UCD School of Chemical & Bioprocess Engineering
Scoil na hInnealtóireachta Ceimicí agus Bithphróisis UCD
Professor Mohamed Al-Rubeai BSc, PhD
Contact Details
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Biography:
Professor Mohamed Al-Rubeai graduated from the University of Baghdad in 1969 and obtained his PhD in Genetics from QMC, University of London in 1979. Immediately after receiving his PhD he joined the University of Garyounis as a lecturer in Biology. He returned to the UK to work as a research fellow at the university of Surrey. He moved to the University of Birmingham in 1988 and was appointed to the Chair of Biotechnology in 2000. In 2005 he moved to University College Dublin to take up the newly established Chair of Biochemical Engineering. He remained as an adjunct professor at the University of Birmingham until 2008. Professor Al-Rubeai is the editor of "Cell Engineering", reviews editor of "Cytotechnology", member of editorial board of "Biotechnology and Bioengineering" and "Biotechnology and Applied Biochemistry", recipient of the Donald Medal 2008, fellow of the Society of Biology, member of Sigma-Aldrich and Vivalis advisory boards, scientific advisor to the President of Iraq and advisor to UNESCO. He is a co-author of "Engineering a Knowledge Island 2020". He has authored over 450 professional papers, reviews, chapters and patents that reflect his broad interest in production of iopharmaceuticals, mammalian cell culture, tissue engineering, stem cell bioprocessing, metabolic engineering and biomaterials. He supervised 40 PhD and 45 MSc dissertations, gave more than 50 invited talks in international conferences, lectured in more than 50 universities, research institutes and biopharmaceutical companies and awarded in excess of 15M Euro as research grants. |
Research Interests
| The Animal Cell Culture Technology Group conceived with the SFI support in 2005 in the School of Chemical and Bioprocess Engineering and Conway Institute of Biomolecular & Biomedical Research at the University College Dublin is the first and only such group in Ireland dedicated to the process engineering of biotechnological processes involving animal cells based on a combination of engineering, analytical, biological and physiological skills. The research objectives of the group concern the provision of design bases for the more effective and economic application of intensive production methods for mammalian cells. In particular, the intensification of such processes is dependent upon understanding the physiological determinants of cell growth and death, and of product synthesis and secretion, and also the physical determinants of culture performance in the intensified bioreactor environment. The group approach to cell culture development and optimisation is to provide an understanding of the relationship between gene and protein expression and growth and productivity. On the basis of this improved understanding novel strategies for optimisation of cell culture should be possible. These strategies include the development of methods to improve cell culture, survival and proliferation of mammalian cells. Underlying these efforts is the need for rapid, reliable techniques for selection of high producers and monitoring cell viability and physiology. Underlying the work its central coherence with existing key research themes within the Conway Institute (e.g. gene array analysis, proteomics and cytomics). The programme is focused exclusively on strategically important themes in the development of mammalian cell culture processes for enhanced and optimised production of biopharmaceuticals. Mammalian cell culture processes face numerous challenges related to compressed product development cycles, capacity shortages, and the proliferation and productivity of cell lines and culture conditions. Exploitation of the advances in molecular biology will help to resolve many of the problems associated with large scale production. The group is also interested in research in the following areas of cell culture technology: § In-line bioprocess monitoring by cytometric methods Conventional off-line techniques for monitoring culture conditions are time- and labour-intensive, and incompatible with modern development and manufacturing timelines. The development of flow cytometric techniques has greatly advanced our ability to identify and characterise the morphological and biochemical heterogeneity of cell populations, permitting a rapid and sensitive cell analysis. If it is to make a real impact on the control of cell culture processes, however, the technique must become available on-line. This proposal is to eliminate this critical limitations for extensive investigations of single cell parameters. The obtained results have convinced us that the time is ready for the next step of development in single cell analysis that promises significant further advances in studying, monitoring and controlling cell cultures. Project objectives: 1. To build a prototype of an automatic sample handling and staining device and interface it with a dedicated bioreactor/flow cytometer system for on-line analysis of cell populations. 2. To develop protocols for on-line staining of cell populations. The steps performed automatically will include sample dilution, cell fixation and cell staining to permit quantitation of the macromolecular composition of individual cells. The staining steps will be carried out in a specifically designed microchamber.This work is part of a programme funded EI Bioindustry Led Research Project on bioprocess application of process analytical technology (apPAT) which is based on previously funded project by EI (BioMon), which developed a prototype device for the automated preparation of process samples for cell culture characterisation based on flow cytometric measurements. This project (apPAT) will demonstrate and validate a capability for improved process monitoring and control using Process Analytical Technology (PAT). This project will address the integration of these technologies with a commercial data management and batch monitoring and control system which will provide the platform for the required data collection, analysis and control loop implementation. The project will address the critical issue of aseptic automated sampling through a rigorous evaluation of available sampling systems, with appropriate modification where necessary. It is anticipated that the monitoring protocols developed will provide a basis for routine automated sampling and measurement for cell culture bioreactors. § Development of scalable systems for human red blood cell production from heamatopoietic stem cells Ex vivo expansion of erythroid progenitors from cord blood and other sources is a potential source for supply of blood products which would significantly improve the transfusion capacity of blood centres (Neildez-Nguyen et al. 2002 Nature Biotechnol. 