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Featured Researcher: Dr Rosemary Kane

My Research

Idiopathic pulmonary fibrosis (IPF) is a chronic and fatal pulmonary disorder. Abnormalities in fibroblast and humoral response mechanisms may play a role in the pathogenesis of fibrosis in IPF.

IL-13, a cytokine which plays a critical role in inflammatory immune responses, has been shown to have an important role in animal models of pulmonary fibrosis. IL-13 mediates it effects through a complex receptor system that includes IL-4Ralpha, IL-13Ralpha1 and IL-13Ralpha2.  IL-13Ralpha2 binds IL-13 with high affinity and traditionally has been considered a decoy receptor, limiting the bioavailability of IL-13.

This has led us to hypothesise that IL-13Ralpha2 acts to regulate the type 2 response and attenuate the fibrotic effects of IL-13. Stat6 is a known mediator of type 2 responses and more specifically Stat6 is known to be involved in IL-13 signal transduction. We are currently investigating the role Stat6 plays in pulmonary fibroblasts in response to IL-13, and other possible alternative signalling pathways for IL-13.

Role

I am a senior research scientist working with Professor Michael Keane

Hometown

Dublin

Education

2004-2008: Health Research Board Postdoctoral Research Fellow. UCD School of Medicine and Medical Science & UCD Conway Institute of Biomolecular and Biomedical Research (PI: Prof Catherine Godson). Research included investigating the role of chordin-like 1, a BMP antagonist, in diabetic retinopathy.
2001- 2004: Postdoctoral Research Fellow, UCD School of Medicine and Medical Science & UCD Conway Institute of Biomolecular and Biomedical Research. (PI: Prof Catherine Godson), research included investigating the response of retinal pericytes to various diabetic stimuli and the development of EMT in RPE cells.
2001: Postdoctoral fellow, Department of Clinical Medicine, Trinity College Dublin
2001: PhD in Pharmacology, University College Dublin
1996: Honours Degree in Pharmacology, University College Dublin

Publications

Browne, J.G., Ho, S.L., Kane, R., Oliver, N., Clark, A.F., O'Brien, C.J. and Crean, J.K. (2011). Connective tissue growth factor is increased in pseudoexfoliation glaucoma. Investigative Ophthalmology and Visual Science. In Press

Kane, R., Godson, C. and O’Brien, C. (2008). Chordin-like 1, a BMP-4 antagonist, is upregulated by hypoxia in human retinal pericytes and plays a role in regulating angiogenesis. Molecular Vision  14:1138-1148

Lee, H., O'Meara, S.J., O'Brien, C. and Kane, R. (2007). The role of Gremlin, a BMP antagonist, and epithelial-to-mesenchymal transition in proliferative vitreoretinopathy. Investigative Ophthalmology and Visual Science. 48:4291-4299

Kane R, Stevenson L, Godson C, Stitt AW, O'Brien C. (2005) Gremlin gene expression in bovine retinal pericytes exposed to elevated glucose. Br J Ophthalmol. 89(12):1638-42

Kane, R., Murtagh, J., Finlay, D., Marti, A., Jaggi, R., Blachford, D., Wilde, C. and Martin, F. (2002) Transcription factor NFIC undergoes N-glycosylation during early mammary gland involution. Journal of Biological Chemistry 277:25893-25903

Why choose UCD Conway?

UCD Conway Institute has a broad range of groups, resulting in a research population with a huge variety of skills, providing plenty of opportunities for collaboration and discussion.

Meet more Conway researchers



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