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Featured Researcher: Dr. Jens Rauch

Dr Jens RauchMy Research

I am currently focussed primarily on investigating the role of Raf signalling in cancer, differentiation, and metabolism. More specifically, I am intersted in alternative splice isoforms of A-Raf kinase and their contribution to signalling in tumour cells. Furthermore, I am interested in the spatial and temporal regulation of Raf kinases. Raf kinases are found at different localisations within a cell. I want to understand what kind of specific function is associated with this spatial and temporal regulation of signalling and which factors are involved.

Role

Postdoctoral researcher working with Professor Walter Kolch

Hometown

Munich, Germany

Career Path

1996-2001: Studies in Biochemistry, University of Leipzig, Germany,
2001: ERASMUS-student with Dr. Andrew Morby, Cardiff School of Biosciences, Cardiff University, UK
2001: MSc Biochemistry, University of Leipzig, Germany
2006: PhD in Biochemistry, University of Munich: PhD Thesis: 'Identification, validation and functional characterisation of specific tumour markers for head and neck carcinomas'
2006: Postdoctoral position with Prof. Olivier Gires in the Clinical Cooperation Group Molecular Oncology, University of Munich, Germany
2007-2009: Postdoctoral position with Prof. Walter Kolch, Proteomics and Signalling Networks group, The Beatson Institute for Cancer Research, Glasgow, UK
2009 - present: Postdoctoral position with Prof. Walter Kolch, Systems Biology Ireland, UCD

Selected Publications

Rauch, J., Volinsky, N., Romano, D., and Kolch, W. (2011). The secret life of kinases: functions beyond catalysis (Review). Cell Communication and Signaling : CCS 9, 23.

Rauch, J., Moran-Jones, K., Albrecht, V., Schwarzl, T., Hunter, K., Gires, O., and Kolch, W. (2011). c-Myc regulates RNA splicing of the A-Raf kinase and its activation of the ERK pathway. Cancer Research 71, 4664-4674.

Rauch, J., O'Neill, E., Mack, B., Matthias, C., Munz, M., Kolch, W., and Gires, O. (2010). Heterogeneous Nuclear Ribonucleoprotein H Blocks MST2-Mediated Apoptosis in Cancer Cells by Regulating a-raf Transcription. Cancer Research 70, 1679-1688.

Rauch, J., Ahlemann, M., Schaffrik, M., Mack, B., Ertongur, S., Andratschke, M., Zeidler, R., Lang, S., and Gires, O. (2004). Allogenic antibody-mediated identification of head and neck cancer antigens. Biochem Biophys Res Commun 323, 156-162.

Gires, O., Munz, M., Schaffrik, M., Kieu, C., Rauch, J., Ahlemann, M., Eberle, D., Mack, B., Wollenberg, B., Lang, S., et al. (2004). Profile identification of disease-associated humoral antigens using AMIDA, a novel proteomics-based technology. Cell Mol Life Sci 61, 1198-1207.

Why choose UCD Conway?

The UCD Conway Institute provides outstanding research facilities and infrastructure. The institute covers a wide range of research interests and multidisciplinary fields, providing great opportunities for collaborations.

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