UCD School of Chemical & Bioprocess Engineering
Scoil na hInnealtóireachta Ceimicí agus Bithphróisis UCD
Dr Susan McDonnell BSc, PhD
Contact Details
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Biography:
Susan McDonnell received a BSc in Biochemistry from University College Dublin in 1982 and then completed a PhD in Cell Biology in Dublin City University (DCU). She then spent four years working as a postdoctoral research fellow in Vanderbilt University, Nashville, Tennessee. In 1992 she was appointed lecturer in the School of Biotechnology, in DCU and moved to the Department of Chemical and Biochemical Engineering at UCD in 2004. Susan was awarded a Fulbright Scholarship in 1997 and spent a year's sabbatical in Memorial-Sloan Kettering Cancer Center, New York. Susan is a member of both the Irish and American Association for Cancer Research (AACR) and is council member of the Irish Association for Cancer Research |
Research Interests
Book Chapters
| Murray, D., Gorreta, F., Grant, G., Chandhoke, V. and McDonnell, S; (2007) 'The investigation of tumour metastasis using cDNA microarrays' In: Appasani, K (eds). Bioarrays: from basics to diagnostics. New Jersey: Humana Press. [Details] |
| McDonnell, S., Murray, D., Hughes, L. and Redmond, A.; (2006) 'Molecular Aspects of Cancer Invasion Chapter 3' In: Sherbet, G.V (eds). The Molecular and Cellular Pathology of Cancer Progression and Prognosis. Research Signpost: Not avaliable. [Details] |
| McDonnell, S., Murray, D., Hughes, L. and A. Redmond; (2006) 'Molecular Aspects of Cancer Invasion ' In: GV Sherbet (eds). The Molecular and Cellular Pathology of Cancer Progression and Prognosis. India: Research Signpost. [Details] |
Mc Donnell, S., O'Connor, A., Murray, D. and Lynch C; (2002) 'Matrix Metalloproteinases' In: AR Genazzani (eds). Hormone Replacement Therapy and Cancer. The current status of research and practice. London: Parthenon Publishing.  [Details] |
| Newell, K., Mc Donnell, S., Witty, J.P., Gaire, M., Rodgers, W.H., and L.M. Matrisian; (1993) 'The stromelysin subclass of metalloproteinases in tumour progression and metastasis' In: AJ Barrett and J Bond (eds). Proceedings of the 9th International ICOP Conference, Proteolysis and Protein Turnover. London: Portland Press. [Details] |
Peer Reviewed Journals
| Jessica Whelan, Eilis Murphy, Alan Pearson, Paul Jeffers, Patricia Kieran, Susan McDonnell and Brian Glennon (2012) 'Use of focussed beam reflectance measurement (FBRM) for monitoring changes in biomass concentration'. Bioprocess and Biosystems Engineering, 35 :963-975. [DOI] [Details] |
| Germano, S., Kennedy, S., Rani, S., Gleeson, G., Clynes, M., Doolan, P., McDonnell, S., Hughes, L., Crown, J., O'Driscoll, L.; (2011) 'MAGE-D4B is a novel marker of poor prognosis and potential therapeutic target involved in breast cancer tumorigenesis'. International Journal of Cancer, . [DOI] [Details] |
| James P. Ryle, Susan McDonnell and John T. Sheridan; (2011) 'Lensless multispectral digital in-line holographic microscope'. Journal of Biomedical Optics, 16 (12). [DOI] [Details] |
| Lau, TYK,Power, KA,Dijon, S,de Gardelle, I,McDonnell, S,Duffy, MJ,Pennington, SR,Gallagher, WM; (2010) 'Prioritization of candidate protein biomarkers from an in vitro model system of breast tumor progression toward clinical verification'. Journal of Proteome Research, 5 :1450-1459. [DOI] [Details] |
| Hughes, L., Malone, C., Chumsri, S., Burger, A. M., McDonnell, S., ; (2008) 'Characterisation of breast cancer cell lines and establishment of a novel isogenic subclone to study migration, invasion and tumourigenicity'. Clinical & Experimental Metastasis, 25 (5):549-557. [Details] |
