubular cell cultures'. Nephrology Dialysis Transplantation, 21 (NA):37-37. [Details]
Quinlan, JF; Watson, RWG; Kelly, G; Kelly, PM; O'Byrne, JM; Fitzpatrick, JM; (2006) 'Transforming growth factor-beta (TGF-beta) in acute injuries of the spinal cord'. Journal of Bone and Joint Surgery-British Volume, 88B (3):406-410. [Details]
O'Kane, HF; Watson, CJ; Johnston, SR; Petak, I; Watson, RWG; Williamson, KE; (2006) 'Targeting death receptors in bladder, prostate and renal cancer'. Journal of Urology, 175 (2):432-438. [Details]
Docherty, NG; O'Sullivan, OE; Healy, DA; Murphy, M; O'Neill, AJ; Fitzpatrick, JM; Watson, RWG; (2006) 'TGF-beta(1)-induced EMT can occur independently of its proapoptotic effects and is aided by EGF receptor activation'. American Journal of Physiology-Renal Physiology, 290 (5):1202-1212. [Details]
Gill, C; Walsh, S; Morrissey, C; Fitzpatrick, JM; Watson, RWG; (2006) 'Sensitisation of prostate cancer cells to apoptosis involves altered expression of IAPs and increased caspase activation'. European Urology Supplements, 5 (14):796-796. [Details]
O'Neill, A; Morrissey, C; Cunningham, K; Taylor, C; Fitzpatrick, JM; Watson, RWG; (2006) 'Effects of hypoxia on MnSOD expression and subsequent epigallocatechin gallate induced prostate cancer cell apoptosis'. European Urology Supplements, 5 (14):797-797. [Details]
Healy, DA; Daly, PJ; Docherty, NG; Murphy, M; Fitzpatrick, JM; Watson, RWG; (2006) 'Heat shock-induced protection of renal proximal tubular epithelial cells from cold storage and rewarming injury'. Journal of the American Society of Nephrology, 17 (3):805-812. [Details]
Docherty, NG; O'Sullivan, OE; Healy, DA; Fitzpatrick, JM; Watson, RWG; (2006) 'Evidence that inhibition of tubular cell apoptosis protects against renal damage and development of fibrosis following ureteric obstruction'. American Journal of Physiology-Renal Physiology, 290 (1):4-13. [Details]
Beddy, D; Mulsow, J; Watson, RWG; Fitzpatrick, JM; O'Connell, PR; (2006) 'Expression and regulation of connective tissue growth factor by transforming growth factor beta and tumour necrosis factor alpha in fibroblasts isolated from strictures in patients with Crohn's disease'. British Journal of Surgery, 93 (10):1290-1296. [Details]
Molloy, EJ; O'Neill, AJ; Doyle, BT; Grantham, JJ; Taylor, CT; Sheridan-Pereira, M; Fitzpatrick, JM; Webb, DW; Watson, RWG; (2006) 'Effects of heat shock and hypoxia on neonatal neutrophil lipopolysaccharide responses: Altered apoptosis, Toll-like receptor-4 and CD11b expression compared with adults'. Biology of the Neonate, 90 (1):34-39. [Details]
Mulsow, JJW; Watson, RWG; Fitzpatrick, JM; O'Connell, PR; (2005) 'Transforming growth factor-beta promotes pro-fibrotic behavior by serosal fibroblasts via PKC and ERK1/2 mitogen activated protein kinase cell signaling'. Annals of Surgery, 242 (6):880-889. [Details]
Morrissey, C; O'Neill, A; Spengler, B; Christoffel, V; Fitzpatrick, JM; Watson, RWG; (2005) 'Apigenin drives the production of reactive oxygen species and initiates a mitochondrial mediated cell death pathway in prostate epithelial cells'. Prostate, 63 (2):131-142. [Details]
Daly, PJA; Power, RE; Healy, DA; Hickey, DP; Fitzpatrick, JM; Watson, RWG; (2005) 'Delayed graft function: a dilemma in renal transplantation'. Bju International, 96 (4):498-501. [Details]
Long, RM; Morrissey, C; Hamilton, HJ; Farrell, N; Fitzpatrick, JM; Watson, RWG; (2005) 'Prostate epithelial cell differentiation is associated with alterations in apoptotic phenotype'. Bju International, 95 (NA):79-79. [Details]
Long, RM; Morrissey, C; Fitzpatrick, JM; Watson, RWG; (2005) 'Prostate epithelial cell differentiation and its relevance to the understanding of prostate cancer therapies'. Clinical Science, 108 (1):1-11. [Details]
Molloy, EJ; O'Neill, AJ; Grantham, JJ; Sheridan-Pereira, M; Fitzpatrick, JM; Webb, DW; Watson, RWG; (2005) 'Granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor have differential effects on neonatal and adult neutrophil survival and function'. Pediatric Research, 57 (6):806-812. [Details]
Docherty, NG; Healy, DA; O'Sullivan, OE; Fitzpatrick, JM; Watson, RWG; (2005) 'The presence of EGF increases proliferation and reduces apoptosis without exerting an anti-fibrotic action during TGF-beta 1 induced EMT of tubular epithelial cells'. Nephrology Dialysis Transplantation, 20 (NA):205-205. [Details]
