Keywords:Genomics, evolution, bioinformatics, model organisms, yeast, data visualisation
Kevin’s research is focused on using genomics to address biological and evolutionary questions in model organisms primarily employing bioinformatics approaches. Yeasts have been a system of particular interest. The visualization and analysis of complex data is a key aspect of his work (for example see ygob.ucd.ie)
Understanding Rhodococcus equi adaptation as intracellular pathogen of macrophages;
Analysis of the structure and dynamics of microbial assemblages associated to mucosal surfaces to understand animal disorders that cannot be explained by a single etiologic agent such as in bovine postpartum endometritis.
Keywords:EGFR network reconstruction, interactome, PRIMES, mass spectrometry
Currently, I am a postdoctoral researcher (L2) in Systems Biology Ireland, involved in PRIMES (Protein Interaction Machines in EGFR Signalling) (FP7-HEALTH-2011-two-stage). PRIMES focuses on the role of protein interactions to assemble dynamic molecular machines that receive and process information to coordinate cellular responses. PRIMES investigates: (i) how protein interactions contribute to the generation of biological specificity in signalling (ii) how pathogenetic perturbations affect protein interaction networks and (iii) how we can exploit protein interactions as therapeutic targets. I was born in Cosenza, Italy, have completed two Ph.D. programmes: Animal Pharmacology & Toxicology and Biomedical & Computer Engineering and spent 7 months as a visiting scientist in John Yates laboratory at Scripps Research Institute, San Diego, California, to improve my knowledge about mass spectrometry and MudPIT techniques.
Keywords:Cancer, systems biology, signalling pathways, A-Raf
I am currently investigating the role of Raf signalling in cancer differentiation and metabolism. More specifically Raf kinases are found at different localisations within a cell and I want to understand what kind of specific function is associated with this spatial and temporal regulation of signalling and which factors are involved.
Keywords:Probiotics, Reactive Oxygen Species (ROS), antioxidants, inflammation.
My research is genetic modification of lactic acid bacteria which express antioxidant enzymes such as catalase or superoxide dismutase (SOD) as therapy of inflammatory diseases such as inflammatory bowel disease (IBD).