20, 467). While the maintenance of erythropoiesis and enucleation mechanisms in vivo depends on a delicate interaction of different growth factors, lineage specific cytokines and haematopoietic microenvironment, recent work has demonstrated that the primitive haematopoietic stem cells (CD34+) could be expanded and converted ex vivo into mature RBCs (Giarratana et al. 2005 Nature Biotechnol. 23, 69). In vitro generated RBCs have all the characteristics of functional, native, adult RBCs in terms of enzyme content, membrane deformability and the capacity to fix and release oxygen. In this project, we are seeking to develop a continuously perfused free suspension or encapsulated system to provide suitable environment for high growth rate with high potential for fully maturation into RBCs and facilitates long term in vitro growth of haematopoietic stem cells and their differentiation into a pure erythroid lineage. § Cell-nanosurface interactions (Precision Programme). Precision is a Strategic Research Cluster supported by Science Foundation Ireland and our Industrial partners. The Cluster aims to develop the scientific and technological knowledge needed for present and future manufacturing applications using plasmas, with a specific emphasis on nano-scale products, process reliability, manufacturing costs and advanced materials processing. It enables the fundamental understanding of plasma processing to be coupled with real word product application in the medical device and food packaging industries. As part of this project, our group will investigate: 1) The influence of surface modifications on progenitor cell (bone marrow mesenchymal cells (MSC)) adhesion and differentiation. 2) The deposition of nano-coatings that contain natural antioxidants onto food packaging material. § Bioprocessing of virally transduced cells for the application of gene therapy. § Process intensification and development of serum free media. § Development of a scaleable disposable bioreactor for animal cell culture. § Application of systems biology to understanding the behaviour of mammalian cells and enhancing their targeted productivity. § Expansion of Chondroprogenitor cells and development of 3D engineered cartilage
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Research Projects
| Sponsor : Science Foundation Ireland (SFI) Title : Precision - Plasma Technology for Nano Manufacturing Start Date / End Date : 01-JAN-09 / 31-DEC-11 |
| Sponsor : Enterprise Ireland (EI) Title : BIO Application of Process Analytical Technology (Bio PAT) Start Date / End Date : 01-JAN-09 / 30-JUN-12 |
| Sponsor : HEA/PRTLI Cycle 4 Grant Title : Use of RNA interference technology to generate apoptotic resistant and highly proliferating cell lines for the Biopharmaceutical industry Start Date / End Date : 01-SEP-08 / 30-SEP-13 |
| Sponsor : Astellas European Foundation Title : Deciphering the Modulation of antibody productivity Start Date / End Date : 01-JAN-08 / 31-DEC-08 |
| Sponsor : Irish Blood Transfusion Service (IBTS) Title : In Vitro Production of human red blood cells Start Date / End Date : 07-JAN-08 / 07-DEC-10 |
| Sponsor : Sigma USA Via University Of Birmingham Title : Cell culture work Start Date / End Date : 15-SEP-06 / 31-DEC-06 |
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| Sponsor : Science Foundation Ireland (SFI) Title : SFI Investigator in Biochemical Engineering. Professor Mohamed Al-Rubeai Start Date / End Date : 01-JAN-05 / 31-DEC-08 |
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| Sponsor : Irish Blood Transfusion Service (IBTS) Title : Development of a reproducible and scalable system for human red blood cell production from haematopoietic progenitor cells Start Date / End Date : 09-NOV-05 / 08-MAY-09 |
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| Sponsor : Irish Research Council for Science Engineering and Technology (IRCSET) Title : Quantitative analysis of virus infected animal cells using proteomic approaches Start Date / End Date : 01-OCT-05 / 31-MAR-09 |
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| Sponsor : Enterprise Ireland (EI) Title : Bioprocess Monitoring Technology Start Date / End Date : 01-MAR-06 / 31-DEC-07 |
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Book Chapters
| Warnock J. N., Daigre C. Al-Rubeai M. ; (2011) 'Introduction to viral vectors' In: Merten O-W and Al-Rubeai M (eds). Viral Vectors for Gene Therapy: Methods and Protocols. Methods in Molecular Biology. New York: Humana Press. [Details] |
| Alfonso B-F. and Al-Rubeai M. ; (2011) 'Flow cytometry' In: Murray Moo-Young (eds). Comprehensive Biotechnology. Germany: Elsevier. [DOI] [Details] |
| Kuystermans D. and Al-Rubeai M. ; (2011) 'Bioreactor systems for the production of antibody from mammalian cells' In: Antibody Expression and Production. Cell Engineering. vol. 7. Dordrecht: Springer. [DOI] [Details] |
| Naciri M. and Al-Rubeai M.; (2010) 'Cell Cycle' In: Encyclopedia of Industrial Biotechnology. USA: John Wiley & Sons, Ltd. [DOI] [Details] |
| Naciri M., Holmes P., Al-Rubeai M.; (2010) 'Cell Cycle Synchronization' In: Encyclopedia of Industrial Biotechnology. USA: John Wiley & Sons, Ltd. [DOI] [Details] |
| Khoo S. H. G., Singh R. P., Al-Rubeai M. ; (2010) 'Apoptosis' In: Encyclopedia of Industrial Biotechnology. USA: John Wiley & Sons, Ltd. [DOI] [Details] | |||||||||
Melero-Martin J. M., Santhalingam S., Al-Rubeai M. ; (2009) 'Methodology for optimal in vitro cell expansion in tissue engineering' In: Bioreactor Systems for Tissue Engineering. Berlin: Springer-Verlag.  [Details] |
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| Browne S. M. and Al-Rubeai M. ; (2009) 'Selection Methods for High-Producing Mammalian Cell Lines' In: Cell Engineering: Cell Line development. Berlin: Springer. [Details] | |||||||||
| Al-Rubeai M.; (2009) 'Cell Engineering ¿ Overview' In: Al-Rubeai M (eds). Cell Engineering. Dordrecht: Springer. [Details] | |||||||||
