Featured Researcher: Dr Eoin Cummins
My Research
I am currently focussed primarily on investigating the contribution and mechanism of micro-environmental factors such as oxygen levels, carbon dioxide levels and pH levels on immunoregulatory and inflammatory signalling pathways.
Role
I am a senior postdoctoral researcher working with Professor Cormac Taylor
Hometown
Firhouse, Dublin
Education
BSc Pharmacology, University College Dublin: 2002
Ph. D from the UCD School of Medicine & Medical Science: 2006
Postdoctoral researcher, Taylor laboratory, UCD Conway Institute: 2006-2008
Senior postdoctoral researcher, Taylor laboratory, UCD Conway Institute: 2008- present
Publications
Cummins, E.P., Berra, E., Comerford, K.M., Fitzgerald, K.T., Seeballuck, F., Godson, C., Nielsen, J.E., Moynagh, P., Pouyssegur, J., Taylor, C.T. (2006) Proc. Natl. Acad. Sci. U S A Nov 28;103(48):18154-9. Prolyl hydroxylase-1 negatively regulates IKKbeta giving insight into hypoxia-induced NFkappaB activity.
Cummins EP, Seeballuck F, Keely SJ, Mangan NE, Callanan JJ, Fallon PJ, Taylor CT. (2008) Gastroenterology Jan;134(1):156-65 The hydroxylase inhibitor dimethyloxalylglycine is protective in a murine model of colitis.
Murtaza M. Tambuwala*, Eoin P. Cummins*, Colin R. Lenihan*, Judith Kiss, Markus Stauch, Carsten C. Scholz, Peter Fraisl, Felix Lasitschka, Martin Mollenhauer, Sean P. Saunders, Patrick H. Maxwell, Peter Carmeliet, Padraic G. Fallon, Martin Schneider, Cormac T. Taylor (2010) Gastroenterology June 30. Epub ahead of publication. Loss of prolyl hydroxylase-1 protects against colitis through reduced epithelial cell apoptosis and increased barrier function.* The authors contributed equally to this manuscript
Eoin P. Cummins, Kathryn M. Oliver, Colin R. Lenihan, Susan F. Fitzpatrick, Ulrike Bruning, Carsten Scholz, Craig Slattery, Martin O. Leonard, Paul McLoughlin and Cormac T. Taylor (2010) Journal of Immunology October 1. NF-kappaB links carbon dioxide sensing to innate immunity and inflammation in mammalian cells.
Susan F. Fitzpatrick, Murtaza M. Tambuwala, Ulrike Bruning, Bettina Schaible, Carsten Scholz, Annette Byrne, Aisling O’Connor, William M. Gallagher, Colin R. Lenihan, John F. Garvey, Padraic G. Fallon, *Eoin P. Cummins and *Cormac T.Taylor (2010) Journal of Immunology (in press) The canonical NF-kappaB pathway is required for cyclooxygenase-2 expression in hypoxia *The authors contributed equally to this manuscript
Why choose UCD Conway?
UCD Conway Institute is a research environment with outstanding facilties and infrastructure. Coupled with the expert mentorship of Prof. Taylor, his collaborators and other members of the Taylor lab, the Conway Institute has been an exciting and productive place to develop my research career.