| Hughes L, O'Brien SL, Gallagher WM and S McDonnell ; (2007) 'DNA microarray-based transcriptomic profiling of an isogenic cell culture model of breast tumour cell invasion'. Anticancer Research, 27 :1353-1360. [Details] | |||||||||
| McSherry, E. A., Donatello, S., Hopkins, A. M., McDonnell, S., ; (2007) 'Molecular basis of invasion in breast cancer'. Cellular and Molecular Life Sciences, 64 (24):3201-3218. [Details] | |||||||||
| Gallagher, W.M., Bergin, O.E., Rafferty, M., Kelly, Z.D., Nolan, I.M., Fox, E.J.P., Culhane, A.E., McArdle, L., Fraga, M.F.,Hughes, L., Currid, C.A., O'Mahony, F., Byrne, A., Murphy, A.A., Moss, C., McDonnell, S., Stallings, R.L., Plumb, J.A., Esteller, M., Brown, B., Dervan, P.A. and Easty, D.J. ; (2005) 'Multiple markers for melanoma progression regulated by DNA methylation: insights from transcriptomic studies'. Molecular Carcinogenesis, 26 (11):1856-1867. [Details] | |||||||||
| Murray, D, Morrin, M. and S. Mc Donnell; (2004) 'Increased invasion and expression of MMP-9 in a human colorectal cell line by a CD44-dependent mechanism'. Anticancer Research, 24 :489-494. [Details] | |||||||||
| Lynch, C.C., Crawford, H.C, Matrisian, L.M. and S. Mc Donnell ; (2004) 'Epidermal growth factor (EGF) upregulates matrix metalloproteinase-7 (MMP-7) expression through activation of PEA3 transcription factors'. International Journal of Oncology, 24 :1565-1572. [Details] | |||||||||
| Liang, Y., Mc Donnell, S., Doolan P. O'Driscoll, L. Oglesby, I. and , M. Clynes; (2004) 'Enhanced in vitro invasiveness and drug resistance with altered gene expression patterns in a human lung carcinoma cell line after pulse selection with anticancer drugs'. International Journal of Cancer, 111 :484-493. [Details] | |||||||||
| Howarth J., Kenny P., Mc Donnell S. and A. O'Connor; (2003) 'The design and synthesis of guanosine compounds with in vitro activity against the colon cancer cell line SW480: Non-taxane derived mimics of taxol?'. Bioorganic and Medicinal Chemistry Letters, 13 :2693-2697. [Details] | |||||||||
| Harmey, J.H., Bucana, C.D., Lu, W., Byrne, A.M., Mc Donnell, S., Lynch, C., Bouchier-Hayes, B., and Z. Dong; (2002) 'Lipopolysaccharide-induced metastatic growth is associated with angiogenesis, vascular permeability and tumor cell invasion'. International Journal of Cancer, 101 :415-422. [Details] | |||||||||
| Morrin, M.Morrin, M.,Murray, D.Murray, D.,McDonnell, S.McDonnell, S.,Delaney, P. V.Delaney, P. V.; (2002) 'Characterisation of effect on colorectal tumour cells of CD44 activation'. British Journal of CancerBritish Journal of CancerBritish Journal of Cancer, 86 . [Details] |
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| Liang, Y., Mc Donnell, S. and M. Clynes; (2002) 'Examining the relationship between cancer invasion/metastasis and drug resistance'. Current Cancer Drug Targets, 2 :257-277. [Details] | |||||||||
| Murray, D.Murray, D.,McDonnell, S.McDonnell, S.; (2002) 'Interactions between CD44, beta-1 integrin and the matrix metalloproteinases in regulating colorectal cancer cell adhesion and invasion'. British Journal of CancerBritish Journal of CancerBritish Journal of Cancer, 86 . [Details] |
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| Liang Y., Meleady P., Cleary I., Mc Donnell, S., Connolly L. and M. Clynes; (2001) 'Selection with melphalan or taxol yields variants with different patterns of multidrug resistance, integrin expression and in vitro invasiveness'. European Journal of Cancer, 37 :1041-1052. [Details] | |||||||||
| Lynch, C. and S. Mc Donnell; (2001) 'Role of matrilysin in leukaemia cell invasion'. Clinical and Experimental Metastasis, 18 :401-406. [Details] | |||||||||