Molloy, EJ; O'Neill, AJ; Grantham, JJ; Sheridan-Pereira, M; Fitzpatrick, JM; Webb, DW; Watson, RW; (2004) 'Labor induces a maternal inflammatory response syndrome'. American Journal of Obstetrics and Gynecology, 190 (2):448-455. [Details]
Beddy, D; Watson, RWG; Fitzpatrick, JM; O'Connell, PR; (2004) 'Increased vascular endothelial growth factor production in fibroblasts isolated from strictures in patients with Crohn's disease'. British Journal of Surgery, 91 (1):72-77. [Details]
Doyle, BT; O'Neill, AJ; Fitzpatrick, JM; Watson, RWG; (2004) 'Differentiation-induced HL-60 cell apoptosis: A mechanism independent of mitochondrial disruption?'. Apoptosis, 9 (3):345-352. [Details]
Galvin, DJ; Watson, RWG; O'Neill, A; Coffey, RNT; Taylor, C; Gillespie, JI; Fitzpatrick, JM; (2004) 'Hypoxia inhibits human bladder smooth muscle cell proliferation: A potential mechanism of bladder dysfunction'. Neurourology and Urodynamics, 23 (4):342-348. [Details]
Power, RE; Doyle, BT; Higgins, D; Brady, HR; Fitzpatrick, JM; Watson, RWG; (2004) 'Mechanical deformation induced apoptosis in human proximal renal tubular epithelial cells is caspase dependent'. Journal of Urology, 171 (1):457-461. [Details]
Beddy, D; Watson, RWG; Fitzpatrick, JM; O'Connell, PR; (2004) 'Increased vascular endothelial growth factor production in fibroblasts isolated from strictures in patients with Crohn's disease - Author's reply'. British Journal of Surgery, 91 (5):646-646. [Details]
Mulsow, J; Watson, RW; Fitzpatrick, JM; O'Connell, R; (2004) 'Transforming growth factor-beta mediates increased production of extracellular matrix by intestinal fibroblasts'. British Journal of Surgery, 91 (NA):64-65. [Details]
Hegarty, P; Watson, RWG; Hegarty, NJ; Coffey, RNT; Fitzpatrick, JM; (2004) 'Pressure effects on cellular systems: Is there a link with benign prostatic hyperplasia?'. Journal of Urology, 64 (2):195-200. [Details]
Molloy, EJ; O'Neill, A; Grantham, JJ; Sheridan-Pereira, M; Fitzpatrick, JM; Webb, DW; Watson, RW; (2004) 'Gender alters neonatal neutrophil survival and lipopolysaccharlde (LPS) responsiveness'. Pediatric Research, 55 (4):398-399. [Details]
O'Neill, AJ; Doyle, BT; Molloy, E; Watson, C; Phelan, D; Greenan, MC; Fitzpatrick, JM; Watson, RWG; (2004) 'Gene expression profile of inflammatory neutrophils: Alterations in the inhibitors of apoptosis proteins during spontaneous and delayed apoptosis'. Shock, 21 (6):512-518. [Details]
McEleny, K; Coffey, R; Morrissey, C; Fitzpatrick, JM; Watson, RWG; (2004) 'Caffeic acid phenethyl ester-induced PC-3 cell apoptosis is caspase-dependent and mediated through the loss of inhibitors of apoptosis proteins'. Bju International, 94 (3):402-406. [Details]
Morrissey, C; Bektic, J; Spengler, B; Galvin, D; Christoffel, V; Klocker, H; Fitzpatrick, JM; Watson, RWG; (2004) 'Phytoestrogens derived from Belamcanda chinensis have an antiproliferative effect on prostate cancer cells in vitro'. Journal of Urology, 172 (6):2426-2433. [Details]
Molloy, EJ; O'Neill, AJ; Grantham, JJ; Sheridan-Pereira, M; Fitzpatrick, JM; Webb, DW; Watson, RWG; (2004) 'Labor promotes neonatal neutrophil survival and lipopolysaccharide responsiveness'. Pediatric Research, 56 (1):99-103. [Details]
Bates, JJ; Watson, RWG; Glynn, CM; O'Neill, AJ; Fitzpatrick, JM; Buggy, DJ; (2004) 'Aspirin preserves neutrophil apoptosis after cardiopulmonary bypass'. Shock, 21 (6):495-499. [Details]
McEleny, K; Coffey, R; Morrissey, C; Williamson, K; Zangemeister-Wittke, U; Fitzpatrick, JM; Watson, RWG; (2004) 'An antisense oligonucleotide to cIAP-1 sensitizes prostate cancer cells to Fas and TNF alpha mediated apoptosis'. Prostate, 59 (4):419-425. [Details]
N.J. Hegarty, L.S. Young, A.J. ONeill, R.W.G. Watson, J.M. Fitzpatrick (2003) 'Endothelin in unilateral ureteral obstruction: vascular and cellular effects'. Clinical Investigation, 104 :171-179. [Details]
J.G. Burke, R.W.G. Watson, D. Conhyea, D. McCormack, F.E. Dowling, M.G. Walsh, J.M. Fitzpatrick. (2003) 'Human Nucleus Pulposis can respond to a Pro-inflammatory Stimulus'. Spine Journal, 28 :2685-2693. [Details]