| Ifandi, V. and Al-Rubeai M.; (2007) 'Engineering of Cell Proliferation via myc Modulation' In: Al-Rubeai, M. and Fussenegger, M (eds). Cell Engineering vol. 5. Systems Biology. London: Springer. [Details] |
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| Khoo, S.H.G. and Al-Rubeai, M.; (2007) 'Metabolomics' In: Al-Rubeai, M. and Fussenegger, M (eds). Cell Engineering vol. 5. Systems Biology. London: Springer. [Details] |
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| Melero-Martin J. M. and Al-Rubeai M.; (2007) 'In vitro expansion of chrondrocytes' In: Ashammakhi, N., Reis, R.L. and Chiallini, E (eds). Topics in Tissue Engineering, Vol 3. internet: E-book: Biomaterials and Tissue Engineering Group. [Details] |
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| Carroll S., Naciri M. Al-Rubeai M.; (2007) 'Monitoring of growth, physiology and productivity of animal cells by flow cytometry' In: R. Portner (eds). Animal Cell Biotechnology, Methods and Protocols. Methods in Biotechnology, vol 24. New Jersey, USA: Humana Press. [Details] |
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| Ishaque A. and Al-Rubeai M; (2007) 'Measurement of apoptosis in cell culture' In: Portner, R (eds). Animal Cell Biotechnology, Methods and Protocols. Methods in Biotechnology, vol 24. New Jersey, USA: Humana Press. [Details] |
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| Warnock, J., Bratch, K. and Al-Rubeai, M.; (2005) 'Packed bed bioreactors' In: Chaudhuri, J. and Al-Rubeai, M (eds). Bioreactors for Tissue Engineering. Dordrecht: Springer. [Details] | |||||||||
| Warnock, J. and Al-Rubeai, M.; (2005) 'Production of biologics from animal cell cultures' In: Nedovic, Viktor, Willaert, Ronnie (eds). Applications of Cell Immobilisation Biotechnology. Series: Focus on Biotechnology. Dordrecht: Springer. [Details] | |||||||||
| Petch A. and M. Al-Rubeai ; (2004) 'Bcl-2 family' In: Cell Engineering IV. Dordrecht: Kluwer Academic Publishers. [Details] | |||||||||
| Mukwena N. T. and M. Al-Rubeai ; (2004) 'Apoptosis in hepatocytes' In: Cell Engineering IV. Dordrecht: Kluwer Academic Publishers. [Details] | |||||||||
| Ishaque A. and M. Al-Rubeai ; (2004) 'Monitoring of Apoptosis' In: Cell Engineering IV. Dordrecht: Kluwer Academic Publishers. [Details] | |||||||||
| Singh R. P. and M. Al-Rubeai ; (2000) 'Apoptosis and bioprocess technology' In: J. Anne, A. van Brekhoven and F. Shapiro (eds). Focus on Biotechnology, vol. 1, Biotechnology for Animal and Human Health. not avaliable: Kluwer Academic Publishers. [Details] | |||||||||
| Holmes P. and M. Al-Rubeai ; (2000) 'Cell cycle synchronization' In: R. E. Spier (eds). Encyclopaedia of Cell Technology. Not avaliable: John Wiley and Sons. [Details] |
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| Singh R. P. and M. Al-Rubeai ; (2000) 'Apoptosis and bioprocess technology' In: J. Anne, A. van Brekhoven and F. Shapiro (eds). Focus on Biotechnology, vol. 1, Biotechnology for Animal and Human Health. not avaliable: Kluwer Academic Publishers. [Details] | |||||||||
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Edited Books
| Merten O-W and Al-Rubeai M (Ed.). (2011) Viral Vectors for Gene Therapy: Methods and Protocols. Methods in Molecular Biology. New York: Humana Press. [Details] |
| Al-Rubeai M (Ed.). (2011) Antibody Expression and Production. Cell Engineering. Vol 7. Dordrecht: Springer. [Details] |
| M. Al-Rubeai (Ed.). (2009) Cell Engineering Vol. 6: Cell Line Development. Springer. [Details] |
| Mohamed Al-Rubeai and Martin Fussenegger (Ed.). (2007) Cell Engineering Vol. 5: Systems Biology. London: Springer. [Details] |
| Chaudhuri J. and M. Al-Rubeai (Ed.). (2007) Bioreactors for Tissue Engineering. Dordrecht: Springer. [Details] |
| Al-Rubeai M. and M. Fussenegger (Ed.). (2004) Cell Engineering. Vol. 4: Apoptosis. Dordrecht: Kluwer Scientific Publisher. [Details] | |||||||||
| Al-Rubeai M (Ed.). (2002) Cell Engineering. Vol. 3: Glycosylation. Dordrecht: Kluwer Scientific Publishers. [Details] | |||||||||
| Al-Rubeai M (Ed.). (2001) Cell Engineering. Vol. 2: Transient Expression. Dordrecht: Kluwer Scientific Publishers. [Details] | |||||||||
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Peer Reviewed Journals
| Tan F., Naciri M., Dowling D., Al-Rubeai M. (2012) 'In Vitro and In Vivo Bioactivity of CoBlast Hydroxyapatite Coating and the Effect of Impaction on its Osteoconductivity'. Biotechnology Advances, . [Details] |
| Tan F., O'Neill F., Naciri M., Dowling D., Al-Rubeai M. (2012) 'Cellular and transcriptomic analysis of human mesenchymal stem cell response to plasma-activated hydroxyaptite coating'. Acta biomaterialia, . [Details] |
| Kuystermans, Darrin; Al-Rubeai, Mohamed (2012) 'Current advances in applications of cell culture Introduction'. Methods, 56 (3):335-337. [DOI] [Details] |
| Kuystermans, Darrin; Mohd, Avesh; Al-Rubeai, Mohamed (2012) 'Automated flow cytometry for monitoring CHO cell cultures'. Methods, 56 (3):358-365. [DOI] [Details] |
| Lahoti, Varun; Murphy, William; Al-Rubeai, Mohamed (2012) 'Mathematical approach for the optimal expansion of erythroid progenitors in monolayer culture'. Journal of Biotechnology, 161 (3). [Details] |
| Tan, F., Naciri, M., Dowling, D.P. and Al-Rubeai, M.; (2011) 'In vitro and in vivo bioactivity of CoBlast hydroxyapatite coating and the effect of impaction on its osteoconductivity'. Biotechnology Advances, . [Details] | |||||||||
| Browne, SM,Al-Rubeai, M; (2011) 'Defining viability in mammalian cell cultures'. Biotechnology Letters, 33 :1745-1749. [DOI] [Details] | |||||||||
| Krampe, B,Fagan, A,Gaora, PO,Al-Rubeai, M; (2011) 'Chemostat-Based Transcriptional Analysis of Growth Rate change and Bcl-2 Over-Expression in NS0 Cells'. Biotechnology and Bioengineering, 108 :1603-1615. [DOI] [Details] | |||||||||
| Tan, F,Naciri, M,Al-Rubeai, M; (2011) 'Osteoconductivity and Growth Factor Production by MG63 Osteoblastic Cells on Bioglass-Coated Orthopedic Implants'. Biotechnology and Bioengineering, 108 :454-464. [DOI] [Details] | |||||||||
| Browne, SM,Al-Rubeai, M; (2011) 'Analysis of an Artificially Selected GS-NS0 Variant With Increased Resistance to Apoptosis'. Biotechnology and Bioengineering, 108 :880-892. [DOI] [Details] | |||||||||
| Kuystermans D., Dunn M. J. and Al-Rubeai M. ; (2010) 'A proteomic study of cMyc improvement of CHO culture'. BMC Biotechnology, 10 . [DOI] [Details] |
