UCD School of Chemical & Bioprocess Engineering
Scoil na hInnealtóireachta Ceimicí agus Bithphróisis UCD
Professor Eoin Casey BE PhD
Contact Details
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Biography:
| Eoin Casey was awarded the BE (Chemical) and PhD degrees from University College Dublin in 1994 and 1999 respectively. He spent one year as a research assistant in the Bioprocess Engineering research group in TU Vienna between 1994 and 1995. He spent three years (1999 to 2002) working in and R&D role at Scale-up Systems Ltd, where he was responsible for consultancy projects for clients in the biotechnology industry. He was appointed as lecturer in the UCD School of Chemical and Bioprocess Engineering since 2002 and is currently Associate Professor. |
Research Interests
| Current Research Interests:
Our main
programme of research concerns bacterial biofilms, with a primary emphasis on
interactions between the physico-chemical microenvironment and physiology. Our
approach involves a combination of experimental investigations with
mathematical modelling. We are using novel scale-down systems to investigate
physiological spatial heterogeneity in biofilms and to use these systems to
investigate, antimicrobial susceptibility, biocatalytic activity and detachment
mechanisms. Current Team
PhD Students Completed:
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Research Projects
| Sponsor : EC Framework Title : AFFIRM Start Date / End Date : 01-OCT-11 / 30-SEP-16 |
| Sponsor : Enterprise Ireland (EI) Title : CF, stage 2, Tech Dev & and Demo of an energy efficient bioreactor Start Date / End Date : 01-JUL-12 / 31-DEC-13 |
| Sponsor : Science Foundation Ireland (SFI) Title : micropollutant removal using nanofiltration membranes Start Date / End Date : 01-SEP-11 / 31-AUG-15 |
| Sponsor : Irish Research Council (IRC) Title : Irish Research Council Embark Scholarship Start Date / End Date : 01-SEP-12 / 31-AUG-15 |
| Sponsor : University College Dublin (UCD) Title : PI time for Fusion Start Date / End Date : 01-JUN-12 / 31-MAY-13 |
| Sponsor : University College Dublin (UCD) Title : Strategic Initiative Start Date / End Date : 01-OCT-12 / 30-SEP-13 |
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| Sponsor : Intertrade Ireland Title : FUSION PROJECT Start Date / End Date : 01-APR-12 / 31-MAR-13 |
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| Sponsor : Enterprise Ireland (EI) Title : Coordinator support for FP7 Start Date / End Date : 20-SEP-11 / 12-JAN-12 |
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| Sponsor : Enterprise Ireland (EI) Title : Technical development of an energy efficient bioreactor Start Date / End Date : 01-MAY-11 / 30-JUN-12 |
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| Sponsor : University College Dublin (UCD) Title : Eoin CASEY PI time Start Date / End Date : 01-OCT-11 / 30-SEP-16 |
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| Sponsor : Enterprise Ireland (EI) GKA Technologies Ltd. Title : solvent purification and recovery Start Date / End Date : 01-FEB-11 / 31-AUG-12 |
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| Sponsor : Enterprise Ireland (EI) Title : Network for energy efficient wastewater treatment technologies. Start Date / End Date : 26-OCT-10 / 28-JAN-11 |
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| Sponsor : Lexas Research Ltd. Title : A novel sterilisation system Start Date / End Date : 04-MAY-10 / 14-JUN-10 |
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| Sponsor : Environmental Protection Agency (EPA) Title : The upcycling of post consumer polyethylene to a biodegradable plastic: waste to value added product. Start Date / End Date : 01-OCT-09 / 30-SEP-12 |
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| Sponsor : University College Dublin (UCD) Title : Solute gradients in structurally heterogeneous biofilms: theoretical and experimental studies Start Date / End Date : 01-SEP-03 / 31-AUG-06 |