E.J. Molloy, A.J. ONeill, J. Grantham, M. Sheridan-Pereira, J.M. Fitzpatrick, D.W. Webb, R.W.G. Watson (2003) 'Gender-specific alterations in neutrophil apoptosis: the role of estradiol and progesterone'. Blood, 120 :2653-2659. [Details]
O. Zierau, C. Morrissey, R.W.G. Watson, P. Schwab, S. Kolba, P. Metz, G. Vollmer (2003) 'Antiandrogenic activity of the phtoestrogens naringenin, 6-(1,1-Dimethylallyl)naringen and 8-Prenylnaringenin'. Planta, 69 :856-858. [Details]
T. Lebret, R.W.G. Watson, V. Molinie, A. ONeill, C. Gabriel, J.M. Fitzpatrick, H. Botto (2003) 'Heat shock proteins HSP27, HSP60, HSP70, HSP90 Expression in bladder cancer'. Cancer, 98 :970-977. [Details]
Kell, MR; Sweeney, K; Beddy, D; Connelly, J; Winter, DC; Watson, RGW; Fitzpatrick, JM; Kerin, M; (2003) 'Systemic T-cells are primed for a tumour permissive phenotype in breast cancer patients'. British Journal of Surgery, 90 (5):602-603. [Details]
Beddy, D; Watson, RWG; Fitzpatrick, JM; O'Connell, PR; (2003) 'TNF-alpha regulates expression of cyclooxygenase-2 by fibroblasts in Crohn's disease'. British Journal of Surgery, 90 (5):629-629. [Details]
Zierau, O; Morrissey, C; Watson, RWG; Schwab, P; Kolba, S; Metz, P; Vollmer, G; (2003) 'Antiandrogenic activity of the phytoestrogens naringenin, 6-(1,1-dimethylallyl)naringenin and 8-prenylnaringenin'. Planta Medica, 69 (9):856-858. [Details]
Shaw, CM; Watson, RWG; Fitzpatrick, JM; Kerin, MJ; (2003) 'The impact of extracellular matrix proteins on drug resistance in breast cancer cells'. Breast Cancer Research and Treatment, 82 (NA):88-89. [Details]
Burke, JG; Watson, RWG; Conhyea, D; McCormack, D; Dowling, FE; Walsh, MG; Fitzpatrick, JM; (2003) 'Human nucleus pulposis can respond to a pro-inflammatory stimulus'. Spine, 28 (24):2685-2693. [Details]
Healy, DA; Watson, RWG; Newsholme, P; (2003) 'Polyunsaturated and monounsaturated fatty acids increase neutral lipid accumulation, caspase activation and apoptosis in a neutrophil-like, differentiated HL-60 cell line'. Clinical Science, 104 (2):171-179. [Details]
Hegarty, NJ; Young, LS; O'Neill, AJ; Watson, RWG; Fitzpatrick, JM; (2003) 'Endothelin in unilateral ureteral obstruction: Vascular and cellular effects'. Journal of Urology, 169 (2):740-744. [Details]
Morrissey, O; Watson, RWG; (2003) 'Phytoestrogens and prostate cancer'. Current Drug Targets, 4 (3):231-241. [Details]
Lebret, T; Watson, RWG; Fitzpatrick, JM; (2003) 'Heat shock proteins: Their role in urological tumors'. Journal of Urology, 169 (1):338-346. [Details]
Murphy, BM; O'Neill, AJ; Adrain, C; Watson, RWG; Martin, SJ; (2003) 'The apoptosome pathway to caspase activation in primary human Neutrophils exhibits dramatically reduced requirements for cytochrome c'. Experimental Medicine, 197 (5):625-632. [Details]
Molloy, EJ; O'Neill, AJ; Grantham, JJ; Sheridan-Pereira, M; Fitzpatrick, JM; Webb, DW; Watson, RWG; (2003) 'Sex-specific alterations in neutrophil apoptosis: the role of estradiol and progesterone'. Blood, 102 (7):2653-2659. [Details]
Beddy, D; Watson, RWG; Fitzpatrick, JM; O'Connell, PR; (2003) 'Increased VEGF production in fibroblasts isolated from patients with Crohn's disease'. British Journal of Surgery, 90 (NA):6-6. [Details]
Lebret, T; Watson, RWG; Molinie, V; O'Neill, A; Gabriel, C; Fitzpatrick, JM; Botto, H; (2003) 'Heat shock proteins HSP27, HSP60, HSP70, and HSP90'. Cancer, 98 (5):970-977. [Details]
B.M. Murphy, A.J. ONeill, C. Adrain, R.W.G. Watson, S.J. Martin. (2003) 'The apoptosome pathway to caspase activation in primary human neutrophils exhibits dramatically reduced requirements for cytochrome c'. Experimental Medicine, 197 :625-632. [Details]
Doyle, B., ONeill, A., Newsholme, P., Fitzpatrick, J.M., and Watson, R.W.G. (2002) 'HL-60 cell differentiation and apoptosis is associated with decreased inhibitors of apoptosis proteins expression and increased caspase activity'. Journal of Leukocite Biology, 71 :247-254. [Details]
Pfeil K. , E.I. E.I. Eder, G. Bartsch, A. ONeill, R.W.G. Watson, H. Klocker (2002) 'Differences in the expression of Apoptosis-related proteins in LNCaP and Long-term androgen-ablated LNCaP Prostate cancer cells'. European Urology, (1). [Details]
Barry T. , R.W.G. Watson, D. OHanlon, M. Kennedy, T.F. Gorey, J.M. Fitzpatrick, M.J. Kerin. (2002) 'A mechanism of drug resistance in breast cancer implicating COX-2. Will NSAIDs be the answer'. British Journal of Cancer, 86 (4). [Details]