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| Boehm D., Murphy W. G. and Al-Rubeai M. ; (2010) 'The effect of mild agitation on in vitro erythroid development'. Journal of Immunological Methods, 360 :20-29. [Details] | |||||||||
| Krampe B and Al-Rubeai M. ; (2010) 'Cell death in mammalian cell culture: molecular mechanisms and cell line engineering strategies'. Cytotechnology, 62 (3):175-188. [Details] | |||||||||
| Browne S and Al-Rubeai M. ; (2010) 'Transcriptomic Analysis of an Artificially Selected GS-NS0 Variant with Increased Resistance to Apoptosis. Biotechnology and Bioengineering'. Biotechnology and Bioengineering, . [Details] | |||||||||
| Tan F., Naciri M. and Al-Rubeai M.; (2010) 'Osteoconductivity and Growth Factor Production by MG63 Osteoblastic Cells on Bioglass-coated Orthopaedic Implants. Biotechnology and Bioengineering'. Biotechnology and Bioengineering, . [Details] | |||||||||
| Ardhaoui, M,Naciri, M,Mullen, T,Brugha, C,Keenan, AK,Al-Rubeai, M,Dowling, DP; (2010) 'Cell Behaviour on Atmospheric Plasma Deposited Siloxane and Fluorosiloxane Coatings'. Science, 24 :889-903. [DOI] [Details] | |||||||||
| Boehm, D,Murphy, WG,Al-Rubeai, M; (2010) 'The effect of mild agitation on in vitro erythroid development'. Journal of Immunological Methods, 360 :20-29. [DOI] [Details] | |||||||||
| Ardhaoui, M., Naciri, M., Mullen, T., Brugha, C., Keenan, A., Al-Rubeai, M. and Dowling, D. P.; (2010) 'Evaluation of cell behaviour on atmospheric plasma deposited siloxane and fluorosiloxane coatings'. Journal of Adhesion Science and Technology, 24 (5):889-903. [Details] | |||||||||
| Khoo S. H. G. and Al-Rubeai M.; (2009) 'Detailed understanding of enhanced specific antibody productivity in NS0 myeloma cells'. Biotechnology and Bioengineering, 102 :188-199. [Details] | |||||||||
| Woolley J. F. and Al-Rubeai M; (2009) 'The application of SELDI-TOF mass spectrometry to mammalian cell culture'. Biotechnology Advances, 104 :590-600. [Details] | |||||||||
| Woolley J. F. and Al-Rubeai M ; (2009) 'The isolation and identification of a secreted biomarker associated with cell stress in serum-free CHO cell culture. Biotechnology and Bioengineering'. Biotechnology and Bioengineering, 104 :590-600. [Details] | |||||||||
| Sandhu K. S. and Al-Rubeai M.; (2009) 'The effect of Bcl-2, YAMA, and XIAP over-expression on apoptosis and adenovirus production in HEK293 cell line'. Biotechnology and Bioengineering, 104 :752-765. [Details] | |||||||||
| Boehm, D,Murphy, WG,Al-Rubeai, M; (2009) 'The potential of human peripheral blood derived CD34+cells for ex vivo red blood cell production'. Journal of Biotechnology, 144 :127-134. [DOI] [Details] | |||||||||
| Kuystermans D. and Al-Rubeai M.; (2009) 'cMyc increases cell number through uncoupling of cell division from cell size in CHO cells'. BMC Biotechnology, 9 . [Details] |
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| Khoo S. H. G. and Al-Rubeai M.; (2009) 'Metabolic characterization of a hyper-productive state in an antibody producing NS0 myeloma cell line'. Metabolic Engineering, 11 :199-211. [Details] | |||||||||
| Woolley, JF,Al-Rubeai, M; (2009) 'The Isolation and Identification of a Secreted Biomarker Associated With Cell Stress in Serum-Free CHO Cell Culture'. BIOTECHNOL BIOENG, 104 :590-600. [DOI] [Details] | |||||||||
| Sandhu, KS,Al-Rubeai, M; (2009) 'The Effect of Bcl-2, YAMA, and XIAP Over-Expression on Apoptosis and Adenovirus Production in HEK293 Cell Line'. BIOTECHNOL BIOENG, 104 :752-765. [DOI] [Details] | |||||||||
| Melero-Martin, JM,Santhalingam, S,Al-Rubeai, M; (2009) 'Methodology for Optimal In Vitro Cell Expansion in Tissue Engineering'. Stem, 112 :209-229. [DOI] [Details] | |||||||||
| Swiderek, H., Logan, A., Al-Rubeai, M., ; (2008) 'Cellular and transcriptomic analysis of NS0 cell response during exposure to hypoxia'. Journal of Biotechnology, 134 (1-2):103-111. [Details] | |||||||||
| Astley, K., Al-Rubeai, M., ; (2008) 'The role of Bcl-2 and its combined effect with p21(CIP1) in adaptation of CHO cells to suspension and protein-free culture'. Applied Microbiology and Biotechnology, 78 (3):391-399. [Details] | |||||||||
| Sandhu, K. S., Al-Rubeai, M., ; (2008) 'Monitoring of the adenovirus production process by flow cytometry'. Biotechnology Progress, 24 (1):250-261. [Details] | |||||||||
| Krampe, B., Swiderek, H., Al-Rubeai, M., ; (2008) 'Transcriptome and proteome analysis of antibody-producing mouse myeloma NS0 cells cultivated at different cell densities in perfusion culture'. Biotechnology and Applied Biochemistry, 50 :133-141. [Details] | |||||||||
| Naciri M., Kuystermans D., Al-Rubeai M.; (2008) 'Monitoring pH and dissolved oxygen in mammalian cell culture using optical sensors'. Cytotechnology, 57 :245-250. [Details] | |||||||||
| Swiderek, H., Al-Rubeai, M., ; (2008) 'Functional genome-wide analysis of antibody producing NSO cell line cultivated at different temperatures'. Biotechnology and Bioengineering, 100 (4):838-838. [Details] | |||||||||
| Kuystermans D, Krampe B, Swiderek H, Al-Rubeai M; (2007) 'Using cell engineering and omic tools for the improvement of cell culture processes'. Cytotechnology, 53 :3-22. [Details] | |||||||||
| Khoo, SHG, Falciani, F, Al-Rubeai, M, ; (2007) 'A genome-wide transcriptional analysis of producer and non-producer NS0 myeloma cell lines'. Biotechnology and Applied Biochemistry, 47 :85-95. [Details] | |||||||||
| Turner, P, Petch, A, Al-Rubeai, M, ; (2007) 'Encapsulation of viral vectors for gene therapy applications'. Biotechnology Progress, 23 :423-429. [Details] | |||||||||
| Turner, P., Petch, A., and Al-Rubeai, M. ; (2007) 'Encapsulation of viral vectors for gene therapy applications'. Biotechnology Progress, 23 (2):423-429. [Details] | |||||||||
| Majid, F. A. A., Butler, M., and Al-Rubeai, M.; (2007) 'Glycosylation of an immunoglobulin produced from a murine hybridoma cell line: The effect of culture mode and the anti-apoptotic gene, bcl-2'. Biotechnology and Bioengineering, 97 (1):156-169. [Details] | |||||||||
| Khoo, S.H.G. and Al-Rubeai, M. ; (2007) 'Metabolomics as a complementary tool in cell culture'. Biotechnology and Applied Biochemistry, 47 :71-84. [Details] | |||||||||
| Browne, S.M. and Al-Rubeai, M.; (2007) 'Selection methods for high-producing mammalian cell lines'. Trends in Biotechnology, 25 (9):425-432. [Details] | |||||||||
| Swiderek, H. and Al-Rubeai, M.; (2007) 'Functional genome-wide analysis of antibody producing NS0 cell line cultivated at different temperatures'. Biotechnology and Bioengineering, 98 (3):616-630. [Details] | |||||||||