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| Sponsor : Enterprise Ireland (EI) Title : Scale-up strategies for the MABR Start Date / End Date : 06-APR-05 / 28-APR-06 |
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| Sponsor : Enterprise Ireland (EI) Title : A novel biorector with superior energy efficency Start Date / End Date : 01-JAN-07 / 30-JUN-08 |
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| Sponsor : Enterprise Ireland (EI) Title : Development of a novel drug delivery system for biofilm associated infections Start Date / End Date : 01-OCT-04 / 30-SEP-05 |
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| Sponsor : Science Foundation Ireland (SFI) Title : Investigation of the factors that determine physiological heterogeneity in biofilms Start Date / End Date : 06-SEP-04 / 31-MAR-08 |
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| Sponsor : Enterprise Ireland (EI) Title : Quantitative investigation of Biofilm Heterogeneity Start Date / End Date : 01-MAY-04 / 30-MAY-04 |
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| Sponsor : University College Dublin (UCD) Title : Commercialisation of the MABR Start Date / End Date : 03-OCT-05 / 31-JAN-06 |
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| Sponsor : Higher Education Authority (HEA) Title : Removal of toxic compounds from waste streams using a pseudomonas biofilm Start Date / End Date : 01-SEP-06 / 31-AUG-09 |
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| Sponsor : Science Foundation Ireland (SFI) Title : A fluid-structure interaction approach for the study of detachments from bacterial biofilms Start Date / End Date : 01-SEP-06 / 28-FEB-10 |
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| Sponsor : University College Dublin (UCD) Title : Development of a biofilm imaging facility Start Date / End Date : 01-SEP-06 / 31-AUG-07 |
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| Sponsor : University College Dublin (UCD) Title : Stability testing of a novel drug delivery system for biofilm associated infections Start Date / End Date : 01-JUL-06 / 31-JUL-06 |
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Book Chapters
E Casey; (2008) 'Membrane bioreactors' In: Anil Kumar Pabby, Ana Maria Sastre, and Syed S.H. Rizvi (eds). Handbook of Membrane Separations: Chemical, Pharmaceutical, and Biotechnological Applications. USA: CRC Press.  [Details] |
Peer Reviewed Journals
| Cotter JJ, Maguire P, Soberon F, Daniels S, O'Gara JP, Casey E.; (2011) 'Disinfection of meticillin-resistant Staphylococcus aureus and Staphylococcus epidermidis biofilms using a remote non-thermal gas plasma'. Journal of Hospital Infection, 78 (3):204-207. [DOI] [Details] |
| Nikodinovic-Runic, J, Casey, E, Duane, G.F., Mitic, D., Hume, A.R., Kenny, S.T., O'Connor, K.E., ; (2011) 'Process analysis of the conversion of styrene to biomass and medium chain length polyhydroxyalkanoate (mcl-PHA) in a two-phase bioreactor'. Biotechnology and Bioengineering, . [Details] |
| Misiak, K., Casey, E. and Murphy, CD; (2011) 'Factors influencing 4-fluorobenzoate degradation in biofilm cultures of Pseudomonas knackmussii B-13'. Water Research, 45 (11):3512-3520. [Details] |
| M Barrett, D O'Grady,E Casey, B Glennon; (2011) 'Role of Meso-Mixing in Anti-Solvent Crystallization Processes'. Chemical Engineering Science, . [Details] |
| Cotter JJ, O'Gara JP, Stewart PS, Pitts B, Casey E.; (2010) 'Characterization of a modified rotating disk reactor for the cultivation of Staphylococcus epidermidis biofilm'. Journal of Applied Microbiology, 109 (6):2105-2117. [Details] |
| Heffernan, B., Murphy, C., Syron, E. and Casey, E.; (2009) 'Treatment of fluoroacetate by a Pseudomonas fluorescens biofilm grown in a membrane aerated biofilm reactor'. Environmental Science and Technology, 43 :6776-6785. [DOI] [Details] |