R.W.G. Watson. (2002) 'Redox Regulation of Neutrophil Apoptosis'. 4 :97-104. [Details]
McEleny K. , R.W.G. Watson, A. ONeill, R.N. Coffey, J.M. Fitzpatrick (2002) 'The Inhibitors of Apoptosis Proteins in Prostate Cancer Cell Lines'. Prostate, 51 :131-140. [Details]
Burke J.G. , R.W.G. Watson, D. McCormack, F.E. Dowling, M.G. Walsh, J.M. Fitzpatrick. (2002) 'Spontaneous production of monocyte chemoattractant protein-1 and interleukin-8 by the human lumbar intervertebral dics: A possible mechanism of herniated disc resorption'. Spine Journal, 27 :1402-1407. [Details]
Hegarty P.K. , R.W.G. Watson, R.N.T. Coffey, M.M. Webber, J.M. Fitzpatrick. (2002) 'Effects of cyclic stretch on prostatic cell in culture'. Journal of Urology, 168 :2291-2295. [Details]
Higgins, DF; Lappin, DWP; Isaka, Y; Watson, RW; Godson, C; Imai, E; Fitzpatrick, JM; Brady, HR; (2002) 'Transcriptomic responses underpinning renal tubulointerstitial fibrosis as identified by DNA oligonucleotide microarray technology'. Journal of the American Society of Nephrology, 13 (NA):560-560. [Details]
Murphy D., J.M. Fitzpatrick, R.W.G. Watson. (2002) 'Changes in the apoptotic phenotype of prostatic epithelial cells during their differentiation from basal to luminal secretory'. British Journal of Cancer, 86 (4). [Details]
Galvin D.J. , R.W.G. Watson, A. ONeill, R.N.T. Coffey, H. Brady, J.I. Gillespie, J.M. Fiztpatrick. (2002) 'Mechanical stretch alters human bladder smooth muscle cell phenotype'. Journal of the American College of Surgeons, 195 (3). [Details]
Barry T., D. Healy, D. OHanlon, R.W.G. Watson, T.F. Gorey, J.M. Fitzpatrick, M.J. Kerins. (2002) 'Cox-2 expression modulates tumour invasion'. Journal of the American College of Surgeons, 195 (3). [Details]
Beddy D., R.W.G. Watson, J.M. Fitzpatrick, P.R. OConnell (2002) 'TNF-a and IL-1b regulate fibroblast ICAM-1 expression in Crohn disease through a jun kinase pathway'. Journal of the American College of Surgeons, 195 (3). [Details]
Beddy D., R.W.G. Watson, J.M. Fitzpatrick, P.R. OConnell. (2002) 'TNF-alpha regulates expression of cyclo-oxygenase-2 by fibroblasts in Crohnn disease. (Winner of the William OKeeffe Memorial Prize for best Oral presentation)'. Irish Journal of Medical Science, 171 (4). [Details]
Power R.W. , R.W.G. Watson, B.T, Doyle, D. Higgins, H.R. Brady, J.M. Fitzpatrick. (2002) 'The mechanism of mechanical stretch-induced apoptosis in human proximal renal tubular epithelial cells'. Irish Journal of Medical Science, 171 (2). [Details]
Burke J.G., R.W.G. Watson, D. McCormack, F.E. Dowling, M.G. Walsh, J.M. Fitzpatrick. . (2002) 'Intervertebral discs which cause low back pain secrete high levels of pro-inflammatory mediators'. Journal of Bone Joint Surgery, 84 :196-201. [Details]
OBrian M.F. , R.W.G. Watson, J.M. Fitzpatrick. B. Doyle, A. ONeill, P. Newsholme, J.M. Fitzpatrick, R.W.G. Watson. (2002) 'HL-60 cell differentiation and apoptosis is associated with decreased inhibitors of apoptosis proteins expression and increased caspase activity'. Journal of Leukocite Biology, 71 :247-254. [Details]
Galvin D., R.W.G. Watson, J. Gillespie, H. Brady, J.M. Fitzpatrick. (2002) 'Mechanical stretch regulates cell survival in human bladder smooth muscle cells in vitro'. American Journal of Physiology, 283 :1192-1199. [Details]
Coffey, RNT; Watson, RWG; O'Neill, AJ; Mc Eleny, K; Fitzpatrick, JM; (2002) 'Androgen-mediated resistance to apoptosis'. Prostate, 53 (4):300-309. [Details]
Hegarty, PK; Watson, RWG; Coffey, RNT; Webber, MM; Fitzpatrick, JM; (2002) 'Effects of cyclic stretch on prostatic cells in culture'. Journal of Urology, 168 (5):2291-2295. [Details]
Burke, JG; Watson, RWG; McCormack, D; Dowling, FE; Walsh, MG; Fitzpatrick, JM; (2002) 'Intervertebral discs which cause low back pain secrete high levels of proinflammatory mediators'. Journal of Bone and Joint Surgery-British Volume, 84B (2):196-201. [Details]
Barry, TL; Watson, RWG; Kennedy, M; Fitzpatrick, JM; Kerin, MJ; (2002) 'Expression versus-activity. A mechanism implicating cyclooxygenase-2 in breast cancer drug resistance'. Journal of Pathology, 198 (NA):28-28. [Details]