| Sandhu, K.S., Naciri, M. and Al-Rubeai, M. ; (2007) 'Prediction of recombinant protein production in an insect cell-baculovirus system using a flow cytometric technique'. Journal of Immunological Methods, 325 (1-2):104-113. [Details] | |||||||||
| Astley, K., Naciri, M., Racher, A., and Al-Rubeai, M. ; (2007) 'The role of p21(cip1) in adaptation of CHO cells to suspension and protein-free culture'. Journal of Biotechnology, 130 (3):282-290. [Details] | |||||||||
| O'Connor, KC; Muhitch, JW; Lacks, DJ; Al-Rubeai, M; ; (2006) 'Modeling suppression of cell death by Bcl-2 over-expression in myeloma NSO 6A1 cells'. BIOTECHNOLOGY LETTERS, 28 (23):1919-1924. [Details] | |||||||||
| Naciri, M; Al-Rubeai, M; ; (2006) 'Non-invasive flow cytometric monitoring of pH(i) in cell culture processes using EGFP'. Journal of Immunological Methods, 315 (1-2):185-190. [Details] | |||||||||
| Warnock, JN; Merten, OW; Al-Rubeai, M; ; (2006) 'Cell culture processes for the production of viral vectors for gene therapy purposes'. CYTOTECHNOLOGY, 50 (1-3):141-162. [Details] | |||||||||
| Warnock, JN; Al-Rubeai, M; ; (2006) 'Bioreactor systems for the production of biopharmaceuticals from animal cells'. Biotechnology and Applied Biochemistry, 45 (NA):1-12. [Details] | |||||||||
| Melero-Martin, JM; Dowling, MA; Smith, M; Al-Rubeai, M; ; (2006) 'Optimal in-vitro expansion of chondroprogenitor cells in monolayer culture'. Biotechnology and Bioengineering, 93 (3):519-533. [Details] | |||||||||
| Crea, F; Sarti, D; Falciani, F; Al-Rubeai, M; ; (2006) 'Over-expression of hTERT in CHOK1 results in decreased apoptosis and reduced serum dependency'. Journal of Biotechnology, 121 (2):109-123. [Details] | |||||||||
| Melero-Martin, JM; Dowling, MA; Smith, M; Al-Rubeai, M; ; (2006) 'Expansion of chondroprogenitor cells on macroporous microcarriers as an alternative to conventional monolayer systems'. Biomaterials, 27 (15):2970-2979. [Details] | |||||||||
| Shah, D; Naciri, M; Clee, P; Al-Rubeai, M; ; (2006) 'NucleoCounter - An efficient technique for the determination of cell number and viability in animal cell culture processes'. CYTOTECHNOLOGY, 51 (1):39-44. [Details] | |||||||||
| Carroll S. and Al-Rubeai M; (2005) 'ACSD labelling and magnetic cell separation: a rapid method of separating antibody secreting cells from non-secreting cells'. Journal of Immunological Methods, 296 :171-178. [Details] | |||||||||
| Ifandi, V; Al-Rubeai, M; ; (2005) 'Regulation of cell proliferation and apoptosis in CHO-K1 cells by the coexpression of c-Myc and Bcl-2'. Biotechnology Progress, 21 (3):671-677. [Details] | |||||||||
| Tey, BT; Al-Rubeai, M; ; (2005) 'Protective effect of Bcl-2 in NS0 myeloma cell culture is greater in more stressful environments'. Biotechnology and Bioprocess Engineering, 10 (6):564-570. [Details] | |||||||||
| Veraitch, FS; Al-Rubeai, M; ; (2005) 'Enhanced growth in NSO cells expressing aminoglycoside phosphotransferase is associated with changes in metabolism, productivity, and apoptosis'. Biotechnology and Bioengineering, 92 (5):589-599. [Details] | |||||||||
| Tey, BT; Al-Rubeai, M; ; (2005) 'Effect of Bcl-2 overexpression on cell cycle and antibody productivity in chemostat cultures of myeloma NS0 cells'. Journal of Bioscience and Bioengineering, 100 (3):303-310. [Details] | |||||||||
| Melero Martin J. M., Smith M., Al-Rubeai M; (2004) 'Cryopreservation and in vitro expansion of chondroprogenitor cells isolated from the superficial zone of articular cartilage'. Biotechnology Progress, 21 :168-177. [Details] | |||||||||
| Bi Jing-Xiu, Shuttleworth J., Al-Rubeai M; (2004) 'Uncoupling of cell growth and proliferation results in enhancement of productivity in p21-arrested CHO cells'. Biotechnology and Bioengineering, 85 :741-749. [Details] | |||||||||
| Mukwena, NT; Al-Rubeai, M; ; (2004) 'Apoptosis and its suppression in hepatocytes culture'. Cytotechnology, 46 (2-3):79-95. [Details] | |||||||||
| Jarman-Smith R. F., Mannix C., Al-Rubeai M; (2004) 'Characterisation of tetraploid and diploid of Spodoptera frugiperda cell lines'. Cytotechnology, 44 :15-25. [Details] | |||||||||
| Turner P., Coombes A. G. A., Al-Rubeai M; (2004) 'Measuring the heterogeneity of protein loading in PLG microspheres using flow cytometry'. Journal of Controlled Release, 96 :193-205. [Details] | |||||||||
| Carroll S. and Al-Rubeai M.; (2004) 'The selection of high-producing cell lines using flow cytometry and cell sorting'. Expert Opinion on Biological Therapy, 4 (11):1821-1829. [Details] | |||||||||
| Tey B. T. and Al-Rubeai M; (2004) 'Suppression of apoptosis in perfusion culture of myeloma NS0 enhances cell growth but reduces antibody productivity'. Apoptosis, 9 (6):843-852. [Details] | |||||||||
| Afandi V. and M. Al-Rubeai ; (2003) 'Stable transfection of CHO cells with the c-myc gene results in increased proliferation rates, reduces serum dependency, and induces anchorage independence'. Cytotechnology, 41 :1-10. [Details] | |||||||||
| Ibara N., Watanabe S., Bi J-X., Shuttleworth J., Al-Rubeai M.; (2003) 'Modulation of cell cycle for enhancement of antibody productivity in perfusion culture of NS0 cells'. Biotechnology Progress, 19 :224-228. [Details] | |||||||||
| Watanabe S., J. Shuttleworth and M. Al-Rubeai ; (2002) 'Regulation of cell cycle and productivity in NS0 cells by the over-expression of p21CIP1'. Biotechnology and Bioengineering, 77 :1-7. [Details] | |||||||||
| McTaggart S. and M. Al-Rubeai ; (2002) 'Retroviral vectors for human gene delivery'. Biotechnology Advances, 20 :1-31. [Details] | |||||||||
| Gueret V., J. A. Negrete-Virgen, A. Lyddiat and M. Al-Rubeai ; (2002) 'Rapid titration of adenoviral infectivity by flow cytometry in batch culture of infected HEK293 cells'. Cytotechnology, 38 :87-97. [Details] | |||||||||
| Jarman-Smith R. F., S. J. Armstrong, C.J. Mannix and M. Al-Rubeai ; (2002) 'Chromosome instability in Spodoptera frugiperda Sf-9 cell line'. Biotechnology Progress, 18 :623-628. [Details] | |||||||||
| Tey B. T., R. P. Singh and M. Al-Rubeai ; (2002) 'Programme cell death- an overiew of apoptosis in cell culture'. Asia Pacific Journal of Molecular Biology & Biotechnology, 9 :79-106. [Details] | |||||||||
| Bratch K. and M. Al-Rubeai ; (2001) 'Culture of primary rat hepatocytes within a flat hollow fibre cassette for potential use as a component of a bioartificial liver support system'. Biotechnology Letters, 23 :137-141. [Details] | |||||||||