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| Cotter, J.J., O'Gara, J. P. and E. Casey; (2009) 'Rapid depletion of dissolved oxygen in 96 well microtitre plate Staphylococcus epidermidis0 biofilm assays promotes biofilm development and is influenced by inoculum cell concentration'. Biotechnology and Bioengineering, 103 (5):1042-1047. [DOI] [Details] |
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| Heffernan,B ., Murphy, C. and Casey, E.; (2009) 'Comparative performance of planktonic and biofilm cultures of Pseudomonas fluorescens DSM 8341 grown on fluoroacetate'. Applied and Environmental Microbiology, 75 (9):2899-2907. [DOI] [Details] |
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| Syron, E., Kelly, H., Casey, E.; (2009) 'Studies on the effect of concentration of a self-inhibitory substrate on biofilm reaction rate under co-diffusion and counter diffusion configurations'. Journal of Membrane Science, 335 (1):76-82. [DOI] [Details] |
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| Cotter, J.J., O'Gara, J.P., Mack, D., Casey, E.; (2009) 'Oxygen-mediated regulation of biofilm development is controlled by the alternative sigma factor sigma(B) in Staphylococcus epidermidis0'. Applied and Environmental Microbiology, 75 (1):261-264. [DOI] [Details] |
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| Syron, E., Casey, E.; (2008) 'Membrane aerated biofilms for high rate biotreatment: performance appraisal, engineering principles, scale-up and development requirements'. Environmental Science and Technology, 42 (6):1833-1844. [Details] |
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| Syron, E., Casey, E.; (2008) 'Model-based comparative performance analysis of membrane aerated biofilm reactor configurations'. Biotechnology and Bioengineering, 99 (6):1361-1373. [Details] |
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| Casey E; (2007) 'Tracer measurements reveal experimental evidence of biofilm consolidation'. Biotechnology and Bioengineering, 98 (4):913-918. [Details] |
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| D. O'Grady, M. Barrett, E. Casey and B. Glennon; (2007) 'The Effect of Mixing on the Metastable Zone Width and Nucleation Kinetics in the Anti-Solvent Crystallization of Benzoic Acid'. Chemical Engineering Research and Design, Transactions, 85 (A7):945-952. [Details] |
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| Faulkner, E; Barrett, M; Okor, S; Kieran, P; Casey, E; Paradisi, F; Engel, P; Glennon, B; ; (2006) 'Use of fed-batch cultivation for achieving high cell densities for the pilot-scale production of a recombinant protein (phenylalanine dehydrogenase) in Escherichia coli'. Biotechnology Progress, 22 (3):889-897. [Details] |
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| Rishell, S., Casey, E., Glennon, B. and G. Hamer; (2004) 'Characteristics of a Methanotrophic Culture in a Membrane-Aerated Biofilm Reactor'. Biotechnology Progress, 20 (4):1082-1090. [Details] |
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| Rishell, S; Casey, E; Glennon, B; Hamer, G; ; (2004) 'Mass transfer analysis of a membrane aerated reactor'. Biochemical Engineering Journal, 18 (3):159-167. [Details] | |||||||||
| E. Casey, S. Rishell, B. Glennon and G. Hamer; (2004) 'Engineering aspects of a mixed methanotrophic culture in a membrane-aerated biofilm reactor'. Water Science Technology, 49 (11-12):255-262. [Details] | |||||||||
| Casey, E., B. Glennon and G. Hamer; (2000) 'Biofilm Development in a Membrane Aerated Biofilm Reactor: Effect of Flow Velocity on Performance'. Biotechnology and Bioengineering, 67 (4):476-486. [Details] | |||||||||
| Casey, E., B. Glennon and G. Hamer; (2000) 'Biofilm Development in a Membrane Aerated Biofilm Reactor: Effect of Intra-Membrane Oxygen Pressure on Performance'. Bioprocess Engineering, 23 (5):457-465. [Details] | |||||||||