Barry, T; Watson, RWG; Hanlon, DO; Kennedy, M; Gorey, TF; Fitzpatrick, JM; Kerin, MJ; (2002) 'A mechanism of drug resistance in breast cancer implicating Cox-2. Will NSAIDs be the answer?'. British Journal of Cancer, 86 (NA):22-22. [Details]
McEleny, KR; Watson, RWG; Williamson, K; Coffey, RNT; Fitzpatrick, J; (2002) 'A novel tri-specific antisense oligonucleotide(AO) to the inhibitors of apoptosis proteins (LAPS) enhances apoptosis in PC3 prostate cancer cells'. British Journal of Cancer, 86 (NA):66-67. [Details]
Murphy, DG; Fitzpatrick, JM; Watson, RWG; (2002) 'Changes in the apoptotic phenotype of prostatic epithelial cells during their differentiation from basal to luminal secretory'. British Journal of Cancer, 86 (NA):81-81. [Details]
Coffey, RNT; Watson, RWG; Taylor, CT; Fitzpatrick, JM; (2002) 'Altered sensitivity to hypoxia in prostate cancer cell lines; Hypoxia-induced apoptosis a mitochondrial independent event'. British Journal of Cancer, 86 (NA):101-101. [Details]
McEleny, KR; Watson, RWG; Coffey, RNT; O'Neill, AJ; Fitzpatrick, JM; (2002) 'Inhibitors of apoptosis proteins in prostate cancer cell lines'. Prostate, 51 (2):133-140. [Details]
Galvin D.J. , R.W.G. Watson, A.J. ONeill, R.N.T. Coffey, C. Taylor, J.I. Gillespie, J.M. Fitzpatrick. . (2002) 'Hypoxia inhibits proliferation in human bladder smooth muscle cells'. Irish Journal of Medical Science, 171 (2). [Details]
Barry T.L. , R.W.G. Watson, D. OHanlon, T.F. Gorey, J.M. Fitzpatrick, M.J. Kerin. (2002) 'Intracellular introduction of cyclo-oxygenase antisense oligonucleotide enhances chemotherapy-induced apoptosis and prevents chemoresistance in breast cancer'. Irish Journal of Medical Science, 171 (2). [Details]
Kells M.R., J. Connelly, D.C. Winters, D. Beddy, C. Canning, R.W.G. Watson, J.M. Fitzpatrick, M. Kerins. (2002) 'Systemic T-cells demonstrate a tumour permissive response in breast cancer patients'. Irish Journal of Medical Science, 171 (2). [Details]
Hegarty N.J., P.K. Hegarty, P. Cunningham, R.N.T. Coffey, R.W.G. Watson, J.M. Fitzpatrick. (2002) 'Alpha-adrenergic antagonists may modify disease processes in prostate cancer and benign prostate hyperplasia'. Prostate Cancer and Prostatic Diseases, 5 (1). [Details]
McEleny K.R., R.W.G. Watson, K. Williamson, R.N.T. Coffey, J.M. Fitzpatrick. (2002) 'A novel tri-specific antisense oligonucleotide (AO) to the inhibitors of apoptosis proteins (IAP) enhances apoptosis in PC3 prostate cancer'. British Journal of Cancer, 86 (1). [Details]
Coffey R.T., R.W.G. Watson, C.T. Taylor, J.M. Fitzpatrick. (2002) 'Altered sensitivity to hypoxia in prostate cancer cell lines: Hypoxia-induced apoptosis a mitochondrial independent event'. British Journal of Cancer, 86 (l1). [Details]
Healy D.A. , R.W.G. Watson, Philip Newsholme. (2002) 'Glucose but not glutamine provides protection from spontaneous and Fas-induced apoptosis in human neutrophils'. Clinical Investigation, 103 :179-189. [Details]
Hegarty N.J. , R.W.G. Watson, L.S. Young, A.J. ONeill, H.R. Brady, J.M. Fitzpatrick. (2002) 'Cytoprotective effects of nitrates in a cellular model of hydronephrosis'. Kidney International, 62 :70-77. [Details]
Brannigan A.E. , R.W.G. Watson, D. Beddy, H. Hurley, J.M. Fitzpatrick, P.R. OConnell. (2002) 'Increased adhesion molecule expression in serosal fibroblasts isolated from patients with Inflammatory Bowel Disease is secondary to inflammation'. Annals of Surgery, 235 :507-511. [Details]
Coffey R.N.T. , R.W.G. Watson, A.J. O' Neill, K. Mc Eleny, J.M. Fitzpatrick (2002) 'Androgen resistance to apoptosis in the LNCaP cell line; attributable to altered caspase and Bcl-2 expression'. Prostate, 53 :300-309. [Details]
Morrissey C., R.W.G. Watson, J.M. Fitzpatrick. (2002) 'The effects of phytoestrogens on prostate cancer cells in vitro'. British Journal of Cancer, 86 (4). [Details]
Galvin D.J., R.W.G. Watson, A.J. ONeill, R.T. Coffey, H. Brady, J.I. Gillespie, J.M. Fitzpatrick. (2002) 'Mechanical stretch alters human bladder smooth muscle phenotype'. European Urology, 1 (1). [Details]
Coffey, R.N.T., Watson, R.W.G., Hegarty, P.K., Watson, Wolohan, C.L., L., Brady, H.R., OKeane, C., and Fitzpatrick, J.M. (2001) 'Priming prostate cell for increased apoptosis is associated with up-regulation of the caspases'. Cancer, 92 :2297-2308. [Details]
