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UCD Conway Institute is an interdisciplinary research centre exploring fundamental mechanisms of chronic disease for novel diagnostic & therapeutic solutions

The following should only be Diabetes people

Keywords: hypertension, heart disease, heart failure

My team focus on translational research in heart failure, specifically on the development of prognostic and diagnostic biomarkers and novel therapeutics for diastolic dysfunction. We also investigate therapeutics for pulmonary fibrosis .

Keywords: arteriosclerosis, macrophage biology, lipid biology, cardiovascular disease

Our current programme of research investigates the fundamental mechanisms governing atherosclerosis regression. Our laboratory has established a novel model of atherosclerosis regression in vivo, achieved by administration of conjugated linoleic acid (CLA) apoE knockout mouse model of atherosclerosis.

Keywords: oral delivery, diabetic drugs, oral peptide and macromolecule delivery, intestinal epithelial biology, in vivo pharmacokinetics, intra-articular delivery of anti-arthritic nanoparticles

The science of oral peptide delivery addresses how to convert normally injected biotech peptides and proteins to convenient oral forms for patients, such as oral insulin. However, the problem is that such molecules are unstable in the gut and are poorly absorbed so they require nanoparticle-based technologies to address these issues. We have a range of technologies and bioassays to contribute. We leverage such technologies into other therapeutic areas with unmet needs, such as delivery of nanoparticle-peptides into joints for arthritis.

Keywords: obesity, diet, metabolic syndrome, metabolomics, nutrigenomics

My research interests revolve around metabolism and altered metabolic pathways in health and disease. We currently employ nutrigenomic techniques (metabolomics, proteomics and transcriptomics) to further our understanding of the relationship between nutrition and health. Of particular interest is the development of metabolomics for nutritional research.

Keywords: Chronic lung disease pathogenesis, hypoxia, pulmonary vasculature, CXCL11/CXCL12 biological axis

I am interested in understanding the lung specific mechanisms through which hypoxia promotes structural changes in blood vessels and increased blood pressure in chronic lung diseases. Understanding these mechanisms may allow us to identify potential therapeutic strategies so as to target the disease process within the lung without causing unwanted adverse effects in other organs. We seek to identify lung-selective genes and lung-selective microRNAs that contribute to the unique response of the pulmonary vasculature to low oxygen levels.

Keywords: fibrosis, growth factors, signalling matrix

My focus is on the interplay between CCN proteins and the TGF? superfamily in diabetic nephropathy.

Keywords: growth, metabolism

My research interests are focused on a family of insulin growth hormone binding proteins (IGFBPs) which regulate IGF bioavailability and thus bioactivity. Reduced IGF-I bioavailability is a feature of type 1 and type 2 diabetes and there is growing evidence that this is an important factor in the pathophysiology of these disorders.

Keywords: Lipid metabolism, insulin signalling, gene expression, cell cycle regulation.

The group works on the SREBP family of transcription factors that control cholesterol and lipid metabolism and play critical roles during adipocyte differentiation and insulin-dependent gene expression. Disturbances in lipid metabolism are at the very core of several major health issues facing modern society, including cardiovascular disease, obesity and diabetes. So, the factors and signals that regulate the function of the SREBP family of proteins are very relevant to metabolic disease.

Keywords: PPAR-gamma, unsaturated lipid type, natural products, protease inhibitors, anti-angiogenic compounds, natural products, analogues

We are engaged in devising new methods for the chemical synthesis of natural products and their analogues with a view to both inventing and exemplifying new types of chemical reactions and also to investigating the biological activities of the synthesised targets. Targets include fatty acid metabolites and alkaloids with a range of biological effects including anti-inflammatory, anti-angiogenic, cytotoxic and CNS activity

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Keywords: Heart & lung transplant pathology, interstitial lung diseases, lung cancer and cardiac/cardiovascular pathology

I provide national expertise in interstitial lung disease and in adult sudden cardiac death, working closely with respiratory consultants and cardiothroacic surgeons. At research levels, I provide expertise in tissue and cell morphology, image analysis, animal models and immunohistochemistry.

Keywords: diabetic kidney disease, resolution of inflammation, diabetic complications, macrophages, signal transduction, gene expression

Our focus is on the molecular mechanisms underlying the initiation, progression and potential regression of diabetic kidney disease; genome wide association study of diabetic kidney disease and lipoxins and lipoxin stable analogues as modulators of inflammatory arthritis

Keywords: structural biology, diabetes, obesity, NMR spectroscopy

Our group is currently working on several research projects to look at the various ways to develop new drugs and alternative therapy in treatment of diabetes and other human diseases.

Keywords: Hypoxia, Inflammation, Fibrosis, Biomarker, Chronic Kidney Disease, Diabetes, Hypertension

my research has focussed intensively on the molecular processes which are altered in diseased kidneys. My studies have identified hypoxia, or insufficient oxygen, as a critical micro-environment which controls both pro-inflammatory and pro-fibrotic processes which are fundamental to kidney disease progression. I am currently examining how hypoxia-regulated pathways may be exploited in an effort to develop novel diagnostic and treatment strategies for DN. This research employs a variety of pre-clinical models of kidney disease along with analysis of CKD patient samples.

Keywords: PTO, vascular haematosis, cardiovascular mechanisms

We aim to elucidate the molecular mechanisms of prostanoid-mediated intracellular signalling and of the factors regulating the transcriptional expression of the TP and IP genes with the objective of obtaining a detailed understanding of TXA2- and prostacyclin-regulated haemostasis and vascular tone as well as their contribution to cardiovascular disease.

Keywords: Cardiovascular, diabetes, regenerative medicine, medical devices, preclinical pharmacology

I have successfully directed several projects in preclinical / clinical pharmacology, specifically in cardiovascular pathophysiology, diabetic complications, medical devices, arthritis, and regenerative medicine, which has resulted in either patentable products and/or high impact publications.

Keywords:

I have shown that early diabetic kidney disease (DKD) in obese patients can be reversed by Roux-en-Y gastric bypass (RYGB) surgery. Understanding the underlying mechanisms of such reversal will provide vital clues for innovative therapies and biomarkers of DKD regression/progression.

Keywords: platelets, megakaryocytes, cardiovascular disease, atherosclerosis, proteomics

We discovered new signalling machinery in platelets, termed WNT signalling, and can demonstrate that activation of a distinct subset of this machinery can negatively control platelet function. We now aim to investigate how the full complement of WNT machinery regulates platelet activity.

Keywords: falcipains inhibitors, malaria, enzyme inhibitors, uPA

We focus on synthesising protease inhibitors and studying how they interact with the proteases in order to help develop drugs for treating breast cancer and malaria

Keywords: pregnancy, fetal medicine, diabetes, ultrasound, fetal cardiology, nutrition

Key research areas are 1) Diabetes in pregnancy; research into the effect on mother and baby of pre pregnancy diabetes and of gestational diabetes 2) Nutrition in pregnancy; examination of the impact of maternal nutrition on maternal health and infant health 3)Ultrasound imaging in pregnancy; expanding the diagnostic role of ultrasound in its assessment of fetal health and fetal growth

Keywords: obesity, high-density lipoprotein (HDL) function, reverse cholesterol transport, inflammation, hepatosteatosis and diet

I am interested in the impact of obesity and inflammation on HDL function and cardiovascular health. A key goal of this research is to establish the effects of the obesigenic environment on the capacity of macrophages to mediate cholesterol efflux to HDL particles.

Keywords: lung disease, hypoxia, pulmonary hypertension, angiogenesis, acute lung injury

My research group is focused on the exploration and understanding of key mechanisms in the development and progression of lung diseases. We aim to identify potential therapeutic strategies that can be used to target the disease process within the lung without causing unwanted adverse effects in other organs.

Keywords: kidney disease, toxicology, cell signalling, biomarker identification and analysis

Our research focus is to investigate some of the causes of kidney disease. We have identified a number of proteins that malfunction during the development of kidney disease and are investigating the importance of these proteins in causing disease so as to identify novel early biomarkers and potential therapeutic strategies.

Keywords: metabolic disease, obesity, hypoxia

Sleep apnoea

Keywords: Diabetes, renal pathophysiology, chemoresistance, cancer biology, fibrogenesis, stenosis, biomarkers

The focus of my research is the identification and functional characterisation of novel therapeutic targets with the aim of developing improved therapeutics and diagnostics for fibrotic disease (including diabetic kidney disease) and more recently for cancer.

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Keywords: high content imaging, predictive toxicology, cardiac biomarkers

We have invented and validated a predictive cell-based assay for screening drug candidates for their risk of producing idiosyncratic hepatotoxicity and various other toxicities. We are further developing this method to enhance its user-friendliness and predictive effectiveness as well as adapting it for use in detection of on-going toxicity in vivo.

Keywords: medical devices, microfluidic devices, cell biomechanics

I am interested in working with clinicians and scientists to identify clinical needs and develop appropriate solutions with a strategic focus on targeted, minimally invasive delivery of next-generation therapeutics

Keywords: obesity

The gut hormone regulation of innate immunity and innate immune cell regulation of weight in adult and paediatric obesity

Keywords: insulin resistance, obesity, nutrition, aging and health, innate inflammation

Our Nutrigenomics Group focuses on the molecular basis of diet induced obesity, insulin resistance and diabetes. There is a strong inflammatory aspect to our work, as we are particularly focused on how dietary/metabolic stressors trigger a pro-inflammatory insulin resistant state.

Keywords: platelets, thrombosis, cell signalling

We are studying the mechanisms of platelet inhibition with the aim of identifying new diagnostic markers of platelet reactivity as well as targets for improved antiplatelet therapy.

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