| Casey, E., B. Glennon and G. Hamer; (1999) 'Oxygen Mass Transfer Characteristics in a Membrane Aerated Biofilm Reactor'. Biotechnology and Bioengineering, 62 (2):183-192. [Details] | |||||||||
| Casey, E., B. Glennon and G. Hamer; (1999) 'Review of Membrane Aerated Biofilm Reactors'. Resources Conservation and Recycling, 27 (1-2):203-215. [Details] | |||||||||
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Conference Publications
| A.J.C. Semiao, G. Gazzola, O. Habimana, R. Heffernan, C. Murphy, E. Casey (2012) Understanding the mechanisms of biofouling on nanofiltration membranes: effect of the biofilm structure on solute removal EUROMEMBRANE 2012 Conference, London [Details] |
| E. Syron, E. Casey (2012) Performance of a pilot scale membrane aerated biofilm reactor for the treatment of landfill leachate Euromembranes conference , London [Details] |
| Guzik M., Duane G., Kenny S., Casey E., O¿Connor K.; (2011) Mathematical modelling of the bioprocess for PHA production European Congress of Applied Biotechnology Berlin, , 25-SEP-11 - 29-SEP-11 [Details] |
| Katarzyna Misiak, Eoin Casey, Cormac Murphy; (2008) Biodegradation of fluorobenzoate using a Pseudomonas sp. B13 biofilm Society for General Microbiology 163rd Meeting , 08-SEP-08 - 11-SEP-08 [Details] |
| Eoin Casey, Eoin Syron, John Shanahan, Michael Semmens; (2008) Comparative economic analysis of full scale MABR configurations North American Membrane Research Conference University of Massachusetts, Amherst, USA, , 12-AUG-08 - 13-AUG-08 [Details] |
| Safari. A., Karac, A., Walter, M., Casey, E, Ivankovic, A; (2008) A two-phase flow model of biofilm detachment 31st Annual Meeting of The Adhesion Society Austin, TX. USA, [Details] | |||||||||
| M. Barrett, E. Casey, B. Glennon ; (2007) The Impact Of Mixing Times Scales And Process Parameters On The Optimisation And Scale Up Of Anti-Solvent Addition Crystallizations AIChE Annual meeting Salt Lake City, USA, [Details] | |||||||||
| Safari, A., Casey, E., Ivankovic, A.; (2007) A Fluid-Structure Interaction Approach to the Investigation of Detachment from Bacterial Biofilms 13th Bioengineering In Ireland Conference Killadeas, Fermanagh, Northern Ireland, [Details] | |||||||||
| John J. Cotter, James P. O'Gara, Philip S. Stewart, Betsey Pitts, Eoin Casey; (2007) Contribution of oxygen to Staphylococcus epidermidis biofilm development and antibiotic susceptibility American Society for Microbiology, Biofilms 2007 Quebec, Canada, , 25-MAR-07 - 29-MAR-07 , pp.172-173 [Details] | |||||||||
| Safari, A., Ivankovic, A., Tukovic, Z., Walter, M., Casey, E.,; (2009) A Fluid-Structure Interaction Study of Biofilm Detachment 1st International Conference on Computational and Mathematical Biomedical Engineering Swansea, UK, [Details] | |||||||||
| Syron, E. and Casey, E.; (2006) Towards a deterministic model of biofilm detachment: an experimental study Biofilms II - Attachment and Detachment in Pure and Mixed Cultures Leipzig, Germany, , 23-MAR-06 - 24-MAR-06 [Details] | |||||||||
| Barry Heffernan, Una Bryan, Cormac Murphy, Eoin Casey; (2007) Investigation of the effect of 2-fluorobenzoate on respiratory location in a stratified Pseudomonas fluorescens biofilm American Society for Microbiology, Biofilms 2007 Quebec, Canada, , 25-MAR-07 - 29-MAR-07 , pp.150-150 [Details] | |||||||||
| E Casey; (2007) Simulation studies of process scale membrane aerated biofilm reactor configurations 4th International Water Association Membranes Conference Harrogate, UK, , 15-MAY-07 - 17-APR-08 [Details] | |||||||||
| Eoin Syron, Eoin Casey; (2007) Characterization of biofilm detachment using a novel bioreactor American Society for Microbiology, Biofilms 2007 Quebec, Canada, , 25-MAR-07 - 29-MAR-07 , pp.141-141 [Details] | |||||||||