| Mc Donnell, S., Morgan, M. and C. Lynch; (1999) 'Role of matrix metalloproteinases in normal and disease processes'. Biochemical Society Transactions, 27 :7734-7740. [Details] | |||||||||
| Mc Donnell, S., Chaudhry. V., Mansilla-Soto, J., Zeng, Z.S., Shu, W.P. and J.G. Guillem; (1999) 'Metastatic and non-metastatic colorectal cancer cells (CRC) induce host metalloproteinase production in vivo'. Clinical and Experimental Metastasis, 17 :341-349. [Details] | |||||||||
| Morgan, M. and S. Mc Donnell; (1999) 'Modulation of matrix metalloproteinases in trophoblast cell lines'. Annals of the New York Academy of Science, 878 :563-565. [Details] | |||||||||
| Morgan, M., Kniss, D. and S. Mc Donnell; (1998) 'Expression of metalloproteinases and their inhibitors in human trophoblast continuous cell lines'. Experimental Cell Research, 242 :18-26. [Details] | |||||||||
| Witty, J.P., Mc Donnell, S., Newell, K., Cannon, P., Navre, M., Tressler, R. and L.M. Matrisian; (1994) 'Modulation of matrilysin levels in colon carcinoma cell lines affects tumorigenicity in vivo'. Cancer Research, 54 :4805-4812. [Details] | |||||||||
| Gaire, M., Magbanua, Z., Mc Donnell, S., Mc Neil, L., Lovett, D.H., and L.M. Matrisian; (1994) 'Structure and expression of the human gene for the matrix metalloproteinase matrilysin'. Journal of Biological Chemistry, 269 :2032-2040. [Details] | |||||||||
| Wright, J.H., Mc Donnell, S., Portella, G., Bowden, G.T., Balmain, A., and L.M. Matrisian; (1994) 'A switch from stromal to tumor cell expression of stromelysin-1 mRNA associated with the conversion of squamous to spindle carcinomas during mouse skin tumor progression'. Molecular Carcinogenesis, 10 :207-215. [Details] | |||||||||
| Mc Donnell, S., Wright, J.H., Gaire, M. and L.M. Matrisian; (1994) 'Expression and regulation of stromelysin and matrilysin by growth factors and oncogenes'. Biochemical Society Transactions, 22 :58-63. [Details] | |||||||||
| Mc Donnell, S. and B. Fingleton; (1993) 'Role of metalloproteinases in invasion and metastasis : biology, diagnosis and inhibitors'. Cytotechnology, 12 :367-384. [Details] | |||||||||
| Busiek, D.F., Ross, F.P., Mc Donnell, S., Murphy, G., Matrisian, L.M., and H.G. Welgus; (1992) 'The matrix metalloproteinase matrilysin (pump) is expressed in developing human mononuclear phagocytes'. Journal of Biological Chemistry, 267 :9087-9092. [Details] | |||||||||
| Mc Donnell, S., Coffey, R.J., Navre, M. and L.M. Matrisian; (1991) 'Expression and localization of the matrix metalloproteinase Pump in human colorectal and gastric carcinomas'. Molecular Carcinogenesis, 4 :527-533. [Details] | |||||||||
| Matrisian, L.M., Mc Donnell, S., Miller, D.B., Navre, M., Seftor, E.A., and M.J.C. Hendrix; (1991) 'The role of the matrix metalloproteinase stromelysin in the progression of squamous cell carcinomas'. American Journal of Medical Science, 303 :157-162. [Details] | |||||||||
| Mc Donnell, S., and L.M. Matrisian; (1990) 'Stromelysin in tumour progression and metastasis'. Cancer Metastasis Review, 9 :305-319. [Details] | |||||||||
| Mc Donnell, S., Kerr, L.D., and L.M. Matrisian; (1990) 'Epidermal growth factor stimulation of stromelysin in rat fibroblasts requires induction of the proto-oncogenes c-fos and c-jun and activation of protein kinase C'. Molecular Cell Biology, 10 :4284-4293. [Details] | |||||||||
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Conference Publications
| Rani, S, O'Brien, K, McDonnell, S, Hughes, L, Friel, A. M, Radomski, M. W., Crown, J. and O'Driscoll L (2011) Triple-negative Breast Cancer Cells May Transfer Phenotypic Characteristics via Exosomes European Journal of Cancer , pp.S143-S143 [Details] |
| O¿Brien K, Rani S, McDonnell S, Hughes L, Radomski MW, O¿Driscoll L; (2011) Investigating naturally-occurring nano-sized exosomes in cancer National Pharmacy Meeting [Details] |