| McTaggart S. and M. Al-Rubeai ; (2001) 'Relationship between cell proliferation, cell cycle phase and retroviral vector production in FLYRD18 human packaging cells'. Biotechnology and Bioengineering, 76 :52-60. [Details] | |||||||||
| McTaggart S. and M. Al-Rubeai ; (2000) 'Effects of culture parameters on the production of retroviral vectors by a human packaging cell line'. Biotechnology Progress, 16 :859-865. [Details] | |||||||||
| Tey, B. T., R. P. Singh, L. Piredda, M. Piacentini and M. Al-Rubeai; (2000) 'Influence of bcl-2 over-expression on growth and productivity of a CHO cell line over-expressing a chimeric antibody'. Biotechnology and Bioengineering, 68 :31-43. [Details] | |||||||||
| Tey B. T., R. P. Singh, L. Piredda, M. Piacentini and M. Al-Rubeai; (2000) 'Bcl-2 mediated suppression of apoptosis in myeloma NS0 cultures'. Journal of Biotechnology, 79 :147-159. [Details] | |||||||||
| Lloyd D. R., P. Holmes, L. P. Jackson, A. N. Emery, M. Al-Rubeai; (2000) 'Cell size, cell cycle and specific productivity'. Cytotechnology, 34 :59-70. [Details] | |||||||||
| Harding C. L., D. R. Lloyd, C. M. McFarlane, M. Al-Rubeai ; (2000) 'Using the microcyte flow cytometer to monitor cell number, viability and apoptosis in mammalian cell culture'. Biotechnology Progress, 16 :800-802. [Details] | |||||||||
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Other Journals
| Warnock J. N., Price T., Slade A. Al-Rubeai M; (2004) 'Use of fluidized-bed bioreactor for the production of retroviral vectors for gene therapy applications' BioProcessing Journal 3 (5) :41-45. [Details] |
Conference Publications
| Al-Rubeai M. ; (2011) Cellular and molecular markers of productivity in mammalian cell culture 2nd International Conference on Biotechnology Engineering (ICBioE'11) Kuala Lumpur, [Details] |
| 452. Al-Rubeai M.; (2011) Life, stress and death in bioreactor Stem Cells Europe and BioProcessing, Biologics & Biotherapeutics Edinburgh Conference Centre, [Details] |
| Browne S. and Al-Rubeai M. ; (2010) The transcriptomic and metabolic signature of artificially selected cell lines Cell Culture Engineering XII Banff, Alberta, Canada, , 25-APR-10 - 30-APR-10 [Details] |
| Al-Rubeai M. Boehm D. Lahoti V ; (2010) Development of a reproducible system for production of human red blood cells from haematopoietic stem cells Cell Culture Engineering XII Banff, Alberta, Canada, , 25-APR-10 - 30-APR-10 [Details] |
| Al-Rubeai M.; (2010) In vitro expansion of stem and progenitor cells ESACT-UK 20th Annual Meeting Loughborough, UK, , 06-JAN-10 - 07-JAN-10 [Details] |
| Al-Rubeai M.; (2010) Exploitation of cell line heterogeneity for the selection of improved characteristics BioProcess International conference Vienna, , 19-MAY-10 - 20-MAY-10 [Details] | |||||||||
| Tan F., Naciri M., Dowling D., Al-Rubeai M ; (2010) Cellular and Molecular Analysis of Human Mesenchymal Stem Cell Attachment, Proliferation and Osteogenic Differentiation Supported by Plasma-activated Hydroxyapatite Coating 2nd International Conference on Cellular and Molecular Bioengineering , 02-AUG-10 - 04-AUG-10 [Details] | |||||||||
| Tan F., Naciri M., Dowling D., Al-Rubeai M ; (2010) The Effect of Impaction on the Osteoconductivity of Hydroxyapatite Coating Deposited by a Novel Process. 2nd International Conference on Cellular and Molecular Bioengineering 2nd International Conference on Cellular and Molecular Bioengineering Singapore, , 02-AUG-10 - 04-AUG-10 [Details] | |||||||||
| Tan F., Naciri M., Al-Rubeai ; (2010) In Vitro Osteoblastic Cell Activity on Bioglass-derived Bioceramic Surfaces Deposited by a Novel CoBlast Technique 14th International Biotechnology Symposium and Exhibition Rimini, Italy, , 14-SEP-10 - 18-SEP-10 [Details] | |||||||||
| Krampe, B. and Al-Rubeai, M. ; (2009) The Influence of the microenvironment on cell expansion, maturation and viability in ex vivo erythropoiesis of peripheral blood derived CD34+ cells 19th European Society for Animal Cell Culture (ESACT-UK) Annual Meeting Hinxton, [Details] | |||||||||
| Al-Rubeai M. ; (2009) Life, stress and death in the bioreactor Cell Line Development and Engineering [Details] | |||||||||
| Al-Rubeai M.; (2009) Expansion of stem cells for the production of red blood cells- The role of disposable bioreactors Disposable Biomanufacturing 2009: What is achievable now? London, , 12-NOV-09 [Details] | |||||||||
| Boehm D., Murphy W. G. and Al-Rubeai M.; (2009) The effect of cell crowdedness on ex vivo erythropoiesis of peripheral blood derived CD34+ cells Human pluripotent stem cells symposium Dublin, [Details] | |||||||||
| Krampe B. and Al-Rubeai, M.; (2009) Physiological and transcriptional response to reduced growth rate in NS0 chemostat culture 19th European Society for Animal Cell Culture (ESACT-UK) Annual Meeting Hinxton, UK, , 05-JAN-09 - 06-JAN-09 [Details] | |||||||||
| Boehm D., Murphy W., Al-Rubeai M. ; (2008) Ex-vivo production of red blood cells from peripheral blood derived CD34+ cells Cell Culture Engineering XI [Details] | |||||||||
| Boehm D., Murphy W., Al-Rubeai M. ; (2008) Ex-vivo production of human red blood cells from peripheral blood derived CD34+ cells Stem Cells Europe [Details] | |||||||||
| Al-Rubeai M.; (2008) Cell engineering strategy to improve stability, adaptation and growth of cell lines for bioproduction IV National Congress of Bioengineering, Izmir, Turkey [Details] | |||||||||
| Krampe B. and Al-Rubeai M. ; (2008) Transcriptional profiling of NS0-GS and NS0-Bcl-2 cells producing antibody at different steady states in chemostat culture Cell Culture Engineering XI [Details] | |||||||||
| Al-Rubeai M., Sandhu K., Naciri M.; (2008) Multiparametric flow cytometry for process monitoring and prediction of virus and protein expression Cell Culture Engineering XI [Details] | |||||||||
| Al-Rubeai M. ; (2008) Cell engineering strategy to improve stability, adaptation and growth of cell lines BioProcess International Conference [Details] | |||||||||
| Al-Rubeai M. ; (2008) In vitro expansion of chondroprogenitor cells in 2D and 3D culture XIIth BELACT meeting [Details] | |||||||||
| Krampe B. and Al-Rubeai M.; (2008) Transcriptome analysis of antibody producing NS0 cells in chemostat and perfusion cultures 7th European Symposium on Biochemical Engineering Science (ESBES7) [Details] | |||||||||
| Al-Rubeai M; (2008) Suppression of apoptosis Cell Line Development and Engineering [Details] | |||||||||
| Al-Rubeai M; (2007) Cell line development and cell engineering strategies for the production of biopharmaceuticals from mammalian cells 2nd Asian Biomanufacturing Conference. Kuala Lumpur, Malaysia [Details] | |||||||||
| Al-Rubeai M.; (2007) Cytometric methods in process development and manufacturing BioProduction 2007 [Details] | |||||||||
| Al-Rubeai M.; (2007) Cell engineering of apoptosis Optimizing Cell Culture Development, CHI's Third Annual Meeting Boston USA, [Details] | |||||||||
| Al-Rubeai M; (2007) Deciphering Increased Antibody Productivity in Proliferation-Arrested NS0 Myeloma Cells Biochemical Engineering XV: Engineering Biology from Biomolecules to Complex Systems Quebec Canada, [Details] | |||||||||
| Al-Rubeai M., Swiderek H. Krampe B; (2007) Quantatitive genomic and proteomic analysis of NS0 cells in high density perfusion cultures Biochemical Engineering XV: Engineering Biology from Biomolecules to Complex Systems Quebec Canada, [Details] | |||||||||
| Khoo S. H. G. and Al-Rubeai M; (2007) Toward a system-level understanding of increased specific productivity in proliferation arrested myeloma NS0 cells ESACT meeting Dresden, [Details] | |||||||||
| Kuystermans D. and Al-Rubeai M.; (2007) Differential protein expression induced by c-myc over-expression: proteomic analysis of a CHO cell line with increased proliferation capacity ESACT meeting Dresden, [Details] | |||||||||
| Swiderek H. and Al-Rubeai M.; (2007) Transcriptome analysis of the effect of hypothermia and hypoxia ESACT meeting Dresden, [Details] | |||||||||
| Krampe B., Swiderek H., Al-Rubeai M.; (2007) Transcriptome and proteome analysis of monoclonal antibody producing NS0 cells in high cell density perfusion culture ESACT meeting Dresden, [Details] | |||||||||
| Al-Rubeai M.; (2007) Cell engineering of industrial cell lines for bioprocessing 2nd Annual Cell Line development and Engineering Renaissance Penta Vienna, Austria, [Details] | |||||||||
| Shah D., Clee P., Boisen S., Al-Rubeai M; (2007) NucleoCounter ' An efficient technique for the determination of Cell Number and Viability in Animal Cell Culture Processes . In: Cell Technology for Cell Products. Springer, London. Smith R eds. 19th ESACT Meeting Harrowgate UK, , pp.535-538 [Details] |
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| Veraitch F. and Al-Rubeai M; (2007) The expression of the neo gene in GS-NS0 cells increases their proliferative capacity . In: Cell Technology for Cell Products. Springer, London. Smith R eds. 19th ESACT Meeting Harrowgate UK, , pp.157-162 [Details] |
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| Khoo G., Falciani F., Al-Rubeai M; (2007) Microarray analysis of metabolically engineered NS0 cell lines producing chimeric antibody . In: Cell Technology for Cell Products. Springer, London. Smith R eds. 19th ESACT Meeting Harrowgate UK, , pp.47-52 [Details] |
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| Astley K. L. and Al-Rubeai M; (2007) Adaptation without cell division? Enhanced adaptation to suspension and serum free culture by the co-expression of p21 and Bcl-2 . In: Cell Technology for Cell Products. Springer, London. Smith R eds. 19th ESACT Meeting , pp.107-110 [Details] |
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| Sandhu K. S. and Al-Rubeai M; (2007) Flow cytometry as a tool for process monitoring of virus-cell systems . In: Cell Technology for Cell Products. Springer, London. Smith R eds. 19th ESACT Meeting , pp.571-573 [Details] |
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| Clee P. and Al-Rubeai M; (2007) Media and cell manipulation approaches to the reduction of adaptation time in GS NS0 cell line . In: Cell Technology for Cell Products. Springer, London. Smith R eds. 19th ESACT Meeting , pp.381-383 [Details] |
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| Melero-Martin J., Santhalingam S., Al-Rubeai M; (2007) Large-scale expansion of cells for use as therapeutic agents . In: Cell Technology for Cell Products. Springer, London. Smith R eds. 19th ESACT Meeting Harrowgate UK, , pp.335-338 [Details] |
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| Ifandi V. and Al-Rubeai M; (2007) Influence of c-myc and bcl-2 co-expression on proliferation, apoptosis and survival of CHO cultures . In: Cell Technology for Cell Products. Springer, London. Smith R eds. 19th ESACT Meeting Harrowgate UK, , pp.217-220 [Details] |
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| Buckler A. and Al-Rubeai M; (2007) The effect of genetically modified insulin growth factor on cell proliferation and adenovirus productivity in serum free medium . In: Cell Technology for Cell Products. Springer, London. Smith R eds. 19th ESACT Meeting Harrowgate UK, , 05-JUN-05 - 08-JUN-05 , pp.619-622 [Details] |
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| Crea F., Sarti D., Falciani F., Al-Rubeai M.; (2007) Growth, Apoptosis and Functional Genomics Analysis of CHO-K1 Over-Expressing Telomerase . In: Cell Technology for Cell Products. Springer, London. Smith R eds. 19th ESACT Meeting Harrowgate UK, , pp.41-45 [Details] |
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| Krampe B. and Al-Rubeai M.; (2006) Transcriptomic and proteomic analysis of antibody producing NS0 cells cultivated in high density perfusion culture Global mRNA and protein expression analysis DCU Ireland, [Details] | |||||||||
| Al-Rubeai M. ; (2006) Applications of expression and metabolic profiling in cell culture Global mRNA and protein expression analysis DCU Dublin, [Details] | |||||||||
| Kuystermans D. and Al-Rubeai M.; (2006) Proteomic analysis of differential protein expression induced by c-Myc over-expression in CHO cells Global mRNA and protein expression analysis DCU Ireland, [Details] | |||||||||
| Swiderek H. and Al-Rubeai M; (2006) Transcriptome analysis of antibody producing NS0 cell line cultivated at sub-physiological temperatures Global mRNA and protein expression analysis DCU Ireland, [Details] | |||||||||
| Al-Rubeai M.; (2006) Cell line engineering for controlled proliferation and apoptosis Japanese Association for Animal Cell Technology Kyoto Japan, [Details] | |||||||||
| Al-Rubeai M.; (2006) Multiparametric flow cytometry for monitoring of animal cell processes and selection of high producers BioProduction: Process analytical technologies (PAT) for biologics Dublin Ireland, [Details] | |||||||||
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Published Reports
| Connellan, L. & 15 co-authors (Al-Rubeai, M.); (2005) Engineering a Knowledge Island 2020. Engineers Ireland, Dublin. [Details] |
Invited Seminars
| Al-Rubeai; (2010) QA system for Iraqi universities. Invited Seminars [Details] |
Workshops
| Al-Rubeai M.; (2011) Workshop on QA. Workshops [Details] |
| Al-Rubeai M.; (2011) Scientific Research in Iraq: Situation and Perspectives, Meeting of Core Group of Experts, UNESCO. Workshops [Details] |
| Al-Rubeai M. ; (2011) Quality Assurance Training Workshop Towards Self-Assessment of 12 Iraqi Engineering Colleges. Workshops [Details] |
| Al-Rubeai M. ; (2011) Workshop on Developing Skills in Research Methodology. University of Baghdad: Workshops [Details] |
| Al-Rubeai M.; (2011) Workshop on Cell Culture and Production of Biopharmaceuticals. Koya University: Workshops [Details] |
| Al-Rubeai M.; (2011) Workshop on Developing Skills in Research Methodology. Salahaddin University: Workshops [Details] | |||||||||
| Al-Rubeai M.; (2010) Workshop on Research skills at the Ministry of Science and Technology. Workshops [Details] | |||||||||
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Abstract
| Al-Rubeai M.; (2011) Workshop on Developing Skills in Research Methodology. Raparin University: Abstract [Details] |
Invited Lectures
| Al-Rubeai M.; (2010) Research strategy for Iraqi universities. Invited Lectures [Details] |
| Al-Rubeai M.; (2010) Iraqi universities in the 21st century. Kufa University: Invited Lectures [Details] |
Policy Contribution
| Al-Rubeai M.; (2011) Working group on quality assurance & accreditation. Ministry of Higher Education, Baghdad, Iraq: Policy Contribution [Details] |
| Al-Rubeai M.; (2011) Working group on quality assurance & accreditation. Ministry of Higher Education, KRG, Iraq: Policy Contribution [Details] |
Honours and Awards
| Year: 2008. Title: FIBiol |
| Year: 2009. Title: Donald Medal |
| Year: 2010. Title: FSB |
Associations
| Association: European Federation of Biotechnology (EFB), Function/Role: Member |
| Association: European Society for Animal Cell Technology- UK (ESACT-UK), Function/Role: Member |
| Association: European Cell Death Organisation (ECDO), Function/Role: Member |
| Association: Society for Biological Engineering (SBE), Function/Role: Member |
Patents
| Patent 9715495.9. : Packed-Bed Bioreactor |
| Patent 9819963.1. : Cell Screening and Selection |
| Patent 0113318.0. : Method of production of a protein |
| Patent 7439037B2 : Use of aminoglycoside resistance gene |
Conference Contributions
| Al-Rubeai M. ; (2009) Life, stress and death in the bioreactor. [Invited Lecture], Cell Line Development and Engineering, Berlin , 02-MAR-09 - 06-MAR-09. |
| Krampe B. and Al-Rubeai M.; (2008) Transcriptome analysis of antibody producing NS0 cells in chemostat and perfusion cultures. [Oral Presentation], 7th European Symposium on Biochemical Engineering Science (ESBES7), Faro, Portugal , 07-SEP-08 - 10-SEP-08. |
| M. Al-Rubeai; (2008) Conference. [Keynote Address], IV National Congress of Bioengineering, Izmir, Turkey , 15-OCT-08 - 18-OCT-08. |
| M. Al-Rubeai; (2008) Conference. [Invited Oral Presentation], XIIth BELACT meeting. 3D in vitro models: From nanotoxicology to drug delivery, Belgium , 16-MAY-08 - 16-MAY-08. |
| M. Al-Rubeai; (2008) Conference. [Invited Oral Presentation], BioProcess International conference, Vienna , 21-APR-08 - 22-APR-08. |
| M. Al-Rubeai; (2008) Conference. [Keynote Address], Cell Line Development and Engineering, Prague , 03-MAR-08 - 07-MAR-08. | |||||||||
| Boehm D., Murphy W., Al-Rubeai M.; (2008) Ex-vivo production of human red blood cells from peripheral blood derived CD34+ cells. [Oral Presentation], Stem Cells Europe, Amsterdam, The Netherlands , 01-SEP-08 - 03-SEP-08. | |||||||||
| M. Al-Rubeai; (2007) Conference. [Conference Technical Committee Chairperson], 2nd Asian Biomanufacturing conference, Kula Lumpur , 03-DEC-07 - 04-DEC-07. | |||||||||
| M. Al-Rubeai; (2007) Conference. [Invited Oral Presentation], Optimizing Cell Culture Development, Boston , 17-SEP-07 - 18-SEP-07. | |||||||||
| M. Al-Rubeai; (2007) Conference. [Invited Oral Presentation], BioProduction 2007, Hotel Palace Berlin, Germany , 30-OCT-07 - 31-OCT-07. | |||||||||
| Mohamed Al-Rubeai; (2006) Engineering Conferences International. [Invited Oral Presentation], Cell Culture Engineering X, Whistler, Canada , 23-APR-06. | |||||||||
| Mohamed Al-Rubeai; (2006) IBC conference. [Invited Oral Presentation], CELLutions Summit. Mammalian Cell Culture, Boston , 14-AUG-06. | |||||||||
| Mohamed Al-Rubeai; (2006) 1st International conference on Natural Resources, Engineering and Technology. [Keynote Address], 1st International conference on Natural Resources, Engineering and Technology, Putrajaya, Malaysia , 24-JUL-06 - 26-JUL-06. | |||||||||
| Mohamed Al-Rubeai; (2006) Informa conference. [Conference Organising Committee Member], Cell line development and engineering, Zurich , 23-MAY-06 - 24-MAY-06. | |||||||||
| M. Al-Rubeai; (2006) Conference. [Keynote Address], BioProduction, Dublin , 24-OCT-06 - 25-OCT-06. | |||||||||
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Committees
| Committee : Knowledge Island 2020 Task Force |
| Committee : Engineering Programme Board Member |
| Committee : Faculty of Engineering Research Committee |
| Committee : Research Committee for the (National Institute for Bioprocessing Research and Training, NIBRT) |
| Committee : Flow Cytometry Committee, Conway Institute of Biomolecular & Biomedical Research |
Employment
| Employer: Ministry of Higher Education, Iraq Position: Acting Minister |
| Employer: Iraqi Presidency Position: Honoury Advisor to the President of Iraq |
Education
| Year 1969 Institution: Baghdad University Qualification: BSc Subject: |
| Year 1979 Institution: University of London Qualification: PhD Subject: |
Consultancy
| Client: Sigma-Aldrwich |
| Client: Biotrin Ireland |
| Client: Vivalis |
Reviews
| Biotechnology And Bioengineering: Editor. |
| Cytotechnology: Editor. |
| Biotechnology And Applied Biochemistry: Editor. |
| Cell Engineering: Editor-in-Chief. |
Other Activities
| UNESCO advisor on high education, 2007- |
| Adjunct Professor, University of Birmingham, 2005- |
| Adjunct Professor, University of Queensland, 1997-2000 |
| Member of the panel for project evaluation, Science and Technology Foundation, Portugal |