Barry T. , R.W.G. Watson, D. ODanlon, M. Kennedy, T.F. Gorey, J.M. Fitzpatrick, M.J. Kerin. (2001) 'The Role of Cox-2 expression in apoptotic resistance in breast cancer'. Irish Journal of Medical Science, 170 (1). [Details]
Hurley, H; Doyle, BT; O'Neill, AJ; Fitzpatrick, JM; Watson, RWG; (2001) 'Heat shock protein expression inhibits etoposide induced apoptosis in HL60 cells'. FASEB Journal, 15 (4):315-315. [Details]
Doyle, BT; O'Neill, AJ; Newsholme, P; Fitzpatrick, JM; Watson, RWG; (2001) 'HL-60 cell differentiation and resulting apoptosis is associated with decreased expression of the inhibitors of apoptosis protein'. FASEB Journal, 15 (4):313-313. [Details]
Molloy, EJ; O'Neill, AJ; Sheridan-Pereira, M; Fitzpatrick, JM; Webb, DW; Watson, RWG; (2001) 'Maternal and neonatal apoptosis at delivery: A mechanism for bacterial susceptibility?'. FASEB Journal, 15 (4):369-369. [Details]
O'Neill, AJ; Doyle, BT; Fitzpatrick, JM; Watson, RWG; (2001) 'Inhiitors of apoptosis proteins expressed at a basal level in normal or inflammatory neutrophils'. FASEB Journal, 15 (4):335-335. [Details]
Coffey, RNT; Watson, RWG; Fitzpatrick, JM; (2001) 'Signaling for the caspases: Their role in prostate cell apoptosis'. Journal of Urology, 165 (1):5-14. [Details]
Coffey, RNT; Watson, RWG; Hegarty, PK; Watson, CL; Wolohan, L; Brady, HR; O'Keane, C; Fitzpatrick, JM; (2001) 'Priming prostate carcinoma cells for increased apoptosis is associated with up-regulation of the caspases'. Cancer, 92 (9):2297-2308. [Details]
Kavanagh, EG; Watson, RW; Lederer, JA; Fitzpatrick, JM; O'Connell, PR; (2001) 'Activated neutrophils upregulate T-cell responses in patients with acute pancreatitis'. British Journal of Surgery, 88 (5):745-746. [Details]
O'Brien, MF; Watson, RWG; Fitzpatrick, JM; (2001) 'Insulin-like growth factor I and prostate cancer'. Journal of Urology, 58 (1):1-7. [Details]
Goh, J; Baird, AW; O'Keane, C; Watson, RWG; Cottell, D; Bernasconi, G; Petasis, NA; Godson, C; Brady, HR; MacMathuna, P; (2001) 'Lipoxin A(4) and aspirin-triggered 15-epi-lipoxin A(4) antagonize TNF-alpha-stimulated neutrophil-enterocyte interactions in vitro and attenuate TNF-alpha-induced chemokine release and colonocyte apoptosis in human intestinal mucosa ex vivo'. Immunology, 167 (5):2772-2780. [Details]
N.J. Hegarty, L.S.Young, C.N. Kirwan, A.J. ONeill, D. Bouchier-Hayes, P. Sweeney, R.W.G. Watson, J.M. Fitzpatrick (2001) 'Nitric oxide in unilateral obstruction-effect on regional renal blood flow'. Kidney International, 59 :1059-1065. [Details]
McEleny K.R. , R.W.G. Watson, J.M. Fitzpatrick (2001) 'Defining a Role for the Inhibitors of Apoptosis Proteins in Prostate Cancer'. Prostate Cancer and Prostatic Diseases, 4 :28-32. [Details]
Coffey R.N.T., R.W.G. Watson, P.K. Hegarty, C.L. Watson, L. Wolohan, H.R. Brady, C. OKeane, J.M. Fitzpatrick. . (2001) 'Priming prostate cell for increased apoptosis is associated with up-regulation of the caspases'. Cancer, 92 :2297-2308. [Details]
Goh J., A.W. Baird, C. OKeane, R.W.G. Watson, D. Cottell, G. Bernasconi, N.A. Petasis, C. Godson, H.R. Brady, P. MacMethuna. . (2001) 'Lipoxin A4 and Aspirin-Triggered 15-Epi-Lipoxin A4 Antagonize TNF-(alpha)-Stimulated Neutrophil-Enterocyte Interactions In Vitro and Attenuate TNF-(alpha)-Induced Chemokine Release and Colonocyte Apoptosis in Human Intestinal Mucosa Ex Vivo'. Immunology, 167 :2772-2780. [Details]
Hegarty P.K. , C. OConnell, R.W.G. Watson, D.C. Cottell, J.M. Fitzpatrick. (2001) 'Measuring collagen in the prostate by scanning electron mircoscopy'. Journal of Urology, 165 . [Details]
McEleny K.R. , R.W.G. Watson, R.N.T. Coffey, H.J. Muenchan, J.M. Fitzpatrick. (2001) 'NF-kB manipulation of cIAP-2 alters apoptosis in LNCaP cells'. Journal of Urology, 165 . [Details]
Molloy E.J. , A.J. ONeill, M. Sheridan-Pereira, J.M. Fitzpatrick, D.W. Webb, R.W.G. Watson. (2001) 'Perinatal neutrophil apoptosis: contribution to neonatal bacterial sepsis and maternal neutrophilia'. Irish Journal of Medical Science, 170 (1). [Details]
McEleny K.R. , R.W.G. Watson, R.N.T. Coffey, P.K. Hegarty, J.M. Fitzpatrick. (2001) 'Inhibitors of Apoptosis proteins in prostate cancer cells'. European Urology, 39 (5). [Details]
Hegarty P.K. , R.W.G. Watson, K.R. McEleny, R.N.T. Coffey, J.M. Fitzpatrick (2001) 'The role of tissue pressure in the pathogenesis of benign prostatic hyperplasia'. European Urology, 39 . [Details]
