Featured Researcher: Dr Sinéad Ryan
Senior Postdoctoral Researcher
Cereer Path
1996: National Diploma in Fine Chemicals and Pharmaceutics from Galway-Mayo Institute of Technology
1999: Honours degree in Biochemistry from National University of Ireland Galway, including:
ERASMUS programme at the Physics department of the Ditaktiet Natuurkunde van de Universiteit van Amsterdam, Holland, working on the development of educational biochemistry experiments in conjunction with the IP-Coach software package for the introduction of eLearning in secondary schools.
LEONARDO and Aqua-TT programme with the Necton Micro-algae Research Group in Portugal, working on analytical techniques to identify the pigment profiles of micro-algae.
2005: PhD in Microbiology from the Alimentary Pharmabiotic Centre, BioScience Institute, National University of Ireland, Cork. Research included investigating the genetic and biochemical characterisation of prebiotic activities in Bifidobacterium breve. Joined UCD as a postdoctoral fellow working on a Science Foundation Ireland (SFI) funded project on the oral delivery of novel mucoadhesive polymeric peptide conjugates.
2008: Joined SFI Strategic Research Cluster funded research programme, the ‘Drug Delivery Network Ireland’, working on the development of oral and pulmonary drug delivery systems of therapeutic peptides.
Current research
Working on SFI Strategic Research Cluster funded research programme, the ‘Irish Drug Delivery Network’, which involves:
- Improvement and analysis of unstable therapeutics for drug delivery
- Development of an oral delivery system for salmon calcitonin by site specific PEGylation and complexation with novel comb shaped polymers for the treatment of osteoporosis
Other research interests
The identification and development of potential polymeric therapeutics for treatment of human inflammatory joint disease.
Collaborators
Dr Evelyn Murphy, University College Dublin, Ireland
Dr Jason McMorrow, University College Dublin, Ireland
Dr Woei Ping Cheng, University of Hertfordshire, UK
Dr Colin Thompson, The Robert Gordon University, Aberdeen
Dr Lidia Tajber, Trinity College Dublin, Ireland
Dr Marc DeVocelle, Royal College of Surgeons, Dublin, Ireland
Prof David Haddleton, University of Warwick, UK
Dr Guissepe Mantovani, University of Nottingham, UK
Professional memberships
2005 - Controlled Release Society
2008 - Royal Society of Chemistry
Publications
One-Pot Thiol-ene “Click” Approach to Polymer-Protein Conjugates, by Mathew W. Jones, Giuseppe Mantovania, Sinéad M Ryan, David J. Brayden and David M. Haddleton. Chem Commun (Camb). 2009 Sep 21;(35):5272-4.
Site-specific N-terminus conjugation of poly(mPEG1100) methacrylates to salmon calcitonin: synthesis and preliminary biological evaluation, by Claire T. Sayers, Giuseppe Mantovani, Sinead M. Ryan, Rajan K. Randev, Odin Keiper, Oksana I. Leszczyszyn, Claudia Blindauer, David J. Brayden and David M. Haddleton. Soft Matter, 2009 May 22;(5):3038-3046.
Conjugation of salmon calcitonin to a combed-shaped end functionalized poly(poly(ethylene glycol) methyl ether methacrylate) yields a bioactive stable conjugate, by Ryan SM, Wang X, Mantovani G, Sayers CT, Haddleton DM, Brayden DJ. Journal of Controlled Release 2009 Apr 2;135(1):51-9.
Dexamethasone-pDMAEMA polymeric conjugates reduce inflammatory biomarkers in human intestinal epithelial monolayers, by Keely S, Ryan SM, Haddleton DM, Limer A, Mantovani G, Murphy EP, Colgan SP, Brayden DJ. Journal of Controlled Release 2009 Apr 2;135(1):35-43.
Advances in PEGylation of important biotech molecules: delivery aspects, by Ryan SM, Mantovani G, Wang X, Haddleton DM, Brayden DJ. Journal Expert Opinion Drug Delivery 2008 Apr; 5(4):371-83.
Characterization of ApuB, an extracellular type II amylopullulanasefrom Bifidobacterium breve UCC2003, by O'Connell Motherway M, Fitzgerald GF, Neirynck S, Ryan S, Steidler L, van Sinderen D. Journal Appl Environ Microbiol 2008 Oct; 74(20):6271-9.
Screening for and identification of starch-, amylopectin-, and pullulan-degrading activities in bifidobacterial strains, by Ryan SM, Fitzgerald GF, van Sinderen D. Journal Appl Environ Microbiol 2006 Aug; 72(8):5289-96.
Transcriptional regulation and characterization of a novel β-fructofuranosidase-encoding gene from Bifidobacterium breve UCC2003, by Ryan SM, Fitzgerald G.F, van Sinderen D. Journal Appl Environ Microbiol. 2005 Jul; 71(7):3475-82.