| Whelan, J., McDonnell, S., Glennon, B.; (2011) Tracking Changes in Biomass using Focussed Beam Reflectance Measurement (FBRM) BioProcessing, Biologics & Biotherapeutics Congress [Details] |
| Ryle JP, Moloney KM, McDonnell S, Naughton TJ and JT Sheridan; (2009) Multispectral lensless digital holographic microscrope: imaging MCF-7 and MDA-MB-231 cancer cell cultures Proceeding of SPIE, Optics and Photonics for Information Processing III , pp.Volume 7442-744206 [Details] |
| McGee, S.F., O' Connor, D.P., Mc Donnell, S., Duffy, M.J., Gallagher, W.M; (2009) A functional genomics screen identifies serpinB2 as a key mediator of breast cancer progression The Metastasis Research Society-American Association for Cancer Research Conference on Metastasis [Details] |
| Germano S, Kennedy S, Hughes L, McDonnell S, Mehta JP, Doolan P, Clynes M, O'Driscoll LO; (2009) Characterisation of neuronal calcium sensor-1 (NCS-1) as a novel prognostic biomarker wit potential therapeutic implications for triple negative breast cancer . In: Annals of Oncology eds. IMPAKT Breast Cancer Conference , pp.49-50 [Details] | |||||||||
| Ryle JP, Monaghan DS, McDonnell S and JT Sheridan; (2009) Real world objects: capturing using in-line digital holography projecting using spatial light modulators Proceeding of SPIE, Optics and Photonics for Information Processing III [Details] | |||||||||
| Malone, C., McGee, S., Hughes, L., Gallagher, W.M., and S. McDonnell; (2008) Effect of PLAC8 knockdown in breast cancer cell line growth 4th All Ireland Cancer Conference, Dublin, December, 2008 [Details] | |||||||||
| Malone, C., McGee, S., Hughes, L., Gallagher, W.M. and S McDonnell (; (2008) Study of the Functional Effects of Lentiviral-Mediated RNAi Knockdown of Novel Gene PLAC8 in Breast Cancer Progression Irish Association for Cancer Research, Annual Meeting [Details] | |||||||||
| McDonnell, S, Hughes, L, Malone, C, ; (2007) ANTICANCER RES Microarray analysis of invasion in human cancer cells in vitro , pp.1371-1372 [Details] | |||||||||
| Malone, C., McGee, S., Hughes, L., Gallagher, W.M. and S McDonnel; (2007) Lentiviral-Mediated RNAi Knockdown of Novel Breast Cancer Associated Gene PLAC8 AACR Special Conference in Cancer Research [Details] | |||||||||
| Lau, T.Y., O'Connor, D.P., Hughes, L., McDonnell, S., Duffy, M.J., Martin, F., Pennington, S.R., & Gallagher, W.M.; (2006) Proteomic analysis of models of breast cancer progression EMBO Molecular Medicine Conference: Common Molecular Mechanisms of Mammary Gland Development and Breast Cancer Progression Dublin, Ireland, , 06-JUN-06 - 08-JUN-06 [Details] | |||||||||
| Lau, T.Y., O'Connor, D.P., Hughes, L., McDonnell, S., Duffy, M.J., Martin, F., Pennington, S.R., & Gallagher, W.M.; (2006) Proteomic analysis of models of breast cancer progression 3rd Joint British Society for Proteomics Research/European Bioinformatics Research meeting Hinxton, Cambridge, UK, , 12-JUL-06 - 14-JUL-06 [Details] | |||||||||
| Malone, C., Hughes, L., Gallagher, W.M. & McDonnell, S.; (2006) Investigation of potential markers of breast cancer invasion EMBO Molecular Medican Conference. Common Molecular Mechanisms of Mammary Gland Developmet and Breast Cancer Progression Dublin, Ireland, , 06-JUN-06 - 08-JUN-06 [Details] | |||||||||
| Malone, C., Hughes, L., Gallagher, W.M. & McDonnell, S.; (2006) Identification and expression analysis of candidate markers of breast cancer invaison 19th European Association for Cancer Research Budapest, Hungary, , 01-JUL-06 - 04-JUL-06 [Details] | |||||||||