Coffey R.N.T. , R.W.G. Watson, J.M. Fitzpatrick. (2001) 'Signaling for the Caspases: Their Role in Prostate Cell Apoptosis'. Journal of Urology, 165 :5-14. [Details]
Galvin D.J. , R.W.G. Watson, A. ONeill, R.N.T. Coffey, J.I. Gillespie, H. Bardy, J. M. Fitzpatrick. (2001) 'Mechanical stretch as a mechanism of bladder dysfunction'. Irish Journal of Medical Science, 170 (1). [Details]
McLornan L. , R.W.G. Watson, J.M. Fitzpatrick. (2001) 'Growth factor activation of PI-3kinase/AKT in prostate cancer resistance to apoptosis'. Irish Journal of Medical Science, 170 (1). [Details]
Molloy E., A.J. ONeill, J. Grantham, M. Sheridan-Pereira, J.M. Fitzpatrick, D.W. Webb, R.W.G. Watson. (2001) 'Gender differences and immune function'. Irish Journal of Medical Science, 170 (1). [Details]
Beddy D.J. , D.A. McNamara, R.W.G. Watson, J.M. Fitzpatrick, P.R. OConnell. . (2001) 'Localisation of TNF-alpha and VEGF production in patients with active crohns disease'. Irish Journal of Medical Science, 170 (1). [Details]
Doyle B.T. , H. Hurley, A.J. ONeill, P. Newsholme, J.M. Fitzpatrick, R.W.G. Watson. (2001) 'The Protective role of heat shock protein (HSP) on HL-60 cells apoptosis'. Irish Journal of Medical Science, 170 (1). [Details]
Doyle B.T. , H. Hurley, A.J. ONeill, P. Newsholme, J.M. Fitzpatrick, R.W.G. Watson. (2001) 'The protective role of HSP on HL-60 cell apoptosis'. Biochemical Society Transactions, 29 (5). [Details]
ONeill A.J. , B.T. Doyle, A. Murphy, J.M. Fitzpatrick, R.W.G. Watson. (2001) 'Gene profile of Inflammatory Neutrophils'. Irish Journal of Medical Science, 170 (1). [Details]
Coffey R.N.T. , R.W.G. Watson, J. M. Fitzpatrick. (2001) 'Caspases: Mediators of prostate cancer cell apoptosis'. 88 (1). [Details]
Hegarty P.K., P. Cunningham, R.W.G. Watson, R.N.T. Coffey, J.M. Fitzpatrick. (2001) 'Appha-adrenergic antagonists induce apoptosis in benign and malignant prostatic epithelia'. Journal of Urology, 165 . [Details]
Coffey, R.N.T., Watson, R.W.G., Hegarty, N.J., ONeill, A., Gibbons, N., Brady, H.R., and Fitzpatrick, J.M. (2000) 'Thiol mediated apoptosis in prostate cancer cells'. Cancer, 88 :2092-2104. [Details]
ONeill, S., ONeill, A., Conroy, E., Brady, H.R., Fitzpatrick, J.M., and Watson, R.W.G. (2000) 'Altered caspase expression results in delayed neutrophil apoptosis in acute pancreatiti'. Journal of Leukocite Biology, 68 :15-20. [Details]
Gibbons, NB; Watson, RWG; Coffey, RNT; Brady, HP; Fitzpatrick, JM; (2000) 'Heat-shock proteins inhibit induction of prostate cancer cell apoptosis'. Prostate, 45 (1):58-65. [Details]
O'Neill, S; O'Neill, AJ; Conroy, E; Brady, HR; Fitzpatrick, JM; Watson, RWG; (2000) 'Altered caspase expression results in delayed neutrophil apoptosis in acute pancreatitis'. Journal of Leukocyte Biology, 68 (1):15-20. [Details]
O'Neill, AJ; O'Neill, S; Hegarty, NJ; Coffey, RNT; Gibbons, N; Brady, H; Fitzpatrick, JM; Watson, RWG; (2000) 'Glutathione depletion-induced neutrophil apoptosis is caspase 3 dependent'. Shock, 14 (6):605-609. [Details]
Smith, JD; O'Neill, A; Brady, HR; Fitzpatrick, JM; Watson, RWG; (2000) 'Cellular glutathione extrusion is an integral part of neutrophil apoptosis'. FASEB Journal, 14 (4):194-194. [Details]
O'Neill, AJ; Brady, HR; Fitzpatrick, JM; Watson, RWG; (2000) 'Neutrophil apoptosis is associated with altered caspase processing'. FASEB Journal, 14 (4):194-194. [Details]
Brannigan, AE; O'Connell, PR; Hurley, H; O'Neill, A; Brady, HR; Fitzpatrick, JM; Watson, RWG; (2000) 'Neutrophil apoptosis is delayed in patients with inflammatory bowel disease'. Shock, 13 (5):361-366. [Details]
O'Neill, AJ; Murtagh, JC; Brady, HR; Fitzpatrick, JM; Watson, RWG; (1999) 'Delayed neutrophil apoptosis is associated with altered caspase 3 processing'. Journal of Leukocyte Biology, -1 (NA):25-25. [Details]
O'Neill, S; Conroy, E; O'Neill, A; Brady, HR; Fitzpatrick, JM; Watson, RWG; (1999) 'Altered caspase expression results in delayed neutrophil apoptosis in acute pancreatitis'. FASEB Journal, 13 (5):661-661. [Details]
O'Neill, AJ; Brady, HR; Fitzpatrick, JM; Watson, RWG; (1999) 'Differential role of the mitochondria in neutrophil apoptosis'. FASEB Journal, 13 (5):661-661. [Details]
Watson, R.W.G., Rotstein, O.D., Parodo, J., Bitar, R., and Marshall, J.C. (1998) 'The Interleukin-1converting enzyme (Caspase-1) inhibits apoptosis of inflammatory neutrophils through activation of interleukin-1'. Immunology, 161 :957-962. [Details]
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Other Journals:

Fanning, D.M., Fan, Y., Murphy, B., Klocker, H., Horninger, W., Fitzpatrick, J.M., Watson, R.W.G. (2010) 'A profile of prostate cancer in Ireland --- development and internal validation of a novel panel of blood biomarkers' Irish Journal of Medical Science 179 (Suppl. 6) :238-239. [Details]

O'Connor, K., Gill, C., Tacke, M., Rehmann, F.-J. K., Strohfeldt, K., Sweeney, N., Fitzpatrick, J. M., Watson, R. W. G. (2006) 'Novel Titanocene Anti-Cancer Drugs and their Effect on Apoptosis and the Apoptotic Pathway in Prostate Cancer Cells' Apoptosis . [Details]

Molloy, E.J., O'Neill, A.J., Doyle, B.T., Grantham, J.J., Taylor, C.T., Sheridan-Pereira, M., Fitzpatrick, J.M. Watson, R.W.G. (2006) 'Effects of heat shock and hypoxia on neonatal neutrophil lipopolysaccharide responses: altered apoptosis, toll-like receptor-4 and CD11b expression compared with adults' Biology of the Neonate . [Details]

Conference Publications:

O'Connell PR, Burke JP, Watson RW, Murphy M, Docherty NG, Coffey JC, (2009) The British journal of surgery Simvastatin impairs smad-3 phosphorylation and modulates transforming growth factor beta1-mediated activation of intestinal fibroblasts , pp.541-551 [DOI] [Details]

Watson RW, Fanning DM, Kay E, Fan Y, Fitzpatrick JM, (2009) BJU international Prostate cancer grading: the effect of stratification of needle biopsy Gleason Score 4 + 3 as high or intermediate grade [DOI] [Details]

Dowling, C. M., Cuffe, S., Gill, C., Tacke, M., Fitzpatrick, J. M., Watson, R. W. G., (2008) European Urology Supplements Effects of docetaxel and novel titanocene analogues on cell death in prostate cancer following downregulation of Id-1 and the IAPS , pp.276-276 [Details]

Cuffe, S., Dowling, C., Gill, C., Tacke, M., Fitzpatrick, J. M., Carty, M. P., Watson, R. W. G., (2008) Ejc Supplements Novel titanocene analogues induce apoptosis in prostate cancer epithelial cells by initiating a DNA damage response , pp.29-29 [Details]

D'Arcy, F., Foley, R., Perry, A., Marignol, L., Lawler, M., Gaffney, E., Watson, R. G. W., Fitzpatrick, J. M., Lynch, T. H., (2008) European Urology Supplements No evidence of XMRV in irish prostate cancer patients with the R462q mutation , pp.271-271 [Details]

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O'Connell PR, Beddy D, Mulsow J, Watson RW, Fitzpatrick JM, (2006) The British journal of surgery Expression and regulation of connective tissue growth factor by transforming growth factor beta and tumour necrosis factor alpha in fibroblasts isolated from strictures in patients with Crohn's disease , pp.1290-1296 [DOI] [Details]
Watson RW, O'Connor K, Gill C, Tacke M, Rehmann FJ, Strohfeldt K, Sweeney N, Fitzpatrick JM, (2006) Apoptosis : an international journal on programmed cell death Novel titanocene anti-cancer drugs and their effect on apoptosis and the apoptotic pathway in prostate cancer cells , pp.1205-1214 [DOI] [Details]
Gill, C., Walsh, S., Morrissey, C., Fitzpatrick, J., Watson R.W.G. (2006) Resveratrol downregulates cIAP-1 expression and enhances death receptor-medicated apoptosis of prostate cancer cells American Association for Cancer Research [Details]
Gill, C., Walsh, S., Morrissey, C., Fitzpatrick, J., Watson, R.W.G. (2006) Resveratrol downregulates cIAP-1 expression and enhances death receptor-medicated apoptosis of prostate cancer cells American Association for Cancer Research Washington, USA, , 01-APR-06 - 05-APR-06 [Details]
Gill, C., Walsh, S., Morrissey, C., Fitzpatrick, J., Watson, R.W.G. (2006) Resveratrol downregulates cIAP-1 expression and enhances death receptor-medicated apoptosis of prostate cancer cells American Association for Cancer Research Washington, USA, , 01-APR-06 - 05-APR-06 [Details]
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MarshallJ. C., Watson R.W.G. (1997) 'Apoptosis in the resolution of systemic inflammation' In: * (eds). Yearbook in Intensive Care and Emergency Medicine. [Details]
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