| M. Barrett, D. O'Grady, B. Glennon, E. Casey; (2006) The application of CFD to the Multi-Scale Characterisation of Anti-Solvent Addition Crystallization AIChE Annual Meeting San Francisco, USA, [Details] | |||||||||
| Syron, E. and, Casey, E; (2006) Dynamics of active layer stratification in a membrane-aerated biofilm IWA Conference on Biofilm Systems VI Amsterdam, the Netherlands, , 24-SEP-06 - 27-SEP-06 [Details] | |||||||||
| Heffernan, B., Phelan, S., Murphy, C., Casey, E.; (2006) Investigation of the effect of respiratory location in a stratified Pseudomonas fluorescens biofilm on overall activity for an inhibitory substrate IWA Conference on Biofilm Systems VI Amsterdam, the Netherlands, , 24-SEP-06 - 27-SEP-06 [Details] | |||||||||
| Cotter, J.J., O'Gara J.P., Casey E.; (2006) Analysis of Staphylococcus epidermidis 1457 biofilm grown in a Rotating-Disk Reactor (RDR) under defined oxygen concentrations International Symposium on Staphylococci & Staphylococcal Infections Maastricht, The Netherlands, , 03-SEP-06 - 06-SEP-06 [Details] | |||||||||
| E Syron, E Casey; (2004) Performance benchmarking of the membrane-aerated biofilm reactor: preliminary studies Structure and Activity of Biofilms-IWA Las Vegas, NV, USA, , 24-OCT-04 - 26-OCT-04 [Details] | |||||||||
| Syron, E. and Casey, E.; (2006) Towards a deterministic model of biofilm detachment: an experimental study Biofilms II - Attachment and Detachment in Pure and Mixed Cultures Leipzig, Germany, , 23-MAR-06 - 24-MAR-06 , pp.10-11 [Details] |
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| Casey, E., Rishell, S., Glennon, B., Hamer, G; (2003) Engineering aspects of a mixed methanotrophic culture in a membrane-aerated biofilm reactor 5th IWA Conference on Biofilm Systems Cape Town, South Africa, , 15-SEP-04 - 19-SEP-04 [Details] | |||||||||
| Heffernan, B., Phenlan, S., Murphy, C.D. & Casey, E.; (2005) Investigation of the interactions between biological and physico-chemical processes in a Pseudomonas fluorescens biofilm Recent Advances in Chemical Biology IV Dublin, Ireland, , 02-DEC-05 [Details] | |||||||||
| Barton, K., Irdam, E., Casey, E., Hannon, J., Hearn; (2001) Methodology for Characterization of Reaction Systems and Scale-up Based on Lab Data and Dynamic Simulation North American Mixing Forum: 18th Biennial Conference on Mixing Pocono Manor, Pennsylvania, USA, , 24-JUN-01 - 29-JUN-01 [Details] | |||||||||
| Casey, E., Hamer, G; (2001) Recent advances for the effective treatment of municipal sewage for reuse in hot arid regions . In: N. Al-Awadhi and F.K. Taha eds. Joint Japan/GCC Symposium on Greenery Development Kuwait, Amherst Scientific Publishers, Mass, USA, , 07-DEC-98 - 09-DEC-98 , pp.199-204 [Details] | |||||||||
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Reports
| Schuster, K.C, Gapes, J.R., Casey, E., Friedl, A., Schmidt, A; (1997) Erneuerbare Rohstoffe zur Energie- und Chemierohstoffgewinnung. In: Umweltbiotechnologie in Österreich. Schneider, M. and Gaugitsch, H. (eds.), Monographien Band 85A. Vienna, Austria: Reports [Details] |
Honours and Awards
| Year: 2011. Title: European Research Council Starting Independent Research Grant |
| Year: 2003. Title: UCD Presidents Research Award |
| Year: 1994. Title: Austrian Ministry of Science and Research scholarship |
| Year: 1995. Title: Kerr McGee Research scholarship |
Associations
| Association: International Water Association, Function/Role: |
| Association: Institution of Chemical Engineers, Function/Role: Member |
| Association: American Society for Microbiology, Function/Role: Member |
Conference Contributions
| Eoin Casey, Eoin Syron, John Shanahan, Michael Semmens; (2008) Comparative economic analysis of full scale MABR configurations. [Invited Oral Presentation], North American Membrane Research Conference, University of Massachusetts, Amherst, USA , 12-AUG-08 - 13-AUG-08. |
| Eoin Casey, Eoin Syron; (2008) Comparative economic analysis of MBRs a preliminary study. [Invited Oral Presentation], Membrane bioreactors, Cork, Ireland , 22-JAN-08 - 22-JAN-08. |
| E Casey; (2007) A scale-down approach for the investigation of biofilm systems. [Invited Oral Presentation], SGM Symposium: biofilms, Limerick, Ireland , 19-APR-07 - 20-APR-07. |
| Barton, K., Irdam, E., Casey, E., Hannon, J., Hearn, S.; (2001) Methodology for Characterization of Reaction Systems and Scale-up Based on Lab Data and Dynamic Simulation. [Invited Oral Presentation], North American Mixing Forum: 18th Biennial Conference on Mixing, Pocono Manor, Pennsylvania, USA , 24-JUN-01 - 29-JUN-01. |
| E Casey; (2001) Methodology for scale-up of organic synthesis steps: a lesson from industry. [Poster Presentation], ASEE Chemical Engineering Summer School, University of Colorado, Boulder, USA , 28-JUL-01 - 28-JUL-01. |
| E Casey; (2000) Computational Fluid Dynamics: Physics and Deployment Needs. [Oral Presentation], Chemical Reaction Engineering VII, Québec, Canada , 06-AUG-00 - 11-AUG-00. | |||||||||
| E Casey; (2000) The uses of Computational Fluid Dynamics in developing practical solutions to improving the quality of reservoir waters. [Invited Oral Presentation], Chartered Institution of Water and Environmental Management (CIWEM) meeting on reservoir management, Warrington, UK , 15-MAR-00 - 15-MAR-00. | |||||||||
| Casey, E., Hannon, J, Hearn, S; (2000) Simulation of Mixing and Reaction Processes in Pipes and Channels. [Invited Oral Presentation], IChemE Subject Group Symposium on Fluid Mixing Processes, University of Leeds, UK , 10-MAY-00 - 10-MAY-00. | |||||||||
| Casey, E; (1998) The membrane aerated biofilm reactor. [Oral Presentation], International Symposium of the International Society for Environmental Biotechnology,, Belfast , 15-JUN-98. | |||||||||
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Committees
| Committee : UCD Conway Institute Seminar Committee (2004 to 2006) |
| Committee : UCD Engineering Building committee (2003 to 2006) |
| Committee : Engineering Marks and Standards Working Group (2002-2005) |
Employment
| Employer: University College Dublin Position: Senior Lecturer (2008 to present) |
| Employer: University College Dublin Position: Lecturer (2002 to 2008) |
| Employer: Scale-up systems Ltd (1999 to 2002) Position: Senior Engineer |
| Employer: TU Vienna Position: Research Assistant (Bioprocess Engineering Research Group) (1994 to 1995) |
Education
| Year 1998 Institution: University College Dublin Qualification: PhD Subject: Chemical Engineering |
| Year 1994 Institution: University College Dublin Qualification: BE Subject: |
Other Activities
| External Examiner for PhD thesis, TU Denmark (2009) External Examiner for D. Phil thesis, Queens University, Belfast (2003) External Examiner for M Sc thesis, Dublin City University (2002) Reviewer for the journals: Biotechnology and Bioengineering, Water Research, Journal of Membrane Science, Biotechnology Progress (2002-present) Evaluation Committe for Enterprise Ireland Commecialisation Fund (2004)
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Internal Collaborators
| A fluid-structure interaction approch to detachment from bacterial biofilms Professor Alojz Ivankovic and Dr Denis Dowling, (co-applicants) UCD School of Electrical, Electronic & Mechanical Engineering Removal of toxic compounds from waste streams using a Pseudomonas biofilm Dr Cormac Murphy (Co-PI), UCD School of Biomolecular & Biomedical Science Investigation of the factors that determine physiological heterogeneity in biofilms Dr James O'Gara, (co-applicant) UCD School of Biomolecular & Biomedical Science |
External Collaborators
| Prof Michael Semmens, University of Minnesota, USA Prof Philp Stewart, Montana State University, USA |