| Hughes, L., Malone, C., O'Brien, S., Gallagher, W.M. & McDonnell, S.; (2006) Expression of candidate invasion-specific genes, PLAC8, CTAG1B, Lumican and Decorin in human cancer cell lines Irish Association for Cancer Research Annual Meeting Galway, Ireland, , 03-MAR-06 - 04-MAR-06 [Details] | |||||||||
| Lau, T.Y., O'Connor, D.P., Hughes, L., McDonnell, S., Duffy, M.J., Martin, F., Pennington, S.R., & Gallagher, W.M.; (2006) Proteomic analysis of models of breast cancer progression EMBO Molecular Medicine Conference: Common Molecular Mechanisms of Mammary Gland Development and Breast Cancer Progression Dublin, Ireland, , 06-JUN-06 - 08-JUN-06 [Details] | |||||||||
| Redmond, A., Gray, I., Nolan, K. & McDonnell, S.; (2006) Novel 5-Fluorouracil pro-drug derivatives EMBO Molecular Medican Conference. Common Molecular Mechanisms of Mammary Gland Developmet and Breast Cancer Progression Dublin, Ireland, , 06-JUN-06 - 08-JUN-06 [Details] | |||||||||
| Hughes, L. & McDonnell, S.; (2005) Gene expression profiling of human breast cancers within an Irish population using DNA microarrays Irish Research Council for Science, Engineering and Technology, Third Annual Symposium Dublin, Ireland, , 03-NOV-05 - 03-NOV-05 [Details] | |||||||||
| Hughes, L., Malone, C., O'Brien, S., Gallagher, W.M. & McDonnell, S.; (2005) Development, characterisation and gene expression profiling of a novel more invasive variant established from the human breast cancer cell line Hs578T Development, characterisation and gene expression profiling of a novel more invasive variant established from the human breast cancer cell line Hs578T , pp.88-89 [Details] | |||||||||
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Honours and Awards
| Year: 1987. Title: Fulbright Scholarship |
| Year: 1996. Title: Royal Irish Academy Senior Visiting Scholarship |
Associations
| Association: Irish Association for Cancer Research, Function/Role: Member |
| Association: European Association for Cancer Research, Function/Role: Member |
| Association: American Association for Cancer Research, Function/Role: Member |
Conference Contributions
| Susan McDonnell; (2006) EMBO Molecular Medicine Conference, Common Molecular Mechanisms of Mammary Gland Development and Breast Cancer Progression. [Chaired Session], EMBO Molecular Medicine Conference, Common Molecular Mechanisms of Mammary Gland Development and Breast Cancer Progression, O'Reilly Hall, UCD, Dublin , 06-JUN-06 - 08-JUN-06. |
| Malone C, Hughes L, Gallagher WM, S McDonnell; (2006) European Association for Cancer Research. [Published Abstract], European Association for Cancer Research, Budapest , 01-JUL-06 - 05-JUL-06. |
| Hughes L, Malone C, O'Brien SA, Gallagher WM, S McDonnell; (2006) Irish Association for Cancer Research, Annual Meeting. [Poster Presentation (Refereed)], Irish Association for Cancer Research, Annual Meeting, Galway , 22-MAR-06 - 23-MAR-06. |
Committees
| Committee : UCD Seed Fund |
| Committee : Irish Branch of the European Tissue Culture Society |
| Committee : EMPS Graduate School Board |
Other Activities
| Invited lecturer, Dublin Molecular Medicine Center, Cancer Biology to Cancer Medicine Course |
| Invited lecturer, St. James's Hospital Molecular Medicine Lecture Series |
Internal Collaborators
| Dr. Kieran Nolan, School of Chemical Sciences, Dublin City University, Glasnevin, Dublin. Prof. Martin Clynes, National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin Dr. Judith Harmey, Molecular & Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin . Dr. Margaret Worrall, School of Biomolecular & Biomedical Science, Conway Institute, UCD. Prof. Sean Sheridan, School of Electrical, Electronic & Mechanical Engineering, UCD. |
External Collaborators
| Dr. Angelika Burger, Wayne State University, Karmanos Cancer Institute, Detroit, USA |