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Research

Professor Bill Watson BSc, PhD

Research Interests:

My focus of research is in prostate cancer which can be divided into two areas:

 

 

1. Biomarker discovery and validation: Using the critical mass and bioresource facilities of the Prostate Cancer Research Consortium (of which I am the lead PI) the group undertake to address clinically relevant questions to identify and validate biomarkers for grade and stage of prostate cancer which will inform appropriate treatment strategies.

 

 

 

 

 

 

 

2. Understanding the mechanisms of resistances to therapy of advanced disease. We have established models of resistance to androgen ablation therapy and chemoresistance and using genechip and bioinformatice strategies have identified central transcription factors which represent novel sites for therapeutic manipulation which is carried out as part of the Molecular Therapeutics for Cancer in Ireland SFI cluster and the All Ireland Clinical Oncology Research Group (ICORG)

 

 


Research Projects:

Sponsor : Health Research Board (HRB)
Title : Protein expression profiles of morphologically discrete foci in prostate cancer
Start Date / End Date : 01-OCT-11 / 30-SEP-14
Sponsor : Irish Cancer Society
Title : Integrating biomarkers for the stratification of patients into insignificant and significant prostate cancer
Start Date / End Date : 01-OCT-11 / 30-SEP-14
Sponsor : Health Research Board (HRB)
Title : Validating a panel of serum biomarkers to inform surgical intervention for prostate cancer
Start Date / End Date : 01-JUN-11 / 30-NOV-12
Sponsor : University College Dublin (UCD)
Title : Biomarker Discovery and Validation for Prostate cancer Grade
Start Date / End Date : 01-DEC-10 / 31-DEC-11
Sponsor : Irish Cancer Society
Title : The Identification and Validation of Serum Biomarkers for Biochemical Recurrence in Prostate Cancer
Start Date / End Date : 01-OCT-10 / 30-SEP-13
Sponsor : Science Foundation Ireland (SFI)
Title : Molecular therapeutics for cancer: translational research to individualise therapy with targeted agents
Start Date / End Date : 01-SEP-09 / 